The Correlation of Obesity Status with Serum 25-Hydroxyvitamin D in US Asian Adults：NHANES 2011-2018

Background: There is a correlation between obesity and 25-hydroxyvitamin D (25OHD) that tends to be negative. However, this relationship varies among different races. In this study, Asian adults with and without obesity were compared in terms of their levels of 25OHD. Methods: : We carried out a cross-sectional analysis on 2664 non-Hispanic Asian adults who participated in the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018. To examine the connection between obese status, body mass index (BMI), waist circumference (WC) and weight, and 25OHD, we ran multivariate linear regression models. Results: : In all three models, a negative association was observed between obesity status and 25OHD (model 1: β=-4.535, 95% CI: -6.987, -2.083; model 2 β=-4.249, 95% CI: -6.549, -2.039; model 3 β=-1.734, 95% CI: -7.285, 3.816). After controlling for covariates, there was a significant negative correlation between WC and 25OHD when stratified by gender and obesity status in both males with and without obesity (males with obesity: β=-1.461, 95% CI: -2.485, -0.436; males without obesity: β=-0.855. 95% CI: -1.499, -0.210). In males with obesity, there was a very strong positive connection between body weight and 25OHD (β=0.912, 95% CI: 0.227, 1.597). In addition, neither gender's obese individuals showed a significant link between BMI and 25OHD. Conclusion: This study found a weak correlation between obesity and 25OHD in non-Hispanic Asian individuals. Additionally, among male obese individuals, there was a significant negative correlation between WC and 25OHD, an observation that needs to be validated in further prospective studies.