A Clinical study on anti-angiogenesis therapy for endometriosis

Objecive To investigate the clinical efficacy of anti-angiogenesis therapy for endometriosis.Methods 60 patients with endometriosis who visited our hospital from March 2007 to June 2011(l) were randomly assigned to receive mifepristone combined with laparoscopic surgery ( 30 patients,study group ),or laparoscopic surgery alone ( 30 patients,control group ).The efficacy and microvessel density ( MVD ) were compared and analyzed.Results In the study group,the total effectiveness rate was 83.3％ ( 25 patients ),with eutopic endometrial microvascular density of 14± 3 and ectopic endometrial microvascular density of 13 ± 3; whereas inn the control group,the total effectiveness rate was 56.7％ ( 17 patients ),with eutopic endometrial microvascular density of 23 ± 4 and ectopic endometrial microvascular density of 27 ± 2 ( P ＜ 0.05 ).Conclusions Mifepristone is a great antiangiogenic drug.It can effectively reduce the density of blood vessels in lesions and improve the therapeutic effect. Key words: Endometriosis; Angiogenesis; Clinical research