Effects Of Chinese Materia Medica-Fubao Danggui Jiao On Experimental\nEndometriosis

Sun, Xing, Chen, Lijue, Zeng, Fanbo
2012 · W7009345209
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-16 ⓘ

Fubao Danggui Jiao (FDJ) treatment in rats significantly reduced endometriotic implant volumes and induced histological regression of implant tissue.

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This paper investigated the effects of a Chinese Materia Medica variant, Fubao Danggui Jiao (FDJ), on experimental endometriosis in a rat model. Endometrial tissue was auto-transplanted onto rats’ abdominal walls and allowed to grow for 30 days, after which forty endometriotic rats were randomized to receive water (negative control), FDJ at 2 or 4 ml/kg, or the reference drug danazol (70 mg/kg) for 30 days; implant volumes were measured and implants and normal uterine horns were examined histologically. FDJ significantly decreased the volumes of surviving endometriotic implants, with both FDJ doses showing statistically equivalent effects, and histology showed regression of the epithelium and stroma in the implants. The main caveat is that the findings are based on an experimental animal auto-transplantation model and reported comparative dosing effects without broader clinical context. This paper is centrally about endometriosis — it tests FDJ’s therapeutic effects on experimental endometriotic lesions in rats.

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Abstract

The objective of this paper was to investigate the effects of a Chinese\nMateria Medica variant -Fubao Danggui Jiao (FDJ)-on experimental\nendometriosis. An endometriosis model was created by virtue of\nauto-transplantation of endometrial tissue onto rats’ abdominal\nwalls. The implants were allowed to grow for 30 days until the\nsuccessful completion of the model. After that, forty endometriotic\nrats were randomly divided into four study groups and given different\ntreatments: (1) negative control group (water, 2ml/kg, per os); (2)\nFDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per\nos); (4) Danazol group (70mg/kg, per os). After 30 days with\ntreatments, the volumes of endometriotic implants in each rat were\nmeasured. The implants and normal uterine horns were removed for\nroutine histological examination. FDJ caused significant decreases in\nvolumes of the surviving endometriotic implants, with two different\ndoses having statistically equivalent effects. Upon histological\nexamination, FDJ was observed to cause regression of epithelium and\nstroma of endometriotic implants. FDJ had revealed promising\ntherapeutic effects on endometriosis.
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Abstract

Description The objective of this paper was to investigate the effects of a Chinese Materia Medica variant -Fubao Danggui Jiao (FDJ)-on experimental endometriosis. An endometriosis model was created by virtue of auto-transplantation of endometrial tissue onto rats’ abdominal walls. The implants were allowed to grow for 30 days until the successful completion of the model. After that, forty endometriotic rats were randomly divided into four study groups and given different treatments: (1) negative control group (water, 2ml/kg, per os); (2) FDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per os); (4) Danazol group (70mg/kg, per os). After 30 days with treatments, the volumes of endometriotic implants in each rat were measured. The implants and normal uterine horns were removed for routine histological examination. FDJ caused significant decreases in volumes of the surviving endometriotic implants, with two different doses having statistically equivalent effects. Upon histological examination, FDJ was observed to cause regression of epithelium and stroma of endometriotic implants. FDJ had revealed promising therapeutic effects on endometriosis.

Keywords

Fubao Danggui Jiao, Chinese Materia Medica, Endometriosis, Danazol Citation ISSN Related Outputs Items in TSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

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endometriosis

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