Cyclic Sciatica and Back Pain Responds to Treatment of Underlying Endometriosis: Case Illustration

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This case illustrates that endometriosis, when involving spinal neural elements, can cause cyclic sciatica and back pain that resolves with hormonal therapy or surgical removal of reproductive organs.

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Abstract

BACKGROUND: Multiple causes outside the spine can mimic spinal back pain. Endometriosis is an important gynecologic disorder, which commonly affects the lower region of the female pelvis and less frequently the spine and soft tissues. The lumbosacral trunk is vulnerable to pressure from any abdominal mass originating from the uterus and the ovaries. Therefore symptoms of endometriosis include severe reoccurring pain in the pelvic area as well as lower back and abdominal pain. CASE DESCRIPTION: We report on a 39-year-old gymnast with cyclic sciatica and back pain, whose initial presentation initially led to a spinal fusion at L4/5 and L5/S1, but that procedure did not change her symptoms. Her diagnosis of endometriosis was not made until 2 years after her spinal fusion. Ultimately, once diagnosed with endometriosis of the retroperitoneal spinal and neural elements, her back and leg pain responded completely to hormonal therapy and then to a hysterectomy and a bilateral salpingo-oophorectomy. Because her true diagnosis of endometriosis was unknown and she had some degenerative changes in her spine, she underwent a spinal fusion that would probably not have been done if the diagnosis of endometriosis had been suggested. CONCLUSIONS: It is critical for any clinician who deals with back pain to at least consider the diagnosis of endometriosis in female patients who have a history of pelvic pain. The diagnosis of endometriosis should be considered in candidate patients by asking whether there is a significant hormonal cyclic nature to the symptoms, to prevent such unnecessary surgical adventures.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Low Back Pain Low Back Pain Sciatica Sciatica Adult Diagnosis, Differential Endometriosis Endometriosis Female Humans Low Back Pain Low Back Pain Nerve Compression Syndromes Nerve Compression Syndromes Nerve Compression Syndromes Nerve Compression Syndromes Sciatica Sciatica

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europepmc
last seen: 2026-09-27T09:11:36.575535+00:00
pubmed
last seen: 2026-05-13T22:20:43.714878+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine