Analysis of anesthesia-related prognostic indicators in neurosurgery

Abstract Background: This retrospective study was conducted to identify prognostic predictors for patients undergoing neurosurgery under general anesthesia.Methods: From April 2015 to May 2017, a total of 757 patients undergoing neurosurgery in our hospital were analyzed. Baseline and clinical data including age, gender, etiology, surgery procedures, comorbid and underlying diseases, the Glasgow coma scale (GCS), the APACHE II score, ASA score, anesthesia class, operation time, intraoperative cardiac events, intraoperative blood transfusion, and postoperative fever were collected and analyzed. The Glasgow outcome scale (GOS) was used as outcome measure. Logistic regression analysis was performed to identify the independent prognostic factors. Results: Among the 14 factors analyzed, twelve were significantly correlated to the GOS scores (P < 0.05), including age, etiology, type of surgery, hypertension, anesthesia class, APACHE II score and ASA class, intraoperative cardiac events, intraoperative blood transfusion and postoperative fever. Further logistic regression analysis showed the three parameters had prognostic values with odds ratios of 3.933, 1.812 and 2.910, respectively. On other hand, gender and operation time were not correlated to GOS.Conclusions: Anesthesia class, APACHE II score and ASA class have significant prognostic values for patients undergoing neurosurgical surgery.