Clinical effectiveness of dopamine agonists in treatment of genital endometriosis

Clinical effectiveness of dopamine agonists in treatment of genital endometriosis Maria I. Yarmolinskaya / Elena V. Suslova / N.N.Tkachenko / The objective of the research work was to study the clinical effectiveness of the administration of cabergoline in women who have external genital endometriosis with pain syndrome. Patients and methods. We examined 227 patients aged 23 до 42 years who had a laparoscopically and histologically confirmed diagnosis of GE stage I–III according to the r-ASRM classification and complaints of chronic pain syndrome in the pelvic area, dyspareunia, algomenorrhoea. The control group included 12 women without any gynaecological pathology according to the findings obtained during laparoscopic surgery. Prolactin (PRL) levels in peripheral blood (PB) and peritoneal fluid (PF) were determined by the immunochemiluminescence assay. Pain syndrome was assessed using the McGill Visual Analogue Scale. The Statistica10 programme was used for processing the obtained data. Results. Higher PRL levels in PB and PF were found in patients with GE as compared with the control group. A correlation was found between the stage of GE and the PRL levels in PB (Rs = 0.28, p < 0.05), and also between the PRL levels in PF and the PRL levels in PF (Rs = 0.29, p < 0.05). The administration of cabergoline in combination with standard regimens of hormonal therapy resulted in a significant decrease of pain syndrome and a higher pregnancy rate. Conclusion. The use of cabergoline can be considered an effective targeted therapy for GE. Key words: pain, dopamine, cabergoline, prolactin, therapy, endometriosis. For citation: Yarmolinskaya M.I., Suslova E.V., Tkachenko N.N., Tolibova G.Kh. Clinical effectiveness of dopamine agonists in treatment of genital endometriosis. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2020; 19(3): 5–13. (In Russian). DOI: 10.20953/1726-1678-2020-3-5-13