Risk Factors and Causes of Mortality Among Anesthesiologists: Evidence from a Libyan multicenter observational case-control study

Risk Factors and Causes of Mortality Among Anesthesiologists: Evidence from a Libyan multicenter observational case-control study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Risk Factors and Causes of Mortality Among Anesthesiologists: Evidence from a Libyan multicenter observational case-control study BOSHRA HAGI ABUSAHMIN, MOHAMED Hadi Mohamed ABDELHAMID, ZAKARIA LAKHDARI ELBOUKHARI, and 7 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8372781/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Anesthesiologists are exposed to elevated occupational risks due to prolonged work hours and multifactorial stressors. This study identifies the risk factors of sudden death among resident anesthesiologists in Libya. A multicenter observational case-control study was conducted over seven months (September–December 2022), involving 88 anesthesiologists from nine public hospitals. Participants were chosen using a case-control method, with one death for every 11 anesthesiologists in the same locality. Data collection included a structured electronic questionnaire, WHO-standardized physical measurements, blood sampling, and cardiovascular assessments. Statistical analysis was performed using Power BI, applying Odds ratio χ², t-test, ANOVA, and regression models (p 0.001), with a mean age of 39 (SD = 8.7) years, and married (67.05%; χ² = 14.98, P < 0.001). BMI analysis revealed a high prevalence of overweight (36.36%) and obesity (35.23%). Employment duration and smoking history also demonstrated significant variability (χ² = 34.97 and 39.23, respectively; P < 0.001). Psychosocial stressors were prevalent, with economic hardship (31.82%), family conflict (12.5%), and perceived isolation (15.91%) showing statistically significant disparities (P 0.05). Biomedical findings showed sex-based differences: males had elevated triglycerides (165.0 ± 118.2 mg/dL; p = 0.042), while females had higher HDL (56.5 ± 9.5 mg/dL; p < 0.001) and D-dimer levels (0.3 ± 0.1 µg/mL; p < 0.001). ECG and echocardiography were largely normal, though 26 physicians (29.5%) exhibited unexplained cardiac anomalies. Among these, 73.1% had both SARS-COV-2 infection and vaccination, with the highest anomaly rate among recipients of mixed vaccine doses (34.6%). These findings underscore the need for targeted occupational health strategies, routine cardiovascular screening, and further investigation into post-COVID-19 cardiac effects among frontline medical personnel. Health sciences/Cardiology Health sciences/Diseases Health sciences/Health care Health sciences/Medical research Health sciences/Risk factors Anesthesiologists Burnout Sudden death Risk factors Libya Figures Figure 3 Full Text Additional Declarations No competing interests reported. Supplementary Files Data.xlsx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8372781","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":564147074,"identity":"3c13ff45-f0ee-4287-a72b-a94a6b787695","order_by":0,"name":"BOSHRA HAGI ABUSAHMIN","email":"","orcid":"","institution":"National Center for Disease Control (NCDC)","correspondingAuthor":false,"prefix":"","firstName":"BOSHRA","middleName":"HAGI","lastName":"ABUSAHMIN","suffix":""},{"id":564147076,"identity":"ee26eeb4-f01c-4855-9a05-8e14eafa09ba","order_by":1,"name":"MOHAMED Hadi Mohamed 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study","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Anesthesiologists, Burnout, Sudden death, Risk factors, Libya","lastPublishedDoi":"10.21203/rs.3.rs-8372781/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8372781/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAnesthesiologists are exposed to elevated occupational risks due to prolonged work hours and multifactorial stressors. This study identifies the risk factors of sudden death among resident anesthesiologists in Libya. A multicenter observational case-control study was conducted over seven months (September\u0026ndash;December 2022), involving 88 anesthesiologists from nine public hospitals. Participants were chosen using a case-control method, with one death for every 11 anesthesiologists in the same locality. Data collection included a structured electronic questionnaire, WHO-standardized physical measurements, blood sampling, and cardiovascular assessments. Statistical analysis was performed using Power BI, applying Odds ratio χ\u0026sup2;, t-test, ANOVA, and regression models (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05 and 0.001). Demographically, the cohort was balanced by sex (52.27% male, 47.73% female; χ\u0026sup2; = 0.15, P\u0026thinsp;\u0026gt;\u0026thinsp;0.001), with a mean age of 39 (SD\u0026thinsp;=\u0026thinsp;8.7) years, and married (67.05%; χ\u0026sup2; = 14.98, P\u0026thinsp;\u0026lt;\u0026thinsp;0.001). BMI analysis revealed a high prevalence of overweight (36.36%) and obesity (35.23%). Employment duration and smoking history also demonstrated significant variability (χ\u0026sup2; = 34.97 and 39.23, respectively; P\u0026thinsp;\u0026lt;\u0026thinsp;0.001). Psychosocial stressors were prevalent, with economic hardship (31.82%), family conflict (12.5%), and perceived isolation (15.91%) showing statistically significant disparities (P\u0026thinsp;\u0026lt;\u0026thinsp;0.001). Clinically, chest pain (28.41%), hypertension (17.05%), and a strong familial disease burden (96.59%) were prominent, while fatigue lacked statistical significance (P\u0026thinsp;\u0026gt;\u0026thinsp;0.05). Biomedical findings showed sex-based differences: males had elevated triglycerides (165.0\u0026thinsp;\u0026plusmn;\u0026thinsp;118.2 mg/dL; p\u0026thinsp;=\u0026thinsp;0.042), while females had higher HDL (56.5\u0026thinsp;\u0026plusmn;\u0026thinsp;9.5 mg/dL; p\u0026thinsp;\u0026lt;\u0026thinsp;0.001) and D-dimer levels (0.3\u0026thinsp;\u0026plusmn;\u0026thinsp;0.1 \u0026micro;g/mL; p\u0026thinsp;\u0026lt;\u0026thinsp;0.001). ECG and echocardiography were largely normal, though 26 physicians (29.5%) exhibited unexplained cardiac anomalies. Among these, 73.1% had both SARS-COV-2 infection and vaccination, with the highest anomaly rate among recipients of mixed vaccine doses (34.6%).\u003c/p\u003e \u003cp\u003eThese findings underscore the need for targeted occupational health strategies, routine cardiovascular screening, and further investigation into post-COVID-19 cardiac effects among frontline medical personnel.\u003c/p\u003e","manuscriptTitle":"Risk Factors and Causes of Mortality Among Anesthesiologists: Evidence from a Libyan multicenter observational case-control study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-12-30 00:27:07","doi":"10.21203/rs.3.rs-8372781/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ec5ce067-1993-43f5-b4ad-001e91cf9f56","owner":[],"postedDate":"December 30th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":60069965,"name":"Health sciences/Cardiology"},{"id":60069966,"name":"Health sciences/Diseases"},{"id":60069967,"name":"Health sciences/Health care"},{"id":60069968,"name":"Health sciences/Medical research"},{"id":60069969,"name":"Health sciences/Risk factors"}],"tags":[],"updatedAt":"2025-12-30T00:27:08+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-30 00:27:07","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8372781","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8372781","identity":"rs-8372781","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}