MR hysterosalpingography in a rabbit model

Fred T. Lee, F T Lee, T M Grist, Thomas M. Grist, K G Nelson, Kathleen G. Nelson, Susan G. Chosy, S G Chosy, Alan H. Rappe, A H Rappe, S S Shapiro, Sander S. Shapiro, F Kelcz, Frederick Kelcz
Journal of magnetic resonance imaging : JMRI · 1996 · vol. 6(2) , pp. 300–304 · doi:10.1002/jmri.1880060208 · PMID:9132095 · W2142373648
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MR hysterosalpingography showed high sensitivity and specificity for diagnosing fallopian tube patency in rabbits, comparable to conventional HSG.

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Abstract

Our objective was to evaluate the efficacy of MR imaging as compared with conventional hysterosalpingography (HSG) for the detection of fallopian tube patency after uterine injection of contrast material. Rabbit uterine horns (n= 18) were catheterized transvaginally. Five fallopian tubes were ligated and 11 were left unaltered. T1-weighted gradient-echo MR images were obtained before, during, and after injection of 1.0-3.0 mL of a dilute gadolinium-containing contrast agent. Corresponding conventional studies were performed with an equivalent volume of iohexol. Images were evaluated by two blinded readers. Observers agreed in all cases on the presence (n = 11) or absence (n = 5) of peritoneal spill with conventional HSG. Interpretation of MR HSG concurred with conventional HSG in 14 of 16 cases for each observer (P > .05). Reasons for misdiagnosis included small amounts of spill (n = 2), artifact (n = 1), and subtle spill between bowel loops (n = 1). Sensitivity and specificity for MR HSG were 95.5% and 70%, respectively, for the diagnosis of tubal patency/occlusions. No statistical difference was found between MR HSG and conventional HSG for the diagnosis of fallopian tube patency/obstruction. Potential advantages of MR HSG include no ionizing radiation, potentially diminished local contrast toxicity, superior visualization of uterine fibroids and endometriosis, and visualization of ovaries. We conclude that this technique warrants further study, including the use of a primate model to better simulate human anatomy.

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Condition tags

endometriosis

MeSH descriptors

Contrast Media Fallopian Tubes Magnetic Resonance Imaging Meglumine Organometallic Compounds Pentetic Acid Animals Artifacts Drug Combinations Extravasation of Diagnostic and Therapeutic Materials Extravasation of Diagnostic and Therapeutic Materials Fallopian Tube Diseases Fallopian Tube Diseases Fallopian Tube Patency Tests Fallopian Tubes Female Gadolinium DTPA Hysterosalpingography Iohexol Magnetic Resonance Imaging

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References (18)

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