Effect of early endometriosis on ovarian reserve and reproductive outcome

Kotaro Kitaya
In: Frontiers in Bioscience · 2011 · vol. 7(1) , pp. 40–45 · doi:10.2741/423 · PMID:22201918 · W2312308558
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The provided abstract discusses immunotherapeutic strategies and myeloid-derived cells in cancer, lacking any specific findings or context related to endometriosis, adenomyosis, ovarian reserve, or reproductive outcomes.

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This review examines the impact of early-stage, minimal to mild endometriosis on female reproductive health, contrasting it with the well-documented negative effects of advanced disease. The authors analyze accumulating evidence indicating that early pelvic lesions may deteriorate ovarian reserve, impair luteal function, and reduce fertilization rates in infertile women undergoing assisted reproduction. While the influence of these early lesions remains less clear than that of moderate or severe cases, the paper highlights specific biomarkers like anti-Mullerian hormone and antral follicular count as relevant indicators. This paper is centrally about endometriosis — specifically focusing on the reproductive consequences of its early, minimal, or mild stages.

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Abstract

Improved understanding of the cellular and molecular basis of adaptive immunity has been realized over the past few decades, leading to the development of novel immunotherapeutic strategies capable of promoting host anti-tumor immunity. In order to achieve clinically meaningful results, further understanding of the mechanisms by which tumors suppress host immunity, and the development of therapeutic strategies which overcome tumor-associated immune suppression, will be necessary. Myeloid-derived cells with potent immunosuppressive properties are ubiquitous in human cancers. Improved mechanistic understanding of factors promoting their development, activation and mechanisms of immune suppression are being translated into novel therapeutic approaches, and will be summarized herein.
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Abstract

Accumulating evidence suggests that advanced (moderate/severe) endometriosis negatively affects female fecundity, whereas the influence of early (minimal/mild) endometriosis on human reproduction remains unclear. Recent studies showed that the presence of the early pelvic endometriosis lesions deteriorates the ovarian reserve, luteal function, and fertilization rate in infertile women undergoing

Keywords

- Anti-Mullerian hormone - Antral follicular count - Early endometriosis - Ovarian reserve - Reproductive outcome - Review

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endometriosis

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