Primary Splenic Inflammatory Myofibroblastic Tumor, a rare Case and its Differential Diagnosis

Primary Splenic Inflammatory Myofibroblastic Tumor, a rare Case and its Differential Diagnosis | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 16 September 2025 V1 Latest version Share on Primary Splenic Inflammatory Myofibroblastic Tumor, a rare Case and its Differential Diagnosis Authors : Harsahib Singh Sandhu 0009-0006-0867-5071 [email protected] , Ankur Wadhera , Shubhra Jain , Smiley Joshi , and Vasudeva K 0000-0002-4081-1372 Authors Info & Affiliations https://doi.org/10.22541/au.175801700.03252946/v1 186 views 209 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Primary splenic inflammatory myofibroblastic tumor (PS-IMT) is very rare. We are reporting a case of PS-IMT in a 17-year-old female who presented with low-grade fever, weakness, and weight loss of three months’ duration. Radiological workup revealed a large, well-defined splenic mass lesion. Splenectomy was done, the histopathology of which revealed the diagnosis of PS-IMT. It is a tumor with indeterminate malignant potential, and its exact etiology remains unknown. It is primarily seen in children and young adults, but can occur at any age. Its clinical presentation is variable with no pathognomonic symptoms or signs. Radiologically, there is no characteristic appearance, and findings are usually nonspecific. Due to this, the diagnosis is often delayed. The primary treatment of PS-IMT is splenectomy. In unresectable and recurrent cases, corticosteroids and nonsteroidal anti-inflammatory drugs provide short-lived symptomatic benefit. Chemotherapy regimens based on anthracyclines and alkylating agents induce partial remission in some patients. Targeted therapy based on competitive inhibitors of ALK tyrosine kinase, like crizotinib, provides a more durable response in ALK-positive patients. There is a potential role of immunotherapy, especially in ALK-negative cases. The natural history of IMT is variable; the lesions may remain stable, progress slowly, or even spontaneously regress. TITLE OF THE MANUSCRIPT: Primary Splenic Inflammatory Myofibroblastic Tumor, a rare Case and its Differential Diagnosis RUNNING TITLE: Splenic Inflammatory Myofibroblastic Tumor KEYWORDS: Inflammatory Myofibroblastic Tumor, Splenomegaly, Hematology/oncology- general, Pediatric oncology, Splenectomy CORRESPONDENCE AUTHOR ADDRESS AND EMAIL Dr. Harsahib Singh Sandhu MBBS Intern, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Tiger Circle Road, Madhav Nagar, Manipal, India 576104 Email: [email protected] NAMES AND AFFILIATIONS OF AUTHORS Dr. Harsahib Singh Sandhu MBBS Intern, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Tiger Circle Road, Madhav Nagar, Manipal, India 576104 Email: [email protected] Dr. Ankur Wadhera Assistant Professor of Radiology, Christian Medical College and Hospital, Ludhiana, India 141008 Email: [email protected] Dr. Shubhra Jain Consultant Histopathology , AMPATH Central Reference Laboratory, Hyderabad, India 500019 Email: [email protected] Dr. Smiley Joshi Consultant Medical Oncologist, Sandhu Cancer Centre, Ludhiana, India 141001 Email: [email protected] Dr Vasudeva Bhat Professor and Head, Department of Pediatric Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Tiger Circle Road, Madhav Nagar, Manipal, India 576104 Email: [email protected] ABSTRACT WORD COUNT: 197 TEXT WORD COUNT: 2021 NUMBER OF FIGURES: 7 NUMBER OF TABLES: 0 Supplementary Material File (graphical abstract text.docx) Download 26.53 KB File (manuscript.docx) Download 44.74 KB Information & Authors Information Version history V1 Version 1 16 September 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords cancer biology general hematology/oncology inflammatory myofibroblastic tumor oncology pediatric hematology/oncology sarcomas splenectomy splenomegaly tumor biology tumor markers Authors Affiliations Harsahib Singh Sandhu 0009-0006-0867-5071 [email protected] Kasturba Medical College Manipal View all articles by this author Ankur Wadhera Christian Medical College and Hospital Ludhiana View all articles by this author Shubhra Jain AMPATH Central Reference Laboratory Hyderabad View all articles by this author Smiley Joshi Sandhu Cancer Centre Ludhiana View all articles by this author Vasudeva K 0000-0002-4081-1372 Kasturba Medical College Manipal View all articles by this author Metrics & Citations Metrics Article Usage 186 views 209 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Harsahib Singh Sandhu, Ankur Wadhera, Shubhra Jain, et al. Primary Splenic Inflammatory Myofibroblastic Tumor, a rare Case and its Differential Diagnosis. Authorea . 16 September 2025. DOI: https://doi.org/10.22541/au.175801700.03252946/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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