Refractory Depressed and Anxious States in Hyperthymic Women: A Case Series Generated by a Speaking Engagement.

Manning JS
Primary care companion to the Journal of clinical psychiatry · 2000 · doi:10.4088/pcc.v02n0105 · PMID:15014663 · PMC181104
OA: closed
📄 Open PDF Full text JSON View on PubMed View at publisher
⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-11 · read from full text ⓘ

This case series examines four referrals resulting from a lecture on mixed anxious and depressive illness, focusing on hyperthymic women who experience fatigue and episodic depression despite being energetic and productive. The author posits that these patients exhibit premorbid hypomanic tendencies, suggesting their condition represents a soft form of bipolar illness that responds to somatic pharmacologic interventions similar to classic manic depressive illness. A key limitation noted is the small sample size derived directly from referrals following a speaking engagement rather than a structured clinical trial. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

The author discusses 4 referrals that were the direct result of a case description from his own practice that he presented during a lecture on the treatment of mixed anxious and depressive illness in primary care. The cases depict energetic, productive women who suffer fatigue and episodic depressions. These cases suggest that hyperthymic temperaments complicated by depressive episodes represent a form of mood disorder presentation that is highly recognizable and responsive to pharmacologic intervention. Such premorbid temperamental hypomanic tendencies may represent a soft form of bipolar illness that requires somatic strategies in line with those of classic manic depressive illness. The cases underscore the challenge of treating mood disorders and the need for treatment research to reach primary care practitioners, who see the majority of depressed and anxious patients.
Full text 1,016 characters · extracted from oa-doi-fallback · click to expand
The author discusses 4 referrals that were the direct result of a case description from his own practice that he presented during a lecture on the treatment of mixed anxious and depressive illness in primary care. The cases depict energetic, productive women who suffer fatigue and episodic depressions. These cases suggest that hyperthymic temperaments complicated by depressive episodes represent a form of mood disorder presentation that is highly recognizable and responsive to pharmacologic intervention. Such premorbid temperamental hypomanic tendencies may represent a soft form of bipolar illness that requires somatic strategies in line with those of classic manic depressive illness. The cases underscore the challenge of treating mood disorders and the need for treatment research to reach primary care practitioners, who see the majority of depressed and anxious patients. From the Editors Are you a healthcare provider? Add your NPI to personalize your JCP experience. This PDF is free for all visitors!

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-09-13T09:25:22.628771+00:00