Adenomyosis and oxidative stress. Rationale for comprehensive approach to treatment of patients of reproductive age

A.I. Davydov, R. Chilova, V.A. Lebedev, M.B. Tairova
In: Voprosy ginekologii, akušerstva i perinatologii · 2021 · vol. 20(6) , pp. 155–161 · doi:10.20953/1726-1678-2021-6-155-161 · W4285530345
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that adenomyosis patients exhibited increased lipid peroxidation and decreased antioxidant protection, which improved significantly after organ-preserving endoscopy and drug therapy.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This paper analyzed lipid peroxidation and antioxidant defense in the blood serum of reproductive-age patients with adenomyosis, measuring conjugated dienes and malondialdehyde as oxidative stress markers alongside superoxide dismutase activity and alpha-tocopherol levels, and comparing them with a control group of patients with tubal infertility. Before treatment, adenomyosis patients had significantly higher conjugated dienes, malondialdehyde, superoxide dismutase, and alpha-tocopherol, while SOD activity was reported as almost 2-fold lower and MDA as 2-fold higher than normal values, indicating oxidative stress imbalance; the paper’s limitation is that it does not provide details on sample size or explicit randomization/blinding in the provided text. All patients received organ-preserving intrauterine endoscopy plus postoperative drug therapy, and combination treatment significantly shifted oxidative stress and antioxidant parameters toward control values, with reported improvement of more than 40% for conjugated dienes and superoxide dismutase. This paper is centrally about adenomyosis — it links adenomyosis-related oxidative stress biomarkers to outcomes after organ-preserving endoscopy and postoperative therapy.

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Abstract

The analysis of lipid peroxidation (LPO) and antioxidant protection (concentration of α-tocopherol and superoxide dismutase) in the blood serum of patients with adenomyosis was performed. The levels of conjugated dienes (CD), malondialdehyde (MDA), superoxide dismutase (SOD), and α-tocopherol were significantly higher prior to treatment (organ-preserving endoscopy + drug therapy) than those in the control group (patients with tubal infertility). At the same time, SOD activity was almost 2-fold lower, and MDA levels were 2-fold higher compared to the normal values. After surgery, progestogens, magnesium supplements, and indole-3-carbinol+resveratrol (1 tablet once a day for 3 months) were prescribed to all patients. After combination therapy, all the parameters of free radicals and antioxidant protection changed significantly: they did not reach the control values but were close to them to such an extent that the difference between the levels of MDA, CD, SOD, and α-tocopherol in the blood serum of patients in the control group and that of patients with adenomyosis was found to be insignificant. Moreover, the percentage of variation (improvement) of CD and SOD exceeded 40%. Conclusion. Under certain conditions, intrauterine endoscopy in combination with postoperative drug therapy can provide longterm relief of pathognomonic symptoms of adenomyosis. Key words: adenomyosis, reproductive age, antioxidant system, indole-3-carbinol+resveratrol

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adenomyosisinfertility

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last seen: 2026-06-10T17:14:06.276822+00:00
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