Expression of uPA and uPAR protein in endometrium tissues from endometriosis patients

Aim:To investigate the expression of uPA and uPAR in endometrium tissue of endometriosis.Methods:Immunohistochemistry method was used to detect the expressions of uPA and uPAR protein in 40 cases of ectopic endometrium,40 cases of eutopic endometrium,and 30 cases of normal endometrium without endometriosis.Results:uPA and uPAR protein were found in stromaland cells and epithelial cells from ecpotic,eutopic and normal endometrium.The positive rate of uPA protein in stromal cells of ecpotic endometrium was 85.0%,higher than that of 60.0% in epithelial cells of ecpotic endometrium(χ2=6.72,P0.05),and higher than those of 57.5% and 40.0% in stromal cells of eutopic endometrium and normal endometrium(χ2=16.40,15.41,P0.05).The positive rate of uPAR in epithelial cells of ectopic endometrium was 87.5%,higher than that of 40.0% in stomal cell of ecpotic endometrium(χ2=10.12,P0.05),and also higher than those of 65.0% and 46.7% in epithelial cells of eutopic and normal endometrium(χ2=5.59,13.61,P0.05).The expression of uPA in endometriotic stromal cells had a positive relationship with the expression of uPAR in endometriotic epithelial cells(rp=0.327,P0.05).Conclusion:Overexpression of uPA in endometriotic stromal cells and uPAR protein in endometriotic epithelial cells might be of importance for the migratory,adherance,invasion and growth of ectopic endometrium.