Expression and Function of Tumor Necrosis Factor- α-induced protein 8-like (TIPE) family in glioma

Background: Although novel strategies of glioma are emerging sequentially, the effectiveness of novel treatment remains suboptimal at present. Therefore, profiles of molecular are needed for improving diagnosis, survival prediction and identification of therapeutic targets for glioma. Tumor necrosis factor-α-induced protein 8-like (TNFAIP8/TIPE) family members are involved in tumorigenesis and inflammatory responses but have been poorly studied in glioma. In this study, we aimed to investigate the expression and functions of TIPE family in glioma. Methods: : The expression data of the TIPE family from the Chinese Glioma Genome Atlas (CGGA), the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were conducted to analyze TIPEs expression and functional networks in gliomas. Kaplan-Meier analysis and Cox regression were performed to access the overall survival of these genes. The related functional networks were identified using Gene Set Enrichment Analysis and LinkedOmics. The relationship between TNFAIP8 and tumor immune system were analyzed by TISIDB. Results: : The results shown that TIPEs were generally expression in gliomas. Glioma patients with high TNFAIP8 levels tend to be more malignant than those with low expression and are associated with reduced survival. GSEA identified a variety of oncogenic and immune pathway that were tightly linked with TNFAIP8. TISIDB data found that TINAIP8 expression was significantly positively correlated with immune infiltrates cells and immune-related factors. Conclusions: : TNFAIP8 exhibit crucial role in reduced survival in glioma and could serve as a potential prognostic biomarker. The present study revealed the expression patterns and potential functional networks of TNFAIP8 in glioma, providing insights for future research of the role of TNFAIP8 in carcinogenesis.