PATHOGENESIS AND PATHOGENETICALLY SUBSTANTIATED THERAPY OF CHRONIC ENDOMETRITIS (сlinical lecture)

Sidorova Is, И. О. Макаров, A. L. Unanyan, R. S. Vlasov, D. V. Karpov
In: Акушерство, гинекология и репродукция, Vol 4, Iss 3, Pp 21-24 (2016) · 2016 · W4301757595
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This lecture discusses chronic endometritis pathogenesis, highlighting immune deficiency, angioarchitectonics, and redox imbalance, and proposes Actovegin as a therapy to address these factors by stimulating antioxidant systems and rehabilitating endometrial function.

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The paper is a clinical lecture on chronic endometritis (CE), addressing the lack of a unified pathogenetic concept and proposing that immune deficiency, disrupted endometrial angioarchitecture, and imbalances between pro- and antioxidant systems contribute to disease development. It argues that therapy should stimulate natural antioxidant defenses and provide exogenous antioxidants, describing Actovegin as a drug with biologically active components (amino acids, oligopeptides, nucleosides, oligosaccharides/glycolipides, enzymes, electrolytes, and macro- and micronutrients) aimed at these pathogenic links. A stated rationale is that exacerbation of chronic inflammation can occur after abortion and therapeutic surgical procedures, so rehabilitation of the structural and functional state of the endometrium with Actovegin is presented as an important measure in post-abortion/postpartum CE and around treatment-diagnostic curettage. This paper is centrally about endometriosis—no; it does not explicitly discuss endometriosis or adenomyosis, and it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Chronic endometritis (CE) - a common disease with no unified concept of pathogenesis, characterized by undulating and ever-progressive pathological process. Important pathogenic factors contributing to the development of CE, is immune deficiency and violation of endometrium angioarchitectonics. Currently has been widely discussed question of the pro- and antioxidant systems imbalance role in the pathogenesis of HE. From these positions, it is obvious that the stimulation of natural antioxidant systems, introduction of exogenous antioxidants - one of the essential moments in the treatment of CE. Actovegin is a one of the modern drugs which is best meets the requirements of CE pathogenic-based therapy and has an impact on the above links of pathogenesis. Actovegin contains components with high biological activity: amino acids, oligopeptides, nucleosides, oligosaccharides and glycolipides, enzymes, electrolytes, and a number of important macro- and micronutrients. Exacerbation of already existing chronic inflammation often occurs after an abortion and therapeutic surgical procedures. Therefore, an important measure to prevent the exacerbation of chronic endometritis, an essential part of the treatment of post-abortion or postpartum CE, treatment and diagnostic curettage is the rehabilitation of structural and functional state of the endometrium with the use of Actovegin.
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Акушерство, гинекология и репродукция (Sep 2016) PATHOGENESIS AND PATHOGENETICALLY SUBSTANTIATED THERAPY OF CHRONIC ENDOMETRITIS (сlinical lecture) Abstract Chronic endometritis (CE) - a common disease with no unified concept of pathogenesis, characterized by undulating and ever-progressive pathological process. Important pathogenic factors contributing to the development of CE, is immune deficiency and violation of endometrium angioarchitectonics. Currently has been widely discussed question of the pro- and antioxidant systems imbalance role in the pathogenesis of HE. From these positions, it is obvious that the stimulation of natural antioxidant systems, introduction of exogenous antioxidants - one of the essential moments in the treatment of CE. Actovegin is a one of the modern drugs which is best meets the requirements of CE pathogenic-based therapy and has an impact on the above links of pathogenesis. Actovegin contains components with high biological activity: amino acids, oligopeptides, nucleosides, oligosaccharides and glycolipides, enzymes, electrolytes, and a number of important macro- and micronutrients. Exacerbation of already existing chronic inflammation often occurs after an abortion and therapeutic surgical procedures. Therefore, an important measure to prevent the exacerbation of chronic endometritis, an essential part of the treatment of post-abortion or postpartum CE, treatment and diagnostic curettage is the rehabilitation of structural and functional state of the endometrium with the use of Actovegin.

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