Crossed Cerebellar Diaschisis Secondary to Acute Drug-Induced Liver Failure: A Case Report

Crossed Cerebellar Diaschisis Secondary to Acute Drug-Induced Liver Failure: A Case Report | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Crossed Cerebellar Diaschisis Secondary to Acute Drug-Induced Liver Failure: A Case Report Haimei Zhang¹, Penglong Xu², Wei Tang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7374905/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Crossed cerebellar diaschisis (CCD) is a phenomenon in which a unilateral cerebral lesion provokes reduced neuronal metabolism and hypoperfusion in the contralateral cerebellar hemisphere [ 1 ] . It is most often observed in acute ischemic stroke [ 2 ] and status epilepticus [ 3 ] among other central nervous system emergencies. We present a rare case of CCD secondary to acute druginduced liver failure following acetaminophen overdose, complicated by profound hypoglycemic encephalopathy. This report broadens the etiologic spectrum of CCD and underscores the relevance of systemic metabolic disturbances in its pathophysiology. crossed cerebellar diaschisis acetaminophen poisoning druginduced liver failure hypoglycemic encephalopathy magnetic resonance imaging Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7374905","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":515417651,"identity":"2a0825a4-e3c8-4cfa-a954-6b21681f0133","order_by":0,"name":"Haimei Zhang¹","email":"","orcid":"","institution":"Xinhua Hospital Affiliated to Dalian University","correspondingAuthor":false,"prefix":"","firstName":"Haimei","middleName":"","lastName":"Zhang¹","suffix":""},{"id":515417652,"identity":"e2044da7-ea86-420a-8185-bf8a0513fede","order_by":1,"name":"Penglong Xu²","email":"","orcid":"","institution":"Xuchang Hospital","correspondingAuthor":false,"prefix":"","firstName":"Penglong","middleName":"","lastName":"Xu²","suffix":""},{"id":515417653,"identity":"d27a8b33-b264-4693-ad27-5dbec1e04c73","order_by":2,"name":"Wei Tang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAz0lEQVRIiWNgGAWjYBACNmbmAwckeP7L2R9mPkCcFj52tsQDFjLMxgzH2xKI0yLHz2N8oMKGObHhzBkDYh3GY3DgRg5bYuOMnI833jDYyek2ENTCVnBwxhke42aJ3M2WcxiSjc0OENTCvOGwZI+EbJtE7jZpHoYDidsIa2EwOPz3nwFjj0TOM2K1sBgAAzlBcQbPGTZitbAlALUcMDZgbzO2nGNAhF/k+w8f/gDUImfAzPzwxpsKOzmCWlCABA+RUYOshVQdo2AUjIJRMCIAABpEPxiNVBWyAAAAAElFTkSuQmCC","orcid":"","institution":"Xinhua Hospital Affiliated to Dalian University","correspondingAuthor":true,"prefix":"","firstName":"Wei","middleName":"","lastName":"Tang","suffix":""}],"badges":[],"createdAt":"2025-08-14 14:38:30","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7374905/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7374905/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":95903630,"identity":"5a72a493-73d6-4597-a11d-0b62b7cf1830","added_by":"auto","created_at":"2025-11-14 08:53:36","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":366603,"visible":true,"origin":"","legend":"","description":"","filename":"CrossedCerebellarDiaschisisSecondarytoAcuteDrug.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7374905/v1_covered_04c222fc-5681-406e-a652-3ff03a8fbd10.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Crossed Cerebellar Diaschisis Secondary to Acute Drug-Induced Liver Failure: A Case Report","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"crossed cerebellar diaschisis, acetaminophen poisoning, druginduced liver failure, hypoglycemic encephalopathy, magnetic resonance imaging","lastPublishedDoi":"10.21203/rs.3.rs-7374905/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7374905/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eCrossed cerebellar diaschisis (CCD) is a phenomenon in which a unilateral cerebral lesion provokes reduced neuronal metabolism and hypoperfusion in the contralateral cerebellar hemisphere\u003csup\u003e[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]\u003c/sup\u003e. 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