Endometriosis. Сlinical protocol review from different angles (discussion)

Endometriosis is a common disease characterized by the tissue similar in morphology and function to the endometrium outside the uterine cavity. The review presents a historical background, an overview of the theories concerning the endometriosis pathogenesis, a description of the clinical picture, diagnostic issues and a discussion concerning the clinical recommendations of the Ministry of Health of the Russian Federation on the patient management with endometriosis, which are currently in force. To date, the etiology and pathogenesis of this disease have not been fully clarified, and the development of this pathology is still debated. Endometriosis has significant adverse health outcomes and negatively affects the life quality of patients. Endometriosis-associated infertility contributes to a decrease in fertility, having an adverse impact on the country's economy. The disease clinical debut may be a menstrual disorder, abnormal uterine bleeding, infertility, the development of chronic pelvic pain syndrome, manifested by dyspareunia, dyschezia, dysmenorrhea. The progress of medicine in this area is associated with an individual patient management, where an improvement a woman's life quality, therapy and overcoming infertility, reducing the frequency of relapses and minimizing surgical interventions are highlighted Properly selected individual therapy leads to a decrease in the incidence of endometriosis clinical manifestation, which has a beneficial effect on personal, social, demographic and economic indicators. KEYWORDS: endometriosis, endometrium, endometrial pathogenesis, endometrial disease, endometriosis treatment, clinical recommendations, endometriosis-associated infertility. FOR CITATION: Dobrokhotova Yu.E., Markova E.A., Khlynova S.A., Narimanova M.R. Endometriosis. Сlinical protocol review from different angles (discussion). Russian Journal of Woman and Child Health. 2024;7(2):89–97 (in Russ.). DOI: 10.32364/2618-8430-2024-7-2-1.