Continuous crystallisation in a superstat: Batch kinetics informed theoretical SOP

Continuous crystallisation in a superstat: Batch kinetics informed theoretical SOP | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Short Report Continuous crystallisation in a superstat: Batch kinetics informed theoretical SOP Mayank Vashishtha, Mahmoud Ranjbar, Gavin Walker, Vasanth Kumar Kannuchamy This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4190609/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Developing theory informed standard operating procedure (SOP) for the continuous crystallisation of pharmaceuticals remain a bottleneck. In this communication, we propose a theoretical background and mathematics for superstat based on which we developed the theoretical SOP for the continuous crystallisation of a model compound curcumin in isopropanol. Using the proposed theory, we identified the theoretical optimum dilution rate and the corresponding mass of curcumin crystallised in isopropanol and productivity at steady state conditions as a function of initial supersaturation. Additionally, we estimated the dilution rate that corresponds to the washout conditions or no crystallisation during the continuous manufacturing of crystals. Full Text Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4190609","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Short Report","associatedPublications":[],"authors":[{"id":286576464,"identity":"7f9dceac-1c7f-4145-8a07-0f438cd88ee4","order_by":0,"name":"Mayank Vashishtha","email":"","orcid":"","institution":"University of Limerick","correspondingAuthor":false,"prefix":"","firstName":"Mayank","middleName":"","lastName":"Vashishtha","suffix":""},{"id":286576465,"identity":"76226f72-f47d-4e13-bf09-34f5977ba928","order_by":1,"name":"Mahmoud Ranjbar","email":"","orcid":"","institution":"University of Limerick Faculty of Science and Engineering","correspondingAuthor":false,"prefix":"","firstName":"Mahmoud","middleName":"","lastName":"Ranjbar","suffix":""},{"id":286576466,"identity":"9d27fc25-0fc5-4b81-9a2d-2ab7fadbd60b","order_by":2,"name":"Gavin Walker","email":"","orcid":"","institution":"University of Limerick Faculty of Science and Engineering","correspondingAuthor":false,"prefix":"","firstName":"Gavin","middleName":"","lastName":"Walker","suffix":""},{"id":286576467,"identity":"85472675-0a2a-4bf6-ba96-9bb7cfea4642","order_by":3,"name":"Vasanth Kumar Kannuchamy","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABBElEQVRIiWNgGAWjYFACNghlACI+IEtIEKOFcQbJWph5iNFicIAt8XPhjsPy5uyn06Rt/hzON2/vMWD4UcOQOLMBp5bD0jPPHDbc2ZO7TTq37bDlnDNnDBh7jjEkzsZhi2QDe4M0b9vhBIMDIC0Nhw0kJHIMGHgbGBLn4dbS/Bus5fzbbdIWf4Ba5N8YMP7Fo4Wfge0YxJYbQFsY2EC28Bgwg2zB5TB+ZrY0a962dMMNN95utuxtSzeQ4EkrOCxzTMIYl/fZ2NuMb/O2WcsbnM/deOPHH2sDCfbDGx++qbGRnXEAhzXMCCYLNCY4DA7gi0gU3dD0wv6AKOWjYBSMglEwYgAAodFVsjeKf1wAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0003-4244-4542","institution":"University of Surrey Division of Civil Chemical and Environmental Engineering: University of Surrey Faculty of Engineering and Physical Sciences","correspondingAuthor":true,"prefix":"","firstName":"Vasanth","middleName":"Kumar","lastName":"Kannuchamy","suffix":""}],"badges":[],"createdAt":"2024-03-30 05:00:57","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4190609/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4190609/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":56818556,"identity":"76b51ad1-a401-4e07-b13a-8c450afc7fdf","added_by":"auto","created_at":"2024-05-20 23:41:49","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":464491,"visible":true,"origin":"","legend":"","description":"","filename":"finalv2chemicalpapers.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4190609/v1_covered_61b6e5b2-1356-45bf-b573-2874a56858f6.pdf"}],"financialInterests":"","formattedTitle":"Continuous crystallisation in a superstat: Batch kinetics informed theoretical SOP","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4190609/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4190609/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eDeveloping theory informed standard operating procedure (SOP) for the continuous crystallisation of pharmaceuticals remain a bottleneck. In this communication, we propose a theoretical background and mathematics for \u003cem\u003esuperstat\u003c/em\u003e based on which we developed the theoretical SOP for the continuous crystallisation of a model compound curcumin in isopropanol. Using the proposed theory, we identified the theoretical optimum dilution rate and the corresponding mass of curcumin crystallised in isopropanol and productivity at steady state conditions as a function of initial supersaturation. Additionally, we estimated the dilution rate that corresponds to the washout conditions or no crystallisation during the continuous manufacturing of crystals.\u003c/p\u003e","manuscriptTitle":"Continuous crystallisation in a superstat: Batch kinetics informed theoretical SOP","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-04-05 06:54:21","doi":"10.21203/rs.3.rs-4190609/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4743f34e-1646-4ea6-abb7-8ea50107ab55","owner":[],"postedDate":"April 5th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-05-20T23:33:39+00:00","versionOfRecord":[],"versionCreatedAt":"2024-04-05 06:54:21","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4190609","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4190609","identity":"rs-4190609","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}