Effects of melatonin on disease improvement and serum levels of pro-inflammatory cytokines in patients with non-atypical endometrial hyperplasia

Neda Aslany, Zahra Vahedpour, Habibollah Rahimi, Mohsen Masjedi, Hossein Motedayyen
In: Journal of Immunoassay and Immunochemistry · 2024 · vol. 45(4) , pp. 382–394 · doi:10.1080/15321819.2024.2371583 · PMID:38910356 · W4399981816
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This study compared melatonin plus progesterone versus progesterone alone in treating non-atypical endometrial hyperplasia and found melatonin enhanced improvement and modulated pro-inflammatory cytokine levels.

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Abstract

BACKGROUND: Endometrial hyperplasia (EH), an abnormal proliferation of the endometrial cells, is considered as one of the most common causes of abnormal uterine bleeding. Previous studies have reported that melatonin plays a fundamental role in disease treatment. This study aimed the comparison of the effects of progesterone, as the most common therapeutic approach, and melatonin with progesterone alone in improvement of non-atypical endometrial hyperplasia (NEH) and changes in pro-inflammatory cytokine levels. METHODS: Study population consisted of 40 patients with NEH. Patients were divided into two groups, including 20 subjects treated with melatonin and progesterone and 20 individuals treated with progesterone alone. The blood and endometrial sampling was performed from participants before and after a three-month treatment. The histological examination was microscopically done. The serum levels of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) were measured using ELISA. RESULTS: < 0.001-P < 0.05). CONCLUSION: Melatonin supplementation has a beneficial effect in the treatment of EH due perhaps to enhance the level of IFN-γ and TNF-α.

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