The SmartRX trial: Acute effectS of manipulating stRength eXercise volume on insulin sensitivity in overweight/obese adults: a protocol for a randomized controlled, crossover, clinical trial

The SmartRX trial: Acute effectS of manipulating stRength eXercise volume on insulin sensitivity in overweight/obese adults: a protocol for a randomized controlled, crossover, clinical trial | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The SmartRX trial: Acute effectS of manipulating stRength eXercise volume on insulin sensitivity in overweight/obese adults: a protocol for a randomized controlled, crossover, clinical trial Luis Filipe Rocha Silva, Bruna Caroline Chaves Garcia, Elizabethe Adriana Esteves, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3744670/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background : Type 2 diabetes mellitus is a disease in which insulin action on sensitive tissues is impaired, and even an acute bout of strength exercise can cause positive changes on insulin sensitivity. Current guidelines for strength exercise prescription suggest that 8 to 30 sets should be performed, although it is not known how such variations in volume impact insulin action. Additionally, this means an almost 4-fold difference in time commitment, which might directly impact an individual’s motivation and perceived capacity to exercise. This study will assess the effects of different strength exercise volumes on insulin sensitivity. Methods : Fourteen overweight/obese individuals of both sexes who are over 35 years old will undergo 3 experimental sessions in a random order, with a minimum washout period of 4 days between them, after being thoroughly familiarized with the procedures: Session 1: high-volume (7 exercises, 3 sets per exercise, 21 total sets)]; Session 2: low-volume (7 exercises, 1 set per exercise, 7 total sets); Session 3: control session, where no exercise will be performed. Psychological assessment (affect, enjoyment, and self-efficacy) will be performed after the sessions. All sessions will be held at night, and the next morning, an oral glucose tolerance test will be performed in a local laboratory, from which indexes of insulin sensitivity will be derived. Discussion : We believe this study will aid in strength exercise prescription for those individuals who claim not to have time to exercise and to those who perceive high-volume strength exercise intimidating to adhere to. Trial registration : Clinical trial registry number: ReBEC #RBR-3vj5dc5 (https://ensaiosclinicos.gov.br/rg/RBR-3vj5dc5) World Health Organization Universal Trial Number (UTN): U1111-1287-9212 Open Science Framework (OSF): https://osf.io/4gu87/ resistance exercise strength training exercise volume glucose tolerance oral glucose tolerance test obesity overweight insulin resistance Full Text Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3744670","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":285358990,"identity":"e3e9d6ed-b95d-4267-906a-362bded0f513","order_by":0,"name":"Luis Filipe Rocha Silva","email":"","orcid":"","institution":"UFVJM: Universidade Federal dos Vales do Jequitinhonha e Mucuri","correspondingAuthor":false,"prefix":"","firstName":"Luis","middleName":"Filipe Rocha","lastName":"Silva","suffix":""},{"id":285358991,"identity":"ee0bd714-3b9b-43b2-b533-707c46656170","order_by":1,"name":"Bruna Caroline Chaves 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tolerance test, obesity, overweight, insulin resistance","lastPublishedDoi":"10.21203/rs.3.rs-3744670/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3744670/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e:\u0026nbsp;Type 2 diabetes mellitus is a disease\u0026nbsp;in which\u0026nbsp;insulin action on sensitive tissues is impaired, and even an acute bout of strength exercise can cause positive changes on insulin sensitivity. Current guidelines for strength exercise prescription suggest that 8 to 30 sets should be performed, although it is not known how such variations in volume impact insulin action.\u0026nbsp;Additionally, this means an almost 4-fold difference in time commitment, which might directly impact an individual’s motivation and perceived capacity to exercise. This study will assess the effects of different strength exercise volumes on insulin sensitivity.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e:\u0026nbsp;Fourteen overweight/obese individuals of both sexes who are over 35 years\u0026nbsp;old will undergo 3 experimental sessions in a random order, with a minimum washout period of 4 days between them, after being thoroughly familiarized with the procedures: Session 1: high-volume (7 exercises, 3 sets per exercise, 21 total sets)]; Session 2: low-volume (7 exercises, 1 set per exercise, 7 total sets); Session 3: control session, where no exercise will be performed. Psychological assessment (affect, enjoyment, and self-efficacy) will be performed after the sessions. All sessions will be held at night, and the next morning,\u0026nbsp;an oral glucose tolerance test will be performed in a local laboratory, from which indexes of insulin sensitivity will be derived.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDiscussion\u003c/strong\u003e:\u0026nbsp;We believe this study will aid in strength exercise prescription for those individuals\u0026nbsp;who\u0026nbsp;claim not to have time to exercise and to those\u0026nbsp;who\u0026nbsp;perceive high-volume strength exercise intimidating to adhere to.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTrial registration\u003c/strong\u003e:\u0026nbsp;Clinical trial registry number: ReBEC #RBR-3vj5dc5 (https://ensaiosclinicos.gov.br/rg/RBR-3vj5dc5) World Health Organization Universal Trial Number (UTN): U1111-1287-9212 Open Science Framework (OSF): https://osf.io/4gu87/\u003c/p\u003e","manuscriptTitle":"The SmartRX trial: Acute effectS of manipulating stRength eXercise volume on insulin sensitivity in overweight/obese adults: a protocol for a randomized controlled, crossover, clinical trial","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-04-04 14:28:08","doi":"10.21203/rs.3.rs-3744670/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ba33c69b-25b9-4f30-a9e0-b24d75f5e474","owner":[],"postedDate":"April 4th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-04-26T14:07:22+00:00","versionOfRecord":[],"versionCreatedAt":"2024-04-04 14:28:08","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3744670","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3744670","identity":"rs-3744670","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}