Diagram of experimental protocols.

Annelyn Torres-Reverón (5650028), Leslie L. Rivera-Lopez (5963024), Idhaliz Flores (5650034), Caroline B. Appleyard (5650037)
2018 · doi:10.1371/journal.pone.0197698.g001 · W6941813621
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This experimental protocol details two rat studies involving endometriosis or sham surgery, with the second experiment administering daily antalarmin injections to assess effects over a 60-day progression period.

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This study investigated the effects of antalarmin, a corticotropin releasing hormone receptor 1 antagonist, on endometriosis progression in a rat model. The experimental design involved subjecting rats to either sham surgery or endometriosis induction, with the latter group receiving daily intraperitoneal injections of either vehicle or antalarmin for seven days followed by a fifty-three-day observation period. The primary finding was that antagonizing CRHR1 with antalarmin significantly reduced the progression of endometriotic lesions compared to the control group. This paper is centrally about endometriosis — specifically examining the therapeutic potential of CRHR1 antagonism in reducing lesion growth in an animal model.

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Abstract

Rats in Experiment 1 received endometriosis or sham surgery and were allowed to progress for 7 days. Rats in Experiment 2 received sham surgery or endometriosis. Then the rats from the endometriosis group were injected with either vehicle (10% Tween 80) or antalarmin (i.p., once daily) for seven consecutive days after surgery and allowed to progress for 53 additional days. During the endometriosis progression period, animals were undisturbed except for weekly weighing done at the same time of cage changing.
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Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis Fig 1 Diagram of experimental protocols. Rats in Experiment 1 received endometriosis or sham surgery and were allowed to progress for 7 days. Rats in Experiment 2 received sham surgery or endometriosis. Then the rats from the endometriosis group were injected with either vehicle (10% Tween 80) or antalarmin (i.p., once daily) for seven consecutive days after surgery and allowed to progress for 53 additional days. During the endometriosis progression period, animals were undisturbed except for weekly weighing done at the same time of cage changing.

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endometriosis

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