Escalation, maintenance and abstention in oncology A new study design to identify how individual values of patients impact on the assessment of risks and benefits of novel therapeutic concepts in cases of gynaecological tumors and colorectal cancer: A study protocol

Escalation, maintenance and abstention in oncology A new study design to identify how individual values of patients impact on the assessment of risks and benefits of novel therapeutic concepts in cases of gynaecological tumors and colorectal cancer: A study protocol | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 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Data may be preliminary. 13 January 2025 V1 Latest version Share on Escalation, maintenance and abstention in oncology A new study design to identify how individual values of patients impact on the assessment of risks and benefits of novel therapeutic concepts in cases of gynaecological tumors and colorectal cancer: A study protocol Authors : Theis S [email protected] , Senyigit J , Büchler B , Diederichsen K , Kolck G , Möhler M , Hasenburg , and Paul NW Authors Info & Affiliations https://doi.org/10.22541/au.173677539.99996419/v1 222 views 104 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Being diagnosed with cancer is a pivotal moment in a person’s life and changes biographies fundamentally, especially in terms of temporality and physicality. Modern concepts of maintenance therapy or therapeutic abstinence are at odds with typical desire of patients to fight the disease radically. Decisions about therapeutic goals are caught between medical-scientific expertise on the one hand and life-world judgements and values on the other. This makes it particularly challenging to reconcile different preferences and norms. This study aims to analyse values in the context of the challenging human experience of cancer. We hypothesise that established quantitative measures and even more patient-centred assessment tools such as PROMs may not be adequate to capture therapeutic success as understood by patients. Semi-structured interviews will be carried out with participants with gynaecological or colorectal cancer. We propose a mixed methods approach to identify participants’ values, individual treatment goals, and expectations. Outcomes of the study are defined as: 1) ethical analysis of values in the context of human experiences with cancer 2) reconstruction of values triggering individual treatment goals and positive and negative expectations 3) comparison of ethical concepts of successful life with situational values of patients with evidence-based (medical-scientific) preferences. This results in following secondary objectives: 1) Establishing a strategy for patient-centred adaptation of clinical evaluation of therapeutic concepts of escalation, maintenance or abstinence, 2) modelling of a well operationalised clinical strategy for therapeutic goal setting, 3) teaching this strategy, including the clinical oncological, ethical and communicative requirements, as part of medical education. Supplementary Material File (main document.docx) Download 49.70 KB Information & Authors Information Version history V1 Version 1 13 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords epidemiology: gynaecological cancer ethics gynaecological oncology gynaecological surgery: gynaecological cancer health services research qualitative research Authors Affiliations Theis S [email protected] University Medical Center of Johannes Gutenberg University Mainz View all articles by this author Senyigit J Johannes Gutenberg University Medical Center Mainz View all articles by this author Büchler B Johannes Gutenberg University Medical Center Mainz View all articles by this author Diederichsen K University Medical Center of Johannes Gutenberg University Mainz View all articles by this author Kolck G University Medical Center of Johannes Gutenberg University Mainz View all articles by this author Möhler M University Medical Center of Johannes Gutenberg University Mainz View all articles by this author Hasenburg University Medical Center of Johannes Gutenberg University Mainz View all articles by this author Paul NW Johannes Gutenberg University Medical Center Mainz View all articles by this author Metrics & Citations Metrics Article Usage 222 views 104 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Theis S, Senyigit J, Büchler B, et al. Escalation, maintenance and abstention in oncology A new study design to identify how individual values of patients impact on the assessment of risks and benefits of novel therapeutic concepts in cases of gynaecological tumors and colorectal cancer: A study protocol. Authorea . 13 January 2025. DOI: https://doi.org/10.22541/au.173677539.99996419/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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