Controlled ovarian hyperstimulation: comparison between u-hFSH conventional protocol and a personalized approach.

OBJECTIVE: To investigate the therapeutic effectiveness in infertile couples with anovulatory, mild endometriosis-related and unexplained infertility of a personalized approach to controlled ovarian hyperstimulation (COH) (group A) on the basis of body mass index (BMI) and waist/hip ratio (WHR) in comparison to a conventional protocol (group B). RESULTS: In group A, we obtained a significantly higher pregnancy rate and number of multifollicular cycles in comparison to group B. In addition, the pregnancy rate/ovulatory cycle and the number of ovulatory cycles were higher (but not significantly) in group A. In group B, we observed a not significantly higher number of monofollicular cycles and required length of stimulation in comparison to group A. CONCLUSION: A personalized therapeutic protocol, based on simple criteria such as BMI and WHR, leads to a higher number of single and twin pregnancies, without any significant increase of higher grade multiple pregnancies or severe ovarian hyperstimulation syndrome.