Endometriosis : genetics, imaging, quality of life

A. A. de Graaff
2016 · doi:10.26481/dis.20161207ag · W2784303479
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This dissertation explores the genetic roles of B lymphocyte stimulator and paired-box 2 in endometriosis pathogenesis, the association between MRI characteristics and colorectal endometriosis infiltration depth, and the persistent impact of symptoms on patient quality of life.

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This dissertation investigates three aspects of endometriosis: genetic and molecular factors, imaging correlates, and quality of life. It reports studies of the B lymphocyte stimulator and the paired-box 2 gene, finding both appear to play a role in endometriosis pathogenesis. It also examines whether specific MRI characteristics are associated with the histological infiltration depth of the intestinal wall in patients with colorectal endometriosis, and describes that chronic pelvic pain and dyspareunia tend to persist in women treated in a tertiary hospital, impacting quality of life. This paper is centrally about endometriosis — it focuses on genetic/molecular mechanisms, MRI-imaging correlations in colorectal disease, and quality-of-life outcomes.

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Abstract

Endometriosis is a common and benign gynaecological disease. Common symptoms include menstrual pain, pain during intercourse, chronic pain and impaired fertility. This dissertation presents and describes three aspects of endometriosis: genetic and molecular aspects, imaging and quality of life. The B lymphocyte stimulator and the paired-box 2 gene were studied and both appear to play a role in the pathogenesis of endometriosis. This study also investigated the extent to which certain MRI characteristics are associated with the histological infiltration depth in the intestinal wall of patients with colorectal endometriosis. The last chapter of this dissertation explains that symptoms such as chronic pelvic pain and dyspareunia tend to persist in women with endometriosis, despite the patients having been treated in a tertiary hospital. This has a significant impact on their quality of life.
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Abstract

Endometriosis is a common and benign gynaecological disease. Common symptoms include menstrual pain, pain during intercourse, chronic pain and impaired fertility. This dissertation presents and describes three aspects of endometriosis: genetic and molecular aspects, imaging and quality of life. The B lymphocyte stimulator and the paired-box 2 gene were studied and both appear to play a role in the pathogenesis of endometriosis. This study also investigated the extent to which certain MRI characteristics are associated with the histological infiltration depth in the intestinal wall of patients with colorectal endometriosis. The last chapter of this dissertation explains that symptoms such as chronic pelvic pain and dyspareunia tend to persist in women with endometriosis, despite the patients having been treated in a tertiary hospital. This has a significant impact on their quality of life. | Original language | English | |---|---| | Awarding Institution | - Maastricht University | | Supervisors/Advisors | - Evers, Johannes, Supervisor - Dirksen, Carmen, Supervisor - Dunselman, Gerard, Co-Supervisor | | Award date | 7 Dec 2016 | | Place of Publication | Maasricht | | DOIs | | | Publication status | Published - 2016 |

Keywords

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endometriosischronic_pelvic_paindyspareunia

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