[Experimental research on the treatment of mouse endometriosis model with nanoparticles loaded with CCR5-antibody].

Yuyi Zhang, Y Y Zhang, Zhang YY, Li P, Peng Li, P Li
Zhonghua fu chan ke za zhi · 2019 · vol. 54(10) , pp. 680–686 · doi:10.3760/cma.j.issn.0529-567x.2019.10.006 · PMID:31648444 · W2991239359
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PLGA/anti-CCR5 nanoparticles inhibited mouse endometriosis by reducing macrophage-secreted IL-10 and TGF-β, thereby inhibiting endometrial cell proliferation and invasion.

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Abstract

In mouse endometriosis model, PLGA/anti-CCR5 may inhibit the proliferation and invasion of EEC by inhibiting the secretion of IL-10 and TGF-β by macrophages, suggesting that it provide a new idea for the treatment of clinical endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Lactic Acid Nanoparticles Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer Receptors, CCR5 Animals Endometriosis Endometriosis Female Humans Lactic Acid Mice Nanoparticles Nanoparticles Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer Receptors, CCR5 Treatment Outcome

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europepmc
last seen: 2026-08-21T06:14:13.963979+00:00
openalex
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pubmed
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License: CC0 · commercial use OK