Myocardial deformation in patients with a single left ventricle using 2D cardiovascular magnetic resonance feature tracking: a case-control study

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As studies exclusively examining patients with a single left ventricle (SLV) are sparse, we assessed left ventricular (LV) function in SLV patients by using 2D-cardiovascular magnetic resonance (CMR) feature tracking (2D-CMR-FT) and 2D-speckle tracking echocardiography (2D-STE). Methods 54 SLV patients (11.4, 3.1–38.1 years) and 35 age-matched controls (12.3, 6.3–25.8 years) were included. LV global longitudinal, circumferential and radial strain (GLS, GCS, GRS) and strain rate (GLSR, GCSR, GRSR) were measured using 2D-CMR-FT. LV volumes, ejection fraction (LVEF) and mass were determined from short axis images. 2D-STE was applied in patients to measure peak systolic GLS and GLSR. In a subgroup analysis, we compared double inlet left ventricle (DILV) with tricuspid atresia (TA) patients. Results The population consisted of 19 DILV patients, 24 TA patients and 11 patients with diverse diagnoses. 52 patients were in NYHA class I and 2 patients were in class II. Median LVEF in patients was lower compared to controls (55.6% vs. 61.2%, p = 0.0001). 2D-CMR-FT demonstrated reduced GLS, GCS and GCSR values in patients compared to controls. LVEF correlated with GS values in patients (p < 0.05). There was no significant difference between GLS values from 2D-CMR-FT and 2D-STE in the patient group. LVEF, LV volumes, GS and GSR were not significantly different between DILV and TA patients. Conclusion Although most SLV patients had a preserved EF, our results suggest that, LV deformation and function may behave differently in SLV patients compared to healthy subjects. Cardiac & Cardiovascular Systems Cardiothoracic Surgery Neurology Single ventricle cardiovascular magnetic resonance feature tracking speckle tracking echocardiography Figures Figure 1 Figure 2 Figure 3 Introduction Since the introduction of the Fontan operation, life expectancy of single ventricle (SV) patients steadily improved, and an increasing number of SV patients is reaching adolescence and adulthood. 1 – 3 Despite this success, we must remind ourselves that the Fontan procedure is a palliative approach and that SV patients with Fontan circulation are at risk for various complications. 4 , 5 A well-known complication is systolic and diastolic ventricular dysfunction which impacts morbidity and mortality. 6 , 7 Abnormal hemodynamics due to unfavorable volume and/ or pressure load of the SV, as well as the stepwise surgical procedures, might be a cause for SV dysfunction and heart failure. 8 More recently associations between myocardial fibrosis and adverse SV function have been demonstrated. 9 , 10 Echocardiography and cardiovascular magnetic resonance (CMR) are the standard imaging modalities to evaluate SV function in patients with a Fontan circulation. 11 , 12 Beside traditional techniques, tissue tracking methods such as 2-dimensional (2D) CMR feature tracking (2D-CMR-FT) and 2D speckle tracking echocardiography (2D-STE) have gained popularity to assess global and regional myocardial deformation of the SV. 13 – 15 However, most studies have assessed a mixed cohort of single left (SLV) and single right ventricle (SRV) patients but only few assessed a uniform population of only SLV patients using 2D-STE. 16 , 17 A comparison to healthy controls was only performed in a small cohort in 2 studies. 16 – 18 For the present study, we hypothesized that ventricular function and myocardial deformation in patients with a SLV are impaired compared to healthy controls. We used 2D-CMR-FT and 2D-STE and analyzed myocardial deformation and ventricular function in a relatively large cohort of SLV patients and healthy controls. In addition, patients with tricuspid atresia (TA) were compared to those with a double inlet left ventricle (DILV) and 2D-CMR-FT results were compared to those from 2D-STE. Material And Methods Patient Population This retrospective study was approved by the ethics committee of the medical faculty of the Christian-Albrechts University Kiel (No. D555/19) and included all 54 SLV patients after Fontan completion, who received a CMR examination as part of a routine clinical follow up during 2010 to 2019. 35 age-matched healthy controls were included for comparison. For patients who received several CMR examinations during that period, only the most recent dataset was included in our study. The comparison between 2D-CMR-FT and 2D-STE was conducted in datasets in which an echocardiography was performed within 3 months of the CMR examination. To guarantee comparability, echocardiographic studies in patients who underwent cardiovascular surgery or catheter interventions between echocardiography and CMR were excluded. Age at examination and total cavopulmonary connection (TCPC) as well as gender, weight, height, body surface area (BSA), New York Heart Association (NYHA) functional class, transcutaneous oxygen saturation (SpO 2 ) and number of surgical procedures was collected from medical records. Heart rate (HR), cardiac axis and QRS duration was assessed from 12-lead electrocardiograms (ECG). CMR acquisition and analysis CMR examinations were performed using a 3T MRI system (Achieva TX-Series, Philips Healthcare, Best, Netherlands). In 4 older patients a 1.5T MRI system (Achieva, Philips Healthcare, Best, Netherlands) was used. Patients were sedated using midazolam and propofol according to our clinical protocol, if necessary. Blood Pressure, HR and SpO2 levels were monitored during examination. Short-axis, four-chamber and axial cine images were acquired using steady-state free precession or gradient echo pulse sequences. Field of view and slice thickness varied according to patient size (250–400 x 250–400 mm², 5–8 mm). Volumetric analysis was performed using QMass (Version 8.1, Medis Medical Imaging Systems, BV, Leiden, Netherlands). Left ventricular (LV) end-diastolic and end-systolic volumes (LVEDV, LVESV) were measured from the short-axis images by manual drawing of endocardial and epicardial border at end-diastole and endocardial borders at end-systole (Fig. 1 ). Papillary muscles and large trabeculations were excluded from the ventricular mass and included into the ventricular volumes. The right ventricular volume was excluded as well. Left ventricular ejection fraction (LVEF), stroke volume and end-diastolic myocardial mass (LVMM) were automatically calculated by the software. Volumes and mass were indexed to BSA. 2D-CMR-FT analysis was undertaken using the dedicated software QStrain Research Edition (Version 2.0, Medis Medical Imaging Systems, BV, Leiden, Netherlands). Global longitudinal strain (GLS) and strain rate (GLSR) were measured in the four-chamber view (Fig. 1 ). If the examinations lacked a four-chamber-view, we used comparable axial cine images instead (n = 16). Global and regional circumferential strain (CS) and strain rate (CSR) as well as radial strain (RS) and strain rate (RSR) were analyzed from short axis images. Endocardial and epicardial contours were drawn manually at end-systole, which was defined as the cardiac phase with the smallest LV cavity area. Contours were then tracked automatically by the software during the cardiac cycle. Visual inspection of the epi- and endocardial contours during the cardiac cycle was conducted to evaluate tracking quality and suggested end-diastolic contours were manually adjusted if necessary. In the four-chamber views, the LV was automatically divided into 7 myocardial segments by the software and peak longitudinal strain and strain rate for each segment was obtained. In the short axis, the LV was divided into 3 different levels (basal, mid-ventricular and apical) and 16 segments according to the American Heart association 16-segment-model (Fig. 1 ). 19 Peak circumferential and radial strain and strain rate values were acquired for each segment. Global strain (GS) and global strain rate (GSR) values as well as strain and strain rate values for the three ventricular levels were calculated by averaging the peak values of each segment. 2D-STE analysis Transthoracic echocardiography was performed using a Vivid 7 GE Dimension-System (General Electric Healthcare, Wisconsin, USA). All studies were stored digitally and were therefore available for offline analysis. The data analysis was performed using dedicated STE software (EchoPac, version 113, General Electric Healthcare, Wisconsin, USA) as previously described by our group. 15 Statistics Statistical analysis was performed by using a dedicated software (MedCalc statistical software, version 19.5.1, software, Mariakerke, Belgium). Continuous variables were expressed either as mean ± standard deviation if they were normally distributed, or otherwise as median with range. Normal distribution of the data was assessed using the Shapiro Wilk test. Differences between patients and controls as well as between patient subgroups were analysed using the Mann-Whitney-U test. Comparison between extracted mean values using 2D-CMR-FT and 2D-STE was performed using the paired samples t-test. Adjustments for multiple testing were performed and the significant p-value was reduced to 0.003. Bland-Altman plots were constructed to assess the agreement between 2D-CMR-FT and 2D-STE. Associations between variables were evaluated by the Spearman’s rank method and p values of < 0.05 were considered to indicate statistical significance. Results Characteristics of patients and controls are presented in Table 1. The patient population consisted of 24 patients with TA, 19 patients with DILV and 11 patients with diverse SLV anatomies. All patients were examined after TCPC. Median age of the entire patient group was 11.4 years (range 3.1-38.1 years). All except two patients were in NYHA class I. Global and regional myocardial deformation and function GLS, GLSR and LV volume were determined using a 2D-CMR-FT analysis in all 54 patients. Global and regional CS, CSR, RS and RSR values were acquired in 53 patients in the short axis view. In one patient with DILV the short axis stack did not cover the entire LV. Global systolic function was preserved in 52% (n= 28) of SLVpatients with an LVEF of ≥ 55%. However, compared to the healthy controls LVEF was reduced (Table 2). Median indexed left ventricular end-systolic volume (LVESVi) was significantly higher in patients compared to controls whereas indexed left ventricular end-diastolic volume (LVEDVi) and indexed left ventricular myocardial mass (LVMMi) were not significantly different. There was no difference between TA and DILV patients regarding indexed LV volumes, LVEF and LVMMi (Table 2). Median GS and GSR values from CMR-FT are shown in Table 3. Compared to healthy controls, patients had significantly reduced values for GLS and global circumferential strain (GCS) and global circumferential strain rate (GCSR). There was no difference for GLSR and global radial strain rate (GRSR) as well as for global radial strain (GRS) between patients and controls. GLS, GCS and GRS correlated with LVEF in the entire patient group (Figure 2). When comparing TA and DILV patients there was no statistically significant difference for GLS, GLSR, GCS, GCSR, GRS and GRSR measurements between both groups. Out of the 54 patients, 44 underwent echocardiography within 3 months of the CMR study. 7 patients were excluded from the analysis due to poor image quality or inability to visualize the entire LV. Comparison between 2D-CMR-FT and 2D-STE are illustrated in Table 4. Mean GLSR by CMR-FT was higher than by STE (-1.2 ± 0.4 1/s vs. -0.9 ± 0.2 1/s, p <0.001). No difference was found for GLS and longitudinal strain at basal, mid and apical level. Bland-Altman-Plots are demonstrated in Figure 3 and show that the agreement for the GLS measurements using 2D-CMR-FT and 2D-STE was acceptable. Discussion One of strengths of the present study is that a relatively large cohort of SLV patients (n= 54) were included, and that they were compared to healthy controls. Although median LVEF, GLS and GCS were reduced compared to controls, most patients had a normal NYHA functional class. Myocardial deformation and function in SLV patients compared to controls Strain analyses using 2D-CMR-FT and 2D-STE in SV patients have been performed by other groups, but most studies included small and mixed patient cohorts (17, 20). 17,20 The present study, however, included a relatively large cohort of SLV patients (n=54) and found significantly reduced values for GLS, GCS and GCSR compared to healthy controls. Hu et al. observed significantly reduced GCS and GRS values in Fontan patients compared to controls. 21 Different to our study, they only included patients with a preserved LVEF (>55%) (21) and concluded that global and regional circumferential strains could be used for early detection of abnormal myocardial function. That strain values might be impaired before the ejection fraction (EF) is compromised has been demonstrated also in various other patient groups 22,23 and it has been shown that a preserved EF might be explained mathematically through geometric factors. 24 More than 50% of our SLV patients had a preserved LVEF but compared to controls LVEF in patients was significantly reduced. Similar findings have been reported by Singh et al. in a small (n= 16) SLV patient cohort. 18 They found a lower LVEF and larger volumetric indices in pediatric TA patients compared to healthy subjects. 18 Other groups found a reduced LVEF, however they also included patients with a with SRV. 14 A reduction in LVEF in SLV patients compared to controls might be explained by different hemodynamics in some patients and by a heterogeneity in myocardial function in SLV patients. 18,20 Moreover, an abnormal myoarchitecture as reported in TA patients has to be considered. 25 We were able to show that LVEF from CMR data in SLV patients correlates with GCS, GLS and GRS. Other groups have shown similar relationships between EF and strain values. 24,26 Nevertheless, correlations between myocardial deformation parameters and EF are a matter of debate. Lipiec et al. suggested a non-linear hemi-ellipsoid model to explain the association between systolic GLS and LVEF. 27 More recently a mathematical model has been introduced describing the relationship between LVEF, GCS and GLS. 28 In this model a reduction in LVEF would correspond to reduced GCS and GLS values. 28 Comparison between TA and DILV patients To our knowledge, no study has compared LV myocardial deformation and function in TA and DILV patients using CMR imaging. Our findings do not suggest any major difference in myocardial deformation, function and size between these two entities. An impaired left ventricular function in patients with TA compared to DILV was found in a cardiac catheterization study by Redington et al.. Unfortunately, these results are not comparable with our data from a technical point of view (different imaging modalities). 29 Comparison between CMR-FT and 2D-STE In our study we found clinically acceptable agreement between 2D-CMR-FT and 2D-STE, however, only 37 echocardiographic examinations could be analyzed. Schmidt et al. analyzed a mixed cohort of adult Fontan patients including both SLV and SRV patients. They highlighted the fact that 2D-CMR-FT allows analyzing all myocardial segments whereas STE is commonly limited by the acoustic windows. 14 Similarly, in our study we had to exclude seven echocardiographic studies because of poor image quality but all CMR examinations were suitable for strain analyses. A study from Ghelani et al. assessed the reproducibility of strain measurements in Fontan patients using 2D-CMR-FT and 2D-STE. Their results suggested that deformation analyses from different modalities should not be mixed. 13 Different to them we did not perform intra-modality reproducibility analyses and we are therefore unable to draw a similar conclusion. However, since 2D-CMR-FT was possible in all SLV patients compared to 2D-STE and that it has become more easily available for routine CMR analyses, we believe that 2D-CMR-FT is a good alternative to 2D-STE. Furthermore, CMR reference values for LV strain values in children and adults exist and can be used for comparison. 30,31 Study limitations The retrospective design of the study implies some limitations. First, in some patients certain CMR data sets were missing and were therefore not available for analysis. In addition, GLS was only measured from the 4-chamber view or axial cine images and this might have impacted our strain results. Future studies are needed to evaluate the fate of the LV in SLV patients during follow up. The number of healthy controls was smaller, but since both groups were age-matched this could not influence the study findings. Finally, we did not perform an intermodality reproducibility analysis for CMR-FT and 2D-STE. Conclusions Most SLV patients had a normal NYHA functional class and 52% of patients had a preserved LVEF (≥ 55%). However, compared to controls, LVEF, GLS, GCS and GCSR were reduced. Our results suggest that LV deformation and function in SLV patients may behave differently compared to a normal LV in healthy subjects. Follow up studies evaluating the fate of the LV in SLV patients are needed. 2D-CMR-FT might be a suitable modality in this setting. Declarations Funding: none Conflicts of interest/Competing interests: The authors declare that they have no conflict of interest. Availability of data and material: All data and materials support the published claims and comply with field standards. Code availability: N/A Ethics approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (ethics committee of the medical faculty of the Christian-Albrechts University Kiel, No. D555/19) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Consent to participate: Informed consent was obtained from all individual participants included in the study. Consent for publication: All authors have given their consent for publication. References Schwartz I, McCracken CE, Petit CJ, Sachdeva R (2018) Late outcomes after the Fontan procedure in patients with single ventricle: a meta-analysis. Heart 104:1508-1514. https://doi:10.1136/heartjnl-2017-312807. Poh CL, d'Udekem Y (2018) Life After Surviving Fontan Surgery: A Meta-Analysis of the Incidence and Predictors of Late Death. 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J Cardiovasc Magn Reson 198. https://doi: 10.1186/s12968-016-0310-x. Tables Table 1. Patient characteristics and clinical data Patients (n= 56) Controls (n= 35) P value* Age at CMR examination, y 11.4 (3.1-38.1) 12.3 (6.3-25.8) 0.28 Female, n (%) 27 (50) 13 (37) - Body height, cm 147.0 (97.5-188.0) 155.0 (121.0-174.0) 0.19 Body weight, kg 38.7 (14.3-93.0) 51.0 (19.0-80.0) 0.05 BSA, m 2 1.2 (0.6-2.2) 1.4 (0.8-1.9) 0.07 SpO2, % 93.0 (78.0-98.0) Age at Fontan completion, y 2.7 (1.5-26.3) Time since Fontan completion, y 8.7 (1.0-32.2) Diagnosis, n (%) - Tricuspid atresia 24 (44) - Double inlet left ventricle, 19 (35) - Atrioventricular septal defect with LV dominance 3 (6) - Pulmonary atresia 2 (4) - Other 6 (11) Type of Fontan, n (%) - Intraatrial lateral tunnel 43 (79.6) - Extracardiac conduit 9 (16.7) - Fontan-Bjoerk modification - Atriopulmonary connection 1 (1.9) 1(1.9) Fenestration, n (%) - Open 27 (50) - Closed / non-fenestrated tunnel 27 (50) NYHA functional class, n (%) I 52 (96) II 2 (4) *Comparisons were performed using the Mann-Whitney U test. SpO2, oxygen saturation; y, year. Table 2. Volumetric data from CMR imaging Parameter SLV (n= 53) Controls (n= 35) *p value TA (n= 24) DILV (n= 18) *p value LVEDVi (ml/m 2 ) 81.3 [70.8; 88.9] 74.8 [68.1; 84.3] 0.12 77.7 [73.7; 84.7] 87.3 [81.9; 101.5] 0.06 LVESVi (ml/m 2 ) 35.9 [28.6; 44.0] 28.3 [25.5; 33.8] 0.0009 34.5 [28.7; 43.9] 40.6 [35.9; 45.9] 0.19 LVSVi (ml/m 2 ) 43.9 [40.2; 48.9] 45.5 [41.9; 52.1] 0.44 43.7 [38.9; 47.3] 47.0 [40.6; 56.9] 0.14 LVEF (%) 55.6 [51.4; 60.1] 61.2 [58.1; 64.7] 0.0001 55.1 [49.0; 61.9] 53.1 [51.0; 58.5] 0.67 LVMMi (g/m 2 ) 49.7 [43.4; 58.3] 47.2 [42.8; 55.6] 0.41 48.2 [40.1; 60.1] 51.6 [46.3; 55.5] 0.45 *Comparisons were performed using the Mann-Whitney U test. Statistically significant p values are indicated in bold. Values are presented as median with and 1 st and 3 rd quartile. LVEDVi, indexed left ventricular end-diastolic volume; LVESVi, indexed left ventricular end-systolic volume; LVSVI, indexed left ventricular stroke volume; LVEF, left ventricular ejection fraction; LVMMi indexed left ventricular myocardial mass. Table 3. Comparison of 2D-CMR-FT data between patients and controls as well as between patients with TA and DILV Parameter Single LV (n= 54) Controls (n= 35) *P value TA (n= 24) DILV (n= 18) † *P value GLS (%) -15.8 [-18.3; -14.2] -24.1 [-26.3; -22.5] <0.0001 -15.3 [-18.5; -14.2] -16.3 [-17.6; -14.5] 0.64 GLSR (1/s) -1.2 [-1.5; -1.0] -1.3 [-1.4; -1.1] 0.28 -1.3 [-1.5; -1.0] -1.4 [-1.7; -1.1] 0.69 GCS (%) -20.5 [-23.3; -17.7] -30.2 [-33.5; -29.0] <0.0001 -20.0 [-23.2; -17.2] -19.6 [-23.2; -17.2] 0.48 GCSR (1/s) -1.2 [-1.3; -1.1] -1.8 [-2.0; -1.6] <0.0001 -1.2 [-1.3; -1.1] -1.2 [-1.3; -1.0] 0.78 GRS (%) 51.2 [42.6; 61.8] 55.9 [46.2; 62.4] 0.47 49.7 [44.1; 58.0] 53.6 [43.7; 64.7] 0.46 GRSR (1/s) 2.2 [1.8; 2.7] 2.1 [1.9; 2.6] 0.90 2.2 [1.9; 2.5] 2.3 [1.9; 2.5] 0.67 *Comparisons were performed using the Mann-Whitney U test. Statistically significant p values are indicated in bold. † GLS- and GLSR-Average were measured in 19 patients. Values are presented as median with interquartile range. Table 4. Comparison of global and regional longitudinal deformation parameters measured by 2D-CMR-FT and 2D-STE Myocardial deformation CMR-FT (n= 38) 2D-STE (n= 37) *p value GLS (%) -16.7 ± 3.2 -16.3 ± 3.9 0.63 GLSR (1/s) -1.3 ± 0.3 -0.9 ± 0.2 <0.0001 LS LV base (%) -18.3 ± 7.0 -16.4 ± 4.3 0.16 LS LV mid-cavity (%) -16.5 ± 5.5 -16.5 ± 3.4 0.98 LS LV apex (%) -15.7 ± 5.7 -16.0 ± 8.6 0.88 Statistically significant p values are indicated in bold. Cite Share Download PDF Status: Published Journal Publication published 31 Mar, 2021 Read the published version in The International Journal of Cardiovascular Imaging → Version 1 posted Editorial decision: Minor revisions 12 Mar, 2021 Editor invited by journal 11 Mar, 2021 Reviewers invited by journal 16 Feb, 2021 Reviews received at journal 16 Feb, 2021 Editor assigned by journal 14 Feb, 2021 First submitted to journal 12 Feb, 2021 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-238338","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":12285875,"identity":"db906230-c4dd-4d29-b28c-68a4a07aa5e8","order_by":0,"name":"Fabian Strodka","email":"","orcid":"","institution":"University Hospital Schleswig-Holstein - Campus Kiel: Universitatsklinikum Schleswig-Holstein","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Fabian","middleName":"","lastName":"Strodka","suffix":""},{"id":12285876,"identity":"76a31c95-ccf5-4b0e-9e18-4ccf1a36a5ec","order_by":1,"name":"Jana Logoteta","email":"","orcid":"","institution":"Universitäts-Kinderspital Zürich: Universitats-Kinderspital Zurich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jana","middleName":"","lastName":"Logoteta","suffix":""},{"id":12285877,"identity":"ee68f0e7-6d68-4fae-bff0-06bbd6451eb6","order_by":2,"name":"Roman Schuwerk","email":"","orcid":"","institution":"University Hospital Schleswig-Holstein - Campus Kiel: Universitatsklinikum Schleswig-Holstein","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Roman","middleName":"","lastName":"Schuwerk","suffix":""},{"id":12285878,"identity":"b75d19c6-28c2-48ba-b5d8-1141b7f7e749","order_by":3,"name":"Mona Salehi Ravesh","email":"","orcid":"","institution":"University Hospital Schleswig-Holstein - Campus Kiel: Universitatsklinikum Schleswig-Holstein","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mona","middleName":"Salehi","lastName":"Ravesh","suffix":""},{"id":12285879,"identity":"22f59418-2c6d-463d-ba34-01df7047a250","order_by":4,"name":"Dominik Daniel Gabbert","email":"","orcid":"","institution":"University Hospital Schleswig-Holstein - Campus Kiel: Universitatsklinikum Schleswig-Holstein","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dominik","middleName":"Daniel","lastName":"Gabbert","suffix":""},{"id":12285880,"identity":"cf998e0e-d574-420a-94d0-d50bda5da917","order_by":5,"name":"Anselm Sebastian Uebing","email":"","orcid":"","institution":"University Hospital Schleswig-Holstein - Campus Kiel: Universitatsklinikum Schleswig-Holstein","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Anselm","middleName":"Sebastian","lastName":"Uebing","suffix":""},{"id":12285881,"identity":"1bc0bf01-2223-4f0f-a739-171e0cf27c39","order_by":6,"name":"Sylvia Krupickova","email":"","orcid":"","institution":"Royal Brompton Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Sylvia","middleName":"","lastName":"Krupickova","suffix":""},{"id":12285882,"identity":"06dd50ba-a4aa-4671-9bd2-7388211b31fd","order_by":7,"name":"Inga Voges","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA+ElEQVRIiWNgGAWjYBACNgST+QCIlAGL8BCnhS2xAaSYoBYkwGPYAFeMTwufdPvFD4xtNnb9/Ge+P2CouMPDJ918gOFNBR6HyZwplmBsS0ueOSN3YwPDmWc8bDLHEhjnnMGjRSInQfrPmcPJBjd4Nzb/bTvMAxQxYOZtw6sl+QcDUIv9+TMPGxjBWvI/MPP+w6cl/ZgEQ8VhOwOGHEaolhwGZt4GvLawWTBUpCVI3EgznAG0DqglzeDgnGO4tcjPSH98g8HAxp6///CDD0Dr5ORnJD988KYGtxZgFBiAyEQUlxzAp4GBgf0BiLTHr2gUjIJRMApGNAAAH4FK59Gam3IAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0001-7406-8006","institution":"Universitatsklinikum Schleswig Holstein Campus Kiel","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Inga","middleName":"","lastName":"Voges","suffix":""}],"badges":[],"createdAt":"2021-02-12 23:17:24","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-238338/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-238338/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s10554-021-02230-2","type":"published","date":"2021-03-31T19:08:41+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":6260059,"identity":"12ab6fcd-bd4b-4e11-86eb-4367d2e30270","added_by":"auto","created_at":"2021-02-23 15:31:54","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":846922,"visible":true,"origin":"","legend":"Assessment of LV circumferential (A), radial (B) and longitudinal (C) strain from short axis and long axis images","description":"","filename":"Fig1.png","url":"https://assets-eu.researchsquare.com/files/rs-238338/v1/877232e60518b077cc07f656.png"},{"id":6260058,"identity":"7f3e6589-0834-448e-aa99-96073fa1fe73","added_by":"auto","created_at":"2021-02-23 15:31:54","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":28521,"visible":true,"origin":"","legend":"Associations between LVEF and global longitudinal, circumferential and radial strain in the entire patient cohort","description":"","filename":"Fig2.png","url":"https://assets-eu.researchsquare.com/files/rs-238338/v1/50992a1a4032c4ab9afa4eec.png"},{"id":6260289,"identity":"ccecb890-d8c6-4145-87fa-9f6adfc75e72","added_by":"auto","created_at":"2021-02-23 15:34:54","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":19242,"visible":true,"origin":"","legend":"Bland-Altman-Plots comparing 2D-CMR–FT and 2D-STE. Horizontal solid lines represent the mean difference between both analysis techniques and the dashed lines indicate the mean ± 1.96 standard deviation of the difference","description":"","filename":"Fig3.png","url":"https://assets-eu.researchsquare.com/files/rs-238338/v1/24648d0e856de2255e85f5c4.png"},{"id":13669421,"identity":"a18256f8-5f1a-428f-8ec7-78fa42123f60","added_by":"auto","created_at":"2021-09-17 11:00:55","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1139851,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-238338/v1/17b2cc9f-085d-4c68-b103-62fcae43c62d.pdf"}],"financialInterests":"","formattedTitle":"Myocardial deformation in patients with a single left ventricle using 2D cardiovascular magnetic resonance feature tracking: a case-control study","fulltext":[{"header":"Introduction","content":" \u003cp\u003eSince the introduction of the Fontan operation, life expectancy of single ventricle (SV) patients steadily improved, and an increasing number of SV patients is reaching adolescence and adulthood.\u003csup\u003e\u003cspan additionalcitationids=\"CR2\" citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u003c/sup\u003e Despite this success, we must remind ourselves that the Fontan procedure is a palliative approach and that SV patients with Fontan circulation are at risk for various complications.\u003csup\u003e\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e,\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e\u003c/sup\u003e A well-known complication is systolic and diastolic ventricular dysfunction which impacts morbidity and mortality.\u003csup\u003e\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e,\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e \u003cp\u003eAbnormal hemodynamics due to unfavorable volume and/ or pressure load of the SV, as well as the stepwise surgical procedures, might be a cause for SV dysfunction and heart failure.\u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u003c/sup\u003e More recently associations between myocardial fibrosis and adverse SV function have been demonstrated.\u003csup\u003e\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e,\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e \u003cp\u003eEchocardiography and cardiovascular magnetic resonance (CMR) are the standard imaging modalities to evaluate SV function in patients with a Fontan circulation.\u003csup\u003e\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e,\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e Beside traditional techniques, tissue tracking methods such as 2-dimensional (2D) CMR feature tracking (2D-CMR-FT) and 2D speckle tracking echocardiography (2D-STE) have gained popularity to assess global and regional myocardial deformation of the SV.\u003csup\u003e\u003cspan additionalcitationids=\"CR14\" citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u003c/sup\u003e However, most studies have assessed a mixed cohort of single left (SLV) and single right ventricle (SRV) patients but only few assessed a uniform population of only SLV patients using 2D-STE.\u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e A comparison to healthy controls was only performed in a small cohort in 2 studies.\u003csup\u003e\u003cspan additionalcitationids=\"CR17\" citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e \u003cp\u003eFor the present study, we hypothesized that ventricular function and myocardial deformation in patients with a SLV are impaired compared to healthy controls. We used 2D-CMR-FT and 2D-STE and analyzed myocardial deformation and ventricular function in a relatively large cohort of SLV patients and healthy controls. In addition, patients with tricuspid atresia (TA) were compared to those with a double inlet left ventricle (DILV) and 2D-CMR-FT results were compared to those from 2D-STE.\u003c/p\u003e "},{"header":"Material And Methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\u003ch2\u003ePatient Population\u003c/h2\u003e\u003cp\u003e This retrospective study was approved by the ethics committee of the medical faculty of the Christian-Albrechts University Kiel (No. D555/19) and included all 54 SLV patients after Fontan completion, who received a CMR examination as part of a routine clinical follow up during 2010 to 2019. 35 age-matched healthy controls were included for comparison. For patients who received several CMR examinations during that period, only the most recent dataset was included in our study. The comparison between 2D-CMR-FT and 2D-STE was conducted in datasets in which an echocardiography was performed within 3 months of the CMR examination. To guarantee comparability, echocardiographic studies in patients who underwent cardiovascular surgery or catheter interventions between echocardiography and CMR were excluded.\u003c/p\u003e\u003cp\u003eAge at examination and total cavopulmonary connection (TCPC) as well as gender, weight, height, body surface area (BSA), New York Heart Association (NYHA) functional class, transcutaneous oxygen saturation (SpO\u003csub\u003e2\u003c/sub\u003e) and number of surgical procedures was collected from medical records. Heart rate (HR), cardiac axis and QRS duration was assessed from 12-lead electrocardiograms (ECG).\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec4\" class=\"Section2\"\u003e\u003ch2\u003eCMR acquisition and analysis\u003c/h2\u003e\u003cp\u003eCMR examinations were performed using a 3T MRI system (Achieva TX-Series, Philips Healthcare, Best, Netherlands). In 4 older patients a 1.5T MRI system (Achieva, Philips Healthcare, Best, Netherlands) was used. Patients were sedated using midazolam and propofol according to our clinical protocol, if necessary. Blood Pressure, HR and SpO2 levels were monitored during examination. Short-axis, four-chamber and axial cine images were acquired using steady-state free precession or gradient echo pulse sequences. Field of view and slice thickness varied according to patient size (250\u0026ndash;400 x 250\u0026ndash;400 mm\u0026sup2;, 5\u0026ndash;8 mm).\u003c/p\u003e\u003cp\u003eVolumetric analysis was performed using QMass (Version 8.1, Medis Medical Imaging Systems, BV, Leiden, Netherlands). Left ventricular (LV) end-diastolic and end-systolic volumes (LVEDV, LVESV) were measured from the short-axis images by manual drawing of endocardial and epicardial border at end-diastole and endocardial borders at end-systole (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). Papillary muscles and large trabeculations were excluded from the ventricular mass and included into the ventricular volumes. The right ventricular volume was excluded as well. Left ventricular ejection fraction (LVEF), stroke volume and end-diastolic myocardial mass (LVMM) were automatically calculated by the software. Volumes and mass were indexed to BSA.\u003c/p\u003e\u003cp\u003e2D-CMR-FT analysis was undertaken using the dedicated software QStrain Research Edition (Version 2.0, Medis Medical Imaging Systems, BV, Leiden, Netherlands). Global longitudinal strain (GLS) and strain rate (GLSR) were measured in the four-chamber view (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). If the examinations lacked a four-chamber-view, we used comparable axial cine images instead (n\u0026thinsp;=\u0026thinsp;16). Global and regional circumferential strain (CS) and strain rate (CSR) as well as radial strain (RS) and strain rate (RSR) were analyzed from short axis images.\u003c/p\u003e\u003cp\u003eEndocardial and epicardial contours were drawn manually at end-systole, which was defined as the cardiac phase with the smallest LV cavity area. Contours were then tracked automatically by the software during the cardiac cycle. Visual inspection of the epi- and endocardial contours during the cardiac cycle was conducted to evaluate tracking quality and suggested end-diastolic contours were manually adjusted if necessary.\u003c/p\u003e\u003cp\u003eIn the four-chamber views, the LV was automatically divided into 7 myocardial segments by the software and peak longitudinal strain and strain rate for each segment was obtained.\u003c/p\u003e\u003cp\u003eIn the short axis, the LV was divided into 3 different levels (basal, mid-ventricular and apical) and 16 segments according to the American Heart association 16-segment-model (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003csup\u003e\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u003c/sup\u003e Peak circumferential and radial strain and strain rate values were acquired for each segment.\u003c/p\u003e\u003cp\u003eGlobal strain (GS) and global strain rate (GSR) values as well as strain and strain rate values for the three ventricular levels were calculated by averaging the peak values of each segment.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec5\" class=\"Section2\"\u003e\u003ch2\u003e2D-STE analysis\u003c/h2\u003e\u003cp\u003eTransthoracic echocardiography was performed using a Vivid 7 GE Dimension-System (General Electric Healthcare, Wisconsin, USA). All studies were stored digitally and were therefore available for offline analysis. The data analysis was performed using dedicated STE software (EchoPac, version 113, General Electric Healthcare, Wisconsin, USA) as previously described by our group.\u003csup\u003e\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec6\" class=\"Section2\"\u003e\u003ch2\u003eStatistics\u003c/h2\u003e\u003cp\u003eStatistical analysis was performed by using a dedicated software (MedCalc statistical software, version 19.5.1, software, Mariakerke, Belgium). Continuous variables were expressed either as mean\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviation if they were normally distributed, or otherwise as median with range. Normal distribution of the data was assessed using the Shapiro Wilk test. Differences between patients and controls as well as between patient subgroups were analysed using the Mann-Whitney-U test. Comparison between extracted mean values using 2D-CMR-FT and 2D-STE was performed using the paired samples t-test. Adjustments for multiple testing were performed and the significant p-value was reduced to 0.003. Bland-Altman plots were constructed to assess the agreement between 2D-CMR-FT and 2D-STE. Associations between variables were evaluated by the Spearman\u0026rsquo;s rank method and p values of \u0026lt;\u0026thinsp;0.05 were considered to indicate statistical significance.\u003c/p\u003e\u003c/div\u003e"},{"header":"Results","content":"\u003cp\u003eCharacteristics of patients and controls are presented in Table 1.\u003c/p\u003e\n\u003cp\u003eThe patient population consisted of 24 patients with TA, 19 patients with DILV and 11 patients with diverse SLV anatomies. All patients were examined after TCPC. Median age of the entire patient group was 11.4 years (range 3.1-38.1 years). All except two patients were in NYHA class I.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eGlobal and regional myocardial deformation and function \u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGLS, GLSR and LV volume were determined using a 2D-CMR-FT analysis in all 54 patients. Global and regional CS, CSR, RS and RSR values were acquired in 53 patients in the short axis view. In one patient with DILV the short axis stack did not cover the entire LV.\u003c/p\u003e\n\u003cp\u003eGlobal systolic function was preserved in 52% (n= 28) of SLVpatients with an LVEF of \u0026ge; 55%. However, compared to the healthy controls LVEF was reduced (Table 2). Median indexed left ventricular end-systolic volume (LVESVi) was significantly higher in patients compared to controls whereas indexed left ventricular end-diastolic volume (LVEDVi) and indexed left ventricular myocardial mass (LVMMi) were not significantly different. There was no difference between TA and DILV patients regarding indexed LV volumes, LVEF and LVMMi (Table 2).\u003c/p\u003e\n\u003cp\u003eMedian GS and GSR values from CMR-FT are shown in Table 3. Compared to healthy controls, patients had significantly reduced values for GLS and global circumferential strain (GCS) and global circumferential strain rate (GCSR). There was no difference for GLSR and global radial strain rate (GRSR) as well as for global radial strain (GRS) between patients and controls. GLS, GCS and GRS correlated with LVEF in the entire patient group (Figure 2). When comparing TA and DILV patients there was no statistically significant difference for GLS, GLSR, GCS, GCSR, GRS and GRSR measurements between both groups.\u003c/p\u003e\n\u003cp\u003eOut of the 54 patients, 44 underwent echocardiography within 3 months of the CMR study. 7 patients were excluded from the analysis due to poor image quality or inability to visualize the entire LV. Comparison between 2D-CMR-FT and 2D-STE are illustrated in Table 4. Mean GLSR by CMR-FT was higher than by STE (-1.2 \u0026plusmn; 0.4 1/s vs. -0.9 \u0026plusmn; 0.2 1/s, p \u0026lt;0.001). No difference was found for GLS and longitudinal strain at basal, mid and apical level. Bland-Altman-Plots are demonstrated in Figure 3 and show that the agreement for the GLS measurements using 2D-CMR-FT and 2D-STE was acceptable.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eOne of strengths of the present study is that a relatively large cohort of SLV patients (n= 54) were included, and that they were compared to healthy controls. Although median LVEF, GLS and GCS were reduced compared to controls, most patients had a normal NYHA functional class.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eMyocardial deformation and function in SLV patients compared to controls\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eStrain analyses using 2D-CMR-FT and 2D-STE in SV patients have been performed by other groups, but most studies included small and mixed patient cohorts (17, 20).\u003csup\u003e17,20\u003c/sup\u003e The present study, however, included a relatively large cohort of SLV patients (n=54) and found significantly reduced values for GLS, GCS and GCSR compared to healthy controls. Hu et al. observed significantly reduced GCS and GRS values in Fontan patients compared to controls.\u003csup\u003e21\u003c/sup\u003e Different to our study, they only included patients with a preserved LVEF (\u0026gt;55%) (21) and concluded that global and regional circumferential strains could be used for early detection of abnormal myocardial function. That strain values might be impaired before the ejection fraction (EF) is compromised has been demonstrated also in various other patient groups\u003csup\u003e22,23\u003c/sup\u003e and it has been shown that a preserved EF might be explained mathematically through geometric factors.\u003csup\u003e24\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eMore than 50% of our SLV patients had a preserved LVEF but compared to controls LVEF in patients was significantly reduced. Similar findings have been reported by Singh et al. in a small (n= 16) SLV patient cohort.\u003csup\u003e18\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eThey found a lower LVEF and larger volumetric indices in pediatric TA patients compared to healthy subjects.\u003csup\u003e18\u003c/sup\u003e Other groups found a reduced LVEF, however they also included patients with a with SRV.\u003csup\u003e14\u003c/sup\u003e A reduction in LVEF in SLV patients compared to controls might be explained by different hemodynamics in some patients and by a heterogeneity in myocardial function in SLV patients.\u003csup\u003e18,20\u003c/sup\u003e Moreover, an abnormal myoarchitecture as reported in TA patients has to be considered.\u003csup\u003e25\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eWe were able to show that LVEF from CMR data in SLV patients correlates with GCS, GLS and GRS. Other groups have shown similar relationships between EF and strain values.\u003csup\u003e24,26\u003c/sup\u003e Nevertheless, correlations between myocardial deformation parameters and EF are a matter of debate. Lipiec et al. suggested a non-linear hemi-ellipsoid model to explain the association between systolic GLS and LVEF.\u003csup\u003e27\u003c/sup\u003e More recently a mathematical model has been introduced describing the relationship between LVEF, GCS and GLS.\u003csup\u003e28\u003c/sup\u003e In this model a reduction in LVEF would correspond to reduced GCS and GLS values.\u003csup\u003e28\u003c/sup\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eComparison between TA and DILV patients\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo our knowledge, no study has compared LV myocardial deformation and function in TA and DILV patients using CMR imaging. Our findings do not suggest any major difference in myocardial deformation, function and size between these two entities. An impaired left ventricular function in patients with TA compared to DILV was found in a cardiac catheterization study by Redington et al.. Unfortunately, these results are not comparable with our data from a technical point of view (different imaging modalities).\u003csup\u003e29\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eComparison between CMR-FT and 2D-STE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn our study we found clinically acceptable agreement between 2D-CMR-FT and 2D-STE, however, only 37 echocardiographic examinations could be analyzed. Schmidt et al. analyzed a mixed cohort of adult Fontan patients including both SLV and SRV patients. They highlighted the fact that 2D-CMR-FT allows analyzing all myocardial segments whereas STE is commonly limited by the acoustic windows.\u003csup\u003e14\u003c/sup\u003e Similarly, in our study we had to exclude seven echocardiographic studies because of poor image quality but all CMR examinations were suitable for strain analyses. A study from Ghelani et al. assessed the reproducibility of strain measurements in Fontan patients using 2D-CMR-FT and 2D-STE. Their results suggested that deformation analyses from different modalities should not be mixed.\u003csup\u003e13\u003c/sup\u003e Different to them we did not perform intra-modality reproducibility analyses and we are therefore unable to draw a similar conclusion. However, since 2D-CMR-FT was possible in all SLV patients compared to 2D-STE and that it has become more easily available for routine CMR analyses, we believe that 2D-CMR-FT is a good alternative to 2D-STE. Furthermore, CMR reference values for LV strain values in children and adults exist and can be used for comparison.\u003csup\u003e30,31\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStudy limitations\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe retrospective design of the study implies some limitations. First, in some patients certain CMR data sets were missing and were therefore not available for analysis. In addition, GLS was only measured from the 4-chamber view or axial cine images and this might have impacted our strain results.\u003c/p\u003e\n\u003cp\u003eFuture studies are needed to evaluate the fate of the LV in SLV patients during follow up.\u003c/p\u003e\n\u003cp\u003eThe number of healthy controls was smaller, but since both groups were age-matched this could not influence the study findings.\u003c/p\u003e\n\u003cp\u003eFinally, we did not perform an intermodality reproducibility analysis for CMR-FT and 2D-STE.\u003c/p\u003e"},{"header":"Conclusions","content":" \u003cp\u003eMost SLV patients had a normal NYHA functional class and 52% of patients had a preserved LVEF (\u0026ge;\u0026thinsp;55%). However, compared to controls, LVEF, GLS, GCS and GCSR were reduced. Our results suggest that LV deformation and function in SLV patients may behave differently compared to a normal LV in healthy subjects. Follow up studies evaluating the fate of the LV in SLV patients are needed. 2D-CMR-FT might be a suitable modality in this setting.\u003c/p\u003e "},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eFunding:\u003c/strong\u003e none\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflicts of interest/Competing interests:\u003c/strong\u003e The authors declare that they have no conflict of interest.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material: \u003c/strong\u003eAll data and materials support the published claims and comply with field standards.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCode availability:\u003c/strong\u003e N/A\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval:\u003c/strong\u003e All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (ethics committee of the medical faculty of the Christian-Albrechts University Kiel, No. D555/19) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to participate:\u003c/strong\u003e\u0026nbsp;Informed consent was obtained from all individual participants included in the study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication:\u003c/strong\u003e All authors have given their consent for publication.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eSchwartz I, McCracken CE, Petit CJ, Sachdeva R (2018) Late outcomes after the Fontan procedure in patients with single ventricle: a meta-analysis. 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JACC Cardiovasc Imaging 12:1893-95. https://doi: 10.1016/j.jcmg.2019.03.019.\u003c/li\u003e\n\u003cli\u003eRedington AN, Knight B, Oldershaw PJ, Shinebourne EA, Rigby ML (1988) Left ventricular function in double inlet left ventricle before the Fontan operation: comparison with tricuspid atresia. Br Heart J 60:324-31. https://doi: 10.1136/hrt.60.4.324.\u003c/li\u003e\n\u003cli\u003eKawel-Boehm N, Hetzel SJ, Ambale-Venkatesh B, Captur G, Francois CJ, Jerosch-Herold M, Salerno M, Teague SD, Valsangiacomo-Buechel E, van der Geest RJ, Bluemke DA (2020) Reference ranges (\"normal values\") for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update. J Cardiovasc Magn Reason 22:87. https://doi: 10.1186/s12968-020-00683-3.\u003c/li\u003e\n\u003cli\u003eAndr\u0026eacute; F, Robbers-Visser D, Helling-Bakki A, F\u0026ouml;ll A, Voss A, Katus HA, Helbing WA, Buss SJ, Eichhorn JG (2016) Quantification of myocardial deformation in children by cardiovascular magnetic resonance feature tracking: determination of reference values for left ventricular strain and strain rate. J Cardiovasc Magn Reson 198. https://doi: 10.1186/s12968-016-0310-x.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cstrong\u003eTable 1.\u003c/strong\u003e \u003cstrong\u003ePatient characteristics and clinical data\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e\u003cstrong\u003ePatients (n= 56)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u003cstrong\u003eControls (n= 35)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u003cstrong\u003eP value*\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eAge at CMR examination, y\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e11.4 (3.1-38.1)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e12.3 (6.3-25.8)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e0.28\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eFemale, n (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e27 (50)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e13 (37)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eBody height, cm\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e147.0 (97.5-188.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e155.0 (121.0-174.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e0.19\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eBody weight, kg\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e38.7 (14.3-93.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e51.0 (19.0-80.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e0.05\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eBSA, m\u003csup\u003e2\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e1.2 (0.6-2.2)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e1.4 (0.8-1.9)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e0.07\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eSpO2, %\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e93.0 (78.0-98.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eAge at Fontan completion, y\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e2.7 (1.5-26.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eTime since Fontan completion, y\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e8.7 (1.0-32.2)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eDiagnosis, n (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Tricuspid atresia\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e24 (44)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Double inlet left ventricle,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e19 (35)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Atrioventricular septal defect with LV dominance\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e3 (6)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Pulmonary atresia\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"170\"\u003e\n\u003cp\u003e2 (4)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"171\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Other\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e6 (11)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eType of Fontan, n (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Intraatrial lateral tunnel\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e43 (79.6)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Extracardiac conduit\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e9 (16.7)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Fontan-Bjoerk\u0026nbsp;modification\u003c/p\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Atriopulmonary connection\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e1 (1.9)\u003c/p\u003e\n\u003cp\u003e1(1.9)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eFenestration, n (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Open\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e27 (50)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003e-\u0026nbsp;\u0026nbsp; Closed / non-fenestrated tunnel\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e27 (50)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eNYHA functional class, n (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eI\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e52 (96)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\n\u003cp\u003eII\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\n\u003cp\u003e2 (4)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"176\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"143\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd width=\"152\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd width=\"18\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd width=\"157\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd width=\"14\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd width=\"129\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*Comparisons were performed using the Mann-Whitney U test.\u003c/p\u003e\n\u003cp\u003eSpO2, oxygen saturation; y, year.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2. Volumetric data from CMR imaging\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003e\u003cstrong\u003eParameter\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"105\"\u003e\n\u003cp\u003e\u003cstrong\u003eSLV\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 53)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003e\u003cstrong\u003eControls\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 35)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"82\"\u003e\n\u003cp\u003e\u003cstrong\u003e*p value\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"108\"\u003e\n\u003cp\u003e\u003cstrong\u003eTA\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 24)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"110\"\u003e\n\u003cp\u003e\u003cstrong\u003eDILV\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 18)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"71\"\u003e\n\u003cp\u003e\u003cstrong\u003e*p value \u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003eLVEDVi (ml/m\u003csup\u003e2\u003c/sup\u003e)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"105\"\u003e\n\u003cp\u003e81.3 [70.8; 88.9]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003e74.8 [68.1; 84.3]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"82\"\u003e\n\u003cp\u003e0.12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"108\"\u003e\n\u003cp\u003e77.7 [73.7; 84.7]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"110\"\u003e\n\u003cp\u003e87.3 [81.9; 101.5]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"71\"\u003e\n\u003cp\u003e0.06\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003eLVESVi (ml/m\u003csup\u003e2\u003c/sup\u003e)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"105\"\u003e\n\u003cp\u003e35.9 [28.6; 44.0]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003e28.3 [25.5; 33.8]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"82\"\u003e\n\u003cp\u003e\u003cstrong\u003e0.0009\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"108\"\u003e\n\u003cp\u003e34.5 [28.7; 43.9]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"110\"\u003e\n\u003cp\u003e40.6 [35.9; 45.9]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"71\"\u003e\n\u003cp\u003e0.19\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003eLVSVi (ml/m\u003csup\u003e2\u003c/sup\u003e)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"105\"\u003e\n\u003cp\u003e43.9 [40.2; 48.9]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003e45.5 [41.9; 52.1]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"82\"\u003e\n\u003cp\u003e0.44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"108\"\u003e\n\u003cp\u003e43.7 [38.9; 47.3]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"110\"\u003e\n\u003cp\u003e47.0 [40.6; 56.9]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"71\"\u003e\n\u003cp\u003e0.14\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003eLVEF (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"105\"\u003e\n\u003cp\u003e55.6 [51.4; 60.1]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003e61.2 [58.1; 64.7]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"82\"\u003e\n\u003cp\u003e\u003cstrong\u003e0.0001\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"108\"\u003e\n\u003cp\u003e55.1 [49.0; 61.9]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"110\"\u003e\n\u003cp\u003e53.1 [51.0; 58.5]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"71\"\u003e\n\u003cp\u003e0.67\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003eLVMMi (g/m\u003csup\u003e2\u003c/sup\u003e)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"105\"\u003e\n\u003cp\u003e49.7 [43.4; 58.3]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"116\"\u003e\n\u003cp\u003e47.2 [42.8; 55.6]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"82\"\u003e\n\u003cp\u003e0.41\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"108\"\u003e\n\u003cp\u003e48.2 [40.1; 60.1]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"110\"\u003e\n\u003cp\u003e51.6 [46.3; 55.5]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"71\"\u003e\n\u003cp\u003e0.45\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*Comparisons were performed using the Mann-Whitney U test. Statistically significant p values are indicated in bold.\u003c/p\u003e\n\u003cp\u003eValues are presented as median with and 1\u003csup\u003est\u003c/sup\u003e and 3\u003csup\u003erd\u003c/sup\u003e quartile.\u003c/p\u003e\n\u003cp\u003eLVEDVi, indexed left ventricular end-diastolic volume; LVESVi, indexed left ventricular end-systolic volume; LVSVI, indexed left ventricular stroke volume; LVEF, left ventricular ejection fraction; LVMMi indexed left ventricular myocardial mass.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3. Comparison of 2D-CMR-FT data between patients and controls as well as between patients with TA and DILV\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" width=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"131\"\u003e\n\u003cp\u003e\u003cstrong\u003eParameter\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e\u003cstrong\u003eSingle LV\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 54)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e\u003cstrong\u003eControls\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 35)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"73\"\u003e\n\u003cp\u003e\u003cstrong\u003e*P\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003evalue\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e\u003cstrong\u003eTA \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 24)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e\u003cstrong\u003eDILV \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 18)\u003csup\u003e\u0026dagger;\u003c/sup\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"84\"\u003e\n\u003cp\u003e\u003cstrong\u003e*P\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003evalue\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"131\"\u003e\n\u003cp\u003eGLS (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e-15.8 [-18.3; -14.2]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e-24.1 [-26.3; -22.5]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"73\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026lt;0.0001\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e-15.3 [-18.5; -14.2]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e-16.3 [-17.6; -14.5]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"84\"\u003e\n\u003cp\u003e0.64\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"131\"\u003e\n\u003cp\u003eGLSR (1/s)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e-1.2 [-1.5; -1.0]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e-1.3 [-1.4; -1.1]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"73\"\u003e\n\u003cp\u003e0.28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e-1.3 [-1.5; -1.0]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e-1.4 [-1.7; -1.1]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"84\"\u003e\n\u003cp\u003e0.69\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"131\"\u003e\n\u003cp\u003eGCS (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e-20.5 [-23.3; -17.7]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e-30.2 [-33.5; -29.0]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"73\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026lt;0.0001\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e-20.0 [-23.2; -17.2]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e-19.6 [-23.2; -17.2]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"84\"\u003e\n\u003cp\u003e0.48\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"131\"\u003e\n\u003cp\u003eGCSR (1/s)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e-1.2 [-1.3; -1.1]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e-1.8 [-2.0; -1.6]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"73\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026lt;0.0001\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e-1.2 [-1.3; -1.1]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e-1.2 [-1.3; -1.0]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"84\"\u003e\n\u003cp\u003e0.78\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"131\"\u003e\n\u003cp\u003eGRS (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e51.2 [42.6; 61.8]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e55.9 [46.2; 62.4]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"73\"\u003e\n\u003cp\u003e0.47\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e49.7 [44.1; 58.0]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e53.6 [43.7; 64.7]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"84\"\u003e\n\u003cp\u003e0.46\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"131\"\u003e\n\u003cp\u003eGRSR (1/s)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e2.2 [1.8; 2.7]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"149\"\u003e\n\u003cp\u003e2.1 [1.9; 2.6]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"73\"\u003e\n\u003cp\u003e0.90\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e2.2 [1.9; 2.5]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"156\"\u003e\n\u003cp\u003e2.3 [1.9; 2.5]\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"84\"\u003e\n\u003cp\u003e0.67\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*Comparisons were performed using the Mann-Whitney U test. Statistically significant p values are indicated in bold.\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u0026dagger;\u003c/sup\u003eGLS- and GLSR-Average were measured in 19 patients. Values are presented as median with interquartile range.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 4. \u0026nbsp;\u003c/strong\u003e\u003cstrong\u003eComparison of global and regional longitudinal deformation parameters measured by 2D-CMR-FT and 2D-STE\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e\u003cstrong\u003eMyocardial deformation\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e\u003cstrong\u003eCMR-FT\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 38)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e\u003cstrong\u003e2D-STE\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e(n= 37)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e\u003cstrong\u003e*p value\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003eGLS (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-16.7 \u0026plusmn; 3.2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-16.3 \u0026plusmn; 3.9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e0.63\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003eGLSR (1/s)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-1.3 \u0026plusmn; 0.3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-0.9 \u0026plusmn; 0.2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026lt;0.0001\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003eLS LV base (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-18.3 \u0026plusmn; 7.0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-16.4 \u0026plusmn; 4.3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e0.16\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003eLS LV mid-cavity (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-16.5 \u0026plusmn; 5.5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-16.5 \u0026plusmn; 3.4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e0.98\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003eLS LV apex (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-15.7 \u0026plusmn; 5.7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e-16.0 \u0026plusmn; 8.6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"175\"\u003e\n\u003cp\u003e0.88\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eStatistically significant p values are indicated in bold.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"the-international-journal-of-cardiovascular-imaging","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"caim","sideBox":"Learn more about [The International Journal of Cardiovascular Imaging](https://www.springer.com/journal/10554)","snPcode":"10554","submissionUrl":"https://submission.nature.com/new-submission/10554/3","title":"The International Journal of Cardiovascular Imaging","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Single ventricle, cardiovascular magnetic resonance, feature tracking, speckle tracking echocardiography","lastPublishedDoi":"10.21203/rs.3.rs-238338/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-238338/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose\u003c/h2\u003e \u003cp\u003eVentricular dysfunction is a well-known complication in single ventricle patients in Fontan circulation. As studies exclusively examining patients with a single left ventricle (SLV) are sparse, we assessed left ventricular (LV) function in SLV patients by using 2D-cardiovascular magnetic resonance (CMR) feature tracking (2D-CMR-FT) and 2D-speckle tracking echocardiography (2D-STE).\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003e54 SLV patients (11.4, 3.1\u0026ndash;38.1 years) and 35 age-matched controls (12.3, 6.3\u0026ndash;25.8 years) were included. LV global longitudinal, circumferential and radial strain (GLS, GCS, GRS) and strain rate (GLSR, GCSR, GRSR) were measured using 2D-CMR-FT. LV volumes, ejection fraction (LVEF) and mass were determined from short axis images. 2D-STE was applied in patients to measure peak systolic GLS and GLSR. In a subgroup analysis, we compared double inlet left ventricle (DILV) with tricuspid atresia (TA) patients.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eThe population consisted of 19 DILV patients, 24 TA patients and 11 patients with diverse diagnoses. 52 patients were in NYHA class I and 2 patients were in class II. Median LVEF in patients was lower compared to controls (55.6% vs. 61.2%, p\u0026thinsp;=\u0026thinsp;0.0001). 2D-CMR-FT demonstrated reduced GLS, GCS and GCSR values in patients compared to controls. LVEF correlated with GS values in patients (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05). There was no significant difference between GLS values from 2D-CMR-FT and 2D-STE in the patient group. LVEF, LV volumes, GS and GSR were not significantly different between DILV and TA patients.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eAlthough most SLV patients had a preserved EF, our results suggest that, LV deformation and function may behave differently in SLV patients compared to healthy subjects.\u003c/p\u003e","manuscriptTitle":"Myocardial deformation in patients with a single left ventricle using 2D cardiovascular magnetic resonance feature tracking: a case-control study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-02-23 15:31:52","doi":"10.21203/rs.3.rs-238338/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revisions","date":"2021-03-12T05:25:33+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"The International Journal of Cardiovascular Imaging","date":"2021-03-12T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewersInvited","content":"","date":"2021-02-17T00:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-02-17T00:00:00+00:00","index":0,"fulltext":""},{"type":"editorAssigned","content":"","date":"2021-02-15T00:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"The International Journal of Cardiovascular Imaging","date":"2021-02-12T18:17:13+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"the-international-journal-of-cardiovascular-imaging","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"caim","sideBox":"Learn more about [The International Journal of Cardiovascular Imaging](https://www.springer.com/journal/10554)","snPcode":"10554","submissionUrl":"https://submission.nature.com/new-submission/10554/3","title":"The International Journal of Cardiovascular Imaging","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"5b832480-7a02-4ff8-8bd3-444486a25653","owner":[],"postedDate":"February 23rd, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":2503844,"name":"Cardiac \u0026 Cardiovascular Systems"},{"id":2503845,"name":"Cardiothoracic Surgery"},{"id":2503846,"name":"Neurology"}],"tags":[],"updatedAt":"2021-08-18T19:27:35+00:00","versionOfRecord":{"articleIdentity":"rs-238338","link":"https://doi.org/10.1007/s10554-021-02230-2","journal":{"identity":"the-international-journal-of-cardiovascular-imaging","isVorOnly":false,"title":"The International Journal of Cardiovascular Imaging"},"publishedOn":"2021-03-31 19:08:41","publishedOnDateReadable":"March 31st, 2021"},"versionCreatedAt":"2021-02-23 15:31:52","video":"","vorDoi":"10.1007/s10554-021-02230-2","vorDoiUrl":"https://doi.org/10.1007/s10554-021-02230-2","workflowStages":[]},"version":"v1","identity":"rs-238338","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-238338","identity":"rs-238338","version":["v1"]},"buildId":"ApUGefWb6u5IBVtyqm6d5","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}