Splenic peliosis with spontaneous splenic rupture in a patient with immune thrombocytopenia treated with danazol.

Francisco‐Javier Peñalver, Nieves Somolinos, Càndid Villanueva, Jesús Salgado Sánchez, Dolores Monteagudo, Rosa Gallego
In: Haematologica · 1998 · vol. 83(7) , pp. 666–7 · PMID:9718876 · W2249920516
article OA: closed CC0 ⤵ 2 in-corpus citations
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A patient with immune thrombocytopenia treated with danazol developed splenic peliosis, which led to spontaneous splenic rupture and death.

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Abstract

We present a 79-year-old man diagnosed with immune thrombocytopenia (ITP), treated with danazol, who died as a result of a spontaneously ruptured spleen. The histopathological diagnosis was splenic peliosis. This patient presents a chronological association between the treatment with danazol and the development of peliosis, which suggests a clear cause-effect relationship. Facing an individual patient with ITP, clinicians should weigh the potential benefits of danazol with the possible development of serious complications, such as hepatic failure or splenic rupture due to peliosis.

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