Study on VEGF bFGF and TGF-Beta 1 in the endometrium of Norplant users.

This study investigated the relationship between abnormal uterine bleeding and endometrial vascular endothelial growth factor (VEGF) basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF-beta1) expressions in Norplant users. A total of 36 endometrium samples from Norplant users with normal and abnormal bleeding obtained from the Family Planning Clinic at Chaoyang Hospital in Beijing China were studied morphologically and immunohistochemically for VEGF bFGF and TGF-beta1 expression. 6 normal samples of proliferate endometria were studied as controls. In the Norplant users the characteristics of the endometrium changed and glands decreased in numbers. VEGF expression in the epithelium and vascular endothelium was low in those with abnormal uterine bleeding. However no difference was detected for bFGF and TGF-beta1 expression. The results suggest that the decline of VEGF expression may relate to the abnormal uterine bleeding in Norplant users.