Case Report: Erythema gyratum repens associated with adenomyosis and endometriosis: an immunological twist?

A 37-year-old non-Caucasian woman presented with a 2-year history of pruritic, concentric erythematous plaques refractory to multiple topical and systemic therapies. The clinical findings were highly suggestive of erythema gyratum repens (EGR), a rare figurate dermatosis classically associated with paraneoplastic syndromes. Routine laboratory investigations and an autoantibody panel were unremarkable, except for a significantly elevated CA-125 level. A targeted gynecological assessment, prompted by a chronic history of pelvic pain and menorrhagia, identified severe adenomyosis with concomitant endometriosis. Given the severity of her symptoms, the patient underwent a total hysterectomy. Following surgery, the cutaneous eruption resolved completely within 2 months without additional dermatologic intervention. This case broadens the spectrum of non-paraneoplastic conditions associated with EGR and suggests that such eruptions may arise within the context of chronic inflammatory gynecological disease. Clinicians should remain aware of both paraneoplastic and non-paraneoplastic etiologies in patients presenting with EGR to ensure accurate diagnosis, appropriate malignancy screening, and tailored management. 1 Introduction Erythema gyratum repens (EGR) is a rare figurate dermatosis characterized by pruritic, concentric plaques with centrifugal spread. It typically involves the trunk and proximal extremities while sparing the hands, feet, and face (). Although most cases are paraneoplastic, EGR has also been reported in non-paraneoplastic settings, including autoimmune disorders, infections, drug reactions, and other benign dermatoses (, ). Here, we report a case of non-paraneoplastic EGR in a patient with severe adenomyosis and endometriosis that resolved following hysterectomy. We also review the spectrum of paraneoplastic and non-paraneoplastic triggers associated with EGR and summarize proposed pathogenetic mechanisms underlying the condition. 2 Case presentation A 37-year-old non-Caucasian woman presented to our dermatology clinic with a 2-year history of pruritic, concentric erythematous plaques with trailing scales, involving approximately 20% of her body surface area. The lesions progressively extended from the chest to the inframammary regions, flanks, and axillae (Figure 1). The patient reported that the lesions initially appeared as small erythematous patches (1–2 cm in diameter) that gradually coalesced into larger plaques measuring 8–22 cm, with apparent fluctuation in size in relation to her menstrual cycle. She also reported chronic pelvic pain and menorrhagia. Figure 1 Her medical history included hypertension, type 2 diabetes mellitus, two full-term pregnancies, and one miscarriage. She was a non-smoker, with no relevant occupational exposures or family history of malignancy. Prior empiric treatments included topical clobetasol propionate 0.05% ointment twice daily for 6 weeks, oral prednisone (0.5 mg/kg/day) for 2 weeks, topical ketoconazole 2% cream for 4 weeks, and oral fluconazole 150 mg weekly for 4 weeks, all without clinical improvement. Although the clinical presentation was highly suggestive of EGR, the differential diagnosis included erythema annulare centrifugum, erythema migrans, necrolytic migratory erythema, psoriasis, pityriasis rubra pilaris, tinea corporis, cutaneous T-cell lymphoma, lupus erythematosus, and drug-induced eruptions. Given that EGR is predominantly a paraneoplastic phenomenon, a definitive differentiation between a paraneoplastic and a non-paraneoplastic etiology could not be made on clinical or histopathological grounds alone. Therefore, an exhaustive oncologic search was required. A stepwise, multidisciplinary diagnostic work-up was initiated to exclude an underlying neoplasm. Laboratory testing, histopathology, and imaging were performed. Routine blood tests, inflammatory markers, and an autoantibody panel (ANA titer <1:40) were within normal limits. Tumor markers (CA 19-9, CEA, AFP) were within reference ranges, except for an elevated CA-125 level at 181.8 IU/mL (reference <35 IU/mL). Skin biopsy revealed mild acanthosis and spongiosis with a sparse superficial perivascular lymphocytic infiltrate and scattered eosinophils (Figure 2). Direct immunofluorescence performed on three separate sections was negative for IgG, IgA, IgM, and C3. Overall, histopathological findings were nonspecific but supportive of EGR by exclusion. Mycological examination, including direct microscopy and culture, was negative. Figure 2 Cross-sectional screening imaging, including mammography and contrast-enhanced computed tomography of the chest, abdomen, and pelvis, showed no evidence of malignancy. In view of persistent pelvic symptoms, a targeted gynecological ultrasound demonstrated an enlarged, globular uterus with heterogeneous myometrial texture, suggestive of adenomyosis. These findings were confirmed by a specialist gynecological assessment, which established a diagnosis of severe adenomyosis with concomitant endometriosis. A comprehensive multidisciplinary evaluation involving dermatology, gynecology, radiology, and internal medicine was instrumental in guiding the management strategy. The patient’s menorrhagia and chronic pelvic pain had been severely debilitating and refractory to multiple prior lines of conservative medical management, including oral contraceptives and non-steroidal anti-inflammatory drugs (NSAIDs). Crucially, the decision to proceed with a total abdominal hysterectomy with bilateral salpingectomy was purely therapeutic—aimed at treating her severe, symptomatic adenomyosis and endometriosis—rather than diagnostic, as comprehensive cross-sectional imaging had already ruled out pelvic malignancy. The patient strongly preferred definitive surgical intervention over further conservative or uterine-sparing strategies due to the profound impact of the symptoms on her quality of life. Histopathological examination of the surgical specimen confirmed severe adenomyosis and extensive endometriosis, with no evidence of atypia or malignancy. Strikingly, at the 2-month follow-up after surgery, the cutaneous lesions had completely resolved without additional dermatologic treatment (Figure 3). The patient was subsequently lost to follow-up, limiting long-term assessment. Figure 3 3 Discussion EGR is a rare figurate dermatosis most commonly reported in Caucasian populations (, ). It shows a male predominance (male-to-female ratio ≈ 2:1) and typically affects older adults (mean age around 63 years) (–). First described by Gammel in 1952, EGR was initially reported in a patient who developed the condition 9 months prior to a diagnosis of breast adenocarcinoma (). Since then, it has been classically considered a paraneoplastic dermatosis, with associated malignancies reported in approximately 70–82% of cases (, ). Nevertheless, an increasing number of non-paraneoplastic cases have been described (, , –), expanding the clinical spectrum (Table 1). Reported non-paraneoplastic associations include chronic inflammatory skin diseases (~52%), idiopathic cases (~32%), autoimmune disorders (~8%), systemic infections (~4%), and drug exposures (~4%) (–). Table 1 | Category | Entities | References | |---|---|---| | Malignancies | Lung cancer, esophageal cancer, breast cancer, stomach cancer, genitourinary cancer, lymphoma, multiple myeloma | Gammel JA () Silva et al. () Boehner et al. () | | Chronic inflammatory skin diseases | Psoriasis, pityriasis rubra pilaris, ichthyosis | Verma et al. () Demonchy (), Almaani et al. () Ridge et al. () | | Autoimmune disorders | Rheumatoid arthritis, CREST syndrome | Lo Schiavo et al. () Rongioletti et al. () | | Systemic infections | Tuberculosis, Helicobacter pylori | Barber et al. () Boehner et al. () | | Drug exposure | Azathioprine, interferon | von Rainer Günther et al. () Rongioletti et al. () | | Immunizations | COVID-19 vaccination | Chiquito et al. () | Clinical entities reported in association with EGR. Although these associations are well recognized, the pathogenesis of EGR remains incompletely understood. Proposed mechanisms, mainly derived from paraneoplastic cases, include tumor-driven immune responses with cross-reactivity to epidermal antigens, circulating immune complexes, and antigenic stimulation at the dermoepidermal junction (, ). However, these hypotheses do not fully explain the characteristic clinical morphology—rapidly migrating concentric erythematous bands with a “wood-grain” pattern (~1 cm/day)—highlighting the still elusive pathophysiology of the disease. Histopathology remains nonspecific, serving primarily to rule out alternative diagnoses rather than to confirm EGR, thereby reinforcing that the condition remains a clinical diagnosis of exclusion (). Our case suggests that EGR may not be confined to older or Caucasian populations with underlying malignancy. In this non-Caucasian woman in her late thirties, no evidence of cancer was found, and the cutaneous lesions resolved within 2 months following a therapeutic total hysterectomy performed for benign, refractory gynecological disease. Although this temporal relationship is notable, causality cannot be definitively established, and the medium-term recurrence risk remains unknown. Limitations of this report include the short follow-up period and the absence of specific immunologic markers directly linking benign gynecological conditions to EGR, making mechanistic interpretations purely hypothesis-generating. From a pathogenetic perspective, adenomyosis and endometriosis are characterized by immune dysregulation, hormonal influences, and increased pro-inflammatory mediators (). Adenomyosis has been associated with a relative reduction in regulatory T cells (Tregs), an increased Th17/Treg ratio, and activation of the HMGB1/TLR4 pathway, contributing to a chronic pro-inflammatory environment (). Endometriosis is characterized by macrophage infiltration, reduced natural killer (NK) cell cytotoxicity, and a cytokine milieu that includes IL-1β, IL-6, TNF-α, IL-10, and TGF-β (). Biomarkers such as VEGF, MCP-1, and CA-125 have shown diagnostic utility for endometriosis, particularly in relation to the menstrual cycle phase (). In line with these findings, our patient presented with elevated serum CA-125 and a sparse, non-specific lymphocytic infiltrate on skin biopsy. Previous studies in EGR have reported immune complex deposition (IgG and C3) and systemic immunologic alterations, including decreased T-cell populations and impaired cell-mediated immunity (). However, available data remain limited and heterogeneous. Future studies are needed to clarify the precise immunopathogenic mechanisms linking EGR with both paraneoplastic and non-paraneoplastic inflammatory conditions, including endometriosis-related disorders. 4 Conclusion This case expands the spectrum of non-paraneoplastic EGR and suggests a possible, though unproven, association with adenomyosis and endometriosis. While causality cannot be inferred due to the limited follow-up, the case supports the notion that EGR may arise within diverse immunologic or inflammatory contexts. Clinicians should consider both paraneoplastic and non-paraneoplastic etiologies in patients presenting with EGR. Comprehensive, age-appropriate malignancy screening remains essential to exclude underlying neoplasia and ensure timely management. Furthermore, a multidisciplinary approach is crucial in guiding the diagnostic evaluation and therapeutic decision-making, thereby reducing the potential morbidity associated with unrecognized triggers of EGR. Statements Data availability statement The datasets presented in this article are not readily available because the authors obtained written informed consent from the patient for the publication of the photograph and medical information in print and online, with the understanding that this information may be publicly available. Requests to access the datasets should be directed to [email protected]. Ethics statement The authors obtained written informed consent from the patient for the publication of the photograph and medical information in print and online, with the understanding that this information may be publicly available. The consent form was not provided to the journal but is retained by the authors. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. Author contributions ES: Writing – original draft. DS: Investigation, Resources, Writing – review & editing. AK: Investigation, Resources, Writing – review & editing. FP: Resources, Validation, Writing – review & editing. LF: Resources, Writing – review & editing. FR: Conceptualization, Writing – original draft, Writing – review & editing. Funding The author(s) declared that financial support was not received for this work and/or its publication. Acknowledgments The authors gratefully acknowledge the multidisciplinary team for their invaluable contributions to the diagnostic work-up and therapeutic management of this case. Conflict of interest The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Generative AI statement The author(s) declared that generative AI was used in the creation of this manuscript. The author(s) declared that generative AI was used in the creation of this manuscript. The authors acknowledge the use of ChatGPT (OpenAI, San Francisco, CA, USA) and Gemini (Google, Mountain View, CA, USA) for language editing and text refinement. All content was critically reviewed, and the authors take full responsibility for the final manuscript. 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adenomyosis, case report, endometriosis, erythema gyratum repens, hysterectomy Citation Scala E, Sordi D, Kalaja A, Passarelli F, Francesconi L and Russo F (2026) Case Report: Erythema gyratum repens associated with adenomyosis and endometriosis: an immunological twist?. Front. Immunol. 17:1835278. doi: 10.3389/fimmu.2026.1835278 Received 20 March 2026 Revised 15 June 2026 Accepted 25 June 2026 Published 10 July 2026 Volume 17 - 2026 Edited by Pablo C Ortiz-Lazareno, Centro de Investigación Biomédica de Occidente (CIBO), Mexico Reviewed by Jorge Raul Vazquez Urrutia, The Pennsylvania State University, PA, United States Mohammed Misbah Ul Haq, Deccan School of Pharmacy, India Updates Copyright © 2026 Scala, Sordi, Kalaja, Passarelli, Francesconi and Russo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: Filomena Russo, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.