The expression and significance of VEGF in endometriosis

Objective:To detect the expression of VEGF(Vascular Endothelium Growth Factor) in uterine endometrium of endometriosis patients,and to study the relationship between VEGF and pathogenic mechanism of endometriosis.Methods:Using immunohistochemical method to detect VEGF in endometrium of 48 cases of endometriosis and of 24 cases of normal women.Results:①VEGF was expressed in both endometriosis endometrium and normal endometrium.The expression of VEGF was much stronger in endometriosis endometrium than in normal endometrium.There was significant difference between two groups(P0.01);②As for the endometriosis endometrium,the expression of VEGF was much stronger in proliferative phase than in secretory phase(P0.01),which shows that the expression of VEGF was periodically changed during menstrual cycle.Conclusion:VEGF is an important factor for promotion of vascular growth.VEGF is correlated with the pathogenic mechanism of endometriosis,and may act an important function in the occurrence and development of endometriosis.