Critical Factors Involved in Chronic Inflammation in the Pathophysiology of Endometriosis

Wan‐Ning Li
In: Adaptive Medicine · 2018 · vol. 10(1) , pp. 1–9 · doi:10.4247/am.2018.abi197 · W2802166510
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This review discusses how inflammation-related factors, including cytokine imbalances and immune deficiencies, critically influence cell phenotypes and drive the chronic inflammation characteristic of endometriosis pathophysiology.

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Abstract

Chronic inflammation is the cause and effect in the pathogenesis of endometriosis. Characterized as an imbalance of various kinds of cytokines and deficient immune-surveillance in the peritoneal cavity, endometriosis creates its own system to maintain the survival of endometriotic cells outside of the uterus. Characteristics of the cells present in the microenvironment including immune cells and endometriotic cells have been changed by cytokines and other protein molecules, which are the critical keys that determine the development of the disease. In this review, we will focus on the effects from the inflammation-related factors on the phenotypic changes in cells in the pathogenesis of endometriosis to discuss.
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- 期刊 - OpenAccess Chronic inflammation is the cause and effect in the pathogenesis of endometriosis. Characterized as an imbalance of various kinds of cytokines and deficient immune-surveillance in the peritoneal cavity, endometriosis creates its own system to maintain the survival of endometriotic cells outside of the uterus. Characteristics of the cells present in the microenvironment including immune cells and endometriotic cells have been changed by cytokines and other protein molecules, which are the critical keys that determine the development of the disease. In this review, we will focus on the effects from the inflammation-related factors on the phenotypic changes in cells in the pathogenesis of endometriosis to discuss.

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endometriosis

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