Influence of Hormonal Status and Menstrual Cycle Phase on Psychopatology in Acute Admitted Patients with Schizophrenia.

Miroslav Herceg, Krešimir Puljić, Mirna Sisek-Šprem, Dora Herceg
In: Psychiatria Danubina · 2018 · vol. 30(Suppl 4) , pp. 175–179 · PMID:29864756 · W3024709765
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study found that women with schizophrenia were significantly more likely to be admitted during the luteal phase of their menstrual cycle, though sex hormones did not significantly impact admission rates or psychopathology.

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Abstract

BACKGROUND: The gender differences in onset, symptom severity, and outcome of schizophrenia are now thought to support the hypothesis that sex hormones may also have a role in etiology, as well as treatment, of schizophrenia. A number of reproductive hormones may be implicated, including testosterone, progesterone, or luteinising hormone, and thus it is important to acknowledge that there is a complex interplay of hormones occurring. This study was introduced to highlight the effect of the menstrual cycle, and sex hormones on female patients with schizophrenia. SUBJECTS AND METHODS: The sample consisted of 31 consecutively acute admitted women, aged 18 to 45 years with schizophrenia diagnosed by DSM-5 criteria. The sample consisted of women who were regulary menstruating and to be undergoing regular hormonal fluxes. Each subject was enrolled and received psychopathology and hormone (estradiole, progesterone, testosterone) assessments. Psychopathology was measured with Positive end Negative Syndrome Scale (PANSS). The subjects were divided into folicular (high estrogen) and luteal (low estrogen) phase admissions. Data were analyzed by regression analysis and t-test for independent samples. Values are given as means ±SD. RESULTS: There were no differences between the folicular and luteal phase admission grups with regard to age, duration of illness and age at onset of illness. We found that significantly more women were admitted during the luteal (low estrogen) phase of menstrual cycle (68%) as compared to follicular (high estrogen) phase (32%). CONCLUSION: There was a significant increase in hospital admissions in the luteal phase of menstrual cycle in women suffering from exacerbation of schizophrenia. The influence of particulary sex hormones (estrogen, progesterone and testosterone) on admission rate and clinical psychopatology was found insignificant.

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chemicals 12
testosterone progesterone estradiol progesterone testosterone estrogen estrogen estrogen sex hormone estrogen progesterone testosterone
organisms 3
noordeloos 2009062 noordeloos 2009062 noordeloos 2009062

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