The science of printing and polishing 3D printed dentures

preprint OA: closed
Full text JSON View at publisher
Full text 128,450 characters · extracted from preprint-html · click to expand
The science of printing and polishing 3D printed... | F1000Research "use strict";function _typeof(t){return(_typeof="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t})(t)}!function(){var t=function(){var t,e,o=[],n=window,r=n;for(;r;){try{if(r.frames.__tcfapiLocator){t=r;break}}catch(t){}if(r===n.top)break;r=r.parent}t||(!function t(){var e=n.document,o=!!n.frames.__tcfapiLocator;if(!o)if(e.body){var r=e.createElement("iframe");r.style.cssText="display:none",r.name="__tcfapiLocator",e.body.appendChild(r)}else setTimeout(t,5);return!o}(),n.__tcfapi=function(){for(var t=arguments.length,n=new Array(t),r=0;r 3&&2===parseInt(n[1],10)&&"boolean"==typeof n[3]&&(e=n[3],"function"==typeof n[2]&&n[2]("set",!0)):"ping"===n[0]?"function"==typeof n[2]&&n[2]({gdprApplies:e,cmpLoaded:!1,cmpStatus:"stub"}):o.push(n)},n.addEventListener("message",(function(t){var e="string"==typeof t.data,o={};if(e)try{o=JSON.parse(t.data)}catch(t){}else o=t.data;var n="object"===_typeof(o)&&null!==o?o.__tcfapiCall:null;n&&window.__tcfapi(n.command,n.version,(function(o,r){var a={__tcfapiReturn:{returnValue:o,success:r,callId:n.callId}};t&&t.source&&t.source.postMessage&&t.source.postMessage(e?JSON.stringify(a):a,"*")}),n.parameter)}),!1))};"undefined"!=typeof module?module.exports=t:t()}(); dataLayer = dataLayer || []; // Standard GTM initialization - Google Consent Mode handles consent automatically (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl+ '>m_auth=hzk0Vc3qFsQYhCrIoHz68A>m_preview=env-1>m_cookies_win=x';f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MWFK8L5J'); ;window.NREUM||(NREUM={});NREUM.init={distributed_tracing:{enabled:true},privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]}}; ;NREUM.loader_config={accountID:"438030",trustKey:"438030",agentID:"772317073",licenseKey:"97f8f67f26",applicationID:"772317073"} ;NREUM.info={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net",licenseKey:"97f8f67f26",applicationID:"772317073",sa:1} ;/*! For license information please see nr-loader-spa-1.236.0.min.js.LICENSE.txt */ (()=>{"use strict";var e,t,r={5763:(e,t,r)=>{r.d(t,{P_:()=>l,Mt:()=>g,C5:()=>s,DL:()=>v,OP:()=>T,lF:()=>D,Yu:()=>y,Dg:()=>h,CX:()=>c,GE:()=>b,sU:()=>_});var n=r(8632),i=r(9567);const o={beacon:n.ce.beacon,errorBeacon:n.ce.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.D)(t,o),(0,n.Qy)(e,a[e],"info")}var u=r(7056);const d=()=>{const e={blockSelector:"[data-nr-block]",maskInputOptions:{password:!0}};return{allow_bfcache:!0,privacy:{cookies_enabled:!0},ajax:{deny_list:void 0,enabled:!0,harvestTimeSeconds:10},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},session:{domain:void 0,expiresMs:u.oD,inactiveMs:u.Hb},ssl:void 0,obfuscate:void 0,jserrors:{enabled:!0,harvestTimeSeconds:10},metrics:{enabled:!0},page_action:{enabled:!0,harvestTimeSeconds:30},page_view_event:{enabled:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,long_task:!1},session_trace:{enabled:!0,harvestTimeSeconds:10},harvest:{tooManyRequestsDelay:60},session_replay:{enabled:!1,harvestTimeSeconds:60,sampleRate:.1,errorSampleRate:.1,maskTextSelector:"*",maskAllInputs:!0,get blockClass(){return"nr-block"},get ignoreClass(){return"nr-ignore"},get maskTextClass(){return"nr-mask"},get blockSelector(){return e.blockSelector},set blockSelector(t){e.blockSelector+=",".concat(t)},get maskInputOptions(){return e.maskInputOptions},set maskInputOptions(t){e.maskInputOptions={...t,password:!0}}},spa:{enabled:!0,harvestTimeSeconds:10}}},f={};function l(e){if(!e)throw new Error("All configuration objects require an agent identifier!");if(!f[e])throw new Error("Configuration for ".concat(e," was never set"));return f[e]}function h(e,t){if(!e)throw new Error("All configuration objects require an agent identifier!");f[e]=(0,i.D)(t,d()),(0,n.Qy)(e,f[e],"config")}function g(e,t){if(!e)throw new Error("All configuration objects require an agent identifier!");var r=l(e);if(r){for(var n=t.split("."),i=0;i {r.d(t,{D:()=>i});var n=r(50);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.Z)("Setting a Configurable requires an object as input");if(!t||"object"!=typeof t)return(0,n.Z)("Setting a Configurable requires a model to set its initial properties");const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.Z)("An error occurred while setting a property of a Configurable",e)}return r}catch(e){(0,n.Z)("An error occured while setting a Configurable",e)}}},6818:(e,t,r)=>{r.d(t,{Re:()=>i,gF:()=>o,q4:()=>n});const n="1.236.0",i="PROD",o="CDN"},385:(e,t,r)=>{r.d(t,{FN:()=>a,IF:()=>u,Nk:()=>f,Tt:()=>s,_A:()=>o,il:()=>n,pL:()=>c,v6:()=>i,w1:()=>d});const n="undefined"!=typeof window&&!!window.document,i="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),o=n?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),a=""+o?.location,s=/iPad|iPhone|iPod/.test(navigator.userAgent),c=s&&"undefined"==typeof SharedWorker,u=(()=>{const e=navigator.userAgent.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),d=Boolean(n&&window.document.documentMode),f=!!navigator.sendBeacon},1117:(e,t,r)=>{r.d(t,{w:()=>o});var n=r(50);const i={agentIdentifier:"",ee:void 0};class o{constructor(e){try{if("object"!=typeof e)return(0,n.Z)("shared context requires an object as input");this.sharedContext={},Object.assign(this.sharedContext,i),Object.entries(e).forEach((e=>{let[t,r]=e;Object.keys(i).includes(t)&&(this.sharedContext[t]=r)}))}catch(e){(0,n.Z)("An error occured while setting SharedContext",e)}}}},8e3:(e,t,r)=>{r.d(t,{L:()=>d,R:()=>c});var n=r(2177),i=r(1284),o=r(4322),a=r(3325);const s={};function c(e,t){const r={staged:!1,priority:a.p[t]||0};u(e),s[e].get(t)||s[e].set(t,r)}function u(e){e&&(s[e]||(s[e]=new Map))}function d(){let e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:"",t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"feature";if(u(e),!e||!s[e].get(t))return a(t);s[e].get(t).staged=!0;const r=[...s[e]];function a(t){const r=e?n.ee.get(e):n.ee,a=o.X.handlers;if(r.backlog&&a){var s=r.backlog[t],c=a[t];if(c){for(var u=0;s&&u {let[t,r]=e;return r.staged}))&&(r.sort(((e,t)=>e[1].priority-t[1].priority)),r.forEach((e=>{let[t]=e;a(t)})))}function f(e,t){var r=e[1];(0,i.D)(t[r],(function(t,r){var n=e[0];if(r[0]===n){var i=r[1],o=e[3],a=e[2];i.apply(o,a)}}))}},2177:(e,t,r)=>{r.d(t,{c:()=>f,ee:()=>u});var n=r(8632),i=r(2210),o=r(1284),a=r(5763),s="nr@context";let c=(0,n.fP)();var u;function d(){}function f(e){return(0,i.X)(e,s,l)}function l(){return new d}function h(){u.aborted=!0,u.backlog={}}c.ee?u=c.ee:(u=function e(t,r){var n={},c={},f={},g=!1;try{g=16===r.length&&(0,a.OP)(r).isolatedBacklog}catch(e){}var p={on:b,addEventListener:b,removeEventListener:y,emit:v,get:x,listeners:w,context:m,buffer:A,abort:h,aborted:!1,isBuffering:E,debugId:r,backlog:g?{}:t&&"object"==typeof t.backlog?t.backlog:{}};return p;function m(e){return e&&e instanceof d?e:e?(0,i.X)(e,s,l):l()}function v(e,r,n,i,o){if(!1!==o&&(o=!0),!u.aborted||i){t&&o&&t.emit(e,r,n);for(var a=m(n),s=w(e),d=s.length,f=0;fn,p:()=>i});var n=r(2177).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},4322:(e,t,r)=>{r.d(t,{X:()=>o});var n=r(5546);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.E,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.E);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3239:(e,t,r)=>{r.d(t,{bP:()=>s,iz:()=>c,m$:()=>a});var n=r(385);let i=!1,o=!1;try{const e={get passive(){return i=!0,!1},get signal(){return o=!0,!1}};n._A.addEventListener("test",null,e),n._A.removeEventListener("test",null,e)}catch(e){}function a(e,t){return i||o?{capture:!!e,passive:i,signal:t}:!!e}function s(e,t){let r=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3?arguments[3]:void 0;window.addEventListener(e,t,a(r,n))}function c(e,t){let r=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3?arguments[3]:void 0;document.addEventListener(e,t,a(r,n))}},4402:(e,t,r)=>{r.d(t,{Ht:()=>u,M:()=>c,Rl:()=>a,ky:()=>s});var n=r(385);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n._A?.crypto||n._A?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(31))),i.split("").map((e=>"x"===e?o(t,++r).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n._A?.crypto||n._A?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(31)));const a=[];for(var s=0;s {r.d(t,{Bq:()=>n,Hb:()=>o,oD:()=>i});const n="NRBA",i=144e5,o=18e5},7894:(e,t,r)=>{function n(){return Math.round(performance.now())}r.d(t,{z:()=>n})},7243:(e,t,r)=>{r.d(t,{e:()=>o});var n=r(385),i={};function o(e){if(e in i)return i[e];if(0===(e||"").indexOf("data:"))return{protocol:"data"};let t;var r=n._A?.location,o={};if(n.il)t=document.createElement("a"),t.href=e;else try{t=new URL(e,r.href)}catch(e){return o}o.port=t.port;var a=t.href.split("://");!o.port&&a[1]&&(o.port=a[1].split("/")[0].split("@").pop().split(":")[1]),o.port&&"0"!==o.port||(o.port="https"===a[0]?"443":"80"),o.hostname=t.hostname||r.hostname,o.pathname=t.pathname,o.protocol=a[0],"/"!==o.pathname.charAt(0)&&(o.pathname="/"+o.pathname);var s=!t.protocol||":"===t.protocol||t.protocol===r.protocol,c=t.hostname===r.hostname&&t.port===r.port;return o.sameOrigin=s&&(!t.hostname||c),"/"===o.pathname&&(i[e]=o),o}},50:(e,t,r)=>{function n(e,t){"function"==typeof console.warn&&(console.warn("New Relic: ".concat(e)),t&&console.warn(t))}r.d(t,{Z:()=>n})},2587:(e,t,r)=>{r.d(t,{N:()=>c,T:()=>u});var n=r(2177),i=r(5546),o=r(8e3),a=r(3325);const s={stn:[a.D.sessionTrace],err:[a.D.jserrors,a.D.metrics],ins:[a.D.pageAction],spa:[a.D.spa],sr:[a.D.sessionReplay,a.D.sessionTrace]};function c(e,t){const r=n.ee.get(t);e&&"object"==typeof e&&(Object.entries(e).forEach((e=>{let[t,n]=e;void 0===u[t]&&(s[t]?s[t].forEach((e=>{n?(0,i.p)("feat-"+t,[],void 0,e,r):(0,i.p)("block-"+t,[],void 0,e,r),(0,i.p)("rumresp-"+t,[Boolean(n)],void 0,e,r)})):n&&(0,i.p)("feat-"+t,[],void 0,void 0,r),u[t]=Boolean(n))})),Object.keys(s).forEach((e=>{void 0===u[e]&&(s[e]?.forEach((t=>(0,i.p)("rumresp-"+e,[!1],void 0,t,r))),u[e]=!1)})),(0,o.L)(t,a.D.pageViewEvent))}const u={}},2210:(e,t,r)=>{r.d(t,{X:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},1284:(e,t,r)=>{r.d(t,{D:()=>n});const n=(e,t)=>Object.entries(e||{}).map((e=>{let[r,n]=e;return t(r,n)}))},4351:(e,t,r)=>{r.d(t,{P:()=>o});var n=r(2177);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}}}},3960:(e,t,r)=>{r.d(t,{K:()=>a,b:()=>o});var n=r(3239);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.bP)("load",e,t)}function a(e){if(i())return e();(0,n.iz)("DOMContentLoaded",e)}},8632:(e,t,r)=>{r.d(t,{EZ:()=>u,Qy:()=>c,ce:()=>o,fP:()=>a,gG:()=>d,mF:()=>s});var n=r(7894),i=r(385);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return i._A.NREUM||(i._A.NREUM={}),void 0===i._A.newrelic&&(i._A.newrelic=i._A.NREUM),i._A.NREUM}function s(){let e=a();return e.o||(e.o={ST:i._A.setTimeout,SI:i._A.setImmediate,CT:i._A.clearTimeout,XHR:i._A.XMLHttpRequest,REQ:i._A.Request,EV:i._A.Event,PR:i._A.Promise,MO:i._A.MutationObserver,FETCH:i._A.fetch}),e}function c(e,t,r){let i=a();const o=i.initializedAgents||{},s=o[e]||{};return Object.keys(s).length||(s.initializedAt={ms:(0,n.z)(),date:new Date}),i.initializedAgents={...o,[e]:{...s,[r]:t}},i}function u(e,t){a()[e]=t}function d(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},7956:(e,t,r)=>{r.d(t,{N:()=>i});var n=r(3239);function i(e){let t=arguments.length>1&&void 0!==arguments[1]&&arguments[1],r=arguments.length>2?arguments[2]:void 0,i=arguments.length>3?arguments[3]:void 0;return void(0,n.iz)("visibilitychange",(function(){if(t)return void("hidden"==document.visibilityState&&e());e(document.visibilityState)}),r,i)}},1214:(e,t,r)=>{r.d(t,{em:()=>v,u5:()=>N,QU:()=>S,_L:()=>I,Gm:()=>L,Lg:()=>M,gy:()=>U,BV:()=>Q,Kf:()=>ee});var n=r(2177);const i="nr@original";var o=Object.prototype.hasOwnProperty,a=!1;function s(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");var a,s,c,u="-"===n.charAt(0);for(c=0;c 2?n-2:0),o=2;o {r(A[T],e,w),r(E[T],e,w)})),r(l._A,"fetch",y),t.on(y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(y+"done",[null,r],n)}else t.emit(y+"done",[e],n)})),t}const O={},j=["pushState","replaceState"];function S(e){const t=function(e){return(e||n.ee).get("history")}(e);return!l.il||O[t.debugId]++||(O[t.debugId]=1,s(t).inPlace(window.history,j,"-")),t}var P=r(3239);const C={},R=["appendChild","insertBefore","replaceChild"];function I(e){const t=function(e){return(e||n.ee).get("jsonp")}(e);if(!l.il||C[t.debugId])return t;C[t.debugId]=!0;var r=s(t),i=/[?&](?:callback|cb)=([^&#]+)/,o=/(.*)\.([^.]+)/,a=/^(\w+)(\.|$)(.*)$/;function c(e,t){var r=e.match(a),n=r[1],i=r[3];return i?c(i,t[n]):t[n]}return r.inPlace(Node.prototype,R,"dom-"),t.on("dom-start",(function(e){!function(e){if(!e||"string"!=typeof e.nodeName||"script"!==e.nodeName.toLowerCase())return;if("function"!=typeof e.addEventListener)return;var n=(a=e.src,s=a.match(i),s?s[1]:null);var a,s;if(!n)return;var u=function(e){var t=e.match(o);if(t&&t.length>=3)return{key:t[2],parent:c(t[1],window)};return{key:e,parent:window}}(n);if("function"!=typeof u.parent[u.key])return;var d={};function f(){t.emit("jsonp-end",[],d),e.removeEventListener("load",f,(0,P.m$)(!1)),e.removeEventListener("error",l,(0,P.m$)(!1))}function l(){t.emit("jsonp-error",[],d),t.emit("jsonp-end",[],d),e.removeEventListener("load",f,(0,P.m$)(!1)),e.removeEventListener("error",l,(0,P.m$)(!1))}r.inPlace(u.parent,[u.key],"cb-",d),e.addEventListener("load",f,(0,P.m$)(!1)),e.addEventListener("error",l,(0,P.m$)(!1)),t.emit("new-jsonp",[e.src],d)}(e[0])})),t}var k=r(5763);const H={};function L(e){const t=function(e){return(e||n.ee).get("mutation")}(e);if(!l.il||H[t.debugId])return t;H[t.debugId]=!0;var r=s(t),i=k.Yu.MO;return i&&(window.MutationObserver=function(e){return this instanceof i?new i(r(e,"fn-")):i.apply(this,arguments)},MutationObserver.prototype=i.prototype),t}const z={};function M(e){const t=function(e){return(e||n.ee).get("promise")}(e);if(z[t.debugId])return t;z[t.debugId]=!0;var r=n.c,o=s(t),a=k.Yu.PR;return a&&function(){function e(r){var n=t.context(),i=o(r,"executor-",n,null,!1);const s=Reflect.construct(a,[i],e);return t.context(s).getCtx=function(){return n},s}l._A.Promise=e,Object.defineProperty(e,"name",{value:"Promise"}),e.toString=function(){return a.toString()},Object.setPrototypeOf(e,a),["all","race"].forEach((function(r){const n=a[r];e[r]=function(e){let i=!1;[...e||[]].forEach((e=>{this.resolve(e).then(a("all"===r),a(!1))}));const o=n.apply(this,arguments);return o;function a(e){return function(){t.emit("propagate",[null,!i],o,!1,!1),i=i||!e}}}})),["resolve","reject"].forEach((function(r){const n=a[r];e[r]=function(e){const r=n.apply(this,arguments);return e!==r&&t.emit("propagate",[e,!0],r,!1,!1),r}})),e.prototype=a.prototype;const n=a.prototype.then;a.prototype.then=function(){var e=this,i=r(e);i.promise=e;for(var a=arguments.length,s=new Array(a),c=0;c e())),t};function m(e,t){i.inPlace(t,["onreadystatechange"],"fn-",E)}function b(){var e=this,t=r.context(e);e.readyState>3&&!t.resolved&&(t.resolved=!0,r.emit("xhr-resolved",[],e)),i.inPlace(e,f,"fn-",E)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,p),p.prototype=o.prototype,i.inPlace(p.prototype,J,"-xhr-",E),r.on("send-xhr-start",(function(e,t){m(e,t),function(e){h.push(e),a&&(y?y.then(A):u?u(A):(w=-w,x.data=w))}(t)})),r.on("open-xhr-start",m),a){var y=c&&c.resolve();if(!u&&!c){var w=1,x=document.createTextNode(w);new a(A).observe(x,{characterData:!0})}}else t.on("fn-end",(function(e){e[0]&&e[0].type===d||A()}));function A(){for(var e=0;e {r.d(t,{t:()=>n});const n=r(3325).D.ajax},6660:(e,t,r)=>{r.d(t,{A:()=>i,t:()=>n});const n=r(3325).D.jserrors,i="nr@seenError"},3081:(e,t,r)=>{r.d(t,{gF:()=>o,mY:()=>i,t9:()=>n,vz:()=>s,xS:()=>a});const n=r(3325).D.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},4649:(e,t,r)=>{r.d(t,{t:()=>n});const n=r(3325).D.pageAction},7633:(e,t,r)=>{r.d(t,{Dz:()=>i,OJ:()=>a,qw:()=>o,t9:()=>n});const n=r(3325).D.pageViewEvent,i="firstbyte",o="domcontent",a="windowload"},9251:(e,t,r)=>{r.d(t,{t:()=>n});const n=r(3325).D.pageViewTiming},3614:(e,t,r)=>{r.d(t,{BST_RESOURCE:()=>i,END:()=>s,FEATURE_NAME:()=>n,FN_END:()=>u,FN_START:()=>c,PUSH_STATE:()=>d,RESOURCE:()=>o,START:()=>a});const n=r(3325).D.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState"},7836:(e,t,r)=>{r.d(t,{BODY:()=>A,CB_END:()=>E,CB_START:()=>u,END:()=>x,FEATURE_NAME:()=>i,FETCH:()=>_,FETCH_BODY:()=>v,FETCH_DONE:()=>m,FETCH_START:()=>p,FN_END:()=>c,FN_START:()=>s,INTERACTION:()=>l,INTERACTION_API:()=>d,INTERACTION_EVENTS:()=>o,JSONP_END:()=>b,JSONP_NODE:()=>g,JS_TIME:()=>T,MAX_TIMER_BUDGET:()=>a,REMAINING:()=>f,SPA_NODE:()=>h,START:()=>w,originalSetTimeout:()=>y});var n=r(5763);const i=r(3325).D.spa,o=["click","submit","keypress","keydown","keyup","change"],a=999,s="fn-start",c="fn-end",u="cb-start",d="api-ixn-",f="remaining",l="interaction",h="spaNode",g="jsonpNode",p="fetch-start",m="fetch-done",v="fetch-body-",b="jsonp-end",y=n.Yu.ST,w="-start",x="-end",A="-body",E="cb"+x,T="jsTime",_="fetch"},5938:(e,t,r)=>{r.d(t,{W:()=>o});var n=r(5763),i=r(2177);class o{constructor(e,t,r){this.agentIdentifier=e,this.aggregator=t,this.ee=i.ee.get(e,(0,n.OP)(this.agentIdentifier).isolatedBacklog),this.featureName=r,this.blocked=!1}}},9144:(e,t,r)=>{r.d(t,{j:()=>m});var n=r(3325),i=r(5763),o=r(5546),a=r(2177),s=r(7894),c=r(8e3),u=r(3960),d=r(385),f=r(50),l=r(3081),h=r(8632);function g(){const e=(0,h.gG)();["setErrorHandler","finished","addToTrace","inlineHit","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId"].forEach((t=>{e[t]=function(){for(var r=arguments.length,n=new Array(r),i=0;i 1?r-1:0),i=1;i {e.exposed&&e.api[t]&&o.push(e.api[t](...n))})),o.length>1?o:o[0]}(t,...n)}}))}var p=r(2587);function m(e){let t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},m=arguments.length>2?arguments[2]:void 0,v=arguments.length>3?arguments[3]:void 0,{init:b,info:y,loader_config:w,runtime:x={loaderType:m},exposed:A=!0}=t;const E=(0,h.gG)();y||(b=E.init,y=E.info,w=E.loader_config),(0,i.Dg)(e,b||{}),(0,i.GE)(e,w||{}),(0,i.sU)(e,x),y.jsAttributes??={},d.v6&&(y.jsAttributes.isWorker=!0),(0,i.CX)(e,y),g();const T=function(e,t){t||(0,c.R)(e,"api");const h={};var g=a.ee.get(e),p=g.get("tracer"),m="api-",v=m+"ixn-";function b(t,r,n,o){const a=(0,i.C5)(e);return null===r?delete a.jsAttributes[t]:(0,i.CX)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),x(m,n,!0,o||null===r?"session":void 0)(t,r)}function y(){}["setErrorHandler","finished","addToTrace","inlineHit","addRelease"].forEach((e=>h[e]=x(m,e,!0,"api"))),h.addPageAction=x(m,"addPageAction",!0,n.D.pageAction),h.setCurrentRouteName=x(m,"routeName",!0,n.D.spa),h.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,i.OP)(e).customTransaction=(r||"http://custom.transaction")+t,x(m,"setPageViewName",!0)()},h.setCustomAttribute=function(e,t){let r=arguments.length>2&&void 0!==arguments[2]&&arguments[2];if("string"==typeof e){if(["string","number"].includes(typeof t)||null===t)return b(e,t,"setCustomAttribute",r);(0,f.Z)("Failed to execute setCustomAttribute.\nNon-null value must be a string or number type, but a type of was provided."))}else(0,f.Z)("Failed to execute setCustomAttribute.\nName must be a string type, but a type of was provided."))},h.setUserId=function(e){if("string"==typeof e||null===e)return b("enduser.id",e,"setUserId",!0);(0,f.Z)("Failed to execute setUserId.\nNon-null value must be a string type, but a type of was provided."))},h.interaction=function(){return(new y).get()};var w=y.prototype={createTracer:function(e,t){var r={},i=this,a="function"==typeof t;return(0,o.p)(v+"tracer",[(0,s.z)(),e,r],i,n.D.spa,g),function(){if(p.emit((a?"":"no-")+"fn-start",[(0,s.z)(),i,a],r),a)try{return t.apply(this,arguments)}catch(e){throw p.emit("fn-err",[arguments,this,"string"==typeof e?new Error(e):e],r),e}finally{p.emit("fn-end",[(0,s.z)()],r)}}}};function x(e,t,r,i){return function(){return(0,o.p)(l.xS,["API/"+t+"/called"],void 0,n.D.metrics,g),i&&(0,o.p)(e+t,[(0,s.z)(),...arguments],r?null:this,i,g),r?void 0:this}}function A(){r.e(439).then(r.bind(r,7438)).then((t=>{let{setAPI:r}=t;r(e),(0,c.L)(e,"api")})).catch((()=>(0,f.Z)("Downloading runtime APIs failed...")))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{w[e]=x(v,e,void 0,n.D.spa)})),h.noticeError=function(e,t){"string"==typeof e&&(e=new Error(e)),(0,o.p)(l.xS,["API/noticeError/called"],void 0,n.D.metrics,g),(0,o.p)("err",[e,(0,s.z)(),!1,t],void 0,n.D.jserrors,g)},d.il?(0,u.b)((()=>A()),!0):A(),h}(e,v);return(0,h.Qy)(e,T,"api"),(0,h.Qy)(e,A,"exposed"),(0,h.EZ)("activatedFeatures",p.T),T}},3325:(e,t,r)=>{r.d(t,{D:()=>n,p:()=>i});const n={ajax:"ajax",jserrors:"jserrors",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.ajax]:5,[n.sessionTrace]:6,[n.pageAction]:7,[n.spa]:8,[n.sessionReplay]:9}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>(({78:"page_action-aggregate",147:"metrics-aggregate",242:"session-manager",317:"jserrors-aggregate",348:"page_view_timing-aggregate",412:"lazy-feature-loader",439:"async-api",538:"recorder",590:"session_replay-aggregate",675:"compressor",733:"session_trace-aggregate",786:"page_view_event-aggregate",873:"spa-aggregate",898:"ajax-aggregate"}[e]||e)+"."+{78:"ac76d497",147:"3dc53903",148:"1a20d5fe",242:"2a64278a",317:"49e41428",348:"bd6de33a",412:"2f55ce66",439:"30bd804e",538:"1b18459f",590:"cf0efb30",675:"ae9f91a8",733:"83105561",786:"06482edd",860:"03a8b7a5",873:"e6b09d52",898:"998ef92b"}[e]+"-1.236.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d {s.onerror=s.onload=null,clearTimeout(h);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},h=setTimeout(l.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=l.bind(null,s.onerror),s.onload=l.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.j=364,i.p="https://js-agent.newrelic.com/",(()=>{var e={364:0,953:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u {i.r(o);var e=i(3325),t=i(5763);const r=Object.values(e.D);function n(e){const n={};return r.forEach((r=>{n[r]=function(e,r){return!1!==(0,t.Mt)(r,"".concat(e,".enabled"))}(r,e)})),n}var a=i(9144);var s=i(5546),c=i(385),u=i(8e3),d=i(5938),f=i(3960),l=i(50);class h extends d.W{constructor(e,t,r){let n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3];super(e,t,r),this.auto=n,this.abortHandler,this.featAggregate,this.onAggregateImported,n&&(0,u.R)(e,r)}importAggregator(){let e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};if(this.featAggregate||!this.auto)return;const r=c.il&&!0===(0,t.Mt)(this.agentIdentifier,"privacy.cookies_enabled");let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let t;try{if(r){const{setupAgentSession:e}=await Promise.all([i.e(860),i.e(242)]).then(i.bind(i,3228));t=e(this.agentIdentifier)}}catch(e){(0,l.Z)("A problem occurred when starting up session manager. This page will not start or extend any session.",e)}try{if(!this.shouldImportAgg(this.featureName,t))return void(0,u.L)(this.agentIdentifier,this.featureName);const{lazyFeatureLoader:r}=await i.e(412).then(i.bind(i,8582)),{Aggregate:o}=await r(this.featureName,"aggregate");this.featAggregate=new o(this.agentIdentifier,this.aggregator,e),n(!0)}catch(e){(0,l.Z)("Downloading and initializing ".concat(this.featureName," failed..."),e),this.abortHandler?.(),n(!1)}};c.il?(0,f.b)((()=>o()),!0):o()}shouldImportAgg(r,n){return r!==e.D.sessionReplay||!1!==(0,t.Mt)(this.agentIdentifier,"session_trace.enabled")&&(!!n?.isNew||!!n?.state.sessionReplay)}}var g=i(7633),p=i(7894);class m extends h{static featureName=g.t9;constructor(r,n){let i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(super(r,n,g.t9,i),("undefined"==typeof PerformanceNavigationTiming||c.Tt)&&"undefined"!=typeof PerformanceTiming){const n=(0,t.OP)(r);n[g.Dz]=Math.max(Date.now()-n.offset,0),(0,f.K)((()=>n[g.qw]=Math.max((0,p.z)()-n[g.Dz],0))),(0,f.b)((()=>{const t=(0,p.z)();n[g.OJ]=Math.max(t-n[g.Dz],0),(0,s.p)("timing",["load",t],void 0,e.D.pageViewTiming,this.ee)}))}this.importAggregator()}}var v=i(1117),b=i(1284);class y extends v.w{constructor(e){super(e),this.aggregatedData={}}store(e,t,r,n,i){var o=this.getBucket(e,t,r,i);return o.metrics=function(e,t){t||(t={count:0});return t.count+=1,(0,b.D)(e,(function(e,r){t[e]=w(r,t[e])})),t}(n,o.metrics),o}merge(e,t,r,n,i){var o=this.getBucket(e,t,n,i);if(o.metrics){var a=o.metrics;a.count+=r.count,(0,b.D)(r,(function(e,t){if("count"!==e){var n=a[e],i=r[e];i&&!i.c?a[e]=w(i.t,n):a[e]=function(e,t){if(!t)return e;t.c||(t=x(t.t));return t.min=Math.min(e.min,t.min),t.max=Math.max(e.max,t.max),t.t+=e.t,t.sos+=e.sos,t.c+=e.c,t}(i,a[e])}}))}else o.metrics=r}storeMetric(e,t,r,n){var i=this.getBucket(e,t,r);return i.stats=w(n,i.stats),i}getBucket(e,t,r,n){this.aggregatedData[e]||(this.aggregatedData[e]={});var i=this.aggregatedData[e][t];return i||(i=this.aggregatedData[e][t]={params:r||{}},n&&(i.custom=n)),i}get(e,t){return t?this.aggregatedData[e]&&this.aggregatedData[e][t]:this.aggregatedData[e]}take(e){for(var t={},r="",n=!1,i=0;i t.max&&(t.max=e),e 2&&void 0!==arguments[2])||arguments[2];super(e,r,j.t,n),c.il&&((0,t.OP)(e).initHidden=Boolean("hidden"===document.visibilityState),(0,N.N)((()=>(0,s.p)("docHidden",[(0,p.z)()],void 0,j.t,this.ee)),!0),(0,O.bP)("pagehide",(()=>(0,s.p)("winPagehide",[(0,p.z)()],void 0,j.t,this.ee))),this.importAggregator())}}var P=i(3081);class C extends h{static featureName=P.t9;constructor(e,t){let r=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];super(e,t,P.t9,r),this.importAggregator()}}var R,I=i(2210),k=i(1214),H=i(2177),L={};try{R=localStorage.getItem("__nr_flags").split(","),console&&"function"==typeof console.log&&(L.console=!0,-1!==R.indexOf("dev")&&(L.dev=!0),-1!==R.indexOf("nr_dev")&&(L.nrDev=!0))}catch(e){}function z(e){try{L.console&&z(e)}catch(e){}}L.nrDev&&H.ee.on("internal-error",(function(e){z(e.stack)})),L.dev&&H.ee.on("fn-err",(function(e,t,r){z(r.stack)})),L.dev&&(z("NR AGENT IN DEVELOPMENT MODE"),z("flags: "+(0,b.D)(L,(function(e,t){return e})).join(", ")));var M=i(6660);class B extends h{static featureName=M.t;constructor(r,n){let i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];super(r,n,M.t,i),this.skipNext=0;try{this.removeOnAbort=new AbortController}catch(e){}const o=this;o.ee.on("fn-start",(function(e,t,r){o.abortHandler&&(o.skipNext+=1)})),o.ee.on("fn-err",(function(t,r,n){o.abortHandler&&!n[M.A]&&((0,I.X)(n,M.A,(function(){return!0})),this.thrown=!0,(0,s.p)("err",[n,(0,p.z)()],void 0,e.D.jserrors,o.ee))})),o.ee.on("fn-end",(function(){o.abortHandler&&!this.thrown&&o.skipNext>0&&(o.skipNext-=1)})),o.ee.on("internal-error",(function(t){(0,s.p)("ierr",[t,(0,p.z)(),!0],void 0,e.D.jserrors,o.ee)})),this.origOnerror=c._A.onerror,c._A.onerror=this.onerrorHandler.bind(this),c._A.addEventListener("unhandledrejection",(t=>{const r=function(e){let t="Unhandled Promise Rejection: ";if(e instanceof Error)try{return e.message=t+e.message,e}catch(t){return e}if(void 0===e)return new Error(t);try{return new Error(t+(0,D.P)(e))}catch(e){return new Error(t)}}(t.reason);(0,s.p)("err",[r,(0,p.z)(),!1,{unhandledPromiseRejection:1}],void 0,e.D.jserrors,this.ee)}),(0,O.m$)(!1,this.removeOnAbort?.signal)),(0,k.gy)(this.ee),(0,k.BV)(this.ee),(0,k.em)(this.ee),(0,t.OP)(r).xhrWrappable&&(0,k.Kf)(this.ee),this.abortHandler=this.#e,this.importAggregator()}#e(){this.removeOnAbort?.abort(),this.abortHandler=void 0}onerrorHandler(t,r,n,i,o){"function"==typeof this.origOnerror&&this.origOnerror(...arguments);try{this.skipNext?this.skipNext-=1:(0,s.p)("err",[o||new F(t,r,n),(0,p.z)()],void 0,e.D.jserrors,this.ee)}catch(t){try{(0,s.p)("ierr",[t,(0,p.z)(),!0],void 0,e.D.jserrors,this.ee)}catch(e){}}return!1}}function F(e,t,r){this.message=e||"Uncaught error with no additional information",this.sourceURL=t,this.line=r}let U=1;const q="nr@id";function G(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===c._A?0:(0,I.X)(e,q,(function(){return U++}))}function V(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,D.P)(e).length}catch(e){return}}}var X=i(7243);class W{constructor(e){this.agentIdentifier=e,this.generateTracePayload=this.generateTracePayload.bind(this),this.shouldGenerateTrace=this.shouldGenerateTrace.bind(this)}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var r=(0,t.DL)(this.agentIdentifier);if(!r)return null;var n=(r.accountID||"").toString()||null,i=(r.agentID||"").toString()||null,o=(r.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,_.M)(),s=(0,_.Ht)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof c._A?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,D.P)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var r=!1,n={};if((0,t.Mt)(this.agentIdentifier,"distributed_tracing")&&(n=(0,t.P_)(this.agentIdentifier).distributed_tracing),e.sameOrigin)r=!0;else if(n.allowed_origins instanceof Array)for(var i=0;i 2&&void 0!==arguments[2])||arguments[2];super(r,n,Z.t,i),(0,t.OP)(r).xhrWrappable&&(this.dt=new W(r),this.handler=(e,t,r,n)=>(0,s.p)(e,t,r,n,this.ee),(0,k.u5)(this.ee),(0,k.Kf)(this.ee),function(r,n,i,o){function a(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=E,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){_(t,e)}),(0,O.m$)(!1)),c.IF||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,O.m$)(!1))}function s(e){this.params={method:e[0]},T(this,e[1]),this.metrics={}}function u(e,n){var i=(0,t.DL)(r);i.xpid&&this.sameOrigin&&n.setRequestHeader("X-NewRelic-ID",i.xpid);var a=o.generateTracePayload(this.parsedOrigin);if(a){var s=!1;a.newrelicHeader&&(n.setRequestHeader("newrelic",a.newrelicHeader),s=!0),a.traceContextParentHeader&&(n.setRequestHeader("traceparent",a.traceContextParentHeader),a.traceContextStateHeader&&n.setRequestHeader("tracestate",a.traceContextStateHeader),s=!0),s&&(this.dt=a)}}function d(e,t){var r=this.metrics,i=e[0],o=this;if(r&&i){var a=V(i);a&&(r.txSize=a)}this.startTime=(0,p.z)(),this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof t.onload)&&"function"==typeof o.end)&&o.end(t)}catch(e){try{n.emit("internal-error",[e])}catch(e){}}};for(var s=0;s 1?e[1]=i:e.push(i)}else e[0]&&e[0].headers&&s(e[0].headers,n)&&(this.dt=n);function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function x(e,t){this.params={},this.metrics={},this.startTime=(0,p.z)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof Y?r=i.url:c._A?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),T(this,r);var o=(""+(i&&i instanceof Y&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.txSize=V(n.body)||0}function A(t,r){var n;this.endTime=(0,p.z)(),this.params||(this.params={}),this.params.status=r?r.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);var o={txSize:this.txSize,rxSize:n,duration:(0,p.z)()-this.startTime};i("xhr",[this.params,o,this.startTime,this.endTime,"fetch"],this,e.D.ajax)}function E(t){var r=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(var o=0;o 2&&void 0!==arguments[2])||arguments[2];super(e,t,we.t,r),this.importAggregator()}}new class{constructor(e){let t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:(0,_.ky)(16);c._A?(this.agentIdentifier=t,this.sharedAggregator=new y({agentIdentifier:this.agentIdentifier}),this.features={},this.desiredFeatures=new Set(e.features||[]),this.desiredFeatures.add(m),Object.assign(this,(0,a.j)(this.agentIdentifier,e,e.loaderType||"agent")),this.start()):(0,l.Z)("Failed to initial the agent. Could not determine the runtime environment.")}get config(){return{info:(0,t.C5)(this.agentIdentifier),init:(0,t.P_)(this.agentIdentifier),loader_config:(0,t.DL)(this.agentIdentifier),runtime:(0,t.OP)(this.agentIdentifier)}}start(){const t="features";try{const r=n(this.agentIdentifier),i=[...this.desiredFeatures];i.sort(((t,r)=>e.p[t.featureName]-e.p[r.featureName])),i.forEach((t=>{if(r[t.featureName]||t.featureName===e.D.pageViewEvent){const n=function(t){switch(t){case e.D.ajax:return[e.D.jserrors];case e.D.sessionTrace:return[e.D.ajax,e.D.pageViewEvent];case e.D.sessionReplay:return[e.D.sessionTrace];case e.D.pageViewTiming:return[e.D.pageViewEvent];default:return[]}}(t.featureName);n.every((e=>r[e]))||(0,l.Z)("".concat(t.featureName," is enabled but one or more dependent features has been disabled (").concat((0,D.P)(n),"). This may cause unintended consequences or missing data...")),this.features[t.featureName]=new t(this.agentIdentifier,this.sharedAggregator)}})),(0,T.Qy)(this.agentIdentifier,this.features,t)}catch(e){(0,l.Z)("Failed to initialize all enabled instrument classes (agent aborted) -",e);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,T.fP)();return delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.[t],delete this.sharedAggregator,r.ee?.abort(),delete r.ee?.get(this.agentIdentifier),!1}}}({features:[J,m,S,class extends h{static featureName=oe;constructor(t,r){if(super(t,r,oe,!(arguments.length>2&&void 0!==arguments[2])||arguments[2]),!c.il)return;const n=this.ee;let i;(0,k.QU)(n),this.eventsEE=(0,k.em)(n),this.eventsEE.on(se,(function(e,t){this.bstStart=(0,p.z)()})),this.eventsEE.on(ae,(function(t,r){(0,s.p)("bst",[t[0],r,this.bstStart,(0,p.z)()],void 0,e.D.sessionTrace,n)})),n.on(ce+ne,(function(e){this.time=(0,p.z)(),this.startPath=location.pathname+location.hash})),n.on(ce+ie,(function(t){(0,s.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,e.D.sessionTrace,n)}));try{i=new PerformanceObserver((t=>{const r=t.getEntries();(0,s.p)(te,[r],void 0,e.D.sessionTrace,n)})),i.observe({type:re,buffered:!0})}catch(e){}this.importAggregator({resourceObserver:i})}},C,xe,B,class extends h{static featureName=de;constructor(e,r){if(super(e,r,de,!(arguments.length>2&&void 0!==arguments[2])||arguments[2]),!c.il)return;if(!(0,t.OP)(e).xhrWrappable)return;try{this.removeOnAbort=new AbortController}catch(e){}let n,i=0;const o=this.ee.get("tracer"),a=(0,k._L)(this.ee),s=(0,k.Lg)(this.ee),u=(0,k.BV)(this.ee),d=(0,k.Kf)(this.ee),f=this.ee.get("events"),l=(0,k.u5)(this.ee),h=(0,k.QU)(this.ee),g=(0,k.Gm)(this.ee);function m(e,t){h.emit("newURL",[""+window.location,t])}function v(){i++,n=window.location.hash,this[ve]=(0,p.z)()}function b(){i--,window.location.hash!==n&&m(0,!0);var e=(0,p.z)();this[pe]=~~this[pe]+e-this[ve],this[ye]=e}function y(e,t){e.on(t,(function(){this[t]=(0,p.z)()}))}this.ee.on(ve,v),s.on(be,v),a.on(be,v),this.ee.on(ye,b),s.on(ge,b),a.on(ge,b),this.ee.buffer([ve,ye,"xhr-resolved"],this.featureName),f.buffer([ve],this.featureName),u.buffer(["setTimeout"+le,"clearTimeout"+fe,ve],this.featureName),d.buffer([ve,"new-xhr","send-xhr"+fe],this.featureName),l.buffer([me+fe,me+"-done",me+he+fe,me+he+le],this.featureName),h.buffer(["newURL"],this.featureName),g.buffer([ve],this.featureName),s.buffer(["propagate",be,ge,"executor-err","resolve"+fe],this.featureName),o.buffer([ve,"no-"+ve],this.featureName),a.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"],this.featureName),y(l,me+fe),y(l,me+"-done"),y(a,"new-jsonp"),y(a,"jsonp-end"),y(a,"cb-start"),h.on("pushState-end",m),h.on("replaceState-end",m),window.addEventListener("hashchange",m,(0,O.m$)(!0,this.removeOnAbort?.signal)),window.addEventListener("load",m,(0,O.m$)(!0,this.removeOnAbort?.signal)),window.addEventListener("popstate",(function(){m(0,i>1)}),(0,O.m$)(!0,this.removeOnAbort?.signal)),this.abortHandler=this.#e,this.importAggregator()}#e(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}],loaderType:"spa"})})(),window.NRBA=o})(); window.jQuery || document.write(' ') CKEDITOR_BASEPATH='https://f1000research.com/js/vendor/ckeditor/' window.reactTheme = 'research'; window.MathJax = { CommonHTML: { linebreaks: { automatic: true } }, 'HTML-CSS': { linebreaks: { automatic: true } }, SVG: { linebreaks: { automatic: true } }, AuthorInit: function() { MathJax.Hub.Register.MessageHook('End Process', function () { let timeout = false; // holder for timeout id const delay = 250; // delay after event is "complete" to run callback const reflowMath = function() { const dispFormulas = document.querySelectorAll('.disp-formula.panel'); if (!dispFormulas) { return; } for (const dispFormula of dispFormulas) { const child = dispFormula.querySelector('.MathJax_Preview').nextSibling.firstChild; const isMultiline = MathJax.Hub.getAllJax(dispFormula)[0].root.isMultiline; if (dispFormula.offsetWidth < child.offsetWidth || isMultiline) { MathJax.Hub.Queue(['Rerender', MathJax.Hub, dispFormula]); } } }; window.addEventListener('resize', function() { clearTimeout(timeout); // clear the timeout timeout = setTimeout(reflowMath, delay); // start timing for event "completion" }); }); }, }; if (window.location.hash == '#_=_'){ window.location = window.location.href.split('#')[0] } !function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function() {n.callMethod? n.callMethod.apply(n,arguments):n.queue.push(arguments)} ;if(!f._fbq)f._fbq=n; n.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0; t.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window, document,'script','https://connect.facebook.net/en_US/fbevents.js'); fbq('init', '1641728616063202'); fbq('track', "PixelInitialized", {}); (function(h,o,t,j,a,r){ h.hj=h.hj||function(){(h.hj.q=h.hj.q||[]).push(arguments)}; h._hjSettings={hjid:2318163,hjsv:6}; a=o.getElementsByTagName('head')[0]; r=o.createElement('script');r.async=1; r.src=t+h._hjSettings.hjid+j+h._hjSettings.hjsv; a.appendChild(r); })(window,document,'https://static.hotjar.com/c/hotjar-','.js?sv='); search file_upload Submit your research search menu close search Browse Gateways & Collections How to Publish Submit your Research My Submissions Article Guidelines Article Guidelines (New Versions) Open Data, Software and Code Guidelines Open Data and Accessible Source Materials Guidelines (HSS) Open Data, Software and Code Guidelines (PSE) Prepublication Checks Production Process Posters and Slides Guidelines Document Guidelines Article Processing Charges Peer Review Finding Article Reviewers About How it Works For Reviewers Our Advisors Policies Glossary FAQs For Developers Newsroom Contact My Research Submissions Content and Tracking Alerts My Details Sign In file_upload Submit your research { "@context": "https://schema.org", "@type": "ScholarlyArticle", "mainEntityOfPage": { "@type": "WebPage", "@id": "https://f1000research.com/articles/13-1266" }, "headline": "The science of printing and polishing 3D printed dentures", "datePublished": "2024-10-23T16:18:47", "dateModified": "2025-01-06T17:22:15", "author": [ { "@type": "Person", "name": "Kavishma Sulaya" }, { "@type": "Person", "name": "Swapna B V" }, { "@type": "Person", "name": "Vaishnavi M Nayak" } ], "publisher": { "@type": "Organization", "name": "F1000Research", "logo": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 480, "width": 60 } }, "image": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 1200, "width": 150 }, "description": " Objective To analyze the effectiveness of various techniques available for printing, finishing and polishing of 3D printed prosthesis. Methods The articles were selected from electronic databases including PubMed and Scopus. Recently, lot of advancements have been observed in the field of 3D printing in dentistry. Results Numerous studies were found explaining the factors affecting the surface roughness such as printing speed, direction, layer thickness, post curing, etc., and the significance in achieving a smooth surface finish of a 3D printed prosthesis. The methods employed to achieve this range, similar to conventional and chairside polishing, are to use advanced coating materials such as light cured glazes to nanoparticles. Conclusion 3D printing is being used in day-to-day practice and the prosthesis must be aesthetic looking to satisfy the patients’ expectations. There is a lack of data supporting any one polishing method for the prosthesis. There is a need for further research on the existing techniques and newer advancements yielding aesthetic prostheses with an optimal surface finish. " } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/13-1266", "name": "The science of printing and polishing 3D printed dentures" } } ] } Home Browse The science of printing and polishing 3D printed dentures ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Sulaya K, B V S and Nayak VM. The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.12688/f1000research.157596.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Review Revised The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] Kavishma Sulaya 1 , Swapna B V https://orcid.org/0000-0002-4991-7157 1 , Vaishnavi M Nayak https://orcid.org/0000-0002-6558-6087 1 Kavishma Sulaya 1 , Swapna B V https://orcid.org/0000-0002-4991-7157 1 , Vaishnavi M Nayak https://orcid.org/0000-0002-6558-6087 1 PUBLISHED 06 Jan 2025 Author details Author details 1 Department of Prosthodontics and Crown & Bridge, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India Kavishma Sulaya Roles: Conceptualization, Data Curation, Writing – Original Draft Preparation, Writing – Review & Editing Swapna B V Roles: Conceptualization, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Vaishnavi M Nayak Roles: Conceptualization, Data Curation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Manipal Academy of Higher Education gateway. Abstract Objective To analyze the effectiveness of various techniques available for printing, finishing and polishing of 3D printed prosthesis. Methods The articles were selected from electronic databases including PubMed and Scopus. Recently, lot of advancements have been observed in the field of 3D printing in dentistry. Results Numerous studies were found explaining the factors affecting the surface roughness such as printing speed, direction, layer thickness, post curing, etc., and the significance in achieving a smooth surface finish of a 3D printed prosthesis. The methods employed to achieve this range, similar to conventional and chairside polishing, are to use advanced coating materials such as light cured glazes to nanoparticles. Conclusion 3D printing is being used in day-to-day practice and the prosthesis must be aesthetic looking to satisfy the patients’ expectations. There is a lack of data supporting any one polishing method for the prosthesis. There is a need for further research on the existing techniques and newer advancements yielding aesthetic prostheses with an optimal surface finish. READ ALL READ LESS Keywords Additive manufacturing, 3D printed dentures, Surface roughness, Chairside polishing, Glaze materials. Corresponding Author(s) Vaishnavi M Nayak ( [email protected] ) Close Corresponding author: Vaishnavi M Nayak Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2025 Sulaya K et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Sulaya K, B V S and Nayak VM. The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.12688/f1000research.157596.2 ) First published: 23 Oct 2024, 13 :1266 ( https://doi.org/10.12688/f1000research.157596.1 ) Latest published: 06 Jan 2025, 13 :1266 ( https://doi.org/10.12688/f1000research.157596.2 ) Revised Amendments from Version 1 In this minor revision, we have addressed all reviewer comments to improve clarity and quality. The clinical applications of different 3D printing techniques and DLP technique is elaborated in detail. The studies on build orientation and variation in morphology of dentures to that of the sample geometry are specified. In this minor revision, we have addressed all reviewer comments to improve clarity and quality. The clinical applications of different 3D printing techniques and DLP technique is elaborated in detail. The studies on build orientation and variation in morphology of dentures to that of the sample geometry are specified. See the authors' detailed response to the review by Shizhu Bai READ REVIEWER RESPONSES Introduction Three-dimensional (3D) printing has been introduced in the industrial sector since 1980’s. 1 Its advent in dentistry has led to the revolutionization of the field. The surface finish and polished surface of the prosthesis plays a vital role as there is an increased demand for esthetic restoration and life-like prostheses. This property is of clinical relevance not only for its esthetic reasons but also as it directly or indirectly aids in the retention of microbial plaque on its surface. Increased surface roughness results in high plaque accumulation, thereby increasing surface fatigue and reducing the biocompatibility of the material leading to oral candidiasis and denture stomatitis. Polishing of the prosthesis is either done by mechanical method (Conventional, chairside) or chemical method to reduce the adherence of the microorganisms. Coating materials can be used as an additional layer for additively manufactured prostheses as an alternative to conventional polishing. The Surface roughness is determined using Ra or Rz values. Ra is the average value of the deviation of a measuring profile from a central line along the measuring length. 2 Rz is the deviation from the mean line focusing on the highest peak and valley. It is the average of the five individual values in sequence from individual roughness depth. Estimated Ra value can be calculated by dividing Rz value from 4-7 units, but estimated Rz is calculated by multiplying Ra value by 10-15. According to Fernandaz P et al, a surface roughness (Ra) of 0.2 μm was set as the clinically acceptable value. 2 The surface roughness is affected by the number of layers added, the speed of printing, the material used, the thickness of the material, the polishing technique, and operator’s skills. 3 Conventionally, laboratory polishing of the prosthesis is done with pumice slurry and buff followed using aluminum oxide polishing paste. Chairside polishing is done using various chairside kits such as the Shofu kit, JOTA polishing kit, microdont polishing kit, etc., from coarser to fine grit burs at the speed of 5000 rpm. The major disadvantage of these conventional methods is the dimensional change that may occur, increased risk of fracture etc. Chemical polishing includes placement of the denture base in an ultrasonic bath and coating it with another thin layer of resin, laser polishing, etc. 4 Additively manufactured prostheses are fabricated layer by layer which results in a lot of surface irregularities due to its stepwise effect that require adequate polishing. 2 A combination of multiple methods is required to finely polish the prosthesis to achieve the required results. There is no standard protocol available to polish a 3D printed prosthesis and the available literature to prove which method of polishing is superior to the other is scarce. Hence this narrative review focuses on understanding the 3D printing process and its effect on polished surface. Methods The relevant articles were selected from two databases Pubmed and Scopus after conducting search using the keywords from 1995 to 2024. Recent reviews and original research articles which analysed the data on surface roughness, various polishing and 3d printing techniques were included. Discussion Additive manufacturing Additive manufacturing (AM) is the method in which materials are combined layer by layer to create objects from 3D model data. 5 , 6 The new successive layers are joined to the preceding layers by either melting, fusing, or polymerization processes. American Society for Testing and Materials classifies AM technology into seven categories based on the printing methods. 7 , 8 1) VAT photopolymerization 2) Fused Deposition Modeling 3) Powder Bed Fusion 4) Material jetting or inkjet printing 5) Binder jetting or three-dimensional printing 6) Direct Energy Deposition 7) Manufacturing of laminated objects. Some of the methods used for printing complete dentures include VAT photopolymerization Stereolithography (SLA) This was developed in 1963 and was one of the first additive manufacturing method. This technique is based on light polymerization, in which a chain reaction between the resin and the monomer is initiated by an electron beam or UV light. The polymer resin used for printing dentures is supplied in liquid form which includes photopolymers. The building platform is submerged in a liquid polymer tank, which can be moved up, polymerizing the initial layer by laser beam. The building platform is lowered to descend into the tank to create a subsequent layer. This causes polymer liquid to cover the surface of the previously built layer, repeating the polymerization process as the platform moves. This process is repeated until all the layers are built and the 3D model is completed. The completed model is photo cured for increased strength. The models printed using SLA have high resolution and quality but are expensive and time consuming. 9 The thickness of each layer is controlled by two factors, i.e. energy of the light source and the amount of exposure. 10 , 11 Digital light processing (DLP) In additive manufacturing, digital light processing technology effectively cures photopolymer resin, especially in the dental industry. It projects a two-dimensional pixel pattern and cures entire resin layers at once employing a Digital Micromirror Device (DMD), which is made up of millions of mirrors that can independently switch between on and off states. As a result, build durations are decreased because they are solely influenced by exposure duration and layer thickness, not by layer size or the quantity of structures being constructed. Moving projectors, dual-projector configurations, and high-resolution DMD chips (e.g., 4K) are some of the methods used to preserve accuracy on bigger build platforms. Speed and precision are enhanced by innovations like Carbon3D's Continuous Direct Light Processing (CDLP) and Prodways' Moving Light technology. Systems that optimize object detachment throughout the build process, such as Force Feedback and VAT deflection feedback (VDFS), also improve productivity and print quality. 11 – 13 The materials used and the process of printing are the same as SLA, but the source of light for polymerization used is different. Laser is used for polymerization in SLA, but a digital projector is used in DLP. DLP method prints at a faster speed compared to SLA, and intensity of the light source can be varied. 11 – 13 Fused depositing modeling (FDM) The polymer used in this method has thermoplastic properties, the layers can be joined together throughout the printing process and solidify at room temperature once the printing is complete. The most used materials are polylactic acid, acrylonitrile butadiene styrene, and polycarbonates. 14 , 15 The material should have a low melting point, sufficient viscosity to flow out of the nozzle and adequate strength to support the next layers. High speed, easy processing, and low cost are the advantages of FDM. Limitations include low surface quality, layered appearance, and low mechanical strength. 16 Material jetting It is an injection system in which the photopolymer goes through several nozzles to build the 3-dimensional model layer by layer. The material is cured by UV radiation and shares a chemical foundation with vat photopolymerization. 17 , 18 Clinical applications of different printing techniques in complete denture fabrication SLA and DLP can be vicariously used for the fabrication in clinical and laboratory procedures such as custom tray fabrication, cast fabrication, trial dentures, definitive denture base and teeth. However FDM and MJ has limited applications in fabrication of custom trays and complete denture prototypes. 19 The accuracy and properties of the final product are affected by various printing and processing parameters and material composition. The printing process parameters include printing direction, layer thickness and post curing which affect the final printing product. 10 Printing direction The build direction/angle selection is vital, as it influences the amount of support the structures require which impacts the accuracy of the final product. The printing direction, which establishes the angle between the component layers and the applied force affects the mechanical qualities of the 3D printed denture. 20 Thus, selecting the right printing orientation is crucial for optimizing the mechanical properties of the final product. Yan S et al., evaluated the build angle (0°,45°, and 90°) on the surface characteristics of 3D printed complete denture base samples by DLP method and concluded that 0° built specimens exhibited significantly lower mean roughness when compared with 45° and 90°. They exhibited block-like protrusions on the surface which were evenly distributed and surrounded by depression. The highest mean surface roughness was seen in specimen built at 45° followed by 90° group, while the smoothest surface was seen with 0°. 21 Ataei et al., evaluated the surface roughness of 3D printed samples at 0° orientation and 100 μm layer thickness and later subjected them to thermocycling. They observed that polishing was an effective way to make layered structure disappear in 3D printed resin. There was no variation in the layered structure in the presence or absence of thermal stress. 22 Lee et al., evaluated the surface properties of 3D printed resins with DLP method in three distinct build angles (0,45°, and 90°) and found that the 0° build angle provided a smooth surface, regardless of the thickness. The highest surface roughness was observed at a 45° build angle. However, this study also indicated that decreasing thickness can enhance surface roughness. 23 Similarly, Shim et al., also concluded that 45° printing orientation showed the highest value of surface roughness compared with those of the other groups (0° and 90°). The surface obtained from the 0° printing orientation revealed craters of varied sizes, whereas the 45° orientation group displayed recurring oblique ridges. The 90° orientation group displayed asymmetrical surfaces that blended spherical and non-round geometries. 24 It is to be noted that studies on build orientation and layer thickness in additive manufacturing of denture materials often utilize standardized disc-shaped specimens. When these specimens are oriented horizontally (0°) and sliced, certain surfaces, including those tested, may not exhibit the stepwise effect characteristic of additive manufacturing. 25 This limitation arises because denture morphology features irregular geometries. It is not conclusive that horizontally printed dentures inherently have superior surface properties. Additionally, in horizontal orientations, the influence of layer thickness on surface morphology is primarily observed on the sidewalls rather than the tested surfaces. Layer thickness The layer thickness (LT) is the measurement of the thickness of each slice of the part that builds upon the layer before it. The layer thickness affects the accuracy and other properties of the final denture. 26 Lee et al., evaluated the effect of two different layer thickness (50 and 100 μm) on the surface roughness of 3D printed resins with DLP method. They observed that the surface smoothness achieved with a 100μm layer thickness and 0° built angle was similar to 50 μm layer thickness. These settings could facilitate effective fabrication with favorable surface smoothness, as products with a 100 μm LT could be fabricated faster. 23 Post curing 3D printed resins are photo-polymerized material, and post-curing time affects the performance of the material. The photo initiator initiates the polymerization, using the laser or light projector resulting in partial curing. The unbonded monomers then join to form a polymer, which further develops into a cross-linked macromolecule. The primary surface texture is now developed. The polymerization process is completed by further curing using a light cure unit as a post curing step. The post-curing period as recommended by the manufacturers varies from 20 to 60 minutes to ensure complete polymerization of the material. 27 , 28 Ahmed et al., concluded that 30 minutes is the minimal post-curing time to obtain optimal results since additional curing had no discernible impact on the material’s characteristics. 29 Ping li et al., studied the surface topography and roughness of 3D printed resins after various post-curing methods using different devices and observed no significant differences between the post-cured specimens with various devices. Significantly lower Ra values were exhibited by the 3D printed specimens than the conventional poly methyl methacrylate (PMMA). 30 Polishing techniques In day-to-day clinical practice, acrylic dentures are subjected to modifications by trimming which would create a rougher surface. 4 , 31 , 32 To smooth out rough layers, polishing these acrylic dentures is recommended to reduce the free surface energy. The polished surface improves hygiene of denture as it prevents microbial adherence and colonization. 4 , 33 Routinely, in a laboratory setting acrylic dentures are polished with pumice slurry followed by aluminum oxide polishing paste (Al 2 O 3 ). 4 , 33 , 34 With the advent of digital dentistry, 3D printed dentures are being routinely used for fabrication of removable dentures. Inherently, 3D printed dentures have layers due to their printing nature affecting the surface properties. The increase in the surface roughness of 3D printed dentures could be attributed to the edge stepwise effects. ( Figure 1 ) Additionally, the chairside corrections done during clinical procedures, adds on to the surface roughness. Although the literature on the effect of conventional laboratory polishing techniques on surface roughness of 3D printed dentures is limited, the currently available studies have shown clinically acceptable smooth surfaces which prevents sequelae of plaque accumulation. Figure 1. Stepwise effect in 3D printing. Fernandez et al., compared the surface characteristics of 3D printed and milled denture base materials with conventional heat-cure resins. 2 The study compared resins that were polished or coated to different degrees, such as the intermediate polishing group (pre-polishing with grinding paper 150,180 grit size; brushed along with pumice slurry followed by polishing paste using lathe bristle brush), high gloss polish group (procedure similar to intermediate group, additionally the resin block was polished with polishing paste and soft cloth wheel to attain high gloss), coated resin group (thinly coated with unpolymerized resin for 3D printing procedure and cured with a light curing unit), and coated and polishing (combined procedure of coated and high gloss polished group). 2 They concluded that polishing (high gloss), coating and coating along with polishing resins were within the clinically relevant surface roughness threshold. 2 The high gloss polished 3D printed resins provided lower roughness compared to coated specimens with clinically relevant lower Ra values. 2 The polishing of 3D printed dentures showed superior Ra values when compared to milled dentures. Routinely chairside manipulation of the denture is required leading to practitioners using chairside polishing kits for polishing. Chairside polishing kit has been used as a substitute method of choice in situations where laboratory polishing cannot be performed. 35 With conventionally used heat cured PMMA, the chairside polishing kits have provided clinically acceptable results although inferior to laboratory polishing. 35 Al-Dulaijan et al., compared laboratory and chairside polishing on 3D printed denture resins and concluded that laboratory polishing showed lower Ra values than chairside and unpolished denture base resins. 4 Sandpaper of grit size 1000 and 2500 were used for finishing procedures. The specimens for laboratory polishing group were then polished with pumice slurry and brush for 90 seconds at 1500 rpm, followed by universal polishing paste and lathe brush for 15 seconds at 3000 rpm respectively. For chairside polishing three commercially available kits Microdont, Acrypoint and Shofu were used with 3 polishing burs of coarse, medium and fine grain for a minute each. Although conventional polishing showed superior results, the author concluded that chairside polishing kits are an efficient technique when access to laboratory method is limited. 4 Quezada et al., investigated the surface roughness of Computer aided designing and Computer aided manufacturing (CAD/CAM) denture resins to conventional PMMA using chairside polishing kit JOTA and found that 3D printed resin specimen showed lower Ra values to conventional heat cured dentures. 3 Coating materials on 3D-printed resins To decrease surface roughness, light-cured glazes and coatings have been applied to digitally manufactured dentures. 36 – 38 Additionally, it reduces surface porosity and imperfections, prevents microleakage, and strengthens resin and increases resistance to stains. 36 – 38 Dickinson et al., reported that a low viscosity sealant lowered the surface roughness in acrylic resins (Ra values = 0.2 μm). 3 , 39 Pigmented light cure glaze materials can also be used for the characterization of teeth and gingiva masking the monolithic appearance of the dentures. Silica and titanium nanoparticles are incorporated in dental glaze materials which improve the resin’s surface properties and lower the surface energy, reducing biofilm adhesion. 36 , 40 Choi et al., evaluated the surface of different light polymerized denture glaze materials and concluded that the glaze materials lowered the surface roughness values. 36 Ra values varied from 0.26 to 0.15 μm exceeding the threshold limit. 36 Along the acceptable polished surface, glaze materials with nanoparticles such as silica dioxide and titanium dioxide also improved the surface hardness and elastic modulus. 36 , 41 This could be attributed to coupling agents such as 3-trimethoxysilylpropyl methacrylate which creates a bond between both the inorganic and organic phases of acrylic resins. 36 Fernandez et al., evaluated surface roughness of additively fabricated dentures coated with the same unpolymerized material. 2 Coated specimens demonstrated Ra values of 0.16 μm well within the clinically relevant threshold of 0.2 μm. Although, solely coated specimens did not yield any superior outcome to solely polished specimens. 2 The coated and polished specimens gave superior results. 2 However, coating with unpolymerized material to 3D printed dentures may be regarded as an alternative to conventional polishing. 2 Various polishing methods have been summarised in Figure 2 . Figure 2. Schematic representation of various methods of polishing 3D printing dentures. Conclusions Surface roughness of the printed prosthesis depends on the printing orientation, thickness of the layer and the post-curing process. Advised post-curing time is 20 to 60 minutes, following which polishing can be done by conventional laboratory or chairside methods. Light cured glaze coating materials with incorporated nanomaterials provide acceptable surface roughness values along with better surface hardness and modulus of elasticity. However, the current studies conclude that conventional laboratory polishing of 3D printed dentures is sufficient for achieving a clinically acceptable polish. Still, there is a need for a standardized protocol for finishing and polishing 3D printed prostheses and the potential for various coating materials to be used as an alternative to the conventional polishing method. Data availability No data are associated with this article. Acknowledgements -NIL References 1. Tian Y, Chen C, Xu X, et al. : A review of 3D printing in dentistry: Technologies, affecting factors, and applications. Scanning. 2021; 2021 (1): 1–19. Publisher Full Text 2. Kraemer Fernandez P, Unkovskiy A, Benkendorff V, et al. : Surface characteristics of milled and 3D printed denture base materials following polishing and coating: An in-vitro study. Materials. 2020 Jul 24; 13 (15): 3305. PubMed Abstract | Publisher Full Text | Free Full Text 3. Quezada MM, Salgado H, Correia A, et al. : Investigation of the effect of the same polishing protocol on the surface roughness of denture base acrylic resins. Biomedicines. 2022 Aug 14; 10 (8): 1971. PubMed Abstract | Publisher Full Text | Free Full Text 4. Al-Dulaijan YA: Evaluation of the effects of different polishing protocols on the surface characterizations of 3D-Printed acrylic denture base resins: An in vitro Study. Polymers. 2023 Jun 30; 15 (13): 2913. PubMed Abstract | Publisher Full Text | Free Full Text 5. Van Noort R: The future of dental devices is digital. Dent. Mater. 2012 Jan 1; 28 (1): 3–12. Publisher Full Text 6. Dovbish VM, Zabednov PV, Zlenko MA: Additive tehnologii. I izdelia iz metala. 57. 7. ISO I: 17296-2 Additive Manufacturing—General Principles—Part2: Overview of Process Categories and Feedstock. Geneva, The Switzerland: ISO; 2016. 8. Attarilar S, Ebrahimi M, Djavanroodi F, et al. : 3D printing technologies in metallic implants: a thematic review on the techniques and procedures. Int. J. Bioprinting. 2021; 7 (1): 306. Publisher Full Text 9. Ngo TD, Kashani A, Imbalzano G, et al. : Additive manufacturing (3D printing): A review of materials, methods, applications and challenges. Compos. Part B. 2018 Jun 143; 143 : 172–196. Publisher Full Text 10. Abedini A: A literature review of 3D printing In dental prosthesis. J. Pharm. Negat. Results. 2022 Dec 31; 13 (4): 2039–2050. 11. Melchels FP, Feijen J, Grijpma DW: A review on stereolithography and its applications in biomedical engineering. Biomaterials. 2010 Aug 1; 31 (24): 6121–6130. Publisher Full Text 12. Vinogradov P: 3D printing in medicine: Current challenges and potential applications. 3D Printing Technology in Nanomedicine. Vol. 1 . . Missouri: Elsevier Inc.; 2019 Mar 30. 13. Schweiger J, Edelhoff D, Güth JF: 3D printing in digital prosthetic dentistry: an overview of recent developments in additive manufacturing. J. Clin. Med. 2021 May 7; 10 (9): 2010. PubMed Abstract | Publisher Full Text | Free Full Text 14. Mohamed OA, Masood SH, Bhowmik JL: Optimization of fused deposition modeling process parameters: a review of current research and future prospects. Adv. Manuf. 2015 Mar; 3 : 42–53. Publisher Full Text 15. Sood AK, Ohdar RK, Mahapatra SS: Parametric appraisal of mechanical property of fused deposition modelling processed parts. Mater. Des. 2010 Jan 1; 31 (1): 287–295. Publisher Full Text 16. Chohan JS, Singh R, Boparai KS, et al. : Dimensional accuracy analysis of coupled fused deposition modeling and vapour smoothing operations for biomedical applications. Compos. Part B. 2017 May 15; 117 : 138–149. Publisher Full Text 17. Dou R, Wang T, Guo Y, et al. : Ink-jet printing of zirconia: coffee staining and line stability. J. Am. Ceram. Soc. 2011 Nov; 94 (11): 3787–3792. Publisher Full Text 18. Swapna BV: Digital Complete Dentures-An Overview. Cumhuriyet Dent. J. 2024 Feb 16; 27 (1): 52–58. Publisher Full Text 19. Da Costa LP, Zamalloa SI, Alves FA, et al. : 3D printers in dentistry: a review of additive manufacturing techniques and materials. Clin. Lab. Res. Dent. 2021 Aug 18; Publisher Full Text 20. Li Y, Teng Z: Effect of printing orientation on mechanical properties of SLA 3D-printed photopolymer. Fatigue Fract. Eng. Mater. Struct. 2024 May; 47 (5): 1531–1545. Publisher Full Text 21. Yan S, Zhou JL, Zhang RJ, et al. : Evaluation of the influence of different build angles on the surface characteristics, accuracy, and dimensional stability of the complete denture base printed by digital light processing. Heliyon. 2024 Jan 15; 10 (1): e24095. Publisher Full Text 22. Ataei K, Ghaffari T, Moslehifard E, et al. : Physico-chemical and Mechanical Assessments of a New 3D Printed PMMA-Based Acrylic Denture Base Material. Open Dent. J. 2024 Feb 1; 18 (1). 23. Lee WJ, Jo YH, Yilmaz B, et al. : Effect of build angle, resin layer thickness and viscosity on the surface properties and microbial adhesion of denture bases manufactured using digital light processing. J. Dent. 2023 Oct 1; 137 : 104608. Publisher Full Text 24. Shim JS, Kim JE, Jeong SH, et al. : Printing accuracy, mechanical properties, surface characteristics, and microbial adhesion of 3D-printed resins with various printing orientations. J. Prosthet. Dent. 2020 Oct 1; 124 (4): 468–475. Publisher Full Text 25. AlGhamdi MA, Gad MM: Impact of Printing Orientation on the Accuracy of Additively Fabricated Denture Base Materials: A Systematic Review. Dent. J (Basel). 2024 Jul 22; 12 (7): 230. PubMed Abstract | Publisher Full Text | Free Full Text 26. Cheng W, Fuh JY, Nee AY, et al. : Multi-objective optimization of part-building orientation in stereolithography. Rapid Prototyp. J. 1995 Dec 1; 1 (4): 12–23. Publisher Full Text 27. FORMLABS: Form Cure time and temperature settings.2021. Reference Source 28. Next Dent: 3D systems.2022 Reference Source 29. Altarazi A, Haider J, Alhotan A, et al. : Assessing the physical and mechanical properties of 3D printed acrylic material for denture base application. Dent. Mater. 2022 Dec 1; 38 (12): 1841–1854. Publisher Full Text 30. Li P, Lambart AL, Stawarczyk B, et al. : Postpolymerization of a 3D-printed denture base polymer: Impact of post-curing methods on surface characteristics, flexural strength, and cytotoxicity. J. Dent. 2021 Dec 1; 115 : 103856. Publisher Full Text 31. Kuhar M, Funduk N: Effects of polishing techniques on the surface roughness of acrylic denture base resins. J. Prosthet. Dent. 2005 Jan 1; 93 (1): 76–85. Publisher Full Text 32. Radford DR, Watson TF, Walter JD, et al. : The effects of surface machining on heat cured acrylic resin and two soft denture base materials: a scanning electron microscope and confocal microscope evaluation. J. Prosthet. Dent. 1997 Aug 1; 78 (2): 200–208. Publisher Full Text 33. Gungor H, Gundogdu M, Duymus ZY: Investigation of the effect of different polishing techniques on the surface roughness of denture base and repair materials. J. Prosthet. Dent. 2014 Nov 1; 112 (5): 1271–1277. Publisher Full Text 34. Sofou A, Emmanouil J, Peutzfeldt A, et al. : The effect of different polishing techniques on the surface roughness of acrylic resin materials. Eur. J. Prosthodont. Restor. Dent. 2001 Sep 1; 9 (3-4): 117–122. 35. Sofou A, Emmanouil J, Peutzfeldt A, et al. : The effect of different polishing techniques on the surface roughness of acrylic resin materials. Eur. J. Prosthodont. Restor. Dent. 2001 Sep 1; 9 (3-4): 117–122. 36. Choi JJ, Uy CE, Ramani RS, et al. : Evaluation of surface roughness, hardness and elastic modulus of nanoparticle containing light-polymerized denture glaze materials. J. Mech. Behav. Biomed. Mater. 2020 Mar 1; 103 : 103601. Publisher Full Text 37. Emmanouil JK, Kavouras P, Kehagias T: The effect of photo-activated glazes on the microhardness of acrylic baseplate resins. J. Dent. 2002 Jan 1; 30 (1): 7–10. Publisher Full Text 38. Sahin O, Koroglu A, Dede DÖ, et al. : Effect of surface sealant agents on the surface roughness and color stability of denture base materials. J. Prosthet. Dent. 2016 Oct 1; 116 (4): 610–616. Publisher Full Text 39. Dickinson GL, Leinfelder KF: Assessing the long-term effect of a surface penetrating sealant. J. Am. Dent. Assoc. 1939; 124 (7): 68–72. 1993 Jul 1. Publisher Full Text 40. Kaizer MR, Almeida JR, Gonçalves AP, et al. : Silica coating of nonsilicate nanoparticles for resin-based composite materials. J. Dent. Res. 2016 Nov; 95 (12): 1394–1400. Publisher Full Text 41. Yoshida K, Taira Y, Atsuta M: Properties of opaque resin composite containing coated and silanized titanium dioxide. J. Dent. Res. 2001 Mar; 80 (3): 864–868. Publisher Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 23 Oct 2024 ADD YOUR COMMENT Comment Author details Author details 1 Department of Prosthodontics and Crown & Bridge, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India Kavishma Sulaya Roles: Conceptualization, Data Curation, Writing – Original Draft Preparation, Writing – Review & Editing Swapna B V Roles: Conceptualization, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Vaishnavi M Nayak Roles: Conceptualization, Data Curation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 06 Jan 2025, 13:1266 https://doi.org/10.12688/f1000research.157596.2 version 1 Published: 23 Oct 2024, 13:1266 https://doi.org/10.12688/f1000research.157596.1 Copyright © 2025 Sulaya K et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Sulaya K, B V S and Nayak VM. The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.12688/f1000research.157596.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 06 Jan 2025 Revised Views 0 Cite How to cite this report: Bai S. Reviewer Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.176341.r356575 ) The direct URL for this report is: https://f1000research.com/articles/13-1266/v2#referee-response-356575 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 17 Jan 2025 Shizhu Bai , Air Force Military Medical University, Shaanxi, China Approved VIEWS 0 https://doi.org/10.5256/f1000research.176341.r356575 There is ... Continue reading READ ALL There is no additional comments. Competing Interests: No competing interests were disclosed. Reviewer Expertise: Digital dentistry; 3D printing I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Bai S. Reviewer Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.176341.r356575 ) The direct URL for this report is: https://f1000research.com/articles/13-1266/v2#referee-response-356575 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 23 Oct 2024 Views 0 Cite How to cite this report: Bai S. Reviewer Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.173059.r342684 ) The direct URL for this report is: https://f1000research.com/articles/13-1266/v1#referee-response-342684 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 16 Dec 2024 Shizhu Bai , Air Force Military Medical University, Shaanxi, China Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.173059.r342684 This article presents a well-structured review on 3D-printed denture techniques, analyzing printing and polishing methods and their impact on surface roughness, though some details could be further elaborated. 'Some of the methods used for printing complete dentures ... Continue reading READ ALL This article presents a well-structured review on 3D-printed denture techniques, analyzing printing and polishing methods and their impact on surface roughness, though some details could be further elaborated. 'Some of the methods used for printing complete dentures include…' Can these technologies, such as FDM and MJ, be used directly to fabricate dentures for clinical use or only for making trial dentures or custom trays? It is recommended that this part be combined with practical clinical applications. DLP is the most commonly used printing technology and should be introduced in more detail. The author states that '... which impacts the precision of the final product'. According to ISO 5725-4 , accuracy includes both trueness and precision. Does the author mean accuracy? Currently, studies on build orientation and layer thicknesses are carried out using standardized specimens made of denture material in the form of discs. When such specimens are placed and sliced horizontally (0°), the stepwise effect is not generated on some of their surfaces, possibly including the surface being tested. However, the morphology of dentures is an irregular geometry, and the authors are advised to specify this, and it cannot be argued that the surface properties of horizontally printed dentures are more advantageous. Similarly, when the specimen is placed horizontally, the effect of the layer thickness on the surface morphology will not be demonstrated on the surface tested but on the sidewalls. Is the topic of the review discussed comprehensively in the context of the current literature? Yes Are all factual statements correct and adequately supported by citations? Partly Is the review written in accessible language? Yes Are the conclusions drawn appropriate in the context of the current research literature? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Digital dentistry; 3D printing I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Bai S. Reviewer Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.173059.r342684 ) The direct URL for this report is: https://f1000research.com/articles/13-1266/v1#referee-response-342684 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 06 Jan 2025 Vaishnavi M Nayak , Department of Prosthodontics and Crown & Bridge, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, 576104, India 06 Jan 2025 Author Response Thank you for your insightful feedback and constructive comments on our manuscript. We appreciate the opportunity to improve our work and have made significant revisions based on your suggestions. In ... Continue reading Thank you for your insightful feedback and constructive comments on our manuscript. We appreciate the opportunity to improve our work and have made significant revisions based on your suggestions. In response, we have made the following adjustments: Overall Comment from reviewer : 'Some of the methods used for printing complete dentures include…' Can these technologies, such as FDM and MJ, be used directly to fabricate dentures for clinical use or only for making trial dentures or custom trays? It is recommended that this part be combined with practical clinical applications. DLP is the most commonly used printing technology and should be introduced in more detail. The author states that '... which impacts the precision of the final product'. According to ISO 5725-4 , accuracy includes both trueness and precision. Does the author mean accuracy? Currently, studies on build orientation and layer thicknesses are carried out using standardized specimens made of denture material in the form of discs. When such specimens are placed and sliced horizontally (0°), the stepwise effect is not generated on some of their surfaces, possibly including the surface being tested. However, the morphology of dentures is an irregular geometry, and the authors are advised to specify this, and it cannot be argued that the surface properties of horizontally printed dentures are more advantageous. Similarly, when the specimen is placed horizontally, the effect of the layer thickness on the surface morphology will not be demonstrated on the surface tested but on the sidewalls. Response: Thank you for the thorough feedback, the following additions have been made: We have added the clinical applications of different 3D printing techniques. The DLP technique is elaborated in detail. The term is corrected to accuracy. The studies on build orientation and variation in morphology of dentures to that of the sample geometry are specified. Thank you for your insightful feedback and constructive comments on our manuscript. We appreciate the opportunity to improve our work and have made significant revisions based on your suggestions. In response, we have made the following adjustments: Overall Comment from reviewer : 'Some of the methods used for printing complete dentures include…' Can these technologies, such as FDM and MJ, be used directly to fabricate dentures for clinical use or only for making trial dentures or custom trays? It is recommended that this part be combined with practical clinical applications. DLP is the most commonly used printing technology and should be introduced in more detail. The author states that '... which impacts the precision of the final product'. According to ISO 5725-4 , accuracy includes both trueness and precision. Does the author mean accuracy? Currently, studies on build orientation and layer thicknesses are carried out using standardized specimens made of denture material in the form of discs. When such specimens are placed and sliced horizontally (0°), the stepwise effect is not generated on some of their surfaces, possibly including the surface being tested. However, the morphology of dentures is an irregular geometry, and the authors are advised to specify this, and it cannot be argued that the surface properties of horizontally printed dentures are more advantageous. Similarly, when the specimen is placed horizontally, the effect of the layer thickness on the surface morphology will not be demonstrated on the surface tested but on the sidewalls. Response: Thank you for the thorough feedback, the following additions have been made: We have added the clinical applications of different 3D printing techniques. The DLP technique is elaborated in detail. The term is corrected to accuracy. The studies on build orientation and variation in morphology of dentures to that of the sample geometry are specified. Competing Interests: No competing interests. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 06 Jan 2025 Vaishnavi M Nayak , Department of Prosthodontics and Crown & Bridge, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, 576104, India 06 Jan 2025 Author Response Thank you for your insightful feedback and constructive comments on our manuscript. We appreciate the opportunity to improve our work and have made significant revisions based on your suggestions. In ... Continue reading Thank you for your insightful feedback and constructive comments on our manuscript. We appreciate the opportunity to improve our work and have made significant revisions based on your suggestions. In response, we have made the following adjustments: Overall Comment from reviewer : 'Some of the methods used for printing complete dentures include…' Can these technologies, such as FDM and MJ, be used directly to fabricate dentures for clinical use or only for making trial dentures or custom trays? It is recommended that this part be combined with practical clinical applications. DLP is the most commonly used printing technology and should be introduced in more detail. The author states that '... which impacts the precision of the final product'. According to ISO 5725-4 , accuracy includes both trueness and precision. Does the author mean accuracy? Currently, studies on build orientation and layer thicknesses are carried out using standardized specimens made of denture material in the form of discs. When such specimens are placed and sliced horizontally (0°), the stepwise effect is not generated on some of their surfaces, possibly including the surface being tested. However, the morphology of dentures is an irregular geometry, and the authors are advised to specify this, and it cannot be argued that the surface properties of horizontally printed dentures are more advantageous. Similarly, when the specimen is placed horizontally, the effect of the layer thickness on the surface morphology will not be demonstrated on the surface tested but on the sidewalls. Response: Thank you for the thorough feedback, the following additions have been made: We have added the clinical applications of different 3D printing techniques. The DLP technique is elaborated in detail. The term is corrected to accuracy. The studies on build orientation and variation in morphology of dentures to that of the sample geometry are specified. Thank you for your insightful feedback and constructive comments on our manuscript. We appreciate the opportunity to improve our work and have made significant revisions based on your suggestions. In response, we have made the following adjustments: Overall Comment from reviewer : 'Some of the methods used for printing complete dentures include…' Can these technologies, such as FDM and MJ, be used directly to fabricate dentures for clinical use or only for making trial dentures or custom trays? It is recommended that this part be combined with practical clinical applications. DLP is the most commonly used printing technology and should be introduced in more detail. The author states that '... which impacts the precision of the final product'. According to ISO 5725-4 , accuracy includes both trueness and precision. Does the author mean accuracy? Currently, studies on build orientation and layer thicknesses are carried out using standardized specimens made of denture material in the form of discs. When such specimens are placed and sliced horizontally (0°), the stepwise effect is not generated on some of their surfaces, possibly including the surface being tested. However, the morphology of dentures is an irregular geometry, and the authors are advised to specify this, and it cannot be argued that the surface properties of horizontally printed dentures are more advantageous. Similarly, when the specimen is placed horizontally, the effect of the layer thickness on the surface morphology will not be demonstrated on the surface tested but on the sidewalls. Response: Thank you for the thorough feedback, the following additions have been made: We have added the clinical applications of different 3D printing techniques. The DLP technique is elaborated in detail. The term is corrected to accuracy. The studies on build orientation and variation in morphology of dentures to that of the sample geometry are specified. Competing Interests: No competing interests. Close Report a concern COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Shenoy V. Reviewer Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.173059.r334672 ) The direct URL for this report is: https://f1000research.com/articles/13-1266/v1#referee-response-334672 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 28 Oct 2024 Vidya Shenoy , Department of Prosthodontics, AJ Institute of Dental Sciences, Mangalore, India Approved VIEWS 0 https://doi.org/10.5256/f1000research.173059.r334672 Article is satisfactory and currently, the manuscript presents a well-structured and insightful analysis, contributing meaningfully to the field. Article covers relevant methods of polishing 3D dentures. There is a comprehensive discussion of all the methods including glazing. The facts are ... Continue reading READ ALL Article is satisfactory and currently, the manuscript presents a well-structured and insightful analysis, contributing meaningfully to the field. Article covers relevant methods of polishing 3D dentures. There is a comprehensive discussion of all the methods including glazing. The facts are adequately supported by the current literature. Overall, it meets approval standards. Recommended for indexing Is the topic of the review discussed comprehensively in the context of the current literature? Yes Are all factual statements correct and adequately supported by citations? Yes Is the review written in accessible language? Yes Are the conclusions drawn appropriate in the context of the current research literature? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: GERIATRIC DENTISTRY I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Shenoy V. Reviewer Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.173059.r334672 ) The direct URL for this report is: https://f1000research.com/articles/13-1266/v1#referee-response-334672 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 23 Oct 2024 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 Version 2 (revision) 06 Jan 25 read Version 1 23 Oct 24 read read Vidya Shenoy , AJ Institute of Dental Sciences, Mangalore, India Shizhu Bai , Air Force Military Medical University, Shaanxi, China Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Bai S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 17 Jan 2025 | for Version 2 Shizhu Bai , Air Force Military Medical University, Shaanxi, China 0 Views copyright © 2025 Bai S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions There is no additional comments. Competing Interests No competing interests were disclosed. Reviewer Expertise Digital dentistry; 3D printing I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Bai S. Peer Review Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.176341.r356575) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-1266/v2#referee-response-356575 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Bai S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 16 Dec 2024 | for Version 1 Shizhu Bai , Air Force Military Medical University, Shaanxi, China 0 Views copyright © 2024 Bai S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This article presents a well-structured review on 3D-printed denture techniques, analyzing printing and polishing methods and their impact on surface roughness, though some details could be further elaborated. 'Some of the methods used for printing complete dentures include…' Can these technologies, such as FDM and MJ, be used directly to fabricate dentures for clinical use or only for making trial dentures or custom trays? It is recommended that this part be combined with practical clinical applications. DLP is the most commonly used printing technology and should be introduced in more detail. The author states that '... which impacts the precision of the final product'. According to ISO 5725-4 , accuracy includes both trueness and precision. Does the author mean accuracy? Currently, studies on build orientation and layer thicknesses are carried out using standardized specimens made of denture material in the form of discs. When such specimens are placed and sliced horizontally (0°), the stepwise effect is not generated on some of their surfaces, possibly including the surface being tested. However, the morphology of dentures is an irregular geometry, and the authors are advised to specify this, and it cannot be argued that the surface properties of horizontally printed dentures are more advantageous. Similarly, when the specimen is placed horizontally, the effect of the layer thickness on the surface morphology will not be demonstrated on the surface tested but on the sidewalls. Is the topic of the review discussed comprehensively in the context of the current literature? Yes Are all factual statements correct and adequately supported by citations? Partly Is the review written in accessible language? Yes Are the conclusions drawn appropriate in the context of the current research literature? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Digital dentistry; 3D printing I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 06 Jan 2025 Vaishnavi M Nayak, Department of Prosthodontics and Crown & Bridge, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, 576104, India Thank you for your insightful feedback and constructive comments on our manuscript. We appreciate the opportunity to improve our work and have made significant revisions based on your suggestions. In response, we have made the following adjustments: Overall Comment from reviewer : 'Some of the methods used for printing complete dentures include…' Can these technologies, such as FDM and MJ, be used directly to fabricate dentures for clinical use or only for making trial dentures or custom trays? It is recommended that this part be combined with practical clinical applications. DLP is the most commonly used printing technology and should be introduced in more detail. The author states that '... which impacts the precision of the final product'. According to ISO 5725-4 , accuracy includes both trueness and precision. Does the author mean accuracy? Currently, studies on build orientation and layer thicknesses are carried out using standardized specimens made of denture material in the form of discs. When such specimens are placed and sliced horizontally (0°), the stepwise effect is not generated on some of their surfaces, possibly including the surface being tested. However, the morphology of dentures is an irregular geometry, and the authors are advised to specify this, and it cannot be argued that the surface properties of horizontally printed dentures are more advantageous. Similarly, when the specimen is placed horizontally, the effect of the layer thickness on the surface morphology will not be demonstrated on the surface tested but on the sidewalls. Response: Thank you for the thorough feedback, the following additions have been made: We have added the clinical applications of different 3D printing techniques. The DLP technique is elaborated in detail. The term is corrected to accuracy. The studies on build orientation and variation in morphology of dentures to that of the sample geometry are specified. View more View less Competing Interests No competing interests. reply Respond Report a concern Bai S. Peer Review Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.173059.r342684) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-1266/v1#referee-response-342684 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Shenoy V. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 28 Oct 2024 | for Version 1 Vidya Shenoy , Department of Prosthodontics, AJ Institute of Dental Sciences, Mangalore, India 0 Views copyright © 2024 Shenoy V. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Article is satisfactory and currently, the manuscript presents a well-structured and insightful analysis, contributing meaningfully to the field. Article covers relevant methods of polishing 3D dentures. There is a comprehensive discussion of all the methods including glazing. The facts are adequately supported by the current literature. Overall, it meets approval standards. Recommended for indexing Is the topic of the review discussed comprehensively in the context of the current literature? Yes Are all factual statements correct and adequately supported by citations? Yes Is the review written in accessible language? Yes Are the conclusions drawn appropriate in the context of the current research literature? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise GERIATRIC DENTISTRY I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Shenoy V. Peer Review Report For: The science of printing and polishing 3D printed dentures [version 2; peer review: 2 approved] . F1000Research 2025, 13 :1266 ( https://doi.org/10.5256/f1000research.173059.r334672) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-1266/v1#referee-response-334672 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions Adjust parameters to alter display View on desktop for interactive features Includes Interactive Elements View on desktop for interactive features Competing Interests Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list: Examples of 'Non-Financial Competing Interests' Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper. You have a close personal relationship (e.g. parent, spouse, sibling, or domestic partner) with any of the authors. You are a close professional associate of any of the authors (e.g. scientific mentor, recent student). You work at the same institute as any of the authors. You hope/expect to benefit (e.g. favour or employment) as a result of your submission. You are an Editor for the journal in which the article is published. Examples of 'Financial Competing Interests' You expect to receive, or in the past 4 years have received, any of the following from any commercial organisation that may gain financially from your submission: a salary, fees, funding, reimbursements. You expect to receive, or in the past 4 years have received, shared grant support or other funding with any of the authors. You hold, or are currently applying for, any patents or significant stocks/shares relating to the subject matter of the paper you are commenting on. Stay Updated Sign up for content alerts and receive a weekly or monthly email with all newly published articles Register with F1000Research Already registered? Sign in Not now, thanks close PLEASE NOTE If you are an AUTHOR of this article, please check that you signed in with the account associated with this article otherwise we cannot automatically identify your role as an author and your comment will be labelled as a “User Comment”. If you are a REVIEWER of this article, please check that you have signed in with the account associated with this article and then go to your account to submit your report, please do not post your review here. If you do not have access to your original account, please contact us . All commenters must hold a formal affiliation as per our Policies . The information that you give us will be displayed next to your comment. User comments must be in English, comprehensible and relevant to the article under discussion. We reserve the right to remove any comments that we consider to be inappropriate, offensive or otherwise in breach of the User Comment Terms and Conditions . Commenters must not use a comment for personal attacks. When criticisms of the article are based on unpublished data, the data should be made available. I accept the User Comment Terms and Conditions Please confirm that you accept the User Comment Terms and Conditions. Affiliation ✕ refresh Please enter your institution. Note: To add your institution or organisation, start typing the name and then select the correct name from the list. Where applicable, the name will appear in both the original language and in English. Do not paste in the name. If the name does not appear in the drop-down list, we will display the information you have entered. ✕ refresh Country/Region * USA UK Canada China France Germany Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory British Virgin Islands Brunei Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Cook Islands Costa Rica Cote d'Ivoire Croatia Cuba Cyprus Czech Republic Democratic Republic of the Congo Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands Faroe Islands Federated States of Micronesia Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guam Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and Mcdonald Islands Holy See (Vatican City State) Honduras Hong Kong Hungary Iceland India Indonesia Iran Iraq Ireland Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Kosovo (Serbia and Montenegro) Kuwait Kyrgyzstan Lao People's Democratic Republic Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania Luxembourg Macao Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands Martinique Mauritania Mauritius Mayotte Mexico Minor Outlying Islands of the United States Moldova Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands Antilles New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island North Korea North Macedonia Northern Mariana Islands Norway Oman Pakistan Palau Palestinian Territory Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Puerto Rico Qatar Reunion Romania Russian Federation Rwanda Saint Helena Saint Kitts and Nevis Saint Lucia Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Is South Korea South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syria Taiwan Tajikistan Tanzania Thailand The Gambia The Netherlands Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu UK USA Uganda Ukraine United Arab Emirates United States Virgin Islands Uruguay Uzbekistan Vanuatu Venezuela Vietnam Wallis and Futuna West Bank and Gaza Strip Western Sahara Yemen Zambia Zimbabwe Please select your country/region. You must enter a comment. Competing Interests Please disclose any competing interests that might be construed to influence your judgment of the article's or peer review report's validity or importance. Competing Interests Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list: Examples of 'Non-Financial Competing Interests' Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper. You have a close personal relationship (e.g. parent, spouse, sibling, or domestic partner) with any of the authors. You are a close professional associate of any of the authors (e.g. scientific mentor, recent student). You work at the same institute as any of the authors. You hope/expect to benefit (e.g. favour or employment) as a result of your submission. You are an Editor for the journal in which the article is published. Examples of 'Financial Competing Interests' You expect to receive, or in the past 4 years have received, any of the following from any commercial organisation that may gain financially from your submission: a salary, fees, funding, reimbursements. You expect to receive, or in the past 4 years have received, shared grant support or other funding with any of the authors. You hold, or are currently applying for, any patents or significant stocks/shares relating to the subject matter of the paper you are commenting on. Please state your competing interests The comment has been saved. An error has occurred. Please try again. Cancel Post var lTitle = "The science of printing and polishing 3D...".replace("'", ''); var linkedInUrl = "http://www.linkedin.com/shareArticle?url=https://f1000research.com/articles/13-1266/v2" + "&title=" + encodeURIComponent(lTitle) + "&summary=" + encodeURIComponent('Read the article by '); var deliciousUrl = "https://del.icio.us/post?url=https://f1000research.com/articles/13-1266/v2&title=" + encodeURIComponent(lTitle); var redditUrl = "http://reddit.com/submit?url=https://f1000research.com/articles/13-1266/v2" + "&title=" + encodeURIComponent(lTitle); linkedInUrl += encodeURIComponent('Sulaya K et al.'); var offsetTop = /chrome/i.test( navigator.userAgent ) ? 4 : -10; var addthis_config = { ui_offset_top: offsetTop, services_compact : "facebook,twitter,www.linkedin.com,www.mendeley.com,reddit.com", services_expanded : "facebook,twitter,www.linkedin.com,www.mendeley.com,reddit.com", services_custom : [ { name: "LinkedIn", url: linkedInUrl, icon:"/img/icon/at_linkedin.svg" }, { name: "Mendeley", url: "http://www.mendeley.com/import/?url=https://f1000research.com/articles/13-1266/v2/mendeley", icon:"/img/icon/at_mendeley.svg" }, { name: "Reddit", url: redditUrl, icon:"/img/icon/at_reddit.svg" }, ] }; var addthis_share = { url: "https://f1000research.com/articles/13-1266", templates : { twitter : "The science of printing and polishing 3D printed dentures. Sulaya K et al., published by " + "@F1000Research" + ", https://f1000research.com/articles/13-1266/v2" } }; if (typeof(addthis) != "undefined"){ addthis.addEventListener('addthis.ready', checkCount); addthis.addEventListener('addthis.menu.share', checkCount); } $(".f1r-shares-twitter").attr("href", "https://twitter.com/intent/tweet?text=" + addthis_share.templates.twitter); $(".f1r-shares-facebook").attr("href", "https://www.facebook.com/sharer/sharer.php?u=" + addthis_share.url); $(".f1r-shares-linkedin").attr("href", addthis_config.services_custom[0].url); $(".f1r-shares-reddit").attr("href", addthis_config.services_custom[2].url); $(".f1r-shares-mendelay").attr("href", addthis_config.services_custom[1].url); function checkCount(){ setTimeout(function(){ $(".addthis_button_expanded").each(function(){ var count = $(this).text(); if (count !== "" && count != "0") $(this).removeClass("is-hidden"); else $(this).addClass("is-hidden"); }); }, 1000); } close How to cite this report {{reportCitation}} Cancel Copy Citation Details $(function(){R.ui.buttonDropdowns('.dropdown-for-downloads');}); $(function(){R.ui.toolbarDropdowns('.toolbar-dropdown-for-downloads');}); $.get("/articles/acj/157596/176341") new F1000.Clipboard(); new F1000.ThesaurusTermsDisplay("articles", "article", "176341"); $(document).ready(function() { $( "#frame1" ).on('load', function() { var mydiv = $(this).contents().find("div"); var h = mydiv.height(); console.log(h) }); var tooltipLivingFigure = jQuery(".interactive-living-figure-label .icon-more-info"), titleLivingFigure = tooltipLivingFigure.attr("title"); tooltipLivingFigure.simpletip({ fixed: true, position: ["-115", "30"], baseClass: 'small-tooltip', content:titleLivingFigure + " " }); tooltipLivingFigure.removeAttr("title"); $("body").on("click", ".cite-living-figure", function(e) { e.preventDefault(); var ref = $(this).attr("data-ref"); $(this).closest(".living-figure-list-container").find("#" + ref).fadeIn(200); }); $("body").on("click", ".close-cite-living-figure", function(e) { e.preventDefault(); $(this).closest(".popup-window-wrapper").fadeOut(200); }); $(document).on("mouseup", function(e) { var metricsContainer = $(".article-metrics-popover-wrapper"); if (!metricsContainer.is(e.target) && metricsContainer.has(e.target).length === 0) { $(".article-metrics-close-button").click(); } }); var articleId = $('#articleId').val(); if($("#main-article-count-box").attachArticleMetrics) { $("#main-article-count-box").attachArticleMetrics(articleId, { articleMetricsView: true }); } }); var figshareWidget = $(".new_figshare_widget"); if (figshareWidget.length > 0) { window.figshare.load("f1000", function(Widget) { // Select a tag/tags defined in your page. In this tag we will place the widget. _.map(figshareWidget, function(el){ var widget = new Widget({ articleId: $(el).attr("figshare_articleId") //height:300 // this is the height of the viewer part. [Default: 550] }); widget.initialize(); // initialize the widget widget.mount(el); // mount it in a tag that's on your page // this will save the widget on the global scope for later use from // your JS scripts. This line is optional. //window.widget = widget; }); }); } close Error Close Add Reset F1000.MICROSERVICES.AFFILIATION = ''; $(document).ready(function () { $('.js-affiliations-form').each((index, form) => { new AffiliationForm({ formId: form.id, institutionErrorSelector: '.comment-enter-institution', departmentErrorSelector: '.comment-enter-department', placeSelector: '.js-add-comment-place', stateSelector: '.js-add-comment-state', zipCodeSelector: '.js-add-comment-zipcode', countrySelector: '.js-add-comment-country', countryErrorSelector: '.comment-enter-country', }); }); }); $(document).ready(function () { var reportIds = { "342685": 0, "342684": 20, "342687": 0, "342686": 0, "342681": 0, "342680": 0, "342683": 0, "342682": 0, "342689": 0, "342688": 0, "356805": 0, "356807": 0, "356806": 0, "356813": 0, "356812": 0, "356814": 0, "356809": 0, "356808": 0, "356811": 0, "356810": 0, "334677": 0, "334676": 0, "334679": 0, "334678": 0, "334673": 0, "334672": 19, "334675": 0, "334674": 0, "356575": 6, "356574": 0, "334681": 0, "334680": 0, "337893": 0, "337892": 0, "337895": 0, "337894": 0, "337901": 0, "337900": 0, "337897": 0, "337896": 0, "337899": 0, "337898": 0, "359285": 0, "359284": 0, "359287": 0, "359286": 0, "359283": 0, "359282": 0, "359289": 0, "359288": 0, "359290": 0, }; $(".referee-response-container,.js-referee-report").each(function(index, el) { var reportId = $(el).attr("data-reportid"), reportCount = reportIds[reportId] || 0; $(el).find(".comments-count-container,.js-referee-report-views").html(reportCount); }); var uuidInput = $("#article_uuid"), oldUUId = uuidInput.val(), newUUId = "c0b0dd62-1cda-4d79-90e7-a0942a419e58"; uuidInput.val(newUUId); $("a[href*='article_uuid=']").each(function(index, el) { var newHref = $(el).attr("href").replace(oldUUId, newUUId); $(el).attr("href", newHref); }); }); An innovative open access publishing platform offering rapid publication and open peer review, whilst supporting data deposition and sharing. Browse Gateways Collections How it Works Contact For Developers Cookie Notice Privacy Notice RSS Submit Your Research Follow us © 2012-2026 F1000 Research Ltd. ISSN 2046-1402 | Legal | Partner of Research4Life • CrossRef • ORCID • FAIRSharing R.templateTests.simpleTemplate = R.template(' $text $text $text $text $text '); R.templateTests.runTests(); var F1000platform = new F1000.Platform({ name: "f1000research", displayName: "F1000Research", hostName: "f1000research.com", id: "1", editorialEmail: "[email protected]", infoEmail: "[email protected]", usePmcStats: true }); $(function(){R.ui.dropdowns('.dropdown-for-authors, .dropdown-for-about, .dropdown-for-myresearch');}); // $(function(){R.ui.dropdowns('.dropdown-for-referees');}); $(document).ready(function () { if ($(".cookie-warning").is(":visible")) { $(".sticky").css("margin-bottom", "35px"); $(".devices").addClass("devices-and-cookie-warning"); } $(".cookie-warning .close-button").click(function (e) { $(".devices").removeClass("devices-and-cookie-warning"); $(".sticky").css("margin-bottom", "0"); }); $("#tweeter-feed .tweet-message").each(function (i, message) { var self = $(message); self.html(linkify(self.html())); }); $(".partner").on("mouseenter mouseleave", function() { $(this).find(".gray-scale, .colour").toggleClass("is-hidden"); }); }); Sign In Remember me Forgotten your password? Sign In Cancel Email or password not correct. Please try again Please wait... $(function(){ // Note: All the setup needs to run against a name attribute and *not* the id due the clonish // nature of facebox... $("a[id=googleSignInButton]").click(function(event){ event.preventDefault(); $("input[id=oAuthSystem]").val("GOOGLE"); $("form[id=oAuthForm]").submit(); }); $("a[id=facebookSignInButton]").click(function(event){ event.preventDefault(); $("input[id=oAuthSystem]").val("FACEBOOK"); $("form[id=oAuthForm]").submit(); }); $("a[id=orcidSignInButton]").click(function(event){ event.preventDefault(); $("input[id=oAuthSystem]").val("ORCID"); $("form[id=oAuthForm]").submit(); }); }); If you've forgotten your password, please enter your email address below and we'll send you instructions on how to reset your password. The email address should be the one you originally registered with F1000. Email address not valid, please try again You registered with F1000 via Google, so we cannot reset your password. To sign in, please click here . If you still need help with your Google account password, please click here . You registered with F1000 via Facebook, so we cannot reset your password. To sign in, please click here . If you still need help with your Facebook account password, please click here . Code not correct, please try again Reset password Cancel Email us for further assistance. Server error, please try again. If your email address is registered with us, we will email you instructions to reset your password. If you think you should have received this email but it has not arrived, please check your spam filters and/or contact for further assistance. Please wait... Register $(document).ready(function () { signIn.createSignInAsRow($("#sign-in-form-gfb-popup")); $(".target-field").each(function () { var uris = $(this).val().split("/"); if (uris.pop() === "login") { $(this).val(uris.toString().replace(",","/")); } }); });

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-05-20T01:45:00.602351+00:00