Estimated glomerular filtration rate and postoperative mortality in patients undergoing non-cardiac and non-neuron surgery: a single-center retrospective study

Estimated glomerular filtration rate and postoperative mortality in patients undergoing non-cardiac and non-neuron surgery: a single-center retrospective study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Estimated glomerular filtration rate and postoperative mortality in patients undergoing non-cardiac and non-neuron surgery: a single-center retrospective study Xueying Luo, Sujing Zheng, Baoer Liu, Liping Yang, Ya Li, Feng Li, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-25559/v3 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 06 Mar, 2021 Read the published version in BMC Surgery → Version 3 posted 4 You are reading this latest preprint version Show more versions Abstract Background： There is limited evidence to clarify the specific relationship between preoperative estimated glomerular filtration rate (preop-eGFR) and postoperative thirty-day mortality in Asian patients undergoing non-cardiac and non-neuron surgery. We aimed to investigate details of this relationship. Methods： We reanalyzed a retrospective analysis of the clinical records of 90,785 surgical patients at the Singapore General Hospital from January 1, 2012 to October 31, 2016. The main outcome was postoperative thirty-day mortality. Results ： The average age of these recruited patients was 53.96 ± 16.88 years, of which approximately 51.64% were female. The mean of preop-eGFR distribution was 84.45 ± 38.56mL/min/1.73m 2 . Multivariate logistic regression analysis indicated that preop-eGFR was independently associated with thirty-day mortality (adjusted odds ratio: 0.992; 95% confidence interval [CI]: 0.990-0.995; P < 0.001). A U-shaped relationship was detected between preop-eGFR and thirty-day mortality with an inflection point of 98.688(P for log likelihood ratio test <0.001). The effect sizes and confidence intervals on the right and left sides of the inflection point were 1.013 (1.007 to 1.019) [P < 0.0001] and 0.984 (0.981 to 0.987) [P < 0.0001], respectively. Preoperative comorbidities such as congestive heart failure (CHF), type 1 diabetes, ischemic heart disease (IHD),and anemia were associated with the odds ratio of preop-eGFR to thirty-day mortality (interaction P < 0.05). Discussion ：The relationship between preop-eGFR and thirty-day mortality is U-shaped. The recommended preop-eGFR at which the rate of the thirty-day mortality was lowest was 98.688mL/min/1.73m 2 . Surgery General Surgery Estimated glomerular filtration rate postoperative thirty-day mortality Surgery U-shaped curve Figures Figure 1 Figure 1 1. Background The unmet global burden of surgical disease is enormous [1] With the popularity of surgery, it is especially important to optimize the safety of the operation [2]. Thirty-day mortality is one of the most important indicators of perioperative mortality (POMR) and can be used to effectively indicate the safety of surgery and the risk of postoperative complications [3]. Preoperative renal dysfunction is a ac-knowledgeable risk factor for postoperative mortality, and the risk of patients with moderate to severe kidney insufficiency increases dramatically [2, 4]. Estimated glomerular filtration rate (eGFR), describing filtrate flow through the kidneys, is a universal surrogate indicator for assessing renal function. It has been widely used in the clinical diagnosis of chronic kidney disease (CKD) [5]. Studies have shown that preop-eGFR is a moderately effective predictor of thirty-day mortality in hospitalized surgical patients [4]. However, the current research population is mainly concentrated on patients who have undergone critical surgery such as cardiac surgery[6][7][8] [9][10] [11-14], lack of other surgeries. The ethnicity of these studies is also rarely related to Asians. Moreover, the current studies mainly focus on the relationship between preop-eGFR and perioperative mortality in patients with renal insufficiency [7][15], but several reports address high preop-eGFR levels or any other asymptomatic patient. Only Takashi Ui at.al made it clear among patients undergoing gastrointestinal malignancies that high preop-eGFR is associated with poor surgical outcomes, and also indicated a U-shaped relationship of preop-eGFR and thirty-day mortality [16] .However, data related to non-cardiac and non-neuron surgery are scarce. Our study was designed to explore the details of relationship between preop-eGFR and thirty-day mortality in Asian patients undergoing non-cardiac and non-neuron surgery. Not only limited to patients with renal insufficiency, but also in patients with high preop-eGFR. 2. Methods 2.1 Data source We downloaded the raw data from the DATADRYAD database ( www.datadryad.org ). As Diana Xin Hui Chan, et al. [20] have uploaded the original data and authorized the ownership to the website, we can perform secondary data analysis on this data to verify different scientific assumptions.(Dryad data package: Chan, Diana Xin Hui et al. (2018), Data from: Development of the Combined Assessment of Risk Encountered in Surgery (CARES) surgical risk calculator for prediction of post-surgical mortality and need for intensive care unit admission risk – a single-center retrospective study, Dryad, Dataset, https://doi.org/10.5061/dryad.v142481 ). 2.2 Study population It is important to note that Chan, Diana Xin Hui et al. [20]completed data collection. They conducted a single-center retrospective study at Singapore General Hospital, a 1,700-bed tertiary academic hospital [20]. These clinical data of all surgical patients from January 1, 2012 to October 31, 2016 were obtained from the clinical information system (Sunrise Clinical Manager, Allscripts, Illinois, USA) and stored in SingHealth-IHiS Electronic Health Information System (eHINTS), a data storage and analysis system. Based on exclusion criteria, the study recruited a total of 79,609 surgical cases [20]. Exclusion standards: (1) patients with no surgery performed; (2)patients undergoing cardiac surgery, neurosurgery, transplantation and burn surgery; (3) pediatric cases;(4) cases under local anesthesia;(5) cases under cadaveric harvesting; (6) cases with missing important variables. As the personal information of patients was anonymous, no informed consent was required. Details of ethical license can be found in the data source article [20]. 2.3 Measurement of preop-eGFR, thirty-day mortality and other covariates Variables of the database file included: demographic information; preoperative comorbidities；preoperative laboratory；perioperative blood transfusion data; anesthesia type ;priority of surgery ; surgical risk classification( based on the 2014 ESC/ESA guidelines on non-cardiac surgery[18][19]）;and postoperative thirty-day prognosis. Preoperative comorbidities consisted of anemia,CKD, and medical history [cerebrovascular accidents (CVA), ischemic heart disease (IHD), congestive heart failure (CHF),type1 diabetes].Those medical histories mentioned above were also associated with Revised Cardiac Risk Index (RCRI) score[17].The latest results of preoperative laboratory test were mainly about eGFR, red blood cell distribution width (RDW)(Levels above 15.7% were defined as high RDW ,as the normal reference range was 10.9% to 15.7% [22]), hemoglobin.We listed in detail the covariates used in this study. In short, inclusionary criteria were the following: (1) demographic data; (2) variables that can affect preop-eGFR or thirty-day mortality reported by previous literature [20]; (4) based on our clinical experiences.The most important outcome was postoperative thirty-day mortality, including deaths from the date of surgery to one month later[3].As this is a retrospective study, reducing the possibility of selection bias and observation bias. 2.4 Statistical analysis In data analysis, we represented continuous variables as median (quartile) (skewed distribution) or mean ± standard deviation (normal distribution), and categorical variables as a percentage or frequency. In the process of multivariate regression analysis, there are some confounders with partial missing data. If it is a categorical variable, the missing data would be treated directly as a new independent group; if it is a continues variable, the missing data would be replaced with an average or median value. We use Kruskal-Wallis H test (skewed distribution), one-way ANOVA (normal distribution) or χ2 (categorical variables)to calculate differences between different preop-eGFR group. Our study supposed to figure out the specific relationship between preop-eGFR and postoperative thirty-day mortality (linear or non-linear), and then find out variables interfering with or modifying the relationship between them. After excluding the effects of these potential modifiers and confounders, the independent effect of preop-eGFR on postoperative thirty-day mortality can be determined. Based on analytical principles mentioned above, univariate and multiple linear regression models were used to assess relationships with preop-eGFR and postoperative thirty-day mortality. Three models(an unadjusted model, a demographically adjusted model, and a fully-adjusted model) were constructed according to the STROBE statement[24].As for the fully-adjusted model, those adjusted variables, reported in previous studies, are related covariates that may affect preop-eGFR and/or thirty-day mortality [22][20].Moreover, subgroup analyses were performed by stratified linear regression models. Subgroup interaction test was performed to verity the effect modification by subgroup and then a likelihood ratio test was conducted. The following sensitivity analysis was performed in our research to ensure that the results of the data analysis were reliable. Firstly, the continuous variable preop-eGFR was converted into a categorical one by quartile to observe the possibility of nonlinearity. Secondly, if a nonlinear relationship exited between preop-eGFR and postoperative thirty-day mortality, it would be processed using a generalized additive model. Thirdly, we measured the threshold effect of preop-eGFR on the thirty-day mortality rate via a two-segment linear regression model based on a smoothing graph, determined the saturation of preop-eGFR by a recursive algorithm, and then detected the inflection point to obtain the maximum model likelihood. Based on the p-value of the log-likelihood ratio test, the best-fit model can be determined. All the analyses were performed with the statistical software packages R (The R Foundation,http://www.r-project.org) and EmpowerStats (X&Y Solutions, Inc., Boston, MA, http://www.empowerstats.com). P-value＜0.05 was considered statistically significant. 3. Results 3.1 The selection of participants The original data(N=90,785) for this study was recruited according to exclusion standards by Diana Xin Hui Chan, at al[20]. The missing data on preop-eGFR and thirty-day mortality was about 10830 cases. And after excluding patients with preop-eGFR outliers[25](N=346), 79 609 cases were included to our study（shown in Schedule1）. 3.2 Baseline characteristics of participants Baseline characteristics of the 79,609 participants based on the quartiles of preop-eGFR are shown in Table 1. Overall, the average age of all patients participating in the study was 54.01 ± 16.86 years old, of which approximately 48.47% were male. The participants’ preop-eGFR distribution was mean 84.45±38.56 (min 2.004, max 206.225). The thirty-day postoperative death in the study population was 506 cases (0.64%). The numbers of participants with missing data for each variable are shown in Table 1.Compared with participants with lower preop-eGFR (Q1-Q3),highest preop-eGFR was significantly positively correlated with females, younger age transfusion, emergency surgery, general anesthesia, comorbidities, but lower rate of Chinese (All P-values< 0.001). There were also statistically differences in anemia and RDW with different preop-eGFR. When the intermediate level of preop-eGFR (Q2-3) was reached, the patient was more likely to have none anemia and RDW ≤15.7% (P-value < 0.001). 3.3 Univariate and multivariate analysis Univariate analysis results were seen in Table 2.These results indicates that age, transfusion rate frequency, anemia, priority of surgery, surgical risk ,RDW and comorbidities(CVA, IHD, CHF, DM on insulin) was correlated with higher thirty-day mortality(All P-values 0.05), whereas preop-eGFR and female were related to thirty-day mortality with a statistically significant negative correlation(All P-values< 0.05). The results of univariate and multivariate linear regression models are shown in Table 3. The unadjusted model showed a thirty-day mortality reduction of 1.8% for each additional preop-eGFR unit (95% CI: 0.979, 0.984).It also illustrates different kinds of adjusted model including minimally-adjusted, fully-adjusted model. Compared to the unadjusted model (OR = 0.982, 95% CI: 0.979, 0.984), the preop-eGFR in the minimal adjustment model (only adjusted for age, sex, and race) still negatively related to the thirty-day mortality (OR = 0.983, 95% CI: 0.980, 0.986).In the fully-adjusted model, preop-eGFR significantly functioned as the same but with a little increase in the effect size (OR =0.992, 95% CI: 0.990, 0.995). In the sensitivity analysis, we converted preop-eGFR to a categorical variable classified by quartile to observe P of trend (Table 3).Compared to the reference group(Q1),the effect size of preop-eGFR on thirty-day mortality in group Q3 (preop-eGFR:96.68±4.67)was the smallest among different adjusted model. For instance, in the fully- adjusted model, the effect size of group Q2,Q3 and Q4 were 0.520, 0.356, 0.616 respectively, compared with group(Q1).This kind of non-equidistant changes in effect size indicated a non-linear relationship between preop-eGFR with thirty-day mortality. 3.4 The analyses of non-linear relationship Figure 1 shows the U-shaped non-linear correlation between preop-eGFR and postoperative thirty-day mortality. This non-linear relationship was verified by smooth curve of the generalized additive model. And the P-value of the log likelihood ratio test is less than 0.05 in table 4,which further indicates the two-part linear regression model should be used to fit the relationship, rather than the linear regression model (through linearly fitting) .The inflection point was calculated to be 98.688 by a two-part linear regression model and a recursive algorithm. On the left side of the inflection point, preop-eGFR is one of the independently protective factors of thirty-day mortality (OR=0.984, 95% CI: 0.981 to 0.987, P <0.0001). While on the right side, it acts as a risk factor (OR=1.013, 95% CI: 1.007 to 1.019, P <0.0001). 3.5 The results of subgroup analyses and interaction analysis As is shown in Table 5, the interaction test was significant for patients comorbidities, as DM, CHF, IHD or anemia (P=0.0397, 0.0357, 0.0168,＜0.0001 for interaction, respectively), while the interaction of other covariates was not statistically significant (interaction P value is greater than 0.05). Under the influence of preoperative comorbidities, such as CHF, DM and IHD, the effect of preop-eGFR on the thirty-day postoperative mortality gradually increased. For patients with CHF, an increase of the preop-eGFR unit related to a 1.2% reduction in thirty-day mortality (0.988 (0.984, 0.992)). Without CHF, there’s decreased by 0.5% for each additional unit of Preop-eGFR (0.995 (0.992, 0.998)). The same trend is also observed in in patients with DM (1.3% reduction of thirty-day mortality with DM vs. 0.5% reduction without DM) and IHD (0.9% with IHD vs. 0.4% without IHD). However, the opposite trend was seen in people with anemia. For patients without anemia, an increase unit of preop-eGFR would cost a 2.3% reduction in thirty-day mortality (0.977, 95%CI: 0.971, 0.984). For patients with anemia, the thirty-day mortality was decresaed by 0.5% with each additional unit of preop-eGFR. 4. Discussion In this study, we confirmed an independent nonlinear relationship between preop-eGFR and postoperative thirty-day mortality. A stable U-shaped trend can be seen in this relationship. When preop-eGFR≤98.688 mL/min/1.73m 2 , the thirty-day mortality would be decreased by 1.6% for each additional unit of Preop-eGFR. While preop-eGFR > 98.688 mL/min/1.73m 2 ,there would be a 1.3% increase of thirty-day mortality rate for each additional unit of preop-eGFR. CHF, DM, IHD and anemia complications (CHF, DM, IHD acting as a promoting factor, while anemia as an inhibitory factor) interfere with the effect of preop-eGFR on postoperative thirty-day mortality. Previous studies have also supported the hypothesis that preop-eGFR is a powerful and independent predictor of thirty-day morbidity risk after surgery [4, 10, 13, 26-27][15][16, 26]. Even in some literature reports, preop-eGFR is the strongest predictors of posttransplant survival [26]. Preop-eGFRs is a important indicator of many adverse surgical outcomes[16], as acute kidney injury, significantly related to higher mortality. At the same time, DM, IHD, CVF, and blood transfusion also are risk factors for poor postoperative prognosis [6]. The current research population is mainly concentrated in transplant [26], cardiac [10, 13] and neuro[14] surgery. There is still a lack of research on other surgery. There are two articles that define the study population as non-cardiac surgery patients. Jacek B. Cywinski, at al evaluated 92,888 patients undergoing non-cardiac surgery, and confirmed preop-eGFR is a scientifically feasible predictor of postoperative thirty-day mortality [4].J. R. Prowle et al. reported that significantly increases the risk of death after non-cardiac surgery, according to the data of 36 779 cases[2]. Previous studies mostly focused on the patients of renal insufficiency to verify the important regulatory role of preop-eGFR[12-13, 15]. High preop-eGFR levels have also been connected with greater mortality among nonsurgical patients indicating a potential U-shaped association of preop-eGFR with poor prognosis [28-30]. A recent study revealed the association of the specific trend between preop-eGFR and thirty-day mortality in patients undergoing surgery for gastrointestinal malignancies, without clarifying the inflection point[16]. In addition, the current research population is mainly Europeans and Americans, and rarely Asians. To our best knowledge, it is the first time that the specific U-shaped relationship between preop-eGFR and postoperative thirty-day mortality has been clearly identified in Asian patients undergoing non-cardiac and non-neuro surgery, ranging from minor day cases to major surgeries. Strengths of our study are mentioned as follows: firstly, the generalized additive model was used to evaluate non-linear relations, instead of using the generalized linear model to illustrate the linear relationship only. Secondly, as an observational study, there were some unavoidable potential confounders included in this study. In order to minimize residual confounding, strict statistical adjustment was performed. What’s more, effect modifier factor analysis ameliorates the use of data. Sensitivity analysis was performed of these data to ensure reliability. The findings of this study should be helpful for reducing the risk of postoperative death. The preop-eGFR at which the rate of the perioperative Mortality was lowest was 98.688. It suggests that regulation of preop-eGFR can effectively reduce perioperative mortality, especially with CHF, DM, IHD comorbidities. While has comorbid anemia, it also becomes quite important to control anemia for reducing mortality. This study has several acknowledged limitations. First, as for our study is a secondary analysis based on the published data, we cannot exclude some residual and/or unmeasured confounders (such as socioeconomic factors and inflammatory markers), that may bias the estimated relationship. Secondly, the study population, which only included Asian patients, can be further expanded to conduct multi-center research to increase the reliability of the data. Our choice of outcomes and variables is also limited. We could not investigate the relationship between preop-eGFR with long-term outcomes. What’s more, when it comes to high preop-eGFR, the results would be much more accurate formula based on cystatin C, instead of basing on creatinine. However, cystatin C haven’t be widely used in clinical practice right now[31]. 5. Conclusion In patients undergoing non-cardiac and non-neurological surgery, the level of preop-eGFR is associated with operative adverse events in a U-shape trend. The preop-eGFR with the lowest perioperative mortality was 98.688. CHF, DM, IHD and anemia comorbidities (CHF, DM, IHD as a promoting factor, anemia as an inhibitor) interfere with the effect of preop-eGFR on postoperative thirty-day mortality. List Of Abbreviations Preop-eGFR: preoperative estimated Glomerular Filtration Rate; CHF：Congestive Heart Failure； IHD：Ischemic Heart Disease； DM：Diabetes Mellitus； OR：Odds Ratio； CI：Confidence Interval； POMR：Perioperative Mortality； CKD：Chronic Kidney Disease；CARES：Combined Assessment of Risk Encountered in Surgery；RCRI score：Revised Cardiac Risk Index Score；RDW：Red Cell Distribution Width；eHINTS：SingHealth-IHiS Electronic Health Information System；RP：Renal Group；RBC：Red Blood Cell； FBC：Full Blood Count； MDRD：Modification of Diet in Renal Disease；WHO：World Health Organization； KDIGO：Kidney Disease: Improving Global Outcomes； ANOVA：Analysis of Variance；STROBE：Strengthening the Reporting of Observational Studies in Epidemiology；Q1-4：Quartile 1-4；GAM：Generalized Additive Model；CARES：Combined Assessment of Risk Encountered in Surgery Declarations Ethics approval and consent to participate In the previously published article, Diana Xin Hui Chan, et al. has clearly stated that: the study was conducted in accordance with the Declaration of Helsinki. Since the study was based on a secondary analysis of past data and the patient's personal information in the original data was anonymous, there was no need for informed consent from the participants. The ethical license has been elaborated in the published paper. Consent for publication Not applicable. Availability of data and materials The raw data can be downloaded from the website ( www.Datadryad.org ) of ‘Datadryad’ database. Competing interests The authors declare that they have no competing interests. Funding This work was supported by Shenzhen science and technology innovation international cooperation projects(with University of Minnesota cooperation) [grant numbers GJHZ20180928115030292];Sanming Project of Medicine in Shenzhen [grant numbersSZSM201612010];Shenzhen Key Medical Discipline Construction Fund [No.SZXK017]; Shenzhen High-level Hospital Construction Fund;but the funders had no role in study design,data collection and analyasis,decision to publish,or preparation of the manuscript.The article-processing charges was supported by the funders. Authors' contributions X Y L . : Conceptualization; Data curation; Formal analysis; Investigation; Roles/Writing - original draft;SJ Z :Conceptualization; Data curation; Formal analysis;extracted the data from the MIMIC-III database;BEL,FL and RG : Data curation; Formal analysis; Investigation; Software; LPY: Supervision; Validation; Visualization;YL and HFH : Formal analysis;Project administration;Writing - review & editing. 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[28] Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis, The Lancet, 375 (2010) 2073-2081. [29] M. Tonelli, S.W. Klarenbach, A.M. Lloyd, M.T. James, A.K. Bello, B.J. Manns, B.R. Hemmelgarn, Higher estimated glomerular filtration rates may be associated with increased risk of adverse outcomes, especially with concomitant proteinuria, KIDNEY INT, 80 (2011) 1306-1314. [30] K. Matsushita, B.K. Mahmoodi, M. Woodward, J.R. Emberson, T.H. Jafar, S.H. Jee, K.R. Polkinghorne, A. Shankar, D.H. Smith, M. Tonelli, D.G. Warnock, C. Wen, J. Coresh, R.T. Gansevoort, B.R. Hemmelgarn, A.S. Levey, F.T. Chronic Kidney Disease Prognosis Consortium, Comparison of Risk Prediction Using the CKD-EPI Equation and the MDRD Study Equation for Estimated Glomerular Filtration Rate, JAMA, 307 (2012). [31] A.S. Levey, C. Becker, L.A. Inker, Glomerular Filtration Rate and Albuminuria for Detection and Staging of Acute and Chronic Kidney Disease in Adults, JAMA, 313 (2015) 837. Tables Table 1 Baseline characteristics of participants Preop-eGFR (quartile) Q1 (31.61 ± 18.07) Q2 ( 78.69 ± 6.52 ) Q3 ( 96.68 ± 4.67 ) Q4 ( 130.78 ± 20.86 ) P-value N(cases) 19901 19882 19915 19911 Age year 57.72 ± 17.41 59.96 ± 14.04 52.26 ± 15.56 46.08 ± 16.75 <0.001 SEX n(%) <0.001 MALE 9535 (47.91%) 11493 (57.81%) 10334 (51.89%) 7199 (36.16%) female 10366 (52.09%) 8389 (42.19%) 9581 (48.11%) 12712 (63.84%) Race n(%) <0.001 Chinese 14592 (73.33%) 14943 (75.16%) 14403 (72.32%) 14005 (70.34%) Indian 1540 ( 7.74%) 1602 ( 8.06%) 1809 ( 9.08%) 1875 ( 9.42%) Malay 2166 (10.88%) 1679 ( 8.44%) 1748 ( 8.78%) 1970 ( 9.89%) Others 1601 ( 8.05%) 1658 ( 8.34%) 1955 ( 9.82%) 2060 (10.35%) POSTOP-TRANSFUSION WITHIN 30DAYS <0.001 0 units 19505 (98.01%) 19752 (99.35%) 19815 (99.50%) 19647 (98.67%) 1 unit 244 ( 1.23%) 81 ( 0.41%) 74 ( 0.37%) 177 ( 0.89%) 2 or more units 152 ( 0.76%) 49 ( 0.25%) 26 ( 0.13%) 87 ( 0.44%) INTRAOP-TRANSFUSION <0.001 0 units 18163 (91.27%) 18985 (95.49%) 19184 (96.33%) 18629 (93.56%) 1 unit 1738 ( 8.73%) 897 ( 4.51%) 731 ( 3.67%) 1282 ( 6.44%) PREOP-TRANSFUSION WITHIN 30DAYS <0.001 0 units 19142 (96.19%) 19551 (98.34%) 19683 (98.84%) 19484 (97.86%) 1 unit 374 ( 1.88%) 186 ( 0.94%) 140 ( 0.70%) 241 ( 1.21%) 2 or more units 385 ( 1.93%) 145 ( 0.73%) 92 ( 0.46%) 186 ( 0.93%) ANEMIA.CATEGORY n(%) <0.001 none 11532 (57.95%) 15561 (78.27%) 16381 (82.25%) 14309 (71.86%) mild 3887 (19.53%) 2738 (13.77%) 2197 (11.03%) 2939 (14.76%) moderate and severe 4438 (22.30%) 1540 ( 7.75%) 1287 ( 6.46%) 2611 (13.11%) NA 44 ( 0.22%) 43 ( 0.22%) 50 ( 0.25%) 52 ( 0.26%) priority of surgery n(%) <0.001 Elective 14929 (75.02%) 16786 (84.43%) 16713 (83.92%) 15155 (76.11%) Emergency 4972 (24.98%) 3096 (15.57%) 3202 (16.08%) 4756 (23.89%) anesthesia type n(%) <0.001 ga 15803 (79.41%) 16384 (82.41%) 17453 (87.64%) 17715 (88.97%) ra 4098 (20.59%) 3498 (17.59%) 2462 (12.36%) 2196 (11.03%) surgical risk <0.001 Low 9925 (49.87%) 10165 (51.13%) 10705 (53.75%) 10079 (50.62%) Moderate 8962 (45.03%) 8892 (44.72%) 8599 (43.18%) 9047 (45.44%) High 1014 ( 5.10%) 825 ( 4.15%) 611 ( 3.07%) 785 ( 3.94%) RDW n(%) <0.001 RDW ≤ 15.7% 17300 (87.38%) 18448 (93.27%) 18377 (92.73%) 17368 (87.66%) RDW ＞ 15.7% 2498 (12.62%) 1332 ( 6.73%) 1440 ( 7.27%) 2444 (12.34%) CVA CATEGORY <0.001 no 13231 (66.48%) 13348 (67.14%) 13771 (69.15%) 13558 (68.09%) yes 640 ( 3.22%) 481 ( 2.42%) 211 ( 1.06%) 168 ( 0.84%) NA 6030 (30.30%) 6053 (30.44%) 5933 (29.79%) 6185 (31.06%) IHD CATEGORY <0.001 no 11914 (59.87%) 12581 (63.28%) 13314 (66.85%) 13264 (66.62%) yes 1890 ( 9.50%) 1205 ( 6.06%) 616 ( 3.09%) 406 ( 2.04%) NA 6097 (30.64%) 6096 (30.66%) 5985 (30.05%) 6241 (31.34%) CHF ATEGORY <0.001 no 13934 (70.02%) 14269 (71.77%) 14399 (72.30%) 14022 (70.42%) yes 489 ( 2.46%) 147 ( 0.74%) 64 ( 0.32%) 70 ( 0.35%) NA 5478 (27.53%) 5466 (27.49%) 5452 (27.38%) 5819 (29.23%) DMINSULIN CATEGORY <0.001 no 13235 (66.50%) 13932 (70.07%) 14134 (70.97%) 13670 (68.66%) yes 1074 ( 5.40%) 340 ( 1.71%) 195 ( 0.98%) 301 ( 1.51%) NA 5592 (28.10%) 5610 (28.22%) 5586 (28.05%) 5940 (29.83%) RCRI.SCORE <0.001 I 8549 (42.96%) 10605 (53.34%) 11564 (58.07%) 10864 (54.56%) II 3571 (17.94%) 2935 (14.76%) 2351 (11.81%) 2727 (13.70%) III 1376 ( 6.91%) 520 ( 2.62%) 237 ( 1.19%) 238 ( 1.20%) IV 685 ( 3.44%) 100 ( 0.50%) 43 ( 0.22%) 41 ( 0.21%) NA 5720 (28.74%) 5722 (28.78%) 5720 (28.72%) 6041 (30.34%) thirty-day mortality n(%) <0.001 no 19587 (98.42%) 19800 (99.59%) 19880 (99.82%) 19836 (99.62%) yes 314 ( 1.58%) 82 ( 0.41%) 35 ( 0.18%) 75 ( 0.38%) Abbreviations : GA, general anesthesia ;RA, regional anesthesia ;Preop-eGFR ,preoperative estimated glomerular filtration rates; RDW, red cell distribution; NA, not available; CVA, cerebrovascular accidents; IHD, ischemic heart disease; CHF, congestive heart failure; DM, diabetes mellitus requiring insulin therapy ； Preop ， preoperative; Intraop, intraoperative; Postop, postoperative; RCRI , Revised Cardiac Risk Index ; ASA, American Society of Anesthesiologists . Table2 Effects of risk factors of thirty-day mortality Preop-eGFR (quartile) Statistics OR 95%CI P value Age mean (std), year 53.96 ± 16.88 1.07 (1.06, 1.08) <0.0001 SEX n(%) MALE 38666 (48.36%) 1.0 female 41289 (51.64%) 0.69 (0.58, 0.82) <0.0001 Race n(%) Chinese 58170 (72.76%) 1.0 Indian 6860 (8.58%) 0.91 (0.66, 1.25) 0.5640 Malay 7616 (9.53%) 1.23 (0.94, 1.61) 0.1250 Others 7305 (9.14%) 0.63 (0.44, 0.91) 0.0134 POSTOP-TRANSFUSION WITHIN 30DAYS 0 units 79026 (98.84%) 1.0 1 unit 595 (0.74%) 10.63 (7.43, 15.21) <0.0001 2 or more units 334 (0.42%) 27.31 (19.68, 37.90) <0.0001 INTRAOP-TRANSFUSION 0 units 75228 (94.09%) 1.0 1 unit 4727 (5.91%) 10.72 (8.98, 12.80) <0.0001 PREOP-TRANSFUSION WITHIN 30DAYS 0 units 78160 (97.75%) 1.0 1 unit 963 (1.20%) 12.78 (9.60, 17.00) <0.0001 2 or more units 832 (1.04%) 23.71 (18.59, 30.26) <0.0001 ANEMIA.CATEGORY n(%) none 57906 (72.42%) 1.0 mild 11816 (14.78%) 4.48 (3.40, 5.89) <0.0001 moderate and severe 10044 (12.56%) 17.55 (14.10, 21.86) <0.0001 NA 189 (0.24%) 5.72 (1.40, 23.35) 0.0150 priority of surgery n(%) Elective 63770 (79.76%) 1.0 Emergency 16185 (20.24%) 7.87 (6.57, 9.44) <0.0001 anesthesia type n(%) general anaesthesia 67640 (84.60%) 1.0 regional anaesthesia 12315 (15.40%) 1.18 (0.94, 1.48) 0.1525 surgical risk Low 41001 (51.28%) 1.0 Moderate 35692 (44.64%) 2.31 (1.89, 2.82) <0.0001 High 3262 (4.08%) 7.53 (5.75, 9.84) <0.0001 RDW n(%) RDW ≤ 15.7% 71714 (89.69%) 1.0 RDW ＞ 15.7% 7839 (9.80%) 7.00 (5.88, 8.34) <0.0001 NA 402 (0.50%) 1.79 (0.57, 5.60) 0.3175 CVA CATEGORY no 54149 (67.72%) 1.0 yes 1507 (1.88%) 5.60 (4.03, 7.77) <0.0001 NA 24299 (30.39%) 1.69 (1.41, 2.03) <0.0001 IHD CATEGORY no 51310 (64.17%) 1.0 yes 4126 (5.16%) 8.32 (6.63, 10.44) <0.0001 NA 24519 (30.67%) 2.30 (1.89, 2.80) <0.0001 CHF ATEGORY no 56876 (71.14%) 1.0 yes 776 (0.97%) 9.15 (6.40, 13.09) <0.0001 NA 22303 (27.89%) 1.75 (1.46, 2.10) <0.0001 DMINSULIN CATEGORY no 55206 (69.05%) 1.0 yes 1929 (2.41%) 3.98 (2.84, 5.57) <0.0001 NA 22820 (28.54%) 1.73 (1.44, 2.07) <0.0001 Preop-eGFR 84.45 ± 38.56 0.98 (0.98, 0.98) <0.0001 Table 3 The results of univariate and multivariate analyses Exposure Model 1 Model 2 Model 3 Preop-eGFR 0.982 (0.979, 0.984) <0.00001 0.983 (0.980, 0.986) <0.00001 0.992 (0.990, 0.995)<0.00001 Preop-eGFR(quartile) Q1 (31.61 ± 18.07) Ref Ref Ref Q2 ( 78.69 ± 6.52 ) 0.258 (0.202, 0.330) <0.00001 0.256 (0.201, 0.328) <0.00001 0.520 (0.401, 0.675) <0.00001 Q3 ( 96.68 ± 4.67 ) 0.110 (0.077, 0.156) <0.00001 0.169 (0.119, 0.241) <0.00001 0.356 (0.247, 0.514) <0.00001 Q4 ( 130.78 ± 20.86 ) 0.236 (0.183, 0.304) <0.00001 0.516 (0.396, 0.671) <0.00001 0.616 (0.468, 0.812) 0.00058 p for trend <0.00001 <0.00001 <0.00001 Results is showed in OR (95%CI) P-value ( OR: odd rates; CI: Confidence interval); Model 1(Non-adjusted model): not adjust any covariate Model 2(Minimally-adjusted model): only adjusted age, sex and race Model 3(fully-adjusted model): adjusted age, sex, race, anesthesia type, Revised Cardiac Risk Index (RCRI) score, Transfusion Intra and postop Category, Preop-transfusion within 30days , anesthesia type, priority of surgery, surgical risk , and RDW T able4 the results of two-piecewise linear regression thirty-day mortality(OR,95%CI,P-vaule) Inflection point of preop-eGFR 98.688 ≤ 98.688 0.984 (0.981, 0.987) 98.688 1.013 (1.007, 1.019) <0.0001 P-value for log likelihood ratio test <0.001 adjust ed age, sex, race, the frequency of transfusion(including preoperative, intraoperative ,postoperative), priority of surgery ， anesthesia type ， surgical risk ， red cell distribution width ， anemia category , and comorbidities such as DM on insulin, CVA,CHF,IHD Table5 Results of interaction analysis and subgroup analysis Charateristic Or(95%CI) 2 P for interaction2 Age ( mean ± std) 0.1128 Q1( 26.22 ± 6.97 ) 1.002 (0.984, 1.019) Q2( 41.20 ± 3.78 ) 0.996 (0.988, 1.003) Q3( 53.26 ± 3.16 ) 0.999 (0.993, 1.005) Q4( 62.98 ± 2.55 ) 0.991 (0.986, 0.996) Q5( 75.07 ± 5.69 ) 0.990 (0.987, 0.994) SEX n(%) 0.2265 MALE 0.994 (0.990, 0.997) female 0.991 (0.987, 0.994) Race n(%) 0.5579 Chinese 0.991 (0.989, 0.994) Indian 0.991 (0.982, 1.000) Malay 0.996 (0.988, 1.003) Others 0.997 (0.987, 1.008) POSTOP-TRANSFUSION WITHIN 30DAYS 0.4309 0 units 0.992 (0.990, 0.995) 1 unit 0.997 (0.987, 1.007) 2 or more units 0.988 (0.978, 0.997) INTRAOP-TRANSFUSION 0.1152 0 units 0.991 (0.988, 0.994) 1 unit 0.995 (0.991, 0.998) PREOP-TRANSFUSION WITHIN 30DAYS 0.1362 0 units 0.991 (0.988, 0.994) 1 unit 0.992 (0.984, 1.000) 2 or more units 0.997 (0.992, 1.003) ANEMIA.CATEGORY n(%) <0.0001 none 0.977 (0.971, 0.984) mild 0.995 (0.989, 1.001) moderate and severe 0.995 (0.992, 0.998) priority of surgery n(%) 0.0742 Elective 0.995 (0.991, 0.999) Emergency 0.991 (0.988, 0.994) anesthesia type n(%) 0.2401 general anaesthesia 0.993 (0.990, 0.996) regional anaesthesia 0.989 (0.983, 0.995) surgical risk 0.0755 Low 0.988 (0.983, 0.993) Moderate 0.995 (0.991, 0.998) High 0.992 (0.986, 0.998) RDW n(%) 0.8496 RDW ≤ 15.7% 0.992 (0.989, 0.996) RDW ＞ 15.7% 0.992 (0.989, 0.996) CVA CATEGORY 0.0884 no 0.995 (0.992, 0.998) yes 0.989 (0.979, 0.999) IHD CATEGORY 0.0283 no 0.996 (0.992, 1.000) yes 0.991 (0.985, 0.997) CHF ATEGORY 0.0357 no 0.995 (0.992, 0.998) yes 0.988 (0.984, 0.992) DMINSULIN CATEGORY 0.0397 no 0.995 (0.992, 0.998) yes 0.987 (0.976, 0.998) Note1:Above model is not adjusted for the stratification variable Note 2:In each case, the model adjusted for age, sex, race, anesthesia type, Revised Cardiac Risk Index (RCRI) score, Transfusion Intra and postop Category, Preop-transfusion within 30days , anesthesia type, priority of surgery, surgical risk , and RDW. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-25559","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":4596290,"identity":"21811a0b-cb9c-4c61-8316-6a358933f71c","order_by":0,"name":"Xueying Luo","email":"","orcid":"","institution":"Peking University Shenzhen Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xueying","middleName":"","lastName":"Luo","suffix":""},{"id":4596291,"identity":"fadde536-988b-41c5-a3c0-cebabe2016e1","order_by":1,"name":"Sujing Zheng","email":"","orcid":"","institution":"Shenzhen University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Sujing","middleName":"","lastName":"Zheng","suffix":""},{"id":4596292,"identity":"4420ef2b-3b83-4c1e-87d9-e0bc495d96e7","order_by":2,"name":"Baoer Liu","email":"","orcid":"","institution":"Shenzhen University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Baoer","middleName":"","lastName":"Liu","suffix":""},{"id":4596293,"identity":"6856403a-0037-468c-be8a-5b9fd8519645","order_by":3,"name":"Liping Yang","email":"","orcid":"","institution":"Shenzhen University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Liping","middleName":"","lastName":"Yang","suffix":""},{"id":4596294,"identity":"5df0b66f-015d-40fa-95ac-860736deea3b","order_by":4,"name":"Ya Li","email":"","orcid":"","institution":"Shenzhen University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ya","middleName":"","lastName":"Li","suffix":""},{"id":4596295,"identity":"7d1649aa-a0f4-44a1-820c-34c372fa38d5","order_by":5,"name":"Feng Li","email":"","orcid":"","institution":"Peking University Shenzhen Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Feng","middleName":"","lastName":"Li","suffix":""},{"id":4596296,"identity":"0fb4e0d5-d90a-4294-ae85-5fda5caca994","order_by":6,"name":"Rui Gao","email":"","orcid":"","institution":"Peking University Shenzhen Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Rui","middleName":"","lastName":"Gao","suffix":""},{"id":4596297,"identity":"26b8f090-21e0-42fc-b5cb-279904a9ccec","order_by":7,"name":"Haofei Hu","email":"","orcid":"","institution":"Shenzhen Second People's Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Haofei","middleName":"","lastName":"Hu","suffix":""},{"id":4596298,"identity":"27bb033a-b706-4d2a-bc24-109077aae1bf","order_by":8,"name":"Jinsong He","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3ElEQVRIiWNgGAWjYBACA4YDYJqHjZn/4YOEChvitcjwsfcwGzw4k0aMFgiwkeM5wyb5sO0QYS3mjMcff+bNqeNhk8g9VpHAdoCBv707Aa8Wy4YzZtK82w4DteSl3UjgucMgcebsBvwOO3CGjZl32wGglgSzGwkSzxgMJHIJaQE5bFsdWEtBgsFhYrQcMAA6jJmHjeeMGUNCAlFazphJzgX5hb0tWSLhQBoPYb/cOP74w9ttdfbyzcwHP/78ZyPH396LXwuDxAFUPg9+5SDA30BYzSgYBaNgFIxwAADxPUrplXtZ5gAAAABJRU5ErkJggg==","orcid":"","institution":"Peking University Shenzhen Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Jinsong","middleName":"","lastName":"He","suffix":""}],"badges":[],"createdAt":"2020-04-26 11:06:12","currentVersionCode":3,"declarations":"","doi":"10.21203/rs.3.rs-25559/v3","doiUrl":"https://doi.org/10.21203/rs.3.rs-25559/v3","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12893-020-00958-7","type":"published","date":"2021-03-06T15:05:37+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":3614656,"identity":"ed4ca835-43c2-4984-ae74-4751363068a1","added_by":"auto","created_at":"2020-11-16 20:01:31","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":178020,"visible":true,"origin":"","legend":"Relationship of e-GFR and thirty-day mortality\n（Dotted line:95%Confidence Interval; 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Background","content":"\u003cp\u003eThe unmet global burden of surgical disease is enormous\u0026nbsp;[1]\u0026nbsp;With the popularity of surgery, it is especially important to\u0026nbsp;optimize\u0026nbsp;the safety of the operation\u0026nbsp;[2].\u0026nbsp;Thirty-day\u0026nbsp;mortality is one of the most important indicators of\u0026nbsp;perioperative mortality (POMR) and can be used to effectively indicate the safety of surgery and the risk of postoperative complications\u0026nbsp;[3].\u0026nbsp;Preoperative renal dysfunction is a ac-knowledgeable risk factor\u0026nbsp;for\u0026nbsp;postoperative mortality,\u0026nbsp;and the risk of patients with moderate to severe\u0026nbsp;kidney\u0026nbsp;insufficiency increases dramatically\u0026nbsp;[2, 4].\u0026nbsp;Estimated glomerular filtration rate (eGFR),\u0026nbsp;describing filtrate flow through the kidneys,\u0026nbsp;is a\u0026nbsp;universal\u0026nbsp;surrogate\u0026nbsp;indicator for assessing renal function. It has\u0026nbsp;been widely used in\u0026nbsp;the clinical diagnosis\u0026nbsp;of chronic kidney disease (CKD)\u0026nbsp;[5].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eStudies have shown that preop-eGFR is a moderately effective predictor of\u0026nbsp;thirty-day\u0026nbsp;mortality in hospitalized surgical patients\u0026nbsp;[4].\u0026nbsp;However, the current research population is mainly concentrated on patients who have undergone critical surgery such as cardiac surgery[6][7][8]\u0026nbsp;[9][10]\u0026nbsp;[11-14],\u0026nbsp;lack of other surgeries.\u0026nbsp;The ethnicity of these studies is also rarely related to Asians. Moreover,\u0026nbsp;the current studies\u0026nbsp;mainly\u0026nbsp;focus on the relationship between\u0026nbsp;preop-eGFR\u0026nbsp;and perioperative mortality in patients with renal insufficiency\u0026nbsp;[7][15], but\u0026nbsp;several\u0026nbsp;reports address high\u0026nbsp;preop-eGFR\u0026nbsp;levels or any other\u0026nbsp;asymptomatic patient.\u0026nbsp;Only Takashi Ui at.al made it clear among patients\u0026nbsp;undergoing\u0026nbsp;gastrointestinal malignancies that high\u0026nbsp;preop-eGFR\u0026nbsp;is associated with poor surgical outcomes, and also indicated a U-shaped relationship of\u0026nbsp;preop-eGFR\u0026nbsp;and thirty-day mortality\u0026nbsp;[16]\u0026nbsp;.However,\u0026nbsp;data related to\u0026nbsp;non-cardiac and non-neuron surgery\u0026nbsp;are scarce.\u003c/p\u003e\n\u003cp\u003eOur study was designed to explore the details of relationship between preop-eGFR and thirty-day mortality in Asian patients undergoing non-cardiac and non-neuron surgery. Not only limited to patients with renal insufficiency, but also in patients with high preop-eGFR.\u003c/p\u003e"},{"header":"2. Methods","content":"\u003cp\u003e2.1 Data source\u003c/p\u003e\n\u003cp\u003eWe downloaded the raw data from the DATADRYAD database (\u003ca href=\"http://www.datadryad.org\"\u003ewww.datadryad.org\u003c/a\u003e). As Diana Xin Hui Chan, et al.\u0026nbsp;[20]\u0026nbsp;have uploaded the original data and authorized the ownership to the website, we can perform secondary data analysis on this data to\u0026nbsp;verify different scientific assumptions.(Dryad data package:\u0026nbsp;Chan, Diana Xin Hui et al. (2018), Data from: Development of the Combined Assessment of Risk Encountered in Surgery (CARES) surgical risk calculator for prediction of post-surgical mortality and need for intensive care unit admission risk \u0026ndash; a single-center retrospective study, Dryad, Dataset,\u0026nbsp;\u003ca href=\"https://doi.org/10.5061/dryad.v142481\"\u003ehttps://doi.org/10.5061/dryad.v142481\u003c/a\u003e).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e2.2 Study population\u003c/p\u003e\n\u003cp\u003eIt is important to note that\u0026nbsp;Chan, Diana Xin Hui et al.\u0026nbsp;[20]completed data collection. They conducted a single-center retrospective study at Singapore General Hospital, a 1,700-bed tertiary academic hospital\u0026nbsp;[20].\u0026nbsp;These clinical data of all surgical patients\u0026nbsp;from January 1, 2012 to October 31, 2016\u0026nbsp;were obtained from the clinical information system (Sunrise Clinical Manager, Allscripts, Illinois, USA) and stored in\u0026nbsp;SingHealth-IHiS Electronic Health Information System (eHINTS), a data storage and analysis system. Based on exclusion criteria, the study recruited a total of 79,609 surgical cases\u0026nbsp;[20].\u0026nbsp;Exclusion standards: (1) patients with no surgery performed; (2)patients undergoing cardiac surgery, neurosurgery, transplantation and burn surgery; (3) pediatric cases;(4) cases under local anesthesia;(5) cases under\u0026nbsp;cadaveric harvesting; (6) cases with missing important variables.\u0026nbsp;As the personal information of patients was anonymous,\u0026nbsp;no informed consent\u0026nbsp;was\u0026nbsp;required. Details of ethical license can be found in the data source article\u0026nbsp;[20].\u003c/p\u003e\n\u003cp\u003e2.3 Measurement of\u0026nbsp;preop-eGFR, thirty-day mortality and other covariates\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eVariables of the database file included: demographic information; preoperative comorbidities；preoperative laboratory；perioperative blood transfusion data; anesthesia type ;priority of surgery ; surgical risk classification( based on the 2014 ESC/ESA guidelines on non-cardiac surgery[18][19]）;and postoperative thirty-day prognosis. Preoperative comorbidities consisted of\u0026nbsp;anemia,CKD, and\u0026nbsp;medical history [cerebrovascular accidents (CVA), ischemic heart disease (IHD), congestive heart failure (CHF),type1\u0026nbsp;diabetes].Those medical histories mentioned above were also associated with\u0026nbsp;Revised Cardiac Risk Index (RCRI) score[17].The\u0026nbsp;latest results of preoperative laboratory test\u0026nbsp;were mainly about eGFR, red blood cell distribution width (RDW)(Levels above 15.7% were defined as high RDW ,as the normal reference range was 10.9% to 15.7%\u0026nbsp;[22]), hemoglobin.We listed in detail the covariates used in this study. In short, inclusionary criteria were the following: (1) demographic data; (2) variables that can affect\u0026nbsp;preop-eGFR\u0026nbsp;or thirty-day mortality reported by previous literature\u0026nbsp;[20]; (4) based on our clinical experiences.The most important outcome was\u0026nbsp;postoperative thirty-day mortality, including deaths\u0026nbsp;from the date of surgery to one month later[3].As this is a retrospective study, reducing the possibility of selection bias and observation bias.\u003c/p\u003e\n\u003cp\u003e2.4 Statistical analysis\u003c/p\u003e\n\u003cp\u003eIn data analysis, we represented continuous variables as median (quartile) (skewed distribution) or mean \u0026plusmn; standard deviation (normal distribution), and categorical variables as a percentage or frequency.\u0026nbsp;In the process of multivariate regression analysis, there are some confounders with partial missing data. If it is a categorical variable, the missing data would be treated directly as a new independent group; if it is a continues variable, the missing data would be replaced with an average or median value. We use Kruskal-Wallis H test (skewed distribution), one-way ANOVA (normal distribution) or \u0026chi;2 (categorical variables)to calculate differences between different preop-eGFR group.\u003c/p\u003e\n\u003cp\u003eOur study supposed to figure out the specific relationship between preop-eGFR and postoperative thirty-day mortality (linear or non-linear), and then find out variables interfering with or modifying the relationship between them. After excluding the effects of these potential modifiers and confounders, the independent effect of\u0026nbsp;preop-eGFR\u0026nbsp;on postoperative thirty-day mortality can be determined.\u003c/p\u003e\n\u003cp\u003eBased on analytical principles mentioned above, univariate and multiple linear regression models were used to assess relationships with\u0026nbsp;preop-eGFR\u0026nbsp;and postoperative thirty-day mortality. Three models(an unadjusted model, a demographically adjusted model, and a fully-adjusted model) were constructed according to the STROBE statement[24].As for the fully-adjusted model, those adjusted variables, reported in previous studies, are related covariates that may affect\u0026nbsp;preop-eGFR\u0026nbsp;and/or thirty-day mortality\u0026nbsp;[22][20].Moreover, subgroup analyses were performed by stratified linear regression models.\u0026nbsp;Subgroup interaction test was performed to verity the effect modification by subgroup and then\u0026nbsp;a likelihood ratio test was\u0026nbsp;conducted.\u003c/p\u003e\n\u003cp\u003eThe following sensitivity analysis was performed in our research to ensure that the results of the data analysis were reliable. Firstly,\u0026nbsp;the continuous variable\u0026nbsp;preop-eGFR\u0026nbsp;was converted into a categorical one by quartile to observe the possibility of nonlinearity. Secondly, if a nonlinear relationship exited between\u0026nbsp;preop-eGFR\u0026nbsp;and postoperative thirty-day mortality, it would be processed using a generalized additive model. Thirdly, we measured the threshold effect of preop-eGFR on the thirty-day mortality rate via a two-segment linear regression model based on a smoothing graph, determined the saturation of preop-eGFR by a recursive algorithm, and then detected the inflection point to obtain the maximum model likelihood. Based on the p-value of the log-likelihood ratio test, the best-fit model can be determined.\u003c/p\u003e\n\u003cp\u003eAll the analyses were performed with the statistical software packages R (The R Foundation,http://www.r-project.org) and EmpowerStats (X\u0026amp;Y Solutions, Inc., Boston, MA, http://www.empowerstats.com). P-value＜0.05 was considered statistically significant.\u003c/p\u003e"},{"header":"3. Results","content":"\u003cp\u003e3.1 The selection of participants\u003c/p\u003e\n\u003cp\u003eThe original data(N=90,785) for this study was\u0026nbsp;recruited\u0026nbsp;according to exclusion standards by\u0026nbsp;Diana Xin Hui Chan, at al[20].\u0026nbsp;The missing data on preop-eGFR and thirty-day mortality was about 10830 cases.\u0026nbsp;And after excluding patients with\u0026nbsp;preop-eGFR\u0026nbsp;outliers[25](N=346), 79 609 cases were included to our study（shown in\u0026nbsp;Schedule1）.\u003c/p\u003e\n\u003cp\u003e3.2 Baseline characteristics of participants\u003c/p\u003e\n\u003cp\u003eBaseline characteristics of the 79,609 participants based on the quartiles of preop-eGFR are shown in Table 1. Overall, the average age of all patients participating in the study was 54.01 \u0026plusmn; 16.86 years old, of which approximately 48.47% were male. The participants\u0026rsquo; preop-eGFR distribution was mean 84.45\u0026plusmn;38.56 (min 2.004, max 206.225). The thirty-day postoperative death in the study population was 506 cases (0.64%). The numbers of participants with missing data for each variable are shown in Table 1.Compared with participants with lower preop-eGFR (Q1-Q3),highest preop-eGFR was significantly positively correlated with females, younger age transfusion, emergency surgery, general anesthesia, comorbidities, but lower rate of Chinese (All P-values\u0026lt; 0.001). There were also statistically differences in anemia and RDW with different preop-eGFR. When the intermediate level of preop-eGFR (Q2-3) was reached, the patient was more likely to have none anemia and RDW \u0026le;15.7% (P-value \u0026lt; 0.001). \u003c/p\u003e\n\u003cp\u003e3.3 Univariate and multivariate analysis\u003c/p\u003e\n\u003cp\u003eUnivariate analysis results were seen in Table 2.These results indicates that age, transfusion rate frequency, anemia, priority of surgery, surgical risk ,RDW and comorbidities(CVA, IHD, CHF, DM on insulin) was correlated with higher thirty-day mortality(All P-values\u0026lt; 0.05). We also find that there was no significant difference of thirty-day mortality with different race (P-value \u0026gt; 0.05), whereas preop-eGFR and female were related to thirty-day mortality with a statistically significant negative correlation(All P-values\u0026lt; 0.05).\u003c/p\u003e\n\u003cp\u003eThe results of univariate and multivariate linear regression models are shown in Table 3. The unadjusted model showed a thirty-day mortality reduction of 1.8% for each additional preop-eGFR unit (95% CI: 0.979, 0.984).It also illustrates different kinds of adjusted model including minimally-adjusted, fully-adjusted model. Compared to the unadjusted model (OR = 0.982, 95% CI: 0.979, 0.984), the preop-eGFR in the minimal adjustment model (only adjusted for age, sex, and race) still negatively related to the thirty-day mortality (OR = 0.983, 95% CI: 0.980, 0.986).In the fully-adjusted model, preop-eGFR significantly functioned as the same but with a little increase in the effect size\u0026nbsp;(OR =0.992, 95% CI:\u0026nbsp;0.990, 0.995).\u003c/p\u003e\n\u003cp\u003eIn the sensitivity analysis, we converted preop-eGFR to a categorical variable classified by quartile to observe P of trend (Table 3).Compared to the reference group(Q1),the effect size of preop-eGFR on thirty-day mortality in group Q3 (preop-eGFR:96.68\u0026plusmn;4.67)was the smallest among different adjusted model. For instance, in the fully- adjusted model, the effect size of group Q2,Q3 and Q4 were\u0026nbsp;0.520, 0.356, 0.616\u0026nbsp;respectively, compared with group(Q1).This kind of non-equidistant changes in effect size indicated a non-linear relationship between preop-eGFR with thirty-day mortality.\u003c/p\u003e\n\u003cp\u003e3.4\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eThe analyses of non-linear relationship\u003c/p\u003e\n\u003cp\u003eFigure 1 shows the U-shaped non-linear correlation between\u0026nbsp;preop-eGFR\u0026nbsp;and postoperative thirty-day mortality. This non-linear relationship was verified by smooth curve of the generalized additive model. And the P-value of the log likelihood ratio test is less than 0.05 in table 4,which further indicates the two-part linear regression model should be used to fit the relationship, rather than the linear regression model (through linearly fitting) .The inflection point was calculated to be\u0026nbsp;98.688\u0026nbsp;by a two-part linear regression model and a recursive algorithm. On the left side of the inflection point,\u0026nbsp;preop-eGFR\u0026nbsp;is one of the independently protective factors of thirty-day mortality (OR=0.984, 95% CI: 0.981 to 0.987, P \u0026lt;0.0001).\u0026nbsp;While on the right side, it acts as a risk factor (OR=1.013,\u0026nbsp;95% CI: 1.007\u0026nbsp;to 1.019,\u0026nbsp;P\u0026nbsp;\u0026lt;0.0001).\u003c/p\u003e\n\u003cp\u003e3.5 The results of subgroup analyses and interaction analysis\u003c/p\u003e\n\u003cp\u003eAs is shown in Table 5, the interaction test was significant for patients comorbidities, as DM, CHF, IHD or anemia (P=0.0397, 0.0357, 0.0168,＜0.0001 for interaction, respectively), while the interaction of other covariates was not statistically significant (interaction P value is greater than 0.05). Under the influence of preoperative comorbidities, such as CHF, DM and IHD, the effect of preop-eGFR on the thirty-day postoperative mortality gradually increased. For patients with CHF, an increase of the preop-eGFR unit related to a 1.2% reduction in thirty-day mortality (0.988 (0.984, 0.992)). Without CHF, there\u0026rsquo;s decreased by 0.5% for each additional unit of Preop-eGFR (0.995 (0.992, 0.998)). The same trend is also observed in in patients with DM (1.3% reduction of thirty-day mortality with DM vs. 0.5% reduction without DM) and IHD (0.9% with IHD vs. 0.4% without IHD). However, the opposite trend was seen in people with anemia. For patients without anemia, an increase unit of preop-eGFR would cost a 2.3% reduction in thirty-day mortality (0.977, 95%CI: 0.971, 0.984). For patients with anemia, the thirty-day mortality was decresaed by 0.5% with each additional unit of preop-eGFR.\u0026nbsp;\u003c/p\u003e"},{"header":"4. Discussion","content":"\u003cp\u003eIn this study, we confirmed an independent nonlinear relationship between preop-eGFR and postoperative thirty-day mortality. A stable\u0026nbsp;U-shaped\u0026nbsp;trend can be seen in this relationship. When\u0026nbsp;preop-eGFR\u0026le;98.688\u0026nbsp;mL/min/1.73m\u003csup\u003e2\u003c/sup\u003e, the thirty-day mortality would be decreased by 1.6% for each additional unit of\u0026nbsp;Preop-eGFR.\u0026nbsp;While\u0026nbsp;preop-eGFR\u0026nbsp;\u0026gt;\u0026nbsp;98.688\u0026nbsp;mL/min/1.73m\u003csup\u003e2\u003c/sup\u003e,there would be a 1.3% increase of thirty-day mortality rate for each additional unit of\u0026nbsp;preop-eGFR.\u0026nbsp;CHF, DM, IHD and anemia complications (CHF, DM, IHD acting as a promoting factor, while anemia as an inhibitory factor) interfere with the effect of\u0026nbsp;preop-eGFR\u0026nbsp;on postoperative thirty-day mortality.\u003c/p\u003e\n\u003cp\u003ePrevious studies have also supported the hypothesis that\u0026nbsp;preop-eGFR is a powerful and independent predictor of\u0026nbsp;thirty-day morbidity risk after surgery\u0026nbsp;[4, 10, 13, 26-27][15][16, 26].\u0026nbsp;Even in some literature reports, preop-eGFR is the strongest predictors of posttransplant survival\u0026nbsp;[26]. Preop-eGFRs is a important indicator of many adverse \u0026nbsp;surgical outcomes[16], as acute kidney injury,\u0026nbsp;significantly related to higher mortality.\u0026nbsp;At the same time,\u0026nbsp;DM,\u0026nbsp;IHD, CVF, and blood transfusion also are risk factors for poor postoperative prognosis\u0026nbsp;[6].\u0026nbsp;The current research population is mainly concentrated in\u0026nbsp;transplant\u0026nbsp;[26],\u0026nbsp;cardiac\u0026nbsp;[10, 13]\u0026nbsp;and\u0026nbsp;neuro[14]\u0026nbsp;surgery.\u0026nbsp;There is still a lack of research on other surgery.\u0026nbsp;There are two articles that define the study population as non-cardiac surgery patients. Jacek B. Cywinski, at al evaluated 92,888 patients undergoing non-cardiac surgery, and confirmed preop-eGFR is a scientifically feasible predictor of postoperative thirty-day mortality\u0026nbsp;[4].J. R. Prowle\u0026nbsp;et al. reported that\u0026nbsp;significantly increases the risk of death\u0026nbsp;after non-cardiac surgery, according to the data of\u0026nbsp;36 779\u0026nbsp;cases[2].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ePrevious studies mostly focused on the patients of renal insufficiency to verify the important regulatory role of preop-eGFR[12-13, 15]. High preop-eGFR levels have also been connected with greater mortality among nonsurgical patients indicating a potential U-shaped association of preop-eGFR with poor prognosis\u0026nbsp;[28-30]. A recent study revealed the association of the specific trend between preop-eGFR and thirty-day mortality in patients undergoing surgery for gastrointestinal malignancies, without clarifying the inflection point[16].\u0026nbsp;In addition, the current research population is mainly Europeans and Americans, and rarely Asians.\u003c/p\u003e\n\u003cp\u003eTo our best knowledge, it is the first time\u0026nbsp;that the specific\u0026nbsp;U-shaped\u0026nbsp;relationship between\u0026nbsp;preop-eGFR and postoperative thirty-day mortality\u0026nbsp;has been clearly identified\u0026nbsp;in Asian patients undergoing\u0026nbsp;non-cardiac and non-neuro surgery,\u0026nbsp;ranging from minor day cases to major surgeries.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eStrengths of our study are mentioned as follows:\u0026nbsp;firstly, the generalized additive model was used to evaluate non-linear relations, instead of using the generalized linear model to illustrate the linear relationship only. Secondly, as an observational study, there were some unavoidable potential confounders included in this study. In order to minimize residual confounding, strict statistical adjustment was performed. What\u0026rsquo;s more, effect modifier factor analysis ameliorates the use of data.\u0026nbsp;Sensitivity analysis was performed of these data to ensure reliability.\u003c/p\u003e\n\u003cp\u003eThe findings of this study should be helpful for reducing the risk of postoperative death.\u0026nbsp;The preop-eGFR at which the rate of the\u0026nbsp;perioperative Mortality\u0026nbsp;was lowest was 98.688.\u0026nbsp;It suggests that regulation of preop-eGFR can effectively reduce perioperative mortality,\u0026nbsp;especially with\u0026nbsp;CHF, DM, IHD\u0026nbsp;comorbidities. While has comorbid anemia, it also becomes quite important to control anemia for reducing mortality.\u003c/p\u003e\n\u003cp\u003eThis study has several acknowledged limitations. First, as for our study is a secondary analysis based on the published data, we cannot exclude some residual and/or unmeasured confounders (such as socioeconomic factors and inflammatory markers), that may bias the estimated relationship. Secondly, the study population, which only included Asian patients, can be further expanded to conduct multi-center research to increase the reliability of the data. Our choice of outcomes and variables is also limited. We could not investigate the relationship between preop-eGFR with long-term outcomes. What\u0026rsquo;s more, when it comes to high preop-eGFR, the results would be much more accurate formula based on cystatin C, instead of basing on creatinine. However, cystatin C haven\u0026rsquo;t be widely used in clinical practice right now[31].\u0026nbsp;\u003c/p\u003e"},{"header":"5. Conclusion","content":"\u003cp\u003eIn patients undergoing non-cardiac and non-neurological surgery, the level of preop-eGFR is associated with operative adverse events in a U-shape trend. The preop-eGFR with the lowest perioperative mortality was 98.688. CHF, DM, IHD and anemia comorbidities (CHF, DM, IHD as a promoting factor, anemia as an inhibitor) interfere with the effect of preop-eGFR on postoperative thirty-day mortality.\u003c/p\u003e"},{"header":"List Of Abbreviations","content":"\u003cp\u003ePreop-eGFR: preoperative estimated Glomerular Filtration Rate; CHF：Congestive Heart Failure； IHD：Ischemic Heart Disease； DM：Diabetes Mellitus； OR：Odds Ratio； CI：Confidence Interval； POMR：Perioperative Mortality； CKD：Chronic Kidney Disease；CARES：Combined Assessment of Risk Encountered in Surgery；RCRI score：Revised Cardiac Risk Index Score；RDW：Red Cell Distribution Width；eHINTS：SingHealth-IHiS Electronic Health Information System；RP：Renal Group；RBC：Red Blood Cell； FBC：Full Blood Count； MDRD：Modification of Diet in Renal Disease；WHO：World Health Organization； KDIGO：Kidney Disease: Improving Global Outcomes； ANOVA：Analysis of Variance；STROBE：Strengthening the Reporting of Observational Studies in Epidemiology；Q1-4：Quartile 1-4；GAM：Generalized Additive Model；CARES：Combined Assessment of Risk Encountered in Surgery\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn the previously published article,\u0026nbsp;Diana Xin Hui Chan, et al. has clearly stated that: the study was conducted in accordance with the Declaration of Helsinki.\u0026nbsp;Since the study was based on a secondary analysis of past data and the patient\u0026apos;s personal information in the original data was anonymous, there was no need for informed consent from the participants. The ethical license has been elaborated in the published paper.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe raw data can be downloaded from the website (\u003ca href=\"http://www.Datadryad.org\"\u003ewww.Datadryad.org\u003c/a\u003e) of \u0026lsquo;Datadryad\u0026rsquo; database.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by\u0026nbsp;Shenzhen\u0026nbsp;science and technology innovation international\u0026nbsp;cooperation\u0026nbsp;projects(with University of Minnesota cooperation) [grant numbers GJHZ20180928115030292];Sanming Project of Medicine in Shenzhen\u0026nbsp;[grant numbersSZSM201612010];Shenzhen Key Medical Discipline Construction Fund [No.SZXK017]; Shenzhen High-level Hospital Construction Fund;but the funders had no role in study design,data collection and analyasis,decision to publish,or preparation of the manuscript.The article-processing charges was supported by the funders.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026apos; contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eX\u003c/strong\u003e\u003cstrong\u003eY\u003c/strong\u003e\u003cstrong\u003eL\u003c/strong\u003e\u003cstrong\u003e.\u003c/strong\u003e\u003cstrong\u003e:\u0026nbsp;\u003c/strong\u003eConceptualization; Data curation; Formal analysis; Investigation; Roles/Writing - original draft;SJ\u003cstrong\u003eZ\u003c/strong\u003e:Conceptualization; Data curation; Formal analysis;extracted the data from the MIMIC-III database;BEL,FL and RG\u003cstrong\u003e:\u0026nbsp;\u003c/strong\u003eData curation; Formal analysis; Investigation; Software;\u0026nbsp;LPY:\u0026nbsp;Supervision; Validation; Visualization;YL and HFH\u003cstrong\u003e:\u0026nbsp;\u003c/strong\u003eFormal analysis;Project administration;Writing - review \u0026amp; editing.\u003cstrong\u003eJ\u003c/strong\u003e\u003cstrong\u003eS\u003c/strong\u003e\u003cstrong\u003eH:\u0026nbsp;\u003c/strong\u003eConceptualization; Data curation; Formal analysis;Funding acquisition; Writing - review \u0026amp; editing.All authors approved the version to be published ,and agree to be accountable for all aspects of the working in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments:\u003c/strong\u003eNot applicable\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e\u003cstrong\u003eReferences:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[1] T.G. Weiser, A.B. Haynes, G. Molina, S.R. Lipsitz, M.M. Esquivel, T. Uribe-Leitz, R. Fu, T. Azad, T.E. Chao, W.R. Berry, A.A. Gawande, Estimate of the global volume of surgery in 2012: an assessment supporting improved health outcomes, LANCET, 385 Suppl 2 (2015) S11.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[2] J.R. Prowle, E.P. Kam, T. Ahmad, N.C. Smith, K. Protopapa, Preoperative renal dysfunction and mortality after non-cardiac surgery.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[3] D.A. Watters, M.J. Hollands, R.L. Gruen, K. Maoate, H. Perndt, R.J. McDougall, W.W. Morriss, V. Tangi, K.M. Casey, K.A. McQueen, Perioperative mortality rate (POMR): a global indicator of access to safe surgery and anaesthesia, WORLD J SURG, 39 (2015) 856-864.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[4] J.B. Cywinski, E.J. Mascha, A. Kurz, D.I. Sessler, Estimated glomerular filtration rate better predicts 30-day mortality after non-cardiac surgery than serum creatinine: a retrospective analysis of 92,888 patients, Canadian Journal of Anesthesia/Journal canadien d'anesth\u0026eacute;sie, 62 (2015) 745-752.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[5] D.G. Warnock, Estimated Glomerular Filtration Rate: Fit for What Purpose? NEPHRON, 134 (2016) 43-49.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[6] C. Thongprayoon, W. Cheungpasitporn, M.A. Mao, N. Srivali, W. Kittanamongkolchai, A.M. Harrison, K.L. Greason, K.B. Kashani, Persistent acute kidney injury following transcatheter aortic valve replacement, J CARDIAC SURG, 32 (2017) 550-555.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[7] M. Yamamoto, K. Hayashida, G. Mouillet, T. Hovasse, B. Chevalier, A. Oguri, Y. Watanabe, J. Dubois-Rand\u0026eacute;, M. Morice, T. Lef\u0026egrave;vre, E. Teiger, Prognostic Value of Chronic Kidney Disease After Transcatheter Aortic Valve Implantation, J AM COLL CARDIOL, 62 (2013) 869-877.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[8] M.S. Jang, J.S. Nam, J.Y. Jo, C.H. Kang, S.A. Ryu, E.H. Lee, I.C. Choi, The relationship of preoperative estimated glomerular filtration rate and outcomes after cardiovascular surgery in patients with normal serum creatinine: a retrospective cohort study, BMC ANESTHESIOL, 19 (2019) 88.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;[9] A. Dardashti, S. Nozohoor, L. Algotsson, P. Ederoth, H. Bjursten, The predictive value of s-cystatin C for mortality after coronary artery bypass surgery, The Journal of Thoracic and Cardiovascular Surgery, 152 (2016) 139-146.\u003c/p\u003e\n\u003cp\u003e[10] D. Bissacco, V. Catanese, A. Fossati, S. Salvati, G. Zanella, M. Carmo, P. 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Lassnigg, Impact of preoperative serum creatinine on short- and long-term mortality after cardiac surgery: a cohort study, BRIT J ANAESTH, 114 (2015) 53-62.\u003c/p\u003e\n\u003cp\u003e[14] K. Kim, J. Bang, S. Kim, S. Kim, J.U. Kim, J. Song, Association of preoperative hypoalbuminemia with postoperative acute kidney injury in patients undergoing brain tumor surgery: a retrospective study, J NEUROSURG, 128 (2018) 1115-1122.\u003c/p\u003e\n\u003cp\u003e[15] C.T. Martin, A.J. Pugely, Y. Gao, S.A. Mendoza-Lattes, S.L. Weinstein, The Impact of Renal Impairment on Short-term Morbidity Risk Following Lumbar Spine Surgeries, SPINE, 40 (2015) 909-916.\u003c/p\u003e\n\u003cp\u003e[16] High and low estimated glomerular filtration rates are associated with adverse outcomes in patients undergoing surgery for gastrointestinal malignancies.\u003c/p\u003e\n\u003cp\u003e[17] Derivation and Prospective Validation of a Simple Index for Prediction of Cardiac Risk of.\u003c/p\u003e\n\u003cp\u003e[18] L.G. 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Padhy, Prediction of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) after Thoracic Surgery- The Role of Estimated GFR, JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, (2017).\u003c/p\u003e\n\u003cp\u003e[28] Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis, The Lancet, 375 (2010) 2073-2081.\u003c/p\u003e\n\u003cp\u003e[29] M. Tonelli, S.W. Klarenbach, A.M. Lloyd, M.T. James, A.K. Bello, B.J. Manns, B.R. Hemmelgarn, Higher estimated glomerular filtration rates may be associated with increased risk of adverse outcomes, especially with concomitant proteinuria, KIDNEY INT, 80 (2011) 1306-1314.\u003c/p\u003e\n\u003cp\u003e[30] K. Matsushita, B.K. Mahmoodi, M. Woodward, J.R. Emberson, T.H. Jafar, S.H. Jee, K.R. Polkinghorne, A. Shankar, D.H. Smith, M. Tonelli, D.G. Warnock, C. Wen, J. Coresh, R.T. Gansevoort, B.R. Hemmelgarn, A.S. Levey, F.T. Chronic Kidney Disease Prognosis Consortium, Comparison of Risk Prediction Using the CKD-EPI Equation and the MDRD Study Equation for Estimated Glomerular Filtration Rate, JAMA, 307 (2012).\u003c/p\u003e\n\u003cp\u003e[31] A.S. Levey, C. Becker, L.A. Inker, Glomerular Filtration Rate and Albuminuria for Detection and Staging of Acute and Chronic Kidney Disease in Adults, JAMA, 313 (2015) 837.\u003c/p\u003e"},{"header":"Tables","content":"\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003eTable 1 Baseline characteristics of participants\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\n \u003ctable style=\"width: 4.1e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePreop-eGFR\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;(quartile)\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border-top: 1pt solid windowtext;border-left: 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e11493 (57.81%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e10334 (51.89%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003efemale\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e10366 (52.09%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e8389 (42.19%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e9581 (48.11%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e12712 (63.84%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eRace\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;n(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eChinese\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14592 (73.33%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14943 (75.16%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14403 (72.32%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14005 (70.34%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIndian\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1540 ( 7.74%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1602 ( 8.06%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1809 ( 9.08%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1875 ( 9.42%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eMalay\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e2166 (10.88%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1679 ( 8.44%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1748 ( 8.78%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1970 ( 9.89%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOthers\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1601 ( 8.05%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1658 ( 8.34%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1955 ( 9.82%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2060 (10.35%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 296.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ePOSTOP-TRANSFUSION WITHIN 30DAYS\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0 units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e19505 (98.01%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e19752 (99.35%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e19815 (99.50%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e19647 (98.67%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1 unit\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e244 ( 1.23%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e81 ( 0.41%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e74 ( 0.37%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e177 ( 0.89%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2 or more units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e152 ( 0.76%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e49 ( 0.25%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e26 ( 0.13%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e87 ( 0.44%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 296.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eINTRAOP-TRANSFUSION\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0 units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e18163 (91.27%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e18985 (95.49%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e19184 (96.33%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e18629 (93.56%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1 unit\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1738 ( 8.73%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e897 ( 4.51%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e731 ( 3.67%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1282 ( 6.44%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 367pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePREOP-TRANSFUSION WITHIN 30DAYS\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0 units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e19142 (96.19%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e19551 (98.34%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e19683 (98.84%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e19484 (97.86%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 unit\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e374 ( 1.88%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e186 ( 0.94%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e140 ( 0.70%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e241 ( 1.21%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e2 or more units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e385 ( 1.93%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e145 ( 0.73%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e92 ( 0.46%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e186 ( 0.93%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 367pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eANEMIA.CATEGORY\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003enone\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e11532 (57.95%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e15561 (78.27%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e16381 (82.25%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14309 (71.86%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003emild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e3887 (19.53%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2738 (13.77%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2197 (11.03%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2939 (14.76%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003emoderate and severe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e4438 (22.30%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1540 ( 7.75%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1287 ( 6.46%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e2611 (13.11%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e44 ( 0.22%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e43 ( 0.22%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e50 ( 0.25%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e52 ( 0.26%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 367pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003epriority of surgery\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eElective\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e14929 (75.02%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e16786 (84.43%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e16713 (83.92%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e15155 (76.11%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eEmergency\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e4972 (24.98%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e3096 (15.57%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e3202 (16.08%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e4756 (23.89%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eanesthesia type\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ega\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e15803 (79.41%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e16384 (82.41%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e17453 (87.64%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e17715 (88.97%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003era\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e4098 (20.59%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e3498 (17.59%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2462 (12.36%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2196 (11.03%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003esurgical risk\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e9925 (49.87%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e10165 (51.13%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e10705 (53.75%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e10079 (50.62%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e8962 (45.03%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e8892 (44.72%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e8599 (43.18%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e9047 (45.44%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1014 ( 5.10%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e825 ( 4.15%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e611 ( 3.07%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e785 ( 3.94%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eRDW \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eRDW\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;\"\u003e\u0026le;\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e15.7%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e17300 (87.38%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e18448 (93.27%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e18377 (92.73%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e17368 (87.66%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eRDW\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;color:black;\"\u003e＞\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e15.7%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e2498 (12.62%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1332 ( 6.73%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1440 ( 7.27%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e2444 (12.34%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eCVA CATEGORY\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13231 (66.48%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13348 (67.14%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13771 (69.15%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13558 (68.09%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e640 ( 3.22%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e481 ( 2.42%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e211 ( 1.06%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e168 ( 0.84%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e6030 (30.30%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e6053 (30.44%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5933 (29.79%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e6185 (31.06%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIHD CATEGORY\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e11914 (59.87%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e12581 (63.28%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13314 (66.85%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13264 (66.62%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1890 ( 9.50%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1205 ( 6.06%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e616 ( 3.09%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e406 ( 2.04%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e6097 (30.64%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e6096 (30.66%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5985 (30.05%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e6241 (31.34%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eCHF ATEGORY\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13934 (70.02%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14269 (71.77%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14399 (72.30%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14022 (70.42%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e489 ( 2.46%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e147 ( 0.74%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e64 ( 0.32%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e70 ( 0.35%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5478 (27.53%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5466 (27.49%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5452 (27.38%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5819 (29.23%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 367pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eDMINSULIN CATEGORY\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13235 (66.50%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13932 (70.07%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e14134 (70.97%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e13670 (68.66%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1074 ( 5.40%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e340 ( 1.71%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e195 ( 0.98%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e301 ( 1.51%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5586 (28.05%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5940 (29.83%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eRCRI.SCORE\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e8549 (42.96%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e10605 (53.34%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e11564 (58.07%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e10864 (54.56%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eII\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e3571 (17.94%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2935 (14.76%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2351 (11.81%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2727 (13.70%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eIII\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1376 ( 6.91%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e520 ( 2.62%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e237 ( 1.19%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e238 ( 1.20%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIV\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e685 ( 3.44%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e100 ( 0.50%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e43 ( 0.22%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e41 ( 0.21%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5720 (28.74%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.95pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5722 (28.78%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.25pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5720 (28.72%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.75pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e6041 (30.34%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.15pt;border:none;background:#F2F2F2;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 367pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ethirty-day mortality\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e19587 (98.42%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e19800 (99.59%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e19880 (99.82%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e19836 (99.62%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 87.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75.75pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e314 ( 1.58%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e82 ( 0.41%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e35 ( 0.18%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.75pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e75 ( 0.38%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAbbreviations\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e:\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;GA, general anesthesia ;RA, regional anesthesia ;Preop-eGFR\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;,preoperative\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eestimated glomerular filtration rates;\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eRDW,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;red cell distribution;\u003c/span\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNA,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;background:white;'\u003e\u0026nbsp;not available;\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;CVA,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;cerebrovascular accidents; IHD, ischemic heart disease; CHF, congestive heart failure; DM, diabetes mellitus requiring insulin therapy\u003c/span\u003e\u003cspan style=\"font-size:12px;line-height:115%;font-family:SimSun;\"\u003e；\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePreop\u003c/span\u003e\u003cspan style=\"font-size:12px;line-height:115%;font-family:SimSun;\"\u003e，\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003epreoperative; Intraop, intraoperative; Postop, postoperative; RCRI ,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Revised Cardiac Risk Index\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;; ASA,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;American Society of Anesthesiologists\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e.\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable2 Effects of risk factors of thirty-day mortality\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\n \u003ctable style=\"width: 3.7e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePreop-eGFR\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;(quartile)\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eStatistics\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOR\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e95%CI\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eP value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eAge\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003emean (std), year\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e53.96\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;color:black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;16.88\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.07\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(1.06, 1.08)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eSEX\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eMALE\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e38666 (48.36%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003efemale\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e41289 (51.64%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.69\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(0.58, 0.82)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eRace\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;n(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eChinese\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e58170 (72.76%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eIndian\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e6860 (8.58%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.91\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(0.66, 1.25)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.5640\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMalay\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e7616 (9.53%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.23\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(0.94, 1.61)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.1250\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eOthers\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e7305 (9.14%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.63\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(0.44, 0.91)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.0134\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 226.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePOSTOP-TRANSFUSION WITHIN 30DAYS\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0 units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e79026 (98.84%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 unit\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e595 (0.74%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e10.63\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(7.43, 15.21)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e2 or more units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e334 (0.42%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e27.31\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(19.68, 37.90)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eINTRAOP-TRANSFUSION\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0 units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e75228 (94.09%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 unit\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e4727 (5.91%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e10.72\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(8.98, 12.80)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ePREOP-TRANSFUSION WITHIN 30DAYS\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0 units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e78160 (97.75%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1 unit\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e963 (1.20%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e12.78\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(9.60, 17.00)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e832 (1.04%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e23.71\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eANEMIA.CATEGORY\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e57906 (72.42%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003emild\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e11816 (14.78%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e4.48\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(3.40, 5.89)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003emoderate and severe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e10044 (12.56%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e17.55\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(14.10, 21.86)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e189 (0.24%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e5.72 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(1.40, 23.35)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.0150\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003epriority of surgery\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eElective\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e63770 (79.76%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eEmergency\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e16185 (20.24%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e7.87\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(6.57, 9.44)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eanesthesia type\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003egeneral anaesthesia\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e67640 (84.60%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eregional anaesthesia\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e12315 (15.40%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.18\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(0.94, 1.48)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.1525\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003esurgical risk\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e41001 (51.28%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eModerate\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e54149 (67.72%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1507 (1.88%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e5.60\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(4.03, 7.77)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e24299 (30.39%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.69 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(1.41, 2.03)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIHD CATEGORY\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e51310 (64.17%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e4126 (5.16%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e8.32\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(6.63, 10.44)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e24519 (30.67%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e2.30 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(1.89, 2.80)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e56876 (71.14%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e776 (0.97%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e9.15\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(6.40, 13.09)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e22303 (27.89%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.75\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(1.46, 2.10)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eDMINSULIN CATEGORY\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eno\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e55206 (69.05%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1929 (2.41%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e3.98\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(2.84, 5.57)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eNA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e22820 (28.54%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1.73 \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(1.44, 2.07)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePreop-eGFR\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e84.45\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;38.56\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.98\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(0.98, 0.98)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:13px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:14px;font-family:\"Times New Roman\",serif;'\u003eTable 3 The results of univariate and multivariate analyses\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.1e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 78pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eExposure\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.3pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eModel 1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 119.4pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eModel 2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 103.95pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eModel 3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 78pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ePreop-eGFR\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.3pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.982 (0.979, 0.984) \u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 119.4pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.983 (0.980, 0.986) \u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 103.95pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.992 (0.990, 0.995)\u0026lt;0.00001\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 407.65pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePreop-eGFR(quartile)\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 78pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eQ1\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(31.61\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;color:black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;18.07)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.3pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eRef\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 119.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eRef\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 103.95pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eRef\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 78pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eQ2\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e78.69\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;6.52\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.258 (0.202, 0.330) \u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 119.4pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.256 (0.201, 0.328) \u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 103.95pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.520 (0.401, 0.675) \u0026lt;0.00001\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 78pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eQ3\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e(\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e96.68\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;color:black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;4.67\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.3pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.110 (0.077, 0.156) \u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 119.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.169 (0.119, 0.241) \u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 103.95pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.356 (0.247, 0.514) \u0026lt;0.00001\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 78pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eQ4\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e130.78\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;20.86\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.236 (0.183, 0.304) \u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 119.4pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.516 (0.396, 0.671) \u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 103.95pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.616 (0.468, 0.812) \u0026nbsp;0.00058\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 78pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ep for trend\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 119.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.00001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 103.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:15.0pt;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.00001\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:normal;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eResults is showed in OR (95%CI) P-value (\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eOR: odd rates; CI: Confidence interval);\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:normal;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eModel 1(Non-adjusted model): not adjust any covariate\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:normal;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eModel 2(Minimally-adjusted model): only adjusted age, sex and race\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:normal;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eModel 3(fully-adjusted model): adjusted age, sex, race,\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;anesthesia type,\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Revised Cardiac Risk Index (RCRI) score,\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Transfusion Intra and postop Category, Preop-transfusion within 30days\u003cstrong\u003e,\u003c/strong\u003e\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;anesthesia type,\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;priority of surgery, surgical risk\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e, and RDW\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eT\u003c/span\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003eable4 the results of\u0026nbsp;\u003c/span\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003etwo-piecewise linear regression\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\n \u003ctable style=\"width: 3.6e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 166.25pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:21.1pt;'\u003e\u003cspan style='line-height:115%;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:21.1pt;'\u003e\u003cstrong\u003e\u003cspan style='line-height:115%;font-family: \"Times New Roman\",serif;'\u003ethirty-day mortality(OR,95%CI,P-vaule)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 166.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:21.1pt;'\u003e\u003cstrong\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Inflection point of preop-eGFR\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003e98.688\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 166.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003cspan style=\"line-height:115%;font-family: SimSun;\"\u003e\u0026le;\u003c/span\u003e\u003cstrong\u003e\u003cspan style='line-height:115%;font-family: \"Times New Roman\",serif;'\u003e98.688\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.4pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.984 (0.981, 0.987) \u0026lt;0.0001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 166.25pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;\u0026gt; \u003cstrong\u003e98.688\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.4pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.013 (1.007, 1.019) \u0026lt;0.0001\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 166.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;text-indent:21.1pt;'\u003e\u003cstrong\u003e\u003cspan style='line-height:115%;font-family: \"Times New Roman\",serif;'\u003eP-value for log likelihood ratio test\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.001\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:15.0pt;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eadjust\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eed age, sex, race, the frequency of transfusion(including preoperative, intraoperative ,postoperative), priority of surgery\u003c/span\u003e\u003cspan style=\"font-size:12px;font-family:SimSun;\"\u003e，\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eanesthesia type\u003c/span\u003e\u003cspan style=\"font-size:12px;font-family:SimSun;\"\u003e，\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003esurgical risk\u003c/span\u003e\u003cspan style=\"font-size:12px;font-family:SimSun;\"\u003e，\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ered cell distribution width\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"HelveticaNeueLTStd-Roman\",sans-serif;'\u003e，\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eanemia category\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e,\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eand comorbidities such as DM on insulin, CVA,CHF,IHD\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:left;line-height:15.0pt;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='line-height:115%;font-family:\"Times New Roman\",serif;'\u003eTable5 Results of interaction analysis and subgroup analysis\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\n \u003ctable style=\"width: 3.2e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eCharateristic\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOr(95%CI) 2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eP for interaction2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eAge (\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003emean\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:115%;font-family:SimSun;color:black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003estd)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.1128\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.5579\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eChinese\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.991 (0.989, 0.994)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIndian\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.991 (0.982, 1.000)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eMalay\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.996 (0.988, 1.003)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOthers\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.997 (0.987, 1.008)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003ePOSTOP-TRANSFUSION WITHIN 30DAYS\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.4309\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0 units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.992 (0.990, 0.995)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1 unit\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.997 (0.987, 1.007)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2 or more units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.988 (0.978, 0.997)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eINTRAOP-TRANSFUSION\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.1152\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0 units\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.991 (0.988, 0.994)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e1 unit\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.995 (0.991, 0.998)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePREOP-TRANSFUSION WITHIN 30DAYS\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003enone\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.977 (0.971, 0.984)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.995 (0.989, 1.001)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003emoderate and severe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.995 (0.992, 0.998)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003epriority of surgery\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.0742\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003eElective\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;color:black;'\u003e0.995 (0.991, 0.999)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 158.35pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eEmergency\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eyes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.987 (0.976, 0.998) \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:10px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;text-indent:0in;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNote1:Above model is not adjusted for the stratification variable\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;text-align:justify;text-indent:0in;line-height:115%;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNote 2:In each case, the model adjusted for age, sex, race,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;anesthesia type,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Revised Cardiac Risk Index (RCRI) score,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Transfusion Intra and postop Category, Preop-transfusion within 30days\u003cstrong\u003e,\u003c/strong\u003e\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;anesthesia type,\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;priority of surgery, surgical risk\u003c/span\u003e\u003cspan style='font-size:12px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e, and RDW.\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bsur","sideBox":"Learn more about [BMC Surgery](http://bmcsurg.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bsur/default.aspx","title":"BMC Surgery","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Estimated glomerular filtration rate, postoperative thirty-day mortality, Surgery, U-shaped curve","lastPublishedDoi":"10.21203/rs.3.rs-25559/v3","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-25559/v3","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground：\u003c/strong\u003eThere is limited evidence to clarify the specific relationship between\u003cstrong\u003e \u003c/strong\u003epreoperative estimated glomerular filtration rate (preop-eGFR) and postoperative thirty-day mortality in Asian patients undergoing non-cardiac and non-neuron surgery. We aimed to investigate details of this relationship.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods：\u003c/strong\u003eWe reanalyzed a retrospective analysis of the clinical records of 90,785 surgical patients at the Singapore General Hospital from January 1, 2012 to October 31, 2016. The main outcome was postoperative thirty-day mortality.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults ：\u003c/strong\u003eThe average age of these recruited patients was 53.96 ± 16.88 years, of which approximately 51.64% were female. The mean of preop-eGFR distribution was 84.45 ± 38.56mL/min/1.73m\u003csup\u003e2\u003c/sup\u003e. Multivariate logistic regression analysis indicated that preop-eGFR was independently associated with thirty-day mortality (adjusted odds ratio: 0.992; 95% confidence interval [CI]: 0.990-0.995; P \u0026lt; 0.001). A U-shaped relationship was detected between preop-eGFR and thirty-day mortality with an inflection point of 98.688(P for log likelihood ratio test \u0026lt;0.001). The effect sizes and confidence intervals on the right and left sides of the inflection point were 1.013 (1.007 to 1.019) [P \u0026lt; 0.0001] and 0.984 (0.981 to 0.987) [P \u0026lt; 0.0001], respectively. Preoperative comorbidities such as congestive heart failure (CHF), type\u0026nbsp;1\u003cstrong\u003e\u0026nbsp;diabetes,\u003c/strong\u003e ischemic heart disease (IHD),and anemia were associated with the odds ratio of preop-eGFR to thirty-day mortality (interaction P \u0026lt; 0.05).\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eDiscussion\u003c/strong\u003e：The relationship between preop-eGFR and thirty-day mortality is U-shaped. The recommended preop-eGFR\u0026nbsp;at which the rate of the thirty-day mortality was lowest was 98.688mL/min/1.73m\u003csup\u003e2\u003c/sup\u003e.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Estimated glomerular filtration rate and postoperative mortality in patients undergoing non-cardiac and non-neuron surgery: a single-center retrospective study","msid":"","msnumber":"","nonDraftVersions":[{"code":3,"date":"2020-11-16 20:01:23","doi":"10.21203/rs.3.rs-25559/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Accept","date":"2020-11-11T00:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-11-09T00:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-11-08T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-11-08T23:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bsur","sideBox":"Learn more about [BMC Surgery](http://bmcsurg.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bsur/default.aspx","title":"BMC Surgery","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2020-10-15 20:18:26","doi":"10.21203/rs.3.rs-25559/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-11-05T00:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-11-02T00:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nAll major and minor review comments have been resolved.Authors have provided by changing the title into a more complete one, due to their study, as suggested.Comments on language adequateness have been resolved. Language that is more appropriate for use in journals has been utilized where reviewers have remarked.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-10-11T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-10-08T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-10-08T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-10-08T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nEnglish form has been sufficiently revised, as requested. The presentation of the work, the statistics and the conclusion are clear. The article is eligible for publication.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **'I declare that I have no competing interests'**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"editorAssigned","content":"","date":"2020-10-07T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-10-06T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-10-06T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bsur","sideBox":"Learn more about [BMC Surgery](http://bmcsurg.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bsur/default.aspx","title":"BMC Surgery","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-05-14 15:24:38","doi":"10.21203/rs.3.rs-25559/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-09-26T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-25T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after discretionary revisions\nForm responses:\n---\n\nComments to Author:\n---\nThe study tests the relationship between preoperative estimated glomerular filtration rate (preop-eGFR) and post-operative thirty-day mortality in non cardiac surgery. It finds a U-shaped relationship, with a recommended preop eGFR of 98.688 mL/min/1.73m2. Previous studies have shown that preop-eGFR is a moderately effective predictor of thirty-day mortality in hospitalized surgical patients, but most of them are focalized on cardiac surgery and non-Asian patients. This work is specific for non cardiac surgery and Asian population. It analyzes the correlation also for patients with a good renal function and high preop-eGFR. Although this study is a retrospective analysis, the authors use a very large dataset, from clinical records of 79.609 surgical patients. Moreover, statistical analysis are appropriate. The conclusions are well supported by the results. There are very minor errors to be reviewed.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"editorInvitedReview","content":"","date":"2020-09-19T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nArticle review for manuscript titeld (BSUR-D-20-00427):\"Estimated glomerular filtration rate and postoperative mortality in patients undergoing non-cardiac surgery: a single-center retrospective study.\"\n\nAreas in Need of Revision or Elaboration.\n\nCentral to the paper:\n\n​Abstract: Authors indicate that the population included in the study were patients undergoing non-cardiac surgery, but they later specify the grouping even more to include non-brain surgery patients in addition to other crucial exclusionary criteria. This grouping should be clarified in the abstract. (E. G. Methods, Line 3-9: in the exclusion standards we can see that the criteria is much more that what is mention in the abstract or in the introduction).\n\n​Introduction, Line 10: Authors clarify that the study was conducted only with Asian patients, which needs to be more explicit in the study introduction, since they also mention race as a risk factor.\n\n​LINE 15, Section 3.2, P. 10: Significant findings lack p-values for the correlations. Language also needs to be revised (e.g. highest preop-eGFR was significantly positively correlated with females, younger age etc.)\n\n​LINE 38-41, Section 3.3, p. 10: Report p-values for significant findings (e.g. preop-eGFR-thirty-day mortality and female-thirty-day mortality). Additionally, utilize adequate language in order to report findings (i.e. substitute \"in a negative way\" with a statistically significant negative correlation.\n\nMinor revisions\nLanguage\n\n​LINE 30, Section 2.4, P. 7: Change \"Preoperative comorbidities were consist of\" to \"Preoperative comorbidities consisted of\"\n\n​LINE 47, Section 2.3, P. 7: Consider changing \"their reasons for inclusion included as follows\" to \"inclusionary criteria were the following\" to avoid language repetition.\n\n​LINE 52, Section 2.3, P. 7: Consider changing \"The most important outcomes was\" to \"the most important outcome was\".\n\n​LINE 43, Section 3.1, P. 9: Substitute \"thirty mortality\" for \"thirty-day mortality\".\n\n​LINE 33, Section 3.4, P. 11: change \"liner\" to \"linear\"\n​\n​LINE 9, Section 3.5, P. 12: change \"was gradually increased\" to \"gradually increased\"\n​LINE 15, Section 3.5, P. 12: Language issues; consider substituting \"the same trend has also been seen\" with \"the same trend is also noticed/observed in\"\n\n​LINE 56, Discussion, P. 12: Language issues; Change \"studies has already been proved that\" to sentence similar to \"previous studies have also found/supported the hypothesis that\"\n\n​LINE 9, Discussion, P. 14: Language revision; consider changing \"makes the use of data better\" to \"improves/ameliorates the use of data\".\n​LINE 24, Discussion, P. 14: Sentence clarity; elaborate/reword the following sentence, \"While comorbid with anemia, it becomes the same important to control anemia for reducing mortality\"* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **No**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-05-26T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-05-22T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-05-19T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-04-28T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-04-27T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-04-27T12:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"","date":"2020-04-24T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bsur","sideBox":"Learn more about [BMC Surgery](http://bmcsurg.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bsur/default.aspx","title":"BMC Surgery","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"bb2a0979-4291-414a-8819-5a6846cb2ce9","owner":[],"postedDate":"November 16th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":1096823,"name":"Surgery"},{"id":1096824,"name":"General Surgery"}],"tags":[],"updatedAt":"2021-03-07T15:07:24+00:00","versionOfRecord":{"articleIdentity":"rs-25559","link":"https://doi.org/10.1186/s12893-020-00958-7","journal":{"identity":"bmc-surgery","isVorOnly":false,"title":"BMC Surgery"},"publishedOn":"2021-03-06 15:05:37","publishedOnDateReadable":"March 6th, 2021"},"versionCreatedAt":"2020-11-16 20:01:23","video":"","vorDoi":"10.1186/s12893-020-00958-7","vorDoiUrl":"https://doi.org/10.1186/s12893-020-00958-7","workflowStages":[]},"version":"v3","identity":"rs-25559","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-25559","identity":"rs-25559","version":["v3"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}