Behavioral assessment for anxiety at 7 days after sham or endometriosis surgery.

Annelyn Torres-Reverón (5650028), Leslie L. Rivera-Lopez (5963024), Idhaliz Flores (5650034), Caroline B. Appleyard (5650037)
2018 · doi:10.1371/journal.pone.0197698.g002 · W6904693057
Lab / animal OA: green CC0
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Mice subjected to endometriosis surgery exhibited significantly increased anxiety-like behavior in open field and zero maze tests compared to sham-operated controls at seven days post-surgery.

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The study evaluated anxiety-like behaviors in mice seven days after undergoing either sham surgery or endometriosis induction. Researchers utilized open field and zero maze tests to measure locomotor activity and time spent in central or open areas as indicators of anxiety. The results demonstrated that mice with endometriosis exhibited significantly reduced total distance traveled and less time spent in the center of the arena compared to the sham group, indicating increased anxiety levels following disease induction. This paper is centrally about endometriosis, specifically examining the behavioral and psychological comorbidities associated with the condition through a surgical mouse model.

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Abstract

(A) Total distance traveled during the first 5 minutes of the open field test and (B) time spent in the center of the arena. (C) Total distance traveled in the zero maze during the 5 min duration of the test and the amount of time spent in the open segments of the maze (D). * represents p< 0.05 compared to sham group. n = 8 in each group.
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Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis Fig 2 Behavioral assessment for anxiety at 7 days after sham or endometriosis surgery. (A) Total distance traveled during the first 5 minutes of the open field test and (B) time spent in the center of the arena. (C) Total distance traveled in the zero maze during the 5 min duration of the test and the amount of time spent in the open segments of the maze (D). * represents p< 0.05 compared to sham group. n = 8 in each group.

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endometriosis

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last seen: 2026-05-11T08:51:17.274897+00:00
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