Correlation Between Oscillometry and Spirometry Parameters in Assessing Pulmonary Function in Pediatric Pulmonary Tuberculosis Survivor

Correlation Between Oscillometry and Spirometry Parameters in Assessing Pulmonary Function in Pediatric Pulmonary Tuberculosis Survivor | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Correlation Between Oscillometry and Spirometry Parameters in Assessing Pulmonary Function in Pediatric Pulmonary Tuberculosis Survivor Fezia Tiffani Kartikaning Candra, Ahmedz Widiasta, Dany Hilmanto, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7779560/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 7 You are reading this latest preprint version Abstract Introduction : Despite successful treatment, pulmonary tuberculosis (TB) survivors often have lasting respiratory issues. Spirometry is the standard tool for assessing pulmonary function, but its utility is limited in pediatric populations due to cooperation challenges. Oscillometry offers a non-invasive alternative, yet its use in pediatric pulmonary TB survivor remains underexplored. This study evaluates the correlation between oscillometry and spirometry parameters in assessing pulmonary function among pediatric pulmonary TB survivors. Methods : A cross-sectional analytical study was conducted at Dr. Hasan Sadikin Hospital from January 2022 to April 2025. Pediatric pulmonary TB survivors aged between 5–<18 years underwent impulse oscillometry (PowerCube® ROS Box Ganshorn) to measure impedance (Z), resistance (R), reactance (X), resonance frequency (Fres), and reactance area (AX). Spirometry values included FEV1, FVC, and FEV1/FVC ratio. Pulmonary function patterns were categorized as normal, restrictive, obstructive, or mixed type. Pearson or Spearman correlation tests were used for analysis. Results : Forty-two subjects (66.7% female; mean age 15.93±4.15 years) completed oscillometry, and 34 of them underwent spirometry. The median duration following TB treatment was 17 months. Oscillometry identified restrictive patterns in 66.7% of subjects, whereas spirometry showed obstructive patterns in 35.3%, normal in 32.4%, restrictive in 20.6%, and mixed type in 11.8%. Significant negative correlations were found between R20 and FEV 1 (r = -0.413, p = 0.015), Z5 and FEV 1 (r = -0.458, p = 0.006), and Z5 and FVC (r = -0.419, p = 0.014). A positive correlation was observed between X5 and the FEV 1 /FVC ratio (r = 0.362, p = 0.035). Conclusion : In the population of pediatric pulmonary TB survivors, the results of oscillometry mostly showed pulmonary function with a restrictive pattern, while spirometry examinations provided an image of an obstructive pattern as the most frequent finding. Spirometry and several oscillometry parameters were significantly correlated in identifying respiratory limitation caused by prior pulmonary tuberculosis infection. Oscillometry Spirometry Pulmonary function test Tuberculosis Pediatric Pulmonary Tuberculosis Survivor Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Reviews received at journal 24 Nov, 2025 Reviewers agreed at journal 19 Nov, 2025 Reviewers invited by journal 12 Nov, 2025 Editor invited by journal 13 Oct, 2025 Editor assigned by journal 13 Oct, 2025 Submission checks completed at journal 13 Oct, 2025 First submitted to journal 04 Oct, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7779560","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":547793892,"identity":"e691fa6b-b97c-4ee8-af45-ea6e6fd54412","order_by":0,"name":"Fezia Tiffani Kartikaning Candra","email":"","orcid":"","institution":"Universitas Padjadjaran / Dr. Hasan Sadikin General Hospital","correspondingAuthor":false,"prefix":"","firstName":"Fezia","middleName":"Tiffani Kartikaning","lastName":"Candra","suffix":""},{"id":547793893,"identity":"1f09c13d-7195-43c1-8339-540b680c04bf","order_by":1,"name":"Ahmedz 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Survivor","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-pediatrics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bped","sideBox":"Learn more about [BMC Pediatrics](http://bmcpediatr.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bped/default.aspx","title":"BMC Pediatrics","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Oscillometry, Spirometry, Pulmonary function test, Tuberculosis, Pediatric Pulmonary Tuberculosis Survivor","lastPublishedDoi":"10.21203/rs.3.rs-7779560/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7779560/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eIntroduction\u003c/strong\u003e: Despite successful treatment, pulmonary tuberculosis (TB) survivors often have lasting respiratory issues. Spirometry is the standard tool for assessing pulmonary function, but its utility is limited in pediatric populations due to cooperation challenges. Oscillometry offers a non-invasive alternative, yet its use in pediatric pulmonary TB survivor remains underexplored. This study evaluates the correlation between oscillometry and spirometry parameters in assessing pulmonary function among pediatric pulmonary TB survivors.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: A cross-sectional analytical study was conducted at Dr. Hasan Sadikin Hospital from January 2022 to April 2025. Pediatric pulmonary TB survivors aged between 5–\u0026lt;18 years underwent impulse oscillometry (PowerCube® ROS Box Ganshorn) to measure impedance (Z), resistance (R), reactance (X), resonance frequency (Fres), and reactance area (AX). Spirometry values included FEV1, FVC, and FEV1/FVC ratio. Pulmonary function patterns were categorized as normal, restrictive, obstructive, or mixed type. Pearson or Spearman correlation tests were used for analysis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: Forty-two subjects (66.7% female; mean age 15.93±4.15 years) completed oscillometry, and 34 of them underwent spirometry. The median duration following TB treatment was 17 months. Oscillometry identified restrictive patterns in 66.7% of subjects, whereas spirometry showed obstructive patterns in 35.3%, normal in 32.4%, restrictive in 20.6%, and mixed type in 11.8%. Significant negative correlations were found between R20 and FEV\u003csub\u003e1\u003c/sub\u003e (r = -0.413, p = 0.015), Z5 and FEV\u003csub\u003e1\u003c/sub\u003e (r = -0.458, p = 0.006), and Z5 and FVC (r = -0.419, p = 0.014). A positive correlation was observed between X5 and the FEV\u003csub\u003e1\u003c/sub\u003e/FVC ratio (r = 0.362, p = 0.035).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: In the population of pediatric pulmonary TB survivors, the results of oscillometry mostly showed pulmonary function with a restrictive pattern, while spirometry examinations provided an image of an obstructive pattern as the most frequent finding. Spirometry and several oscillometry parameters were significantly correlated in identifying respiratory limitation caused by prior pulmonary tuberculosis infection.\u003c/p\u003e","manuscriptTitle":"Correlation Between Oscillometry and Spirometry Parameters in Assessing Pulmonary Function in Pediatric Pulmonary Tuberculosis Survivor","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-22 17:25:21","doi":"10.21203/rs.3.rs-7779560/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2025-11-24T16:35:54+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"53237731535191353614266256359485859643","date":"2025-11-19T12:49:51+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-11-12T07:15:31+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-10-13T11:54:54+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-10-13T08:44:39+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-10-13T08:40:57+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Pediatrics","date":"2025-10-04T11:17:25+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-pediatrics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bped","sideBox":"Learn more about [BMC Pediatrics](http://bmcpediatr.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bped/default.aspx","title":"BMC Pediatrics","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"e010eae1-7d99-4517-8999-347b751894d1","owner":[],"postedDate":"November 22nd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2025-11-22T17:25:22+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-22 17:25:21","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7779560","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7779560","identity":"rs-7779560","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}