Ezrin T567 phosphorylation regulates migration and invasion of ectopic endometrial stromal cells by changing actin cytoskeleton

Chen C, Chaolu Chen, Chaoshuang Ye, Ye C, Xia J, Jianmei Xia, Zhou Y, Yong Zhou, Ruijin Wu, Wu R
Life sciences · 2020 · vol. 254 , pp. 117681 · doi:10.1016/j.lfs.2020.117681 · PMID:32380081 · W3022270572
article OA: closed CC0 ⤵ 14 in-corpus citations
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This study investigated how Ezrin T567 phosphorylation influences the migration and invasion of ectopic endometrial stromal cells by altering their actin cytoskeleton.

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Abstract

AimsThe enhanced ability of endometrial cell migration and invasion is the foundation for formation of ectopic lesions in endometriosis. Ezrin has been reported to regulate cell motility by remodeling the cytoskeleton. However, little is known about the mechanisms through which ezrin remodels the cytoskeleton and cell structure to promote cell motility in endometriosis.MethodsIn our study, expression and distribution of ezrin, and Rho pathway were detected through immunohistochemical analysis. The effects of inhibiting ezrin T567 phosphorylation on Rho signaling pathway and cytoskeleton were investigated through western blot, transmission electron microscopy and immunofluorescence analysis.Key findingsWe found that the expression of ezrin and Rho pathway was higher in ectopic endometrium. NSC305787 inhibited the phosphorylation of ezrin T567, resulting in decreased expression of Rho pathway and reduced filopodia formation in ectopic endometrial stromal cells.SignificanceTaken together, our study suggested that ezrin T567 phosphorylation modulated migration and invasion of ectopic ESCs through actin reconstructions, which may serve as a novel therapeutic target in ovarian endometriosis.

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MeSH descriptors

Actin Cytoskeleton Cell Movement Cytoskeletal Proteins Endometrium Stromal Cells Actin Cytoskeleton Cytoskeletal Proteins Endometrium Ezrin Female Humans Phosphorylation Stromal Cells

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