Identification of Spinster Homolog 3 as a novel putative LL-37 receptor

Background Antimicrobial Peptides are primitive components of the innate immune response. LL-37, a human antimicrobial peptide, has been researched for its therapeutic potential in immune-inflammatory diseases. This study aimed to identify novel LL-37 receptors. Methods and Results Using the phage display technique, the sequence GNWSFV was selected and found to bind to LL-37. BLAST analysis revealed that this sequence has a high degree of similarity to a portion of human transmembrane protein Spinster Homolog 3. Conclusion Our study suggests that Spinster Homolog 3 may be a potential therapeutic target for LL-37-related diseases.