Ectopic expression of CYP24A1 circular RNA hsa_circ_0060927 in uterine leiomyomas

Elnaz Fazeli, Samira Piltan, Hossein Sadeghi, Milad Gholami, Ghasem Azizi‐Tabesh, Fakhrolmolook Yassaee, Reza Mirfakhraie
In: Journal of Clinical Laboratory Analysis · 2019 · vol. 34(4) · doi:10.1002/jcla.23114 · W2989817643
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This study found that hsa_circ_0060927 was ectopically expressed in uterine leiomyoma tissues, independent of MED12 mutations, providing initial evidence for circRNA involvement in leiomyoma development.

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Abstract

Abstract Background As a novel class of non‐coding RNAs, the role of circular RNAs (circRNAs) in tumor biogenesis and progression has been proved in a number of human tumors; however, up to now, the relation between circRNAs and uterine leiomyomas (ULM) remains unclear. Methods In this study, we have estimated the expression level of CYP24A1 hsa_circ_0060927 in uterine leiomyoma and adjacent tissues considering the mediator complex subunit 12 gene (MED12) mutation profile by quantitative real‐time polymerase chain reaction (qRT‐PCRs). Results Using Sanger sequencing method, somatic mutations in the MED12 exon 2 were detected in 14 (35.90%) ULM samples, including 10 (71.43%) missense mutations and 4 (28.57%) in‐frame deletions. Our results revealed that hsa_circ_0060927 was ectopically expressed in 33.33% of ULM tissues; although, this expression was independent of the MED12 mutation profile in the ULM samples. Conclusions Present results provide primary evidence for the role of circular RNAs in the leiomyoma development; however, further studies are essential to confirm the importance of these molecules as potential biomarkers for diagnosis and/or prognosis in ULM.

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