Patient and community engagement in clinical platform trials

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AI-generated summary by claude@2026-07, 2026-07-17

This paper presents the Patient and Community Engagement in Platform Trials (PaCEPT) repository, which provides resources for patients, communities, and researchers to facilitate meaningful engagement in complex platform clinical trials.

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AI-generated deep summary by claude@2026-07, 2026-07-17 · read from full text

The paper describes patient and community engagement practices implemented within “clinical platform trials,” outlining how engagement is approached in the context of large, adaptable clinical research frameworks. It provides technical and operational details about trial engagement being integrated into trial infrastructure, but the content provided here is largely dominated by embedded JavaScript/analytics libraries rather than substantive descriptions of study design, participants, outcomes, or results. The key limitation is that, based on the supplied text, there is no clear presentation of findings or explicit caveats about engagement effectiveness, feasibility, or biases. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Platform trials measure the effects of multiple treatments against each other and against one control group simultaneously. Such approaches have the potential to revolutionize how clinical trials are conducted. Treatments can be developed faster, comparisons be made more easily, resources can be saved, and less participants are needed for trials. Within the Innovative Medicines Initiative (IMI) EU Patient Centric Clinical Trial Platform (EU PEARL) project, a public-private consortium aimed to build a framework for patient-centric platform trials together with patients and members of communities affected by four different conditions. The structured involvement of patient and community perspectives and input in research projects is increasingly viewed as a crucial and beneficial trial design factor. However, platform trials are complex endeavours, posing the question of how to involve patients and communities meaningfully. In this paper, we present a repository for Patient and Community Engagement in Platform Trials (PaCEPT), how it was developed, and how it can be used. PaCEPT contains information on general patient and community engagement, which is applicable to platform trials, as well as materials specifically developed for platform trials. The repository can support patients and communities in understanding what platform trials are and how they can benefit them, so that they can make evidence-informed decisions about participating in a platform trial. Further, people interested in becoming actively involved as an advisor for platform trials can gain in-depth insights that can prepare them well for such a role. PaCEPT also features materials that can help researchers to learn about the benefits of patient and community engagement for trial design and execution, and how to approach and include this stakeholder group. We encourage researchers to make use of this resource and call for evaluations of the implementation of the developed materials and the repository as a whole.
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