How Lipid Metabolism Reprograms and Promotes Tumorigenicity in EBV, HPV or KSHV Infected Cells

Tumor cells meet the drastic energy requirements for cell survival and unlimited proliferation through metabolic reprogramming, and one of the important aspects of metabolic reprogramming is changes in lipid metabolism. Increasing evidence suggests that, like tumor cells in general, host cells infected with onco-viruses significantly alter metabolic requirements and generate substances for viral replication and virion production by altering the metabolism of host cells. HPV, EBV and KSHV are the three important contributors to virus-related tumors that appear in people before the age of 50. On the basis of reviewing the changes of lipid metabolism in tumor cells, this review summarizes the interesting association between HPV, EBV or KSHV and lipid metabolism from these three major tumor viruses in order to provide new insight into the treatment of virus-related tumors.