The association between hormonal variation, antioxidant status and oxidative stress in Iraqi women with endometriosis

Tamara Sami Naji, Salwa H. N. Al- Rubae’I, Kismat M. Turki
In: مجلة كلية الطب, Vol 58, Iss 2 (2016) · 2016 · doi:10.32007/jfacmedbagdad.v2192-196 · W4406826302
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study found increased estradiol, uric acid, and oxidative stress markers, along with decreased antioxidant vitamins and Coenzyme Q10, in Iraqi women with endometriosis compared to controls.

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This study investigated hormonal variation, antioxidant status—including serum vitamins A, E, β-carotene, and C and coenzyme Q10—and oxidative stress markers in Iraqi women, comparing 30 laparoscopically evaluated endometriosis patients (mean age 31.16) with 30 healthy controls (mean age 31.96). The researchers reported significantly higher estradiol, uric acid, and oxidative stress (malondialdehyde, MDA) in the endometriosis group, alongside significantly lower coenzyme Q10 and antioxidant vitamin levels. They also found significant correlations between several hormones and vitamin measures, and a positive association between uric acid and increasing MDA. The paper’s limitation is its small sample size and observational case-control design based on these single-group measurements. This paper is centrally about endometriosis — it focuses on hormonal and oxidative stress/antioxidant differences between Iraqi endometriosis patients and controls.

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Abstract

Background: In the last years, Endometriosis affects up to 10 percent of reproductive aged Iraqi women. Little is known about the etiology of endometriosis in Iraqi women. Objectives: The aim of this study is to investigate the hormonal changes, antioxidant status, Coenzyme Q10 and oxidative stress in women patients with endometriosis. Patients and methods: 30 endometriotic women mean aged (31.16±5.61 year ) who were undergoing laparoscopy to participate in this study, and (n=30) healthy women volunteers mean aged (31.96±5.42 year) as control group. Results: The results in this study revealed a highly significant increased (P<0.01) in estradiol (E2), uric acid (UA) and oxidative stress (MDA). The results of the Coenzyme Q10 (CoQ10) and vitamins (A, E, β-carotene, C) showed a highly significant decreased (P<0.01) in the sera levels of patients with endometriosis as compared to control. This study showed, there was a significant negative correlation between the levels of Luteinizing Hormone (LH), Follicle Stimulating Hormones (FSH), Testosterone (Test.), E2 and vitamins, whereas a significant positive correlation was observed in UA level with concomitant increase in MDA levels. Conclusions: The results of this study concluded the increase of oxidative stress and the decrease of antioxidant vitamins and CoQ10. Thus increasing the growth and adhesion of endometrial cells in the peritoneal cavity, which will lead to increase the risk factors of endometriosis.
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مجلة كلية الطب (Jul 2016) The association between hormonal variation, antioxidant status and oxidative stress in Iraqi women with endometriosis Abstract Background: In the last years, Endometriosis affects up to 10 percent of reproductive aged Iraqi women. Little is known about the etiology of endometriosis in Iraqi women. Objectives: The aim of this study is to investigate the hormonal changes, antioxidant status, Coenzyme Q10 and oxidative stress in women patients with endometriosis. Patients and methods: 30 endometriotic women mean aged (31.16±5.61 year ) who were undergoing laparoscopy to participate in this study, and (n=30) healthy women volunteers mean aged (31.96±5.42 year) as control group. Results: The results in this study revealed a highly significant increased (P<0.01) in estradiol (E2), uric acid (UA) and oxidative stress (MDA). The results of the Coenzyme Q10 (CoQ10) and vitamins (A, E, β-carotene, C) showed a highly significant decreased (P<0.01) in the sera levels of patients with endometriosis as compared to control. This study showed, there was a significant negative correlation between the levels of Luteinizing Hormone (LH), Follicle Stimulating Hormones (FSH), Testosterone (Test.), E2 and vitamins, whereas a significant positive correlation was observed in UA level with concomitant increase in MDA levels. Conclusions: The results of this study concluded the increase of oxidative stress and the decrease of antioxidant vitamins and CoQ10. Thus increasing the growth and adhesion of endometrial cells in the peritoneal cavity, which will lead to increase the risk factors of endometriosis. Keywords

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