Role of Klf11 in the regulation of Col1a1 expression.

Gaurang S. Daftary (395672), Ye Zheng (169955), Zaid M. Tabbaa (395673), John K. Schoolmeester (395674), Ravi P. Gada (395675), Adrienne L. Grzenda (395676), Angela J. Mathison (395677), Gary L. Keeney (395678), Gwen A. Lomberk (345905), Raul Urrutia (1537)
2015 · doi:10.1371/journal.pone.0060165.g007 · W6942012043
other OA: green CC0
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Abstract

(A) Collagen 1A1 mRNA expression levels were determined from one of two endometriotic implants in each animal (Klf11-/- and wildtype). Col1a1 mRNA expression levels were increased 7.55±0.48 fold (p<0.05) in implants from Klf11-/- animals compared to wildtype. (B, C) Histochemical evaluation using Masson′s trichrome staining showed that collagen deposition (blue stain, white arrow) was increased in the tissue surrounding peritoneal endometriosis implants in Klf11-/- animals (C) in contrast to wildtype controls (B) Magnification: 100×.

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endometriosis

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