Abstract
POI remains poorly understood and under-researched. Women with POI require integrated care to address physical, psychosocial and reproductive health as well as preventative strategies to maintain long-term health. However, there is an absence of evidence-based guidelines for diagnosis and management. For many aspects of POI research, a prospective international database recruiting many thousands of cases is the only realistic way in which meaningful data will be gathered to answer many of the questions for which there is only speculation at present. As is the case with a number of other centres, we have been collecting data from our cohort of women with POI for a number of years. We have over 500 subjects to date registered in our West London Menopause Centre database. The next step is to amalgamate these data with those of our colleagues globally. We have already had verbal agreement from more than 20 international experts in POI who would be willing to contribute to such a database. An online Website is currently being designed and is due to go live this year. We hope this will ultimately lead to better understanding of the condition and the establishment of refined guidelines for the targeted care of young women with POI to optimise both their short- and long-term outcomes.
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References
Panay N, Fenton A (2008) Premature ovarian failure: a growing concern. Climacteric 11(1):1–3
Sklar CA, Mertens AC, Mitby P, Whitton J, Stovall M, Kasper C et al (2006) Premature menopause in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 98:890–896
Islam R, Cartwright R (2011) The impact of premature ovarian failure on quality of life: results from the UK 1958 Birth Cohort. Paper presented at the ESHRE, Stockholm, June 2011, Abstract 0–270
Singer D, Mann E, Hunter MS, Pitkin J, Panay N (2011) The silent grief: psychosocial aspects of premature ovarian failure. Climacteric 14(4):428–437
Graziottin A (2007) Effect of premature menopause on sexuality. Womens Health 3(4):455–474
Groff AA, Covington SN, Halverson LR, Fitzgerald OR, Vanderhoof V, Calis K, Nelson LM (2005) Assessing the emotional needs of women with spontaneous premature ovarian failure. Fertil Steril 83(6):1734–1741
Sowers M, McConnell D, Gast K, Zheng H, Nan B, McCarthy JD, Randolph JF (2008) Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition. J Clin Endocrinol Metab 93(9):3478–3483
Tehrani FR, Shakeri N, Solaymani-Dodaran M, Azizi F (2011) Predicting age at menopause from serum anti-mullerian hormone concentration. Menopause 18(7):766–770
Broer SL, Eijkemans MJ, Scheffer GJ et al (2011) Anti-mullerian hormone predicts menopause: a long-term follow-up study in normo-ovulatory women. J Clin Endocrinol Metab 96(8):2532–2539
de Villiers TJ, Gass ML, Haines CJ, Hall JE, Lobo RA, Pierroz DD, Rees M (2013) Global consensus statement on menopausal hormone therapy. Climacteric 16:203–204
de Villiers TJ, Pines A, Panay N, Gambacciani M, Archer DF, Baber RJ, Davis SR, Gompel AA, Henderson VW, Langer R, Lobo RA, Plu-Bureau G, Sturdee DW, International Menopause Society (2013) Updated 2013 International Menopause Society recommendations on menopausal hormone therapy and preventive strategies for midlife health. Climacteric 16(3):316–337
Lokkegaard E, Jovanovic Z, Heitmann BL, Keiding N, Ottesen B, Pedersen AT (2006) The association between early menopause and risk of ischaemic heart disease: influence of hormone therapy. Maturitas 53:226–233
Pouilles JM, Tremollieres F, Bonneu M, Ribot C (1994) Influence of early age at menopause on vertebral bone mass. J Bone Miner Res 9:311–315
Rocca W, Bower J, Maraganore DM et al (2007) Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause. Neurology 69:1074–1083
Guttmann H, Weiner Z, Nikolski E et al (2001) Choosing an oestrogen replacement therapy in young adult women with Turner’s syndrome. Clin Endocrinol (Oxf) 54(2):157–158
Cartwright B, Robinson J, Rymer J (2010) Treatment of premature ovarian failure trial: description of an ongoing clinical trial. Menopause Int 16:18–22
White YA, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL (2012) Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. Nat Med 18(3):413–421
Panay N, Fenton A (2012) Premature ovarian insufficiency: working towards an international database. Climacteric 15(4):295–296
Cooper AR, Baker VL, Sterling EW, Ryan ME, Woodruff TK, Nelson LM (2011) The time is now for a new approach to primary ovarian insufficiency. Fertil Steril 95(6):1890–1897
Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ, STRAW + 10 Collaborative Group (2012) Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging. Climacteric 15(2):105–114
Maclaran K, Panay N (2012) Presentation and management of POF: findings from the West London POF database. In: Plenary Session, World Congress of Gynecological Endocrinology, Firenze, Italy, 7–10 March 2012
Panay N (2012) Primary ovarian insufficiency working towards an international database. In: Plenary Session, World Congress of Gynecological Endocrinology, Firenze, Italy, 7–10 March 2012
Maclaran K, Bellone C, Panay N (2012) Premature ovarian failure: development of an international registry. In: 9th European Congress on Menopause and Andropause, Athens Greece, 28–31 March 2012
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Panay, N. (2014). Premature Ovarian Insufficiency: Strategies to Preserve Good Health and Fertility. In: Genazzani, A.R., Brincat, M. (eds) Frontiers in Gynecological Endocrinology. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-319-03494-2_12
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DOI: https://doi.org/10.1007/978-3-319-03494-2_12
Publisher Name: Springer, Cham
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Keywords
- Hormone Replacement Therapy
- Strontium Ranelate
- Antral Follicle Count
- Primary Ovarian Insufficiency
- Premature Menopause
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.