COMPARATIVE NEUROPLASTICITY IN FRONTAL- AND LATERAL-EYED MAMMALS WITH INDUCED-BINOCULAR VISION DYSFUNCTION: INSIGHTS FROM MONOCULAR DEPRIVATION MODELS

COMPARATIVE NEUROPLASTICITY IN FRONTAL- AND LATERAL-EYED MAMMALS WITH INDUCED-BINOCULAR VISION DYSFUNCTION: INSIGHTS FROM MONOCULAR DEPRIVATION MODELS | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL European Journal of Neuroscience This is a preprint and has not been peer reviewed. Data may be preliminary. 27 January 2025 V1 Latest version Share on COMPARATIVE NEUROPLASTICITY IN FRONTAL- AND LATERAL-EYED MAMMALS WITH INDUCED-BINOCULAR VISION DYSFUNCTION: INSIGHTS FROM MONOCULAR DEPRIVATION MODELS Authors : Fabio Amaral Junior 0000-0003-2755-2801 , Thalyta Rodrigues , Nonata Lúcia Silva , Izabela Negrão Diniz , Luciana Morais , Daniel Diniz 0000-0001-7369-2165 , Dora Brites , Daniel Anthony , and Cristovam Picanço Diniz 0000-0001-6611-6880 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173795605.56905468/v1 269 views 125 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Visual cortical plasticity during early postnatal life is profoundly shaped by species-specific ocular anatomy and ecological demands. This review synthesizes comparative evidence on how monocular deprivation (MD) —a classical model of amblyopia — affects visual system development in frontal- vs. lateral-eyed mammals. Frontal-eyed species, including cats and primates, exhibit extensive binocular field overlaps and columnar architecture in the primary visual cortex (V1), making them highly susceptible to MD-induced shifts in ocular dominance and synaptic remodeling. In contrast, lateral-eyed species such as rodents and ungulates possess limited binocular overlaps and lack well-defined ocular dominance columns yet still demonstrate significant MD-induced plasticity involving callosal reorganization, glial activation, and extracellular matrix remodeling. We examine shared and divergent cellular mechanisms underpinning these responses, including the role of parvalbumin-expressing interneurons, perineuronal nets, and neuromodulators like BDNF and NRG1. Rodent models support the notion that even in the absence of classical columnar organization, lateral-eyed species can undergo region-specific structural remodeling in V1 following MD. These distinctions underscore how binocular integration circuits are fine-tuned through extended critical periods in frontal-eyed species, whereas plasticity in lateral-eyed species is more diffusely distributed. The integration of cross-species data revealed conserved principles of visual cortical plasticity and identified mechanisms potentially targetable for amblyopia therapy. Understanding the ecological and anatomical context of plasticity allows for a more accurate interpretation of animal models and supports the development of precision strategies for visual rehabilitation. This comparative framework expands the scope of amblyopia research and offers new avenues for translational interventions. Supplementary Material File (manuscript.docx) Download 174.49 KB Information & Authors Information Version history V1 Version 1 27 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection European Journal of Neuroscience Keywords amblyopia extracellular matrix glial cells monocular deprivation visual cortex Authors Affiliations Fabio Amaral Junior 0000-0003-2755-2801 Universidade Federal do Pará View all articles by this author Thalyta Rodrigues Universidade Federal do Pará View all articles by this author Nonata Lúcia Silva Universidade Federal do Pará View all articles by this author Izabela Negrão Diniz Universidade Federal do Pará View all articles by this author Luciana Morais Universidade Federal do Pará View all articles by this author Daniel Diniz 0000-0001-7369-2165 Universidade Federal do Pará View all articles by this author Dora Brites Universidade de Lisboa View all articles by this author Daniel Anthony University of Oxford View all articles by this author Cristovam Picanço Diniz 0000-0001-6611-6880 [email protected] Universidade Federal do Pará View all articles by this author Metrics & Citations Metrics Article Usage 269 views 125 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Fabio Amaral Junior, Thalyta Rodrigues, Nonata Lúcia Silva, et al. COMPARATIVE NEUROPLASTICITY IN FRONTAL- AND LATERAL-EYED MAMMALS WITH INDUCED-BINOCULAR VISION DYSFUNCTION: INSIGHTS FROM MONOCULAR DEPRIVATION MODELS. Authorea . 27 January 2025. DOI: https://doi.org/10.22541/au.173795605.56905468/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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