Effects of estradiol valerate and dienogest on quality of life and sexual function according to age.

Costantino Di Carlo, Virginia Gargano, Nicoletta De Rosa, Giovanni A. Tommaselli, Stefania Sparice, Carmine Nappi
In: Gynecological Endocrinology · 2014 · vol. 30(12) , pp. 925–928 · doi:10.3109/09513590.2014.975688 · PMID:25366390 · W2018114861
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

The E2V/DNG pill improved general health and vitality scores in women aged 25-45, with varying effects on sexual function domains across age groups but no overall difference by age.

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Abstract

This is an observational study on 102 women aged 25-45 years to evaluate if the E2V/DNG pill has any impact on quality of life (QoL) and sexual function (FSF). Thirty-nine women were younger than 35 years (group A), and 63 women were 35 years old or older (group B). At baseline and after 6 months, patients received the Italian validated version of the Short Form-36 questionnaire and the Italian validated version of the Female Sexual Function Index questionnaire. Group A showed an overall higher perception in all QoL scores at baseline and after 6-months (p < 0.05). E2V/DNG treatment did not exert any significant effect on QoL perception in group A apart from an increase in the GH domain (general health). In group B we observed a significant improvement both in GH and in VT (vitality) scores. We found a significant reduction in "lubrication" after 6 months both in group A and B (p < 0.01) and a significant improvement in "satisfaction" and "pain" scores in group A and in "desire", "satisfaction" and "total" score in group B (p < 0.01). The E2V/DNG pill is associated with a significant improvement of GH and VT and with an improvement in FSF with no difference between age groups.

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