VITALS: An Implantable Sensor Network for Postoperative Cardiac Monitoring in Heart Failure Patients

VITALS: An Implantable Sensor Network for Postoperative Cardiac Monitoring in Heart Failure Patients | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article VITALS: An Implantable Sensor Network for Postoperative Cardiac Monitoring in Heart Failure Patients Ali Kight, Moussa Haidar, Masafumi Shibata, Yoshikazu Ono, Gentaro Ikeda, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5278391/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 9 You are reading this latest preprint version Abstract Heart Failure (HF) is a global epidemic, with high readmission rates and significant morbidity persisting due to gaps in post-acute care. Traditional follow-up assessments often miss gradual postoperative cardiac deterioration occurring outside hospital settings. Advances in remote patient monitoring (RPM) show promise, but continuous, sensitive, and practical methods are lacking. Building on previous work introducing a durable, soft strain sensor, this research presents VITALS, an implantable strain sensing network that enables continuous biventricular, multiaxial monitoring of cardiac function. The sensor’s novel design affords a longer fatigue life than previously possible for soft, large-deformation strain sensors, while effectively minimizing shear loading effects to enhance accuracy. Additionally, the system integrates a sensor on the aorta for synchronous systolic pressure monitoring. Animal studies demonstrate VITALS’ ability to track epicardial strain with high fidelity, detect preload changes rapidly, and differentiate inotropic states. Validation against echocardiographic chamber volumes and global longitudinal strain underscores the sensor’s clinical relevance, offering a practical solution for continuous, accurate cardiac monitoring to improve patient outcomes. Health sciences/Cardiology/Cardiac device therapy Health sciences/Cardiology/Interventional cardiology Health sciences/Medical research/Translational research Full Text Additional Declarations Competing interest reported. A patent application has been filed through Stanford University’s Office of Licensing and Technology, application number 63/443421 filed 2/5/2023 and current pending status, with the United States Patent and Trademark Office. AK, MC, DM, SD, and AM are named inventors. The authors report no other competing interests. Supplementary Files VITALSSupplementaryInformationNPJ.pdf suppmovie.mov Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 03 Dec, 2024 Reviews received at journal 02 Dec, 2024 Reviews received at journal 18 Nov, 2024 Reviewers agreed at journal 28 Oct, 2024 Reviewers agreed at journal 28 Oct, 2024 Reviewers invited by journal 24 Oct, 2024 Editor assigned by journal 22 Oct, 2024 Submission checks completed at journal 22 Oct, 2024 First submitted to journal 16 Oct, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5278391","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":373452611,"identity":"ad3af875-e573-4ed9-80c5-8fb8e02e9af8","order_by":0,"name":"Ali 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Traditional follow-up assessments often miss gradual postoperative cardiac deterioration occurring outside hospital settings. Advances in remote patient monitoring (RPM) show promise, but continuous, sensitive, and practical methods are lacking. Building on previous work introducing a durable, soft strain sensor, this research presents VITALS, an implantable strain sensing network that enables continuous biventricular, multiaxial monitoring of cardiac function. The sensor’s novel design affords a longer fatigue life than previously possible for soft, large-deformation strain sensors, while effectively minimizing shear loading effects to enhance accuracy. Additionally, the system integrates a sensor on the aorta for synchronous systolic pressure monitoring. Animal studies demonstrate VITALS’ ability to track epicardial strain with high fidelity, detect preload changes rapidly, and differentiate inotropic states. 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