Combined release of antiseptic and antibiotic drugs from visible light polymerized biodegradable nanocomposite hydrogels for periodontitis treatment

Combined release of antiseptic and antibiotic drugs from visible light polymerized biodegradable nanocomposite hydrogels for periodontitis treatment | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Combined release of antiseptic and antibiotic drugs from visible light polymerized biodegradable nanocomposite hydrogels for periodontitis treatment József Bakó, Ferenc Tóth, József Gáll, István Varga, Anton Sculean, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-955354/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 28 Apr, 2022 Read the published version in Pharmaceutics → Version 1 posted You are reading this latest preprint version Abstract The in-situ used combination of different types of drugs revolutionized the area of periodontal therapy. The purpose of this study was to develop biodegradable nanocomposite hydrogel (NCHG) as a pH-sensitive drug delivery system. To reach the local applicability of the NCHG in dental practice routinely used blue-light photopolymerization was chosen for the preparation. The reaction time was 60 seconds, which resulted in stable hydrogel structures. Universal Britton-Robinson buffer solutions were used to investigate only the effect of pH for the release of the periodontal pocket useable drugs in the 4-12 range. The release of metronidazole was faster, it came out from the NCHGs within 12 hours, but the chlorhexidine had shown a longer elution time, which was more than 7 days as far as the antiseptic effect was maintained. The release of chlorhexidine showed strong pH depending. The biocompatibility of the NCHGs was proved by Alamar-blue test, and the effectiveness of drug release in the acidic medium was demonstrated. This fast photopolymerizable NCHG can help to approach an ideal locally useable combined drug delivery system which can be used in the amount required of the medicines and can reduce the side effects with the increased effectiveness by following pH changes. Dentistry Drug Delivery Medicinal Chemistry periodontal therapy biodegradable nanocomposite hydrogel pH changes Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 28 Apr, 2022 Read the published version in Pharmaceutics → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-955354","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":55460556,"identity":"658e333e-f4ed-463e-8b37-16e63994d064","order_by":0,"name":"József Bakó","email":"","orcid":"","institution":"University of Debrecen","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"József","middleName":"","lastName":"Bakó","suffix":""},{"id":55460559,"identity":"13458c11-43e0-4a1a-b4cb-e1498f107323","order_by":1,"name":"Ferenc Tóth","email":"","orcid":"","institution":"University of 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