A core gene network linking developmental signaling and immune response in stomach adenocarcinoma revealed by integrated bioinformatics

A core gene network linking developmental signaling and immune response in stomach adenocarcinoma revealed by integrated bioinformatics | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A core gene network linking developmental signaling and immune response in stomach adenocarcinoma revealed by integrated bioinformatics Bo Yang, Hao Li This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8578237/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective This study aims to identify and characterize the core gene network that molecularly integrates developmental signaling pathways with immune responses in stomach adenocarcinoma (STAD), and to evaluate the clinical relevance of the key hub genes within this network as potential prognostic biomarkers and therapeutic targets. Methods We analyzed the TCGA-STAD dataset to identify differentially expressed genes. Protein-protein interaction (PPI) networks were constructed using Cytoscape, and hub genes were screened based on betweenness centrality. High-confidence interactions were extracted from the STRING database. Functional enrichment analysis was performed using GO and KEGG. Clinical relevance was validated through survival analysis and stage-expression correlation. Results From 230 differentially expressed genes, we identified 46 core genes through multi-step screening. Functional enrichment revealed their significant involvement in developmental processes and immune-inflammatory responses. Eight key hub genes (TNF, IL17A, IFNG, SHH, BMP2, ULBP2, JUN, CXCL10) demonstrated significant prognostic value. High expression of TNF, IL17A, and SHH was associated with poor prognosis, whereas IFNG, JUN, and CXCL10 predicted favorable outcomes. ULBP2 exhibited progressive upregulation with advancing tumor stage, suggesting its role in disease progression. Conclusion We identified a core gene network that functionally integrates developmental programming with immune regulation in STAD. This network provides a framework for understanding disease heterogeneity and offers potential biomarkers for prognosis prediction and therapeutic targeting. Stomach adenocarcinoma Core gene network Developmental signaling Immune response Integrated bioinformatics Figures Figure 1 Figure 2 Figure 3 Figure 4 Introduction stomach cancer remains a formidable global health challenge, ranking as the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related mortality worldwide ( 1 ). Among its histological subtypes, stomach adenocarcinoma (STAD) constitutes the vast majority of cases. Despite advancements in diagnostic and therapeutic modalities, the prognosis for patients with advanced or metastatic STAD remains poor, with a 5-year survival rate below 30% ( 2 ). This outcome is largely attributed to high molecular heterogeneity, late diagnosis, and frequent therapy resistance ( 3 ). Thus, deciphering the molecular landscape of STAD pathogenesis is an urgent clinical need, essential for developing effective prognostic biomarkers and novel therapeutic strategies. High-throughput sequencing and collaborative projects such as The Cancer Genome Atlas (TCGA) have profoundly enhanced our understanding of genomic and transcriptomic alterations in STAD ( 4 ). These studies not only catalog driver mutations but also highlight disease heterogeneity, leading to molecular classifications that stratify STAD into distinct subtypes with clinical implications ( 4 , 5 ). Concurrently, systems biology approaches have shifted the perspective from gene-centric to network-centric, revealing that cancer phenotypes often arise from dysfunction within interconnected modules of protein-protein interaction (PPI) networks ( 6 , 7 ) Analyzing these networks enables identification of hub genes occupying critical topological positions, whose perturbation can disrupt cellular signaling and drive oncogenesis ( 8 ). Two pivotal biological processes frequently dysregulated in STAD are embryonic developmental signaling and immune-inflammatory responses. Developmental pathways such as Hedgehog (HH) and Bone Morphogenetic Protein (BMP) signaling, crucial for tissue patterning during embryogenesis, are often reactivated in cancer ( 9 , 10 ). For instance, the Hedgehog ligand SHH is implicated in cancer stem cell maintenance and tumor progression in gastrointestinal malignancies ( 11 ). Meanwhile, the inflammatory tumor microenvironment (TME), characterized by aberrant cytokine and chemokine production (e.g., TNF, IL-17, IFNG, CXCL10), plays dual roles in promoting or suppressing tumor growth ( 12 , 13 ). Chronic inflammation driven by TNF can foster a pro-tumorigenic niche, while chemokines like CXCL10 recruit cytotoxic T cells to mediate anti-tumor immunity (14.15). Additionally, stress-induced ligands such as ULBP2, which activate the NKG2D receptor on immune cells, bridge cellular damage and immune recognition within the TME ( 16 ). Although developmental pathways and immune responses have been studied independently, the existence and clinical significance of a core regulatory network integrating these processes in STAD remain unclear. We hypothesize that such a network exists, with key hub genes orchestrating both developmental reprogramming and immune modulation, ultimately influencing tumor behavior and patient outcomes. To test this hypothesis, we employed an integrated bioinformatics approach. We analyzed the TCGA-STAD dataset to identify differentially expressed genes, constructed a PPI network to identify topologically central hubs, and refined a core gene set through high-confidence interaction filtering. Functional enrichment analysis confirmed co-enrichment of developmental and immune functions. We then validated the clinical relevance of key hub genes by assessing their prognostic value and expression dynamics across tumor stages. Our study reveals a core gene network crosstalking between developmental and immune landscapes in STAD, identifies novel prognostic biomarkers, and highlights ULBP2 as a key player in disease progression, offering fresh insights into the molecular mechanisms of stomach adenocarcinoma. Materials and Methods Data Acquisition and Differential Expression Analysis： RNA-seq data and clinical information for STAD were obtained from TCGA (4). Differential expression analysis was performed using DESeq2 with thresholds of |log2FC| > 1 and FDR 200). High-confidence interactions were validated using STRING (18)database (confidence score > 0.9). Functional Enrichment Analysis： GO and KEGG pathway enrichment analyses were conducted using clusterProfiler. Terms with FDR < 0.05 were considered significant. Survival and Clinical Correlation Analysis： Prognostic value was assessed using Kaplan-Meier Plotter (19). Stage-expression correlations were analyzed through UALCAN database. Reasult Screening of Differentially Expressed Genes and Construction of the Core Gene Network Through differential expression analysis of the TCGA-STAD dataset, we identified a total of 232 genes that were significantly differentially expressed in stomach adenocarcinoma tissues (|log2FC| > 2, FDR 200). To further enhance the biological reliability of the results, we extracted high-confidence interaction relationships (confidence score > 0.9) from the STRING database and intersected them with the original gene set, ultimately obtaining a core gene set comprising 46 genes, which form a highly interconnected functional module. Functional enrichment analysis of core genes reveals an 'immune-development' regulatory network GO functional enrichment analysis showed that the 46 core genes were significantly enriched in multiple important biological processes (Figure 1A). At the biological process (BP) level, the genes were mainly involved in developmental regulation, including regionalization, pattern specification processes, embryonic organ development, and limb morphogenesis. At the molecular function (MF) level, the genes were significantly enriched in DNA-binding transcription activator activity, cytokine activity, cytokine receptor binding, and growth factor activity. Cellular component (CC) analysis indicated that the genes were primarily localized to secretory granule lumens, extracellular matrix, and other locations. KEGG pathway analysis further confirmed the functional characteristics of these genes (Figure 1B), showing that the core genes were significantly enriched in immune-inflammatory-related pathways such as cytokine-cytokine receptor interaction, IL-17 signaling pathway, and TNF signaling pathway, while also exhibiting significant enrichment in autoimmune disease pathways including rheumatoid arthritis and inflammatory bowel disease. Prognostic Value Assessment of Key Hub Genes From the 46 core genes, we selected eight hub genes located at key pathway nodes for an in-depth analysis of their clinical significance. Survival analysis results (Figure 2) showed that these genes exhibited markedly different prognostic values in stomach adenocarcinoma (Table 1). High expression of TNF (HR = 1.34, P = 0.00079), IL17A (HR = 1.59, P = 1.1e-06), and SHH (HR = 1.59, P = 7.9e-08) was significantly associated with shorter overall survival, representing independent risk factors for poor prognosis. In contrast, high expression of IFNG (HR = 0.80, P = 0.035), JUN (HR = 0.54, P = 2.3e-11), and CXCL10 (HR = 0.59, P = 3.1e-07) indicated longer survival, serving as protective factors. Analysis of the Association Between Gene Expression and Tumor Progression By analyzing the relationship between gene expression and tumor clinical staging, we found that ULBP2 exhibits a distinct dynamic expression pattern. The expression level of ULBP2 in Stage IV is significantly higher than in Stage III (P = 0.00078), showing a gradually upregulated trend with tumor progression (Figure 3). Moreover, the expression levels of most core genes (TNF, IFNG, BMP2, JUN, CXCL10) are significantly higher in stomach cancer tissues compared to normal stomach tissues, but remain relatively stable across different tumor stages. Correlation analysis further revealed the relationship between CXCL10 and the tumor immune microenvironment. The expression of CXCL10 was significantly positively correlated with CD8A (R = 0.59, P < 0.001), suggesting that it may exert an antitumor effect by recruiting CD8 T cells (Figure 4). Discussion This study systematically identified a core gene network linking developmental regulation and immune response in stomach adenocarcinoma through the integration of bioinformatics analysis methods. This finding provides a new perspective for understanding the molecular mechanisms of stomach adenocarcinoma and reveals intrinsic connections between previously overlooked biological processes. Synergistic interaction of developmental and immune pathways The research results show that core genes are simultaneously enriched in pathways related to developmental regulation (such as regionalization and pattern specialization) and immune-inflammatory responses, which has significant biological implications. Hedgehog signaling pathway gene SHH and bone morphogenetic protein BMP2 ( 9 ), as important morphogens, play a key role in embryonic development, whereas their abnormal expression in stomach adenocarcinoma may drive tumor dedifferentiation and the maintenance of stem cell-like characteristics. Meanwhile, cytokines such as TNF and IL17A promote tumor progression by creating a pro-inflammatory microenvironment. This co-regulation of developmental and immune programs suggests that tumor cells may "hijack" the regulatory mechanisms of embryonic development to collaboratively promote malignant phenotypes. ULBP2: A bridge connecting tumor progression and immune surveillance The finding that ULBP2 expression is significantly upregulated with tumor stage progression has particular clinical significance. As a ligand of the NKG2D receptor, ULBP2 is usually upregulated under cellular stress, thereby activating NK cells and CD8 T cell-mediated antitumor immunity. However, in advanced tumors, persistent high expression of ULBP2 may reflect adaptive changes of tumor cells under immune editing pressure or function as a mechanism of immune tolerance ( 16 ). This finding provides new insights into the immune evasion mechanisms during the progression of stomach adenocarcinoma and suggests that ULBP2 may serve as a dynamic marker for monitoring disease progression. The Dual Role of Inflammatory Response and Its Therapeutic Implications Our study found that inflammation-related genes exhibit a distinct 'dual nature' in the prognosis of stomach adenocarcinoma. On one hand, TNF and IL17A ( 12 , 20 ), as typical pro-tumor inflammatory factors, indicate poor prognosis when highly expressed; on the other hand, IFNG and CXCL10 show a clear protective effect. This differentiation may be related to their specific functions in the tumor microenvironment: CXCL10 enhances anti-tumor immunity by recruiting cytotoxic T cells ( 21 ), whereas TNF primarily promotes tumor cell survival and proliferation through activation of the NF-κB pathway. This finding has important implications for precision immunotherapy, suggesting that future treatment strategies need to be tailored according to the patient's specific inflammatory factor expression profile. Research Limitations and Future Directions This study has some limitations. First, all analyses were based on retrospective data from public databases, and prospective studies are needed for further validation. Second, the results of bioinformatics analyses require experimental studies for functional verification, especially to confirm the specific mechanisms of these key genes in animal models. In addition, the heterogeneity of the tumor microenvironment may affect the relationship between gene expression and prognosis, and future research using techniques such as single-cell sequencing is needed for deeper investigation. Conclusion This study identified a core gene network integrating developmental regulation and immune response through a systems biology approach, revealing previously underappreciated molecular features in stomach adenocarcinoma. We found that ULBP2 serves as a dynamic biomarker of disease progression and clarified the dual role of inflammation-related genes in prognostic assessment. These findings not only deepen the understanding of STAD pathogenesis but also provide novel candidate biomarkers for prognosis prediction and potential targets for precision immunotherapy. Future studies should validate these genes functionally and explore their therapeutic applicability in preclinical models. Declarations Funding Statement This study did not receive any specific grant from funding agencies in the public, commercial, or non-profit sectors. Ethics and Consent to Participate Statement All data used in this study were derived from the public The Cancer Genome Atlas (TCGA) database. The original data collection was approved by the ethics committee of the TCGA program and obtained informed consent from all participants. As this study only involved secondary analysis of de-identified public data without direct contact with human subjects or access to identifiable personal information, additional ethical approval and informed consent were exempted in accordance with the "Measures for Ethical Review of Life Sciences and Medical Research Involving Humans". Consent to Publish Statement Not applicable. Declaration of Competing Interests All authors declare no competing financial or personal interests that could influence the objectivity of this research. The authors declare that they have no competing interests. The data used in this study are available from the following public databases with specific access details to ensure reproducibility: The Cancer Genome Atlas (TCGA) database (accession: TCGA-STAD; https://portal.gdc.cancer.gov/projects/TCGA-STAD) for RNA-seq data and clinical information. STRING database (version 11; https://string-db.org/cgi/network?taskId=wnbZ8Q4YI9Lz) for high-confidence protein-protein interaction data (confidence score > 0.9). Kaplan-Meier Plotter (https://kmplot.com/analysis/) for survival analysis of hub genes. UALCAN database (https://ualcan.path.uab.edu/) for stage-expression correlation analysis. Gene Ontology (GO) Consortium (http://geneontology.org/page/download-annotations) for functional enrichment analysis (accessed on 2025-01-10). Kyoto Encyclopedia of Genes and Genomes (KEGG;https://www.genome.jp/kegg/tool/map_pathway2.html) for pathway enrichment analysis (accessed on 2025-01-10). All relevant datasets and tools used for PPI network construction, survival analysis, stage-expression correlation, and functional enrichment are publicly accessible via the above direct links, complying with the best practices of data transparency and reproducibility. References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49. Joshi SS, Badgwell BD. Current treatment and recent progress in stomach cancer. CA Cancer J Clin. 2021;71:264–79. Tan P, Yeoh KG. Genetics and molecular pathogenesis of stomach adenocarcinoma. Gastroenterology. 2015;149:1153–62. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of stomach adenocarcinoma. Nature. 2014;513:202–9. Cristescu R, Lee J, Nebozhyn M, Kim KM, Ting JC, Wong SS, et al. Molecular analysis of stomach cancer identifies subtypes associated with distinct clinical outcomes. Nat Med. 2015;21:449–56. Barabási AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011;12:56–68. Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, et al. STRING v11: protein-protein association networks with increased coverage supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607–13. Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY. cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11. Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell. 2008;15:801–12. Hardwick JC, Kodach LL, Offerhaus GJ, van den Brink GR. Bone morphogenetic protein signalling in colorectal cancer. Nat Rev Cancer. 2008;8:806–12. Song Z, Yue W, Wei B, Wang N, Li T, Guan L, et al. Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human stomach cancer. PLoS ONE. 2011;6:e17687. Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009;9:361–71. Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, et al. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014;41:1052–63. Mukaida N, Sasaki SI, Baba T. CCL4 signaling in the tumor microenvironment. Adv Exp Med Biol. 2020;1231:23–32. Karin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;5:749–59. Raulet DH, Gasser S, Gowen BG, Deng W, Jung H. Regulation of ligands for the NKG2D activating receptor. Annu Rev Immunol. 2013;31:413–41. Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–504. Szklarczyk D, et al. The STRING database in 2021: customizable protein-protein networks and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 2021;49:D605–12. Nagy Á, Lánczky A, Menyhárt O, Győrffy B. Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2021;11:17737. Wang K, et al. The role of IL-17 in tumor development and progression. J Exp Clin Cancer Res. 2020;39:142. Liu M, Guo S, Stiles JK. The emerging role of CXCL10 in cancer. Oncol Lett. 2011;2:583–9. Additional Declarations No competing interests reported. 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Among its histological subtypes, stomach adenocarcinoma (STAD) constitutes the vast majority of cases. Despite advancements in diagnostic and therapeutic modalities, the prognosis for patients with advanced or metastatic STAD remains poor, with a 5-year survival rate below 30% (\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e). This outcome is largely attributed to high molecular heterogeneity, late diagnosis, and frequent therapy resistance (\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e). Thus, deciphering the molecular landscape of STAD pathogenesis is an urgent clinical need, essential for developing effective prognostic biomarkers and novel therapeutic strategies.\u003c/p\u003e \u003cp\u003eHigh-throughput sequencing and collaborative projects such as The Cancer Genome Atlas (TCGA) have profoundly enhanced our understanding of genomic and transcriptomic alterations in STAD (\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e). These studies not only catalog driver mutations but also highlight disease heterogeneity, leading to molecular classifications that stratify STAD into distinct subtypes with clinical implications (\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e). Concurrently, systems biology approaches have shifted the perspective from gene-centric to network-centric, revealing that cancer phenotypes often arise from dysfunction within interconnected modules of protein-protein interaction (PPI) networks (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e) Analyzing these networks enables identification of hub genes occupying critical topological positions, whose perturbation can disrupt cellular signaling and drive oncogenesis (\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eTwo pivotal biological processes frequently dysregulated in STAD are embryonic developmental signaling and immune-inflammatory responses. Developmental pathways such as Hedgehog (HH) and Bone Morphogenetic Protein (BMP) signaling, crucial for tissue patterning during embryogenesis, are often reactivated in cancer (\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e). For instance, the Hedgehog ligand SHH is implicated in cancer stem cell maintenance and tumor progression in gastrointestinal malignancies (\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e). Meanwhile, the inflammatory tumor microenvironment (TME), characterized by aberrant cytokine and chemokine production (e.g., TNF, IL-17, IFNG, CXCL10), plays dual roles in promoting or suppressing tumor growth (\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e, \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e). Chronic inflammation driven by TNF can foster a pro-tumorigenic niche, while chemokines like CXCL10 recruit cytotoxic T cells to mediate anti-tumor immunity (14.15). Additionally, stress-induced ligands such as ULBP2, which activate the NKG2D receptor on immune cells, bridge cellular damage and immune recognition within the TME (\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eAlthough developmental pathways and immune responses have been studied independently, the existence and clinical significance of a core regulatory network integrating these processes in STAD remain unclear. We hypothesize that such a network exists, with key hub genes orchestrating both developmental reprogramming and immune modulation, ultimately influencing tumor behavior and patient outcomes.\u003c/p\u003e \u003cp\u003eTo test this hypothesis, we employed an integrated bioinformatics approach. We analyzed the TCGA-STAD dataset to identify differentially expressed genes, constructed a PPI network to identify topologically central hubs, and refined a core gene set through high-confidence interaction filtering. Functional enrichment analysis confirmed co-enrichment of developmental and immune functions. We then validated the clinical relevance of key hub genes by assessing their prognostic value and expression dynamics across tumor stages. Our study reveals a core gene network crosstalking between developmental and immune landscapes in STAD, identifies novel prognostic biomarkers, and highlights ULBP2 as a key player in disease progression, offering fresh insights into the molecular mechanisms of stomach adenocarcinoma.\u003c/p\u003e"},{"header":"Materials and Methods","content":"\u003cp\u003eData Acquisition and Differential Expression Analysis：\u003c/p\u003e\n\u003cp\u003eRNA-seq data and clinical information for STAD were obtained from TCGA\u0026nbsp;(4). Differential expression analysis was performed using DESeq2 with thresholds of |log2FC| \u0026gt; 1 and FDR \u0026lt; 0.05.\u003c/p\u003e\n\u003cp\u003ePPI Network Construction and Hub Gene Identification：\u003c/p\u003e\n\u003cp\u003ePPI networks were built using Cytoscape\u0026nbsp;(17), and hub genes were selected based on betweenness centrality (BC \u0026gt; 200). High-confidence interactions were validated using STRING\u0026nbsp;(18)database (confidence score \u0026gt; 0.9).\u003c/p\u003e\n\u003cp\u003eFunctional Enrichment Analysis：\u003c/p\u003e\n\u003cp\u003eGO and KEGG pathway enrichment analyses were conducted using clusterProfiler. Terms with FDR \u0026lt; 0.05 were considered significant.\u003c/p\u003e\n\u003cp\u003eSurvival and Clinical Correlation Analysis：\u003c/p\u003e\n\u003cp\u003ePrognostic value was assessed using Kaplan-Meier Plotter (19). Stage-expression correlations were analyzed through UALCAN database.\u003c/p\u003e"},{"header":"Reasult","content":"\u003cp\u003eScreening of Differentially Expressed Genes and Construction of the Core Gene Network\u003c/p\u003e\n\u003cp\u003eThrough differential expression analysis of the TCGA-STAD dataset, we identified a total of 232 genes that were significantly differentially expressed in stomach adenocarcinoma tissues (|log2FC| \u0026gt; 2, FDR \u0026lt; 0.05). After constructing a protein-protein interaction (PPI) network with these genes, 130 topologically important hub genes were screened based on betweenness centrality (BC \u0026gt; 200). To further enhance the biological reliability of the results, we extracted high-confidence interaction relationships (confidence score \u0026gt; 0.9) from the STRING database and intersected them with the original gene set, ultimately obtaining a core gene set comprising 46 genes, which form a highly interconnected functional module.\u003c/p\u003e\n\u003cp\u003eFunctional enrichment analysis of core genes reveals an \u0026apos;immune-development\u0026apos; regulatory network\u003c/p\u003e\n\u003cp\u003eGO functional enrichment analysis showed that the 46 core genes were significantly enriched in multiple important biological processes (Figure 1A). At the biological process (BP) level, the genes were mainly involved in developmental regulation, including regionalization, pattern specification processes, embryonic organ development, and limb morphogenesis. At the molecular function (MF) level, the genes were significantly enriched in DNA-binding transcription activator activity, cytokine activity, cytokine receptor binding, and growth factor activity. Cellular component (CC) analysis indicated that the genes were primarily localized to secretory granule lumens, extracellular matrix, and other locations. KEGG pathway analysis further confirmed the functional characteristics of these genes (Figure 1B), showing that the core genes were significantly enriched in immune-inflammatory-related pathways such as cytokine-cytokine receptor interaction, IL-17 signaling pathway, and TNF signaling pathway, while also exhibiting significant enrichment in autoimmune disease pathways including rheumatoid arthritis and inflammatory bowel disease.\u003c/p\u003e\n\u003cp\u003ePrognostic Value Assessment of Key Hub Genes\u003c/p\u003e\n\u003cp\u003eFrom the 46 core genes, we selected eight hub genes located at key pathway nodes for an in-depth analysis of their clinical significance. Survival analysis results (Figure 2) showed that these genes exhibited markedly different prognostic values in stomach adenocarcinoma (Table 1). High expression of TNF (HR = 1.34, P = 0.00079), IL17A (HR = 1.59, P = 1.1e-06), and SHH (HR = 1.59, P = 7.9e-08) was significantly associated with shorter overall survival, representing independent risk factors for poor prognosis. In contrast, high expression of IFNG (HR = 0.80, P = 0.035), JUN (HR = 0.54, P = 2.3e-11), and CXCL10 (HR = 0.59, P = 3.1e-07) indicated longer survival, serving as protective factors.\u003c/p\u003e\n\u003cp\u003e\u003cimg width=\"538\" height=\"234\" 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\" alt=\"survival_analysis_01(2)\"\u003e\u003c/p\u003e\n\u003cp\u003eAnalysis of the Association Between Gene Expression and Tumor Progression\u003c/p\u003e\n\u003cp\u003eBy analyzing the relationship between gene expression and tumor clinical staging, we found that ULBP2 exhibits a distinct dynamic expression pattern. The expression level of ULBP2 in Stage IV is significantly higher than in Stage III (P = 0.00078), showing a gradually upregulated trend with tumor progression (Figure 3). Moreover, the expression levels of most core genes (TNF, IFNG, BMP2, JUN, CXCL10) are significantly higher in stomach cancer tissues compared to normal stomach tissues, but remain relatively stable across different tumor stages.\u003c/p\u003e\n\u003cp\u003eCorrelation analysis further revealed the relationship between CXCL10 and the tumor immune microenvironment. The expression of CXCL10 was significantly positively correlated with CD8A (R = 0.59, P \u0026lt; 0.001), suggesting that it may exert an antitumor effect by recruiting CD8 T cells (Figure 4).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis study systematically identified a core gene network linking developmental regulation and immune response in stomach adenocarcinoma through the integration of bioinformatics analysis methods. This finding provides a new perspective for understanding the molecular mechanisms of stomach adenocarcinoma and reveals intrinsic connections between previously overlooked biological processes.\u003c/p\u003e \u003cp\u003eSynergistic interaction of developmental and immune pathways\u003c/p\u003e \u003cp\u003eThe research results show that core genes are simultaneously enriched in pathways related to developmental regulation (such as regionalization and pattern specialization) and immune-inflammatory responses, which has significant biological implications. Hedgehog signaling pathway gene SHH and bone morphogenetic protein BMP2 (\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e), as important morphogens, play a key role in embryonic development, whereas their abnormal expression in stomach adenocarcinoma may drive tumor dedifferentiation and the maintenance of stem cell-like characteristics. Meanwhile, cytokines such as TNF and IL17A promote tumor progression by creating a pro-inflammatory microenvironment. This co-regulation of developmental and immune programs suggests that tumor cells may \"hijack\" the regulatory mechanisms of embryonic development to collaboratively promote malignant phenotypes.\u003c/p\u003e \u003cp\u003eULBP2: A bridge connecting tumor progression and immune surveillance\u003c/p\u003e \u003cp\u003eThe finding that ULBP2 expression is significantly upregulated with tumor stage progression has particular clinical significance. As a ligand of the NKG2D receptor, ULBP2 is usually upregulated under cellular stress, thereby activating NK cells and CD8 T cell-mediated antitumor immunity. However, in advanced tumors, persistent high expression of ULBP2 may reflect adaptive changes of tumor cells under immune editing pressure or function as a mechanism of immune tolerance (\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e). This finding provides new insights into the immune evasion mechanisms during the progression of stomach adenocarcinoma and suggests that ULBP2 may serve as a dynamic marker for monitoring disease progression.\u003c/p\u003e \u003cp\u003eThe Dual Role of Inflammatory Response and Its Therapeutic Implications\u003c/p\u003e \u003cp\u003eOur study found that inflammation-related genes exhibit a distinct 'dual nature' in the prognosis of stomach adenocarcinoma. On one hand, TNF and IL17A (\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e), as typical pro-tumor inflammatory factors, indicate poor prognosis when highly expressed; on the other hand, IFNG and CXCL10 show a clear protective effect. This differentiation may be related to their specific functions in the tumor microenvironment: CXCL10 enhances anti-tumor immunity by recruiting cytotoxic T cells (\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e), whereas TNF primarily promotes tumor cell survival and proliferation through activation of the NF-κB pathway. This finding has important implications for precision immunotherapy, suggesting that future treatment strategies need to be tailored according to the patient's specific inflammatory factor expression profile.\u003c/p\u003e \u003cp\u003eResearch Limitations and Future Directions\u003c/p\u003e \u003cp\u003eThis study has some limitations. First, all analyses were based on retrospective data from public databases, and prospective studies are needed for further validation. Second, the results of bioinformatics analyses require experimental studies for functional verification, especially to confirm the specific mechanisms of these key genes in animal models. In addition, the heterogeneity of the tumor microenvironment may affect the relationship between gene expression and prognosis, and future research using techniques such as single-cell sequencing is needed for deeper investigation.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis study identified a core gene network integrating developmental regulation and immune response through a systems biology approach, revealing previously underappreciated molecular features in stomach adenocarcinoma. We found that ULBP2 serves as a dynamic biomarker of disease progression and clarified the dual role of inflammation-related genes in prognostic assessment. These findings not only deepen the understanding of STAD pathogenesis but also provide novel candidate biomarkers for prognosis prediction and potential targets for precision immunotherapy. Future studies should validate these genes functionally and explore their therapeutic applicability in preclinical models.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eFunding Statement\u003c/p\u003e\n\u003cp\u003eThis study did not receive any specific grant from funding agencies in the public, commercial, or non-profit sectors.\u003c/p\u003e\n\u003cp\u003eEthics and Consent to Participate Statement\u003c/p\u003e\n\u003cp\u003eAll data used in this study were derived from the public The Cancer Genome Atlas (TCGA) database. The original data collection was approved by the ethics committee of the TCGA program and obtained informed consent from all participants. As this study only involved secondary analysis of de-identified public data without direct contact with human subjects or access to identifiable personal information, additional ethical approval and informed consent were exempted in accordance with the \u0026quot;Measures for Ethical Review of Life Sciences and Medical Research Involving Humans\u0026quot;.\u003c/p\u003e\n\u003cp\u003eConsent to Publish Statement\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003eDeclaration of Competing Interests\u003c/p\u003e\n\u003cp\u003eAll authors declare no competing financial or personal interests that could influence the objectivity of this research.\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests. The data used in this study are available from the following public databases with specific access details to ensure reproducibility:\u003c/p\u003e\n\u003col\u003e\n \u003cli\u003eThe Cancer Genome Atlas (TCGA) database (accession: TCGA-STAD; https://portal.gdc.cancer.gov/projects/TCGA-STAD) for RNA-seq data and clinical information.\u003c/li\u003e\n \u003cli\u003eSTRING database (version 11; https://string-db.org/cgi/network?taskId=wnbZ8Q4YI9Lz) for high-confidence protein-protein interaction data (confidence score \u0026gt; 0.9).\u003c/li\u003e\n \u003cli\u003eKaplan-Meier Plotter (https://kmplot.com/analysis/) for survival analysis of hub genes.\u003c/li\u003e\n \u003cli\u003eUALCAN database (https://ualcan.path.uab.edu/) for stage-expression correlation analysis.\u003c/li\u003e\n \u003cli\u003eGene Ontology (GO) Consortium (http://geneontology.org/page/download-annotations) for functional enrichment analysis (accessed on 2025-01-10).\u003c/li\u003e\n \u003cli\u003eKyoto Encyclopedia of Genes and Genomes (KEGG;https://www.genome.jp/kegg/tool/map_pathway2.html) for pathway enrichment analysis (accessed on 2025-01-10).\u003c/li\u003e\n\u003c/ol\u003e\n\u003cp\u003eAll relevant datasets and tools used for PPI network construction, survival analysis, stage-expression correlation, and functional enrichment are publicly accessible via the above direct links, complying with the best practices of data transparency and reproducibility.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eSung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u0026ndash;49.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eJoshi SS, Badgwell BD. Current treatment and recent progress in stomach cancer. CA Cancer J Clin. 2021;71:264\u0026ndash;79.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTan P, Yeoh KG. Genetics and molecular pathogenesis of stomach adenocarcinoma. Gastroenterology. 2015;149:1153\u0026ndash;62.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCancer Genome Atlas Research Network. Comprehensive molecular characterization of stomach adenocarcinoma. Nature. 2014;513:202\u0026ndash;9.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCristescu R, Lee J, Nebozhyn M, Kim KM, Ting JC, Wong SS, et al. Molecular analysis of stomach cancer identifies subtypes associated with distinct clinical outcomes. Nat Med. 2015;21:449\u0026ndash;56.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBarab\u0026aacute;si AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011;12:56\u0026ndash;68.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSzklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, et al. STRING v11: protein-protein association networks with increased coverage supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607\u0026ndash;13.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eChin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY. cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eJiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell. 2008;15:801\u0026ndash;12.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHardwick JC, Kodach LL, Offerhaus GJ, van den Brink GR. Bone morphogenetic protein signalling in colorectal cancer. Nat Rev Cancer. 2008;8:806\u0026ndash;12.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSong Z, Yue W, Wei B, Wang N, Li T, Guan L, et al. Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human stomach cancer. PLoS ONE. 2011;6:e17687.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBalkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009;9:361\u0026ndash;71.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, et al. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014;41:1052\u0026ndash;63.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMukaida N, Sasaki SI, Baba T. CCL4 signaling in the tumor microenvironment. Adv Exp Med Biol. 2020;1231:23\u0026ndash;32.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKarin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;5:749\u0026ndash;59.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eRaulet DH, Gasser S, Gowen BG, Deng W, Jung H. Regulation of ligands for the NKG2D activating receptor. Annu Rev Immunol. 2013;31:413\u0026ndash;41.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eShannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498\u0026ndash;504.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSzklarczyk D, et al. The STRING database in 2021: customizable protein-protein networks and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 2021;49:D605\u0026ndash;12.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNagy \u0026Aacute;, L\u0026aacute;nczky A, Menyh\u0026aacute;rt O, Győrffy B. Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2021;11:17737.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWang K, et al. The role of IL-17 in tumor development and progression. J Exp Clin Cancer Res. 2020;39:142.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLiu M, Guo S, Stiles JK. The emerging role of CXCL10 in cancer. Oncol Lett. 2011;2:583\u0026ndash;9.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Stomach adenocarcinoma, Core gene network, Developmental signaling, Immune response, Integrated bioinformatics","lastPublishedDoi":"10.21203/rs.3.rs-8578237/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8578237/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eObjective\u003c/h2\u003e \u003cp\u003eThis study aims to identify and characterize the core gene network that molecularly integrates developmental signaling pathways with immune responses in stomach adenocarcinoma (STAD), and to evaluate the clinical relevance of the key hub genes within this network as potential prognostic biomarkers and therapeutic targets.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eWe analyzed the TCGA-STAD dataset to identify differentially expressed genes. Protein-protein interaction (PPI) networks were constructed using Cytoscape, and hub genes were screened based on betweenness centrality. High-confidence interactions were extracted from the STRING database. Functional enrichment analysis was performed using GO and KEGG. Clinical relevance was validated through survival analysis and stage-expression correlation.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eFrom 230 differentially expressed genes, we identified 46 core genes through multi-step screening. Functional enrichment revealed their significant involvement in developmental processes and immune-inflammatory responses. Eight key hub genes (TNF, IL17A, IFNG, SHH, BMP2, ULBP2, JUN, CXCL10) demonstrated significant prognostic value. High expression of TNF, IL17A, and SHH was associated with poor prognosis, whereas IFNG, JUN, and CXCL10 predicted favorable outcomes. ULBP2 exhibited progressive upregulation with advancing tumor stage, suggesting its role in disease progression.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eWe identified a core gene network that functionally integrates developmental programming with immune regulation in STAD. This network provides a framework for understanding disease heterogeneity and offers potential biomarkers for prognosis prediction and therapeutic targeting.\u003c/p\u003e","manuscriptTitle":"A core gene network linking developmental signaling and immune response in stomach adenocarcinoma revealed by integrated bioinformatics","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-02-17 11:47:41","doi":"10.21203/rs.3.rs-8578237/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f7975e8e-25b7-49fc-a9d1-c55498114c9a","owner":[],"postedDate":"February 17th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-03-04T11:41:34+00:00","versionOfRecord":[],"versionCreatedAt":"2026-02-17 11:47:41","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8578237","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8578237","identity":"rs-8578237","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}