Critical Factors Involved in Chronic Inflammation in the Pathophysiology of Endometriosis

Wan‐Ning Li
In: Adaptive Medicine · 2018 · vol. 10(1) , pp. 1–9 · doi:10.4247/am.2018.abi197 · W2802166510
article OA: closed CC0 ⤵ 1 in-corpus citation
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-29 ⓘ

This review discusses how inflammation-related factors, including cytokine imbalances and immune deficiencies, critically influence cell phenotypes and drive the chronic inflammation characteristic of endometriosis pathophysiology.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-28 · read from full text ⓘ

This review examines the role of chronic inflammation in the pathogenesis of endometriosis, highlighting how an imbalance of cytokines and deficient immune surveillance in the peritoneal cavity sustains the survival of ectopic cells. The authors detail how inflammatory factors drive phenotypic changes in both immune and endometriotic cells within the disease microenvironment, thereby facilitating disease progression. While the paper outlines these mechanisms as critical keys to development, it serves primarily as a conceptual overview rather than presenting new primary data. This paper is centrally about endometriosis — specifically focusing on the inflammatory mechanisms that drive its pathophysiology.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Chronic inflammation is the cause and effect in the pathogenesis of endometriosis. Characterized as an imbalance of various kinds of cytokines and deficient immune-surveillance in the peritoneal cavity, endometriosis creates its own system to maintain the survival of endometriotic cells outside of the uterus. Characteristics of the cells present in the microenvironment including immune cells and endometriotic cells have been changed by cytokines and other protein molecules, which are the critical keys that determine the development of the disease. In this review, we will focus on the effects from the inflammation-related factors on the phenotypic changes in cells in the pathogenesis of endometriosis to discuss.
Full text 738 characters · extracted from oa-doi-fallback · click to expand
- 期刊 - OpenAccess Chronic inflammation is the cause and effect in the pathogenesis of endometriosis. Characterized as an imbalance of various kinds of cytokines and deficient immune-surveillance in the peritoneal cavity, endometriosis creates its own system to maintain the survival of endometriotic cells outside of the uterus. Characteristics of the cells present in the microenvironment including immune cells and endometriotic cells have been changed by cytokines and other protein molecules, which are the critical keys that determine the development of the disease. In this review, we will focus on the effects from the inflammation-related factors on the phenotypic changes in cells in the pathogenesis of endometriosis to discuss.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (1)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK