Research of the relationship between polymorphisms of DNA repair gene XRCC3 and endometriosis

Objective To investigate the association of the polymorphisms in DNA repair gene XRCC3 with endometriosis risk.Methods The polymorphisms of DNA repair gene XRCC3 between endometriosis patients and controls were detected and whether XRCC3 were associated with the severity of endometriosis or not was evaluated.Genotypes of XRCC3 were analyzed by PCR-RELP.Results There was significantly difference between endometriosis and control groups of XRCC3 genetic polymorphism(P0.05).The expression of Thr/Met gene was significantly enhanced in endometriosis(P0.05).There was not association between the distributions of genotypes or alleles of XRCC3 and the stage of endometriosis.Conclusion Patients with XRCC3 Thr/Met or Met allele genotype have susceptibility to endometriosis,but the genotype is not associated with the stage of endomtriosis.